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Aliases for CCNA2 Gene

Aliases for CCNA2 Gene

  • Cyclin A2 2 3
  • Cyclin-A 3 4
  • CCN1 3 4
  • CCNA 3 4

External Ids for CCNA2 Gene

Previous HGNC Symbols for CCNA2 Gene

  • CCNA
  • CCN1

Previous GeneCards Identifiers for CCNA2 Gene

  • GC04M123663
  • GC04M123018
  • GC04M123130
  • GC04M123197
  • GC04M123096
  • GC04M122957
  • GC04M122737
  • GC04M118464

Summaries for CCNA2 Gene

Entrez Gene Summary for CCNA2 Gene

  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCNA2 Gene

CCNA2 (Cyclin A2) is a Protein Coding gene. Diseases associated with CCNA2 include thyroid lymphoma and retinoblastoma. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include protein kinase binding. An important paralog of this gene is CCND2.

UniProtKB/Swiss-Prot for CCNA2 Gene

  • Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Wiki entry for CCNA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCNA2 Gene

Genomics for CCNA2 Gene

Regulatory Elements for CCNA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CCNA2 Gene

Chromosome:
4
Start:
121,816,444 bp from pter
End:
121,823,933 bp from pter
Size:
7,490 bases
Orientation:
Minus strand

Genomic View for CCNA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCNA2 Gene

Proteins for CCNA2 Gene

  • Protein details for CCNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20248-CCNA2_HUMAN
    Recommended name:
    Cyclin-A2
    Protein Accession:
    P20248
    Secondary Accessions:
    • A8K7B6
    • Q2M3U6
    • Q4W5P4
    • Q6LER8

    Protein attributes for CCNA2 Gene

    Size:
    432 amino acids
    Molecular mass:
    48551 Da
    Quaternary structure:
    • Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. Interacts with human cytomegalovirus protein UL32 (PubMed:24101496).

    Three dimensional structures from OCA and Proteopedia for CCNA2 Gene

neXtProt entry for CCNA2 Gene

Proteomics data for CCNA2 Gene at MOPED

Post-translational modifications for CCNA2 Gene

  • Polyubiquitinated via Lys-11-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity).
  • Ubiquitination at Lys 54
  • Modification sites at PhosphoSitePlus

Other Protein References for CCNA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CCNA2 Gene

Domains & Families for CCNA2 Gene

Gene Families for CCNA2 Gene

Protein Domains for CCNA2 Gene

Suggested Antigen Peptide Sequences for CCNA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20248

UniProtKB/Swiss-Prot:

CCNA2_HUMAN :
  • Belongs to the cyclin family. Cyclin AB subfamily.
Family:
  • Belongs to the cyclin family. Cyclin AB subfamily.
genes like me logo Genes that share domains with CCNA2: view

Function for CCNA2 Gene

Molecular function for CCNA2 Gene

GENATLAS Biochemistry:
cyclin A,complexing with CDC2,regulating late S and G2 phase of the cell cycle,putative up-regulated c-Myc target gene,
UniProtKB/Swiss-Prot Function:
Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions

Gene Ontology (GO) - Molecular Function for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8411358
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with CCNA2: view
genes like me logo Genes that share phenotypes with CCNA2: view

Animal Models for CCNA2 Gene

MGI Knock Outs for CCNA2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CCNA2 Gene

Localization for CCNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCNA2 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCNA2 Gene COMPARTMENTS Subcellular localization image for CCNA2 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001939 female pronucleus IEA --
GO:0001940 male pronucleus IEA --
GO:0005634 nucleus IDA 16109376
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 23791195
genes like me logo Genes that share ontologies with CCNA2: view

Pathways & Interactions for CCNA2 Gene

SuperPathways for CCNA2 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 DNA Double-Strand Break Repair
3 Cell cycle Cell cycle (generic schema)
4 Cellular Senescence
5 GPCR Pathway
genes like me logo Genes that share pathways with CCNA2: view

PCR Array Products

SIGNOR curated interactions for CCNA2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CCNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0007095 mitotic G2 DNA damage checkpoint TAS 1312467
genes like me logo Genes that share ontologies with CCNA2: view

Drugs & Compounds for CCNA2 Gene

(108) Drugs for CCNA2 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Amsacrine Approved Pharma 8
Celecoxib Approved, Investigational Pharma Inhibition, Inhibitor Selective cyclooxygenase-2 (COX-2) inhibitor 395
Cetrorelix Approved, Investigational Pharma Antagonist 53
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Colchicine Approved Pharma Antagonist Tubulin Inhibitor 103

(47) Additional Compounds for CCNA2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
12-O-Tetradecanoylphorbol 13-acetate
5fluorouracil
8-Bromo cgmp
adenylate
adpribose
genes like me logo Genes that share compounds with CCNA2: view

Transcripts for CCNA2 Gene

mRNA/cDNA for CCNA2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(221) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CCNA2 Gene

Cyclin A2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CCNA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCNA2 Gene

No ASD Table

Relevant External Links for CCNA2 Gene

GeneLoc Exon Structure for
CCNA2
ECgene alternative splicing isoforms for
CCNA2

Expression for CCNA2 Gene

mRNA expression in normal human tissues for CCNA2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CCNA2 Gene



SOURCE GeneReport for Unigene cluster for CCNA2 Gene Hs.58974

genes like me logo Genes that share expression patterns with CCNA2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CCNA2 Gene

Orthologs for CCNA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CCNA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCNA2 35
  • 90.62 (n)
  • 90.7 (a)
CCNA2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCNA2 35
  • 91.82 (n)
  • 91.44 (a)
CCNA2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccna2 35
  • 86.65 (n)
  • 89.32 (a)
Ccna2 16
Ccna2 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCNA2 35
  • 99.46 (n)
  • 99.54 (a)
CCNA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccna2 35
  • 87.85 (n)
  • 89.69 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CCNA2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCNA2 35
  • 68.21 (n)
  • 70.95 (a)
CCNA2 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCNA2 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccna2 35
  • 65.08 (n)
  • 64.91 (a)
Str.6336 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397933 35
zebrafish
(Danio rerio)
Actinopterygii ccna2 35
  • 65.03 (n)
  • 66.24 (a)
ccna2 36
  • 49 (a)
OneToMany
CCNA2 (2 of 2) 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CycA 37
  • 49 (a)
CycA 35
  • 52.83 (n)
  • 49.8 (a)
CycA 36
  • 31 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012413 35
  • 57.14 (n)
  • 56.43 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK507.6 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLN1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CYCA2;4 35
  • 47.65 (n)
  • 39.95 (a)
rice
(Oryza sativa)
Liliopsida Os12g0502300 35
  • 51.94 (n)
  • 46.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10122 36
  • 58 (a)
OneToMany
Species with no ortholog for CCNA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CCNA2 Gene

ENSEMBL:
Gene Tree for CCNA2 (if available)
TreeFam:
Gene Tree for CCNA2 (if available)

Paralogs for CCNA2 Gene

Paralogs for CCNA2 Gene

(4) SIMAP similar genes for CCNA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CCNA2: view

Variants for CCNA2 Gene

Sequence variations from dbSNP and Humsavar for CCNA2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_018819 -

Variation tolerance for CCNA2 Gene

Residual Variation Intolerance Score: 39.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCNA2 Gene

HapMap Linkage Disequilibrium report
CCNA2
Human Gene Mutation Database (HGMD)
CCNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CCNA2 Gene

Disorders for CCNA2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for CCNA2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
thyroid lymphoma
retinoblastoma
  • retinoblastoma, trilateral
lung cancer
  • lung cancer, protection against
colorectal cancer
  • colorectal cancer, somatic
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association
Search CCNA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCNA2

Genetic Association Database (GAD)
CCNA2
Human Genome Epidemiology (HuGE) Navigator
CCNA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCNA2
genes like me logo Genes that share disorders with CCNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCNA2 Gene

Publications for CCNA2 Gene

  1. Clinicopathological variables, immunophenotype, chromosome 1p36 loss and tumour recurrence of 247 meningiomas grade I and II. (PMID: 20054806) Ruiz J. … Sanz-Ortega J. (Histol. Histopathol. 2010) 23 67
  2. Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation. (PMID: 19747539) Lin K.L. … Lin S.R. (Toxicol In Vitro 2010) 23 67
  3. Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway. (PMID: 19889638) Lee D.Y. … Chien S. (J. Biol. Chem. 2010) 23 67
  4. Acetylation of cyclin A: a new cell cycle regulatory mechanism. (PMID: 20074040) Mateo F. … Bachs O. (Biochem. Soc. Trans. 2010) 23 67
  5. Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain. (PMID: 20368335) Chou S.T. … Chen M.S. (J. Biol. Chem. 2010) 23 67

Products for CCNA2 Gene

Sources for CCNA2 Gene

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