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Aliases for AP1G2 Gene

Aliases for AP1G2 Gene

  • Adaptor Related Protein Complex 1 Gamma 2 Subunit 2 3 5
  • Gamma2-Adaptin 3 4
  • G2AD 3 4
  • Clathrin-Associated/Assembly/Adaptor Protein, Large, Gamma-2 3
  • Adaptor-Related Protein Complex 1, Gamma 2 Subunit 2
  • Adaptor-Related Protein Complex 1 Gamma 2 Subunit 2
  • AP-1 Complex Subunit Gamma-Like 2 3

External Ids for AP1G2 Gene

Previous GeneCards Identifiers for AP1G2 Gene

  • GC14M021401
  • GC14M017817
  • GC14M022018
  • GC14M023098
  • GC14M024028
  • GC14M004145

Summaries for AP1G2 Gene

Entrez Gene Summary for AP1G2 Gene

  • Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is compsed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. Several alternatively spliced transcript variants of this gene exist, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

GeneCards Summary for AP1G2 Gene

AP1G2 (Adaptor Related Protein Complex 1 Gamma 2 Subunit) is a Protein Coding gene. Diseases associated with AP1G2 include Cardiac Arrest and Long Qt Syndrome 1. Among its related pathways are CTLA4 Signaling and Clathrin derived vesicle budding. GO annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is AP1G1.

UniProtKB/Swiss-Prot for AP1G2 Gene

  • May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).

Gene Wiki entry for AP1G2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AP1G2 Gene

Genomics for AP1G2 Gene

Regulatory Elements for AP1G2 Gene

Enhancers for AP1G2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G023536 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.5 +31.3 31324 3.8 FOXA2 SIN3A ZNF2 ETS1 ZNF143 ZNF263 MIER2 REST ZNF579 ZNF610 AP1G2 THTPA MYH6 ZFHX2 JPH4 CMTM5 SLC22A17 DHRS4L2 ENSG00000273618
GH14G023566 1.4 Ensembl ENCODE 20.4 +1.2 1222 3.7 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 KHNYN RNA5SP383 MMP14 NYNRIN AP1G2 C14orf119 LOC102724814 NFATC4 HOMEZ ABHD4
GH14G023555 1.1 ENCODE 23.4 +11.9 11912 4.7 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 AP1G2 DHRS4-AS1 ZFHX2 LOC102724814
GH14G023550 1.1 ENCODE 23.3 +18.3 18275 2.2 HDGF MLX ARNT AGO1 ZFP64 ARID4B SIN3A YY1 ZNF143 ZNF263 AP1G2 KHNYN RNA5SP383 LOC102724814 NOP9 BCL2L2-PABPN1 LTB4R2 CIDEB ZFHX2 ENSG00000273618
GH14G023562 1 ENCODE 23.9 +6.2 6198 1.6 PKNOX1 FOXA2 ARID4B SIN3A YY1 TCF12 SLC30A9 ZNF143 FOS REST AP1G2 JPH4 LOC102724814
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around AP1G2 on UCSC Golden Path with GeneCards custom track

Genomic Location for AP1G2 Gene

23,559,563 bp from pter
23,569,545 bp from pter
9,983 bases
Minus strand

Genomic View for AP1G2 Gene

Genes around AP1G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AP1G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AP1G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AP1G2 Gene

Proteins for AP1G2 Gene

  • Protein details for AP1G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AP-1 complex subunit gamma-like 2
    Protein Accession:
    Secondary Accessions:
    • D3DS51
    • O75504

    Protein attributes for AP1G2 Gene

    785 amino acids
    Molecular mass:
    87117 Da
    Quaternary structure:
    • Probably interacts with AP1S1/Sigma1A-adaptin AP1S2/Sigma1B-adaptin. Probably does not interact with APB1. Interacts with HBV major surface antigen L. Interacts with HBV core protein C in a ubiquitin-dependent manner. Binds ubiquitin.
    • Sequence=AAC67390.1; Type=Frameshift; Positions=713; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AP1G2 Gene

neXtProt entry for AP1G2 Gene

Post-translational modifications for AP1G2 Gene

  • Ubiquitination at posLast=77, posLast=145145, and posLast=584584
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for AP1G2 Gene

Domains & Families for AP1G2 Gene

Suggested Antigen Peptide Sequences for AP1G2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the adaptor complexes large subunit family.
  • Belongs to the adaptor complexes large subunit family.
genes like me logo Genes that share domains with AP1G2: view

No data available for Gene Families for AP1G2 Gene

Function for AP1G2 Gene

Molecular function for AP1G2 Gene

UniProtKB/Swiss-Prot Function:
May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV).

Gene Ontology (GO) - Molecular Function for AP1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12505986
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with AP1G2: view

Phenotypes for AP1G2 Gene

genes like me logo Genes that share phenotypes with AP1G2: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AP1G2 Gene

Localization for AP1G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AP1G2 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Mainly localized to perinuclear vesicular structures (PubMed:9733768). Colocalizes with HBV major surface antigen L and HBV core protein C in CD63-containing compartments (PubMed:16867982). Colocalizes with HBV major surface antigen L to cis-Golgi-like structures (PubMed:11333915).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AP1G2 gene
Compartment Confidence
golgi apparatus 5
endosome 4
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for AP1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus TAS 9762922
GO:0005798 Golgi-associated vesicle IDA 9762922
GO:0010008 endosome membrane IEA --
genes like me logo Genes that share ontologies with AP1G2: view

Pathways & Interactions for AP1G2 Gene

genes like me logo Genes that share pathways with AP1G2: view

Pathways by source for AP1G2 Gene

1 GeneGo (Thomson Reuters) pathway for AP1G2 Gene
1 Qiagen pathway for AP1G2 Gene

Gene Ontology (GO) - Biological Process for AP1G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0016032 viral process IEA --
GO:0016192 vesicle-mediated transport IEA,NAS 9733768
genes like me logo Genes that share ontologies with AP1G2: view

No data available for SIGNOR curated interactions for AP1G2 Gene

Drugs & Compounds for AP1G2 Gene

No Compound Related Data Available

Transcripts for AP1G2 Gene

Unigene Clusters for AP1G2 Gene

Adaptor-related protein complex 1, gamma 2 subunit:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for AP1G2 Gene

No ASD Table

Relevant External Links for AP1G2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AP1G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AP1G2 Gene

Protein differential expression in normal tissues from HIPED for AP1G2 Gene

This gene is overexpressed in Lymph node (15.5), Peripheral blood mononuclear cells (11.4), and Testis (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for AP1G2 Gene

Protein tissue co-expression partners for AP1G2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AP1G2 Gene:


SOURCE GeneReport for Unigene cluster for AP1G2 Gene:


mRNA Expression by UniProt/SwissProt for AP1G2 Gene:

Tissue specificity: Expressed in all but one (skeletal muscle) tissues examined.

Evidence on tissue expression from TISSUES for AP1G2 Gene

  • Liver(4.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with AP1G2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AP1G2 Gene

Orthologs for AP1G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AP1G2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AP1G2 34 35
  • 99.7 (n)
(Canis familiaris)
Mammalia AP1G2 34 35
  • 89.31 (n)
(Bos Taurus)
Mammalia AP1G2 34 35
  • 88.47 (n)
(Mus musculus)
Mammalia Ap1g2 34 16 35
  • 86.45 (n)
(Rattus norvegicus)
Mammalia LOC100362547 34
  • 86.22 (n)
(Monodelphis domestica)
Mammalia AP1G2 35
  • 79 (a)
(Danio rerio)
Actinopterygii ap1g2 35
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta AP-1gamma 36 35
  • 57 (a)
(Caenorhabditis elegans)
Secernentea apg-1 35
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR064C 34
  • 45.88 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06579g 34
  • 43.58 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes APL4 34 35
  • 43.51 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
Species where no ortholog for AP1G2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for AP1G2 Gene

Gene Tree for AP1G2 (if available)
Gene Tree for AP1G2 (if available)

Paralogs for AP1G2 Gene

Paralogs for AP1G2 Gene

(2) SIMAP similar genes for AP1G2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with AP1G2: view

Variants for AP1G2 Gene

Sequence variations from dbSNP and Humsavar for AP1G2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000020209 -- 23,562,724(+) AAAGC(A/G)AGACC intron-variant, downstream-variant-500B
rs1000021465 -- 23,563,336(+) GCAAG(G/T)GAGTG intron-variant
rs1000130078 -- 23,569,116(+) CTAGG(A/C)CTCAG upstream-variant-2KB, utr-variant-3-prime
rs1000175614 -- 23,569,344(+) AGACA(A/G)CAACT upstream-variant-2KB, utr-variant-3-prime
rs1000255769 -- 23,569,757(+) CGAGG(A/T)CAGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for AP1G2 Gene

Variant ID Type Subtype PubMed ID
nsv564044 CNV loss 21841781
nsv952817 CNV deletion 24416366

Variation tolerance for AP1G2 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AP1G2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AP1G2 Gene

Disorders for AP1G2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AP1G2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cardiac arrest
  • cardiopulmonary arrest
long qt syndrome 1
  • long qt syndrome 1, acquired
- elite association - COSMIC cancer census association via MalaCards
Search AP1G2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AP1G2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with AP1G2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AP1G2 Gene

Publications for AP1G2 Gene

  1. Identification and characterization of novel clathrin adaptor-related proteins. (PMID: 9733768) Takatsu H. … Nakayama K. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Cloning, expression, and localization of a novel gamma-adaptin-like molecule. (PMID: 9762922) Lewin D.A. … Mellman I. (FEBS Lett. 1998) 2 3 4 22 64
  3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 46 64
  4. gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway. (PMID: 18772139) Rost M. … Prange R. (J. Biol. Chem. 2008) 3 22 64
  5. Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. (PMID: 17553870) Lambert C. … Prange R. (J. Virol. 2007) 3 4 64

Products for AP1G2 Gene

  • Addgene plasmids for AP1G2

Sources for AP1G2 Gene

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