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Aliases for PRPF4B Gene

Aliases for PRPF4B Gene

  • Pre-MRNA Processing Factor 4B 2 3 5
  • PRP4 Pre-MRNA-Processing Factor 4 Homolog 3 4
  • PRP4 Kinase 3 4
  • EC 2.7.11.1 4 63
  • PRP4H 3 4
  • PRP4K 3 4
  • PRP4 3 4
  • PRP4 Pre-MRNA Processing Factor 4 Homolog B (Yeast) 2
  • PRP4 Pre-MRNA Processing Factor 4 Homolog B 3
  • DJ1013A10.1 (PRP4 Protein Kinase Homolog) 3
  • Protein-Serine/Threonine Kinase 3
  • DJ1013A10.1 3
  • KIAA0536 4
  • PR4H 3

External Ids for PRPF4B Gene

Previous GeneCards Identifiers for PRPF4B Gene

  • GC06P004006
  • GC06P003966
  • GC06P003898

Summaries for PRPF4B Gene

Entrez Gene Summary for PRPF4B Gene

  • Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

GeneCards Summary for PRPF4B Gene

PRPF4B (Pre-MRNA Processing Factor 4B) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and protein kinase activity. An important paralog of this gene is CLK4.

UniProtKB/Swiss-Prot for PRPF4B Gene

  • Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

Gene Wiki entry for PRPF4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPF4B Gene

Genomics for PRPF4B Gene

Regulatory Elements for PRPF4B Gene

Genomic Location for PRPF4B Gene

Chromosome:
6
Start:
4,021,267 bp from pter
End:
4,064,983 bp from pter
Size:
43,717 bases
Orientation:
Plus strand

Genomic View for PRPF4B Gene

Genes around PRPF4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRPF4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRPF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPF4B Gene

Proteins for PRPF4B Gene

  • Protein details for PRPF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13523-PRP4B_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PRP4 homolog
    Protein Accession:
    Q13523
    Secondary Accessions:
    • A8K5C9
    • Q5D0F6
    • Q5TAY8
    • Q8IVC3
    • Q8TDP2
    • Q96QT7
    • Q9UEE6

    Protein attributes for PRPF4B Gene

    Size:
    1007 amino acids
    Molecular mass:
    116987 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with Clk1 C-terminus.
    SequenceCaution:
    • Sequence=AAH09844.1; Type=Frameshift; Positions=432; Evidence={ECO:0000305}; Sequence=BAA25462.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRPF4B Gene

neXtProt entry for PRPF4B Gene

Proteomics data for PRPF4B Gene at MOPED

Post-translational modifications for PRPF4B Gene

Other Protein References for PRPF4B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRPF4B (PRP4)

Domains & Families for PRPF4B Gene

Gene Families for PRPF4B Gene

Protein Domains for PRPF4B Gene

Suggested Antigen Peptide Sequences for PRPF4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13523

UniProtKB/Swiss-Prot:

PRP4B_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PRPF4B: view

Function for PRPF4B Gene

Molecular function for PRPF4B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

Enzyme Numbers (IUBMB) for PRPF4B Gene

Gene Ontology (GO) - Molecular Function for PRPF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with PRPF4B: view
genes like me logo Genes that share phenotypes with PRPF4B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PRPF4B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PRPF4B Gene

Localization for PRPF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRPF4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRPF4B Gene COMPARTMENTS Subcellular localization image for PRPF4B gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PRPF4B Gene

Pathways & Interactions for PRPF4B Gene

SuperPathways for PRPF4B Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with PRPF4B: view

Pathways by source for PRPF4B Gene

1 BioSystems pathway for PRPF4B Gene

SIGNOR curated interactions for PRPF4B Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PRPF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
genes like me logo Genes that share ontologies with PRPF4B: view

Drugs & Compounds for PRPF4B Gene

(1) Drugs for PRPF4B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for PRPF4B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PRPF4B: view

Transcripts for PRPF4B Gene

Unigene Clusters for PRPF4B Gene

PRP4 pre-mRNA processing factor 4 homolog B (yeast):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRPF4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ·
SP1: - - - - - - -
SP2: -
SP3: - - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 19c ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22a · 22b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5:
SP6:
SP7: - -
SP8:
SP9:

Relevant External Links for PRPF4B Gene

GeneLoc Exon Structure for
PRPF4B
ECgene alternative splicing isoforms for
PRPF4B

Expression for PRPF4B Gene

mRNA expression in normal human tissues for PRPF4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PRPF4B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRPF4B Gene



SOURCE GeneReport for Unigene cluster for PRPF4B Gene Hs.159014

mRNA Expression by UniProt/SwissProt for PRPF4B Gene

Q13523-PRP4B_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with PRPF4B: view

Protein tissue co-expression partners for PRPF4B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PRPF4B Gene

Orthologs for PRPF4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRPF4B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Prpf4b 35
  • 89.1 (n)
  • 95.23 (a)
Prpf4b 16
Prpf4b 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRPF4B 35
  • 99.8 (n)
  • 99.9 (a)
PRPF4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prpf4b 35
  • 89.1 (n)
  • 95.43 (a)
cow
(Bos Taurus)
Mammalia PRPF4B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRPF4B 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRPF4B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRPF4B 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRPF4B 35
  • 82.02 (n)
  • 89.93 (a)
PRPF4B 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRPF4B 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10066 35
zebrafish
(Danio rerio)
Actinopterygii Dr.4891 35
prpf4ba 36
  • 66 (a)
OneToMany
prpf4bb 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7851 35
fruit fly
(Drosophila melanogaster)
Insecta CG7028 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prpf-4 36
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KNS1 36
  • 18 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.13166 35
rice
(Oryza sativa)
Liliopsida Os.17376 35
corn
(Zea mays)
Liliopsida Zm.16814 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3457 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 72 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
Species with no ortholog for PRPF4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRPF4B Gene

ENSEMBL:
Gene Tree for PRPF4B (if available)
TreeFam:
Gene Tree for PRPF4B (if available)

Paralogs for PRPF4B Gene

Paralogs for PRPF4B Gene

(13) SIMAP similar genes for PRPF4B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PRPF4B Gene

genes like me logo Genes that share paralogs with PRPF4B: view

Variants for PRPF4B Gene

Sequence variations from dbSNP and Humsavar for PRPF4B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_035633 A breast cancer sample
rs9503893 - 4,031,764(+) AAGAG(A/G)TTATT nc-transcript-variant, reference, missense
VAR_047798 -
rs707980 -- 4,043,613(+) GAAGA(A/C)AGAAA intron-variant
rs707981 -- 4,043,665(+) ATTGC(A/G)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRPF4B Gene

Variant ID Type Subtype PubMed ID
nsv349483 CNV Loss 16902084
esv2527172 CNV Deletion 19546169
esv2201190 CNV Deletion 18987734
esv4480 CNV Deletion 18987735
esv993339 CNV Deletion 20482838
nsv349965 CNV Loss 16902084
esv2731501 CNV Deletion 23290073
esv1454617 CNV Deletion 17803354
esv9631 CNV Loss 19470904

Variation tolerance for PRPF4B Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRPF4B Gene

HapMap Linkage Disequilibrium report
PRPF4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRPF4B Gene

Disorders for PRPF4B Gene

Relevant External Links for PRPF4B

Genetic Association Database (GAD)
PRPF4B
Human Genome Epidemiology (HuGE) Navigator
PRPF4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRPF4B

No disorders were found for PRPF4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRPF4B Gene

Publications for PRPF4B Gene

  1. Cloning of human PRP4 reveals interaction with Clk1. (PMID: 11418604) Kojima T. … Hagiwara M. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. (PMID: 20118938) Schneider M. … LA1hrmann R. (Nat. Struct. Mol. Biol. 2010) 3 23
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  4. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. (PMID: 9102632) Gross T. … Kaeufer N.F. (Nucleic Acids Res. 1997) 3 23
  5. PRP4K is a HER2-regulated modifier of taxane sensitivity. (PMID: 25602630) Corkery D.P. … Dellaire G. (Cell Cycle 2015) 3

Products for PRPF4B Gene

Sources for PRPF4B Gene

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