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Aliases for PRPF4B Gene

Aliases for PRPF4B Gene

  • Pre-MRNA Processing Factor 4B 2 3
  • PRP4 3 4 6
  • PRP4 Pre-MRNA-Processing Factor 4 Homolog 3 4
  • PRP4 Kinase 3 4
  • EC 2.7.11.1 4 64
  • PRP4H 3 4
  • PRP4K 3 4
  • PRP4 Pre-MRNA Processing Factor 4 Homolog B (Yeast) 2
  • Serine/Threonine-Protein Kinase PRP4 Homolog 3
  • PRP4 Pre-MRNA Processing Factor 4 Homolog B 3
  • DJ1013A10.1 (PRP4 Protein Kinase Homolog) 3
  • Protein-Serine/Threonine Kinase 3
  • DJ1013A10.1 3
  • KIAA0536 4
  • PR4H 3

External Ids for PRPF4B Gene

Summaries for PRPF4B Gene

Entrez Gene Summary for PRPF4B Gene

  • Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]

GeneCards Summary for PRPF4B Gene

PRPF4B (Pre-MRNA Processing Factor 4B) is a Protein Coding gene. Among its related pathways are Translational Control and mRNA Splicing - Major Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is CLK4.

UniProtKB/Swiss-Prot for PRPF4B Gene

  • Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF

Gene Wiki entry for PRPF4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPF4B Gene

Genomics for PRPF4B Gene

Genomic Location for PRPF4B Gene

Start:
4,021,267 bp from pter
End:
4,064,983 bp from pter
Size:
43,717 bases
Orientation:
Plus strand

Genomic View for PRPF4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRPF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPF4B Gene

Regulatory Elements for PRPF4B Gene

Proteins for PRPF4B Gene

  • Protein details for PRPF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13523-PRP4B_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PRP4 homolog
    Protein Accession:
    Q13523
    Secondary Accessions:
    • A8K5C9
    • Q5D0F6
    • Q5TAY8
    • Q8IVC3
    • Q8TDP2
    • Q96QT7
    • Q9UEE6

    Protein attributes for PRPF4B Gene

    Size:
    1007 amino acids
    Molecular mass:
    116987 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with Clk1 C-terminus.
    SequenceCaution:
    • Sequence=AAH09844.1; Type=Frameshift; Positions=432; Evidence={ECO:0000305}; Sequence=BAA25462.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRPF4B Gene

neXtProt entry for PRPF4B Gene

Proteomics data for PRPF4B Gene at MOPED

Post-translational modifications for PRPF4B Gene

Other Protein References for PRPF4B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PRPF4B Gene

Protein Domains for PRPF4B Gene

UniProtKB/Swiss-Prot:

PRP4B_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q13523
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.:
    • Q13523
genes like me logo Genes that share domains with PRPF4B: view

Function for PRPF4B Gene

Molecular function for PRPF4B Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF

Enzyme Numbers (IUBMB) for PRPF4B Gene

Gene Ontology (GO) - Molecular Function for PRPF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9102632
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 15452250
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PRPF4B: view
genes like me logo Genes that share phenotypes with PRPF4B: view

miRNA for PRPF4B Gene

miRTarBase miRNAs that target PRPF4B

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PRPF4B Gene

Localization for PRPF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRPF4B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRPF4B Gene COMPARTMENTS Subcellular localization image for PRPF4B gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for PRPF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with PRPF4B: view

Pathways for PRPF4B Gene

genes like me logo Genes that share pathways with PRPF4B: view

Pathways by source for PRPF4B Gene

1 Cell Signaling Technology pathway for PRPF4B Gene
1 BioSystems pathway for PRPF4B Gene

Gene Ontology (GO) - Biological Process for PRPF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006468 protein phosphorylation IEA --
GO:0008380 RNA splicing TAS 9102632
genes like me logo Genes that share ontologies with PRPF4B: view

Compounds for PRPF4B Gene

(2) HMDB Compounds for PRPF4B Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with PRPF4B: view

Transcripts for PRPF4B Gene

Unigene Clusters for PRPF4B Gene

PRP4 pre-mRNA processing factor 4 homolog B (yeast):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRPF4B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b ·
SP1: - - - - - - -
SP2: -
SP3: - - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 19c ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22a · 22b
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - - -
SP5:
SP6:
SP7: - -
SP8:
SP9:

Relevant External Links for PRPF4B Gene

GeneLoc Exon Structure for
PRPF4B
ECgene alternative splicing isoforms for
PRPF4B

Expression for PRPF4B Gene

mRNA expression in normal human tissues for PRPF4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRPF4B Gene

SOURCE GeneReport for Unigene cluster for PRPF4B Gene Hs.159014

mRNA Expression by UniProt/SwissProt for PRPF4B Gene

Q13523-PRP4B_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PRPF4B: view

Orthologs for PRPF4B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRPF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRPF4B 36
  • 99.8 (n)
  • 99.9 (a)
PRPF4B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRPF4B 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRPF4B 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prpf4b 36
  • 89.1 (n)
  • 95.23 (a)
Prpf4b 16
Prpf4b 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRPF4B 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRPF4B 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prpf4b 36
  • 89.1 (n)
  • 95.43 (a)
chicken
(Gallus gallus)
Aves PRPF4B 36
  • 82.02 (n)
  • 89.93 (a)
PRPF4B 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRPF4B 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10066 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7851 36
zebrafish
(Danio rerio)
Actinopterygii Dr.4891 36
prpf4ba 37
  • 66 (a)
OneToMany
prpf4bb 37
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7028 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea prpf-4 37
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KNS1 37
  • 18 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.13166 36
corn
(Zea mays)
Liliopsida Zm.16814 36
rice
(Oryza sativa)
Liliopsida Os.17376 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3457 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 72 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
Species with no ortholog for PRPF4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PRPF4B Gene

ENSEMBL:
Gene Tree for PRPF4B (if available)
TreeFam:
Gene Tree for PRPF4B (if available)

Paralogs for PRPF4B Gene

Paralogs for PRPF4B Gene

Selected SIMAP similar genes for PRPF4B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PRPF4B Gene

genes like me logo Genes that share paralogs with PRPF4B: view

Variants for PRPF4B Gene

Sequence variations from dbSNP and Humsavar for PRPF4B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs644150 -- 4,062,431(+) AATAT(A/G)TGTAA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs654954 -- 4,061,537(+) GACAA(A/C)GTAAT utr-variant-3-prime, nc-transcript-variant, intron-variant
rs664264 -- 4,056,939(+) TAGTC(C/T)AAGCT intron-variant, utr-variant-3-prime
rs697745 -- 4,045,280(+) cttac(A/G)aatgt intron-variant
rs707980 -- 4,043,613(+) GAAGA(A/C)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRPF4B Gene

Variant ID Type Subtype PubMed ID
nsv349483 CNV Loss 16902084
esv2527172 CNV Deletion 19546169
esv2201190 CNV Deletion 18987734
esv4480 CNV Deletion 18987735
esv993339 CNV Deletion 20482838
nsv349965 CNV Loss 16902084
esv2731501 CNV Deletion 23290073
esv1454617 CNV Deletion 17803354
esv9631 CNV Loss 19470904

Relevant External Links for PRPF4B Gene

HapMap Linkage Disequilibrium report
PRPF4B

Disorders for PRPF4B Gene

Relevant External Links for PRPF4B

Genetic Association Database (GAD)
PRPF4B
Human Genome Epidemiology (HuGE) Navigator
PRPF4B
genes like me logo Genes that share disorders with PRPF4B: view

No data available for UniProtKB/Swiss-Prot for PRPF4B Gene

Publications for PRPF4B Gene

  1. Cloning of human PRP4 reveals interaction with Clk1. (PMID: 11418604) Kojima T. … Hagiwara M. (J. Biol. Chem. 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue. (PMID: 9102632) Gross T. … Kaeufer N.F. (Nucleic Acids Res. 1997) 3 4 23
  4. Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. (PMID: 20118938) Schneider M. … LA1hrmann R. (Nat. Struct. Mol. Biol. 2010) 3 23
  5. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4

Products for PRPF4B Gene

Sources for PRPF4B Gene

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