Aliases for EIF2B2 Gene
Aliases for EIF2B2 Gene
- Eukaryotic Translation Initiation Factor 2B Subunit Beta 2 3 5
- Eukaryotic Translation Initiation Factor 2B, Subunit 2 Beta, 39kDa 2 3
- EIF-2B GDP-GTP Exchange Factor Subunit Beta 3 4
- S20III15 3 4
- S20I15 3 4
- Eukaryotic Translation Initiation Factor 2B, Subunit 2 (Beta, 39kD) 2
- EIF-2Bbeta 3
- EIF2BB 4
- EIF2B 3
External Ids for EIF2B2 Gene
- HGNC: 3258
- Entrez Gene: 8892
- Ensembl: ENSG00000119718
- OMIM: 606454
- UniProtKB: P49770
Previous GeneCards Identifiers for EIF2B2 Gene
- GC14P072996
- GC14P069286
- GC14P073459
- GC14P074539
- GC14P075469
- GC14P055637
Summaries for EIF2B2 Gene
-
This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]
GeneCards Summary for EIF2B2 Gene
EIF2B2 (Eukaryotic Translation Initiation Factor 2B Subunit Beta) is a Protein Coding gene. Diseases associated with EIF2B2 include Leukoencephalopathy With Vanishing White Matter and Late Infantile Cach Syndrome. Among its related pathways are Gene Expression and Translation Insulin regulation of translation. GO annotations related to this gene include GTP binding and translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF2B2 Gene
-
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF2B2 Gene
Genomics for EIF2B2 Gene
Regulatory Elements for EIF2B2 Gene
Enhancers for EIF2B2 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around EIF2B2 on UCSC Golden Path with GeneCards custom track
Promoters for EIF2B2 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around EIF2B2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the EIF2B2 gene promoter:
Regulatory Element Products
Genomic Location for EIF2B2 Gene
- Chromosome:
- 14
- Start:
- 75,002,909 bp from pter
- End:
- 75,012,366 bp from pter
- Size:
- 9,458 bases
- Orientation:
- Plus strand
Genomic View for EIF2B2 Gene
Genes around EIF2B2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q24.3 by Ensembl
- 14q24.3 by Entrez Gene
- 14q24.3 by HGNC
EIF2B2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for EIF2B2 Gene
Proteins for EIF2B2 Gene
-
Protein details for EIF2B2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49770-EI2BB_HUMAN
- Recommended name:
- Translation initiation factor eIF-2B subunit beta
- Protein Accession:
- P49770
- O43201
Protein attributes for EIF2B2 Gene
- Size:
- 351 amino acids
- Molecular mass:
- 38990 Da
- Quaternary structure:
-
- Complex of five different subunits; alpha, beta, gamma, delta and epsilon.
- SequenceCaution:
-
- Sequence=AAC42002.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Protein Expression for EIF2B2 Gene
Post-translational modifications for EIF2B2 Gene
Other Protein References for EIF2B2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for EIF2B2
- Abcam antibodies for EIF2B2
- Invitrogen Antibodies for EIF2B2
- antibodies-online Antibodies for EIF2B2: See all 35
- GeneTex EIF2B2 antibody for EIF2B2
-
Santa Cruz Biotechnology (SCBT) Antibodies for EIF2B2
Protein Products
-
OriGene Purified Proteins for EIF2B2
- Search Origene for MassSpec and Protein Over-expression Lysates for EIF2B2
- Origene Custom Protein Services for EIF2B2
- antibodies-online Proteins for EIF2B2: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for EIF2B2
Assay Products
No data available for DME Specific Peptides for EIF2B2 Gene
Domains & Families for EIF2B2 Gene
Protein Domains for EIF2B2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for EIF2B2 Gene
Graphical View of Domain Structure for InterPro Entry
P49770- Family:
-
- Belongs to the eIF-2B alpha/beta/delta subunits family.
No data available for Gene Families for EIF2B2 Gene
Function for EIF2B2 Gene
Molecular function for EIF2B2 Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
Phenotypes for EIF2B2 Gene
- MGI mutant phenotypes for EIF2B2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for EIF2B2:
-
- Increased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Decreased NF-kappaB reporter expression
- Decreased viability with paclitaxel
- Decreased POU5F1-GFP protein expression
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased viability with TRAIL
Animal Models for EIF2B2 Gene
- MGI Knock Outs for EIF2B2:
-
- Eif2b2 tm2a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for EIF2B2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF2B2
- GenScript: Design CRISPR guide RNA sequences for EIF2B2
miRNA for EIF2B2 Gene
- miRTarBase miRNAs that target EIF2B2
-
- hsa-mir-155-5p (MIRT020527)
- hsa-mir-16-5p (MIRT031428)
- hsa-mir-455-3p (MIRT037833)
- hsa-mir-92b-3p (MIRT040533)
- hsa-mir-92a-3p (MIRT049061)
- hsa-mir-17-5p (MIRT280206)
- hsa-mir-20a-5p (MIRT280207)
- hsa-mir-93-5p (MIRT280208)
- hsa-mir-106a-5p (MIRT280209)
- hsa-mir-106b-5p (MIRT280210)
- hsa-mir-20b-5p (MIRT280211)
- hsa-mir-526b-3p (MIRT280212)
- hsa-mir-519d-3p (MIRT280213)
- hsa-mir-3686 (MIRT658782)
- hsa-mir-4279 (MIRT658783)
- hsa-mir-6881-3p (MIRT658784)
- hsa-mir-1298-5p (MIRT658785)
- hsa-mir-4742-3p (MIRT658786)
- hsa-mir-6515-3p (MIRT658787)
- hsa-mir-877-3p (MIRT658788)
- hsa-mir-4778-5p (MIRT658789)
- hsa-mir-4686 (MIRT658790)
- hsa-mir-6838-5p (MIRT658791)
- hsa-mir-497-5p (MIRT658792)
- hsa-mir-424-5p (MIRT658793)
- hsa-mir-195-5p (MIRT658794)
- hsa-mir-15b-5p (MIRT658795)
- hsa-mir-15a-5p (MIRT658796)
- hsa-mir-3184-3p (MIRT658797)
- hsa-mir-378a-5p (MIRT664680)
- hsa-mir-6821-3p (MIRT664681)
- hsa-mir-6790-3p (MIRT664682)
- hsa-mir-324-3p (MIRT664683)
- hsa-mir-1913 (MIRT664684)
- hsa-mir-3653-5p (MIRT664685)
- hsa-mir-5193 (MIRT664686)
- hsa-mir-4667-3p (MIRT664687)
- hsa-mir-8079 (MIRT664688)
- hsa-mir-1245a (MIRT664689)
- hsa-mir-5089-5p (MIRT695962)
- hsa-mir-5589-5p (MIRT695963)
- hsa-mir-4731-5p (MIRT695964)
- hsa-mir-6778-3p (MIRT695965)
- hsa-mir-4290 (MIRT695966)
- hsa-mir-6506-5p (MIRT695967)
- hsa-mir-619-5p (MIRT695968)
- hsa-mir-18a-3p (MIRT695969)
- hsa-mir-150-5p (MIRT695970)
- hsa-mir-186-3p (MIRT695971)
- hsa-mir-520h (MIRT695972)
- hsa-mir-520g-3p (MIRT695973)
- hsa-mir-512-3p (MIRT695974)
- hsa-mir-520e (MIRT695975)
- hsa-mir-520d-3p (MIRT695976)
- hsa-mir-520c-3p (MIRT695977)
- hsa-mir-520b (MIRT695978)
- hsa-mir-520a-3p (MIRT695979)
- hsa-mir-373-3p (MIRT695980)
- hsa-mir-372-3p (MIRT695981)
- hsa-mir-302e (MIRT695982)
- hsa-mir-302d-3p (MIRT695983)
- hsa-mir-302c-3p (MIRT695984)
- hsa-mir-302b-3p (MIRT695985)
- hsa-mir-302a-3p (MIRT695986)
miRNA Products
- Search ViGene Biosciences for EIF2B2
Clone Products
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for EIF2B2 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for EIF2B2 Gene
Localization for EIF2B2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| nucleus | 3 |
| plasma membrane | 3 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for EIF2B2 Gene
Pathways & Interactions for EIF2B2 Gene
More details on SuperPathways for EIF2B2| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Viral mRNA Translation |
.76
|
|
| 2 | Translation Insulin regulation of translation | ||
| 3 | NFAT and Cardiac Hypertrophy |
.37
|
|
| 4 | RNA transport | ||
| 5 | Apoptotic Pathways in Synovial Fibroblasts |
.60
|
Pathways by source for EIF2B2 Gene
1 BioSystems pathway for EIF2B2 Gene
6 Reactome pathways for EIF2B2 Gene
1 KEGG pathway for EIF2B2 Gene
2 GeneGo (Thomson Reuters) pathways for EIF2B2 Gene
5 Qiagen pathways for EIF2B2 Gene
Interacting Proteins for EIF2B2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006412 | translation | TAS | -- |
| GO:0006413 | translational initiation | IDA,TAS | 16289705 |
| GO:0006446 | regulation of translational initiation | TAS | 15060152 |
| GO:0007417 | central nervous system development | IMP | 15776425 |
| GO:0009408 | response to heat | TAS | 12499492 |
Drugs & Compounds for EIF2B2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine triphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for EIF2B2 Gene
mRNA/cDNA for EIF2B2 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (261) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for EIF2B2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for EIF2B2
-
Santa Cruz Biotechnology (SCBT) CRISPR for EIF2B2
- GenScript: Design CRISPR guide RNA sequences for EIF2B2
miRNA Products
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Clone Products
- OriGene clones in human for EIF2B2
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for EIF2B2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||
| SP4: |
Expression for EIF2B2 Gene
This gene is overexpressed in Pancreas (15.7) and Peripheral blood mononuclear cells (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF2B2 Gene
SOURCE GeneReport for Unigene cluster for EIF2B2 Gene Hs.409137
- Elite partner
Primer Products
-
OriGene qPCR primer pairs and template standards for EIF2B2
-
OriGene qPCR primer pairs for EIF2B2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF2B2 Gene
Orthologs for EIF2B2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | EIF2B2 35 |
|
||
| EIF2B2 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | EIF2B2 35 |
|
||
| EIF2B2 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Eif2b2 35 |
|
||
| Eif2b2 16 |
|
||||
| Eif2b2 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | EIF2B2 35 |
|
||
| EIF2B2 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Eif2b2 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | EIF2B2 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | EIF2B2 35 |
|
||
| EIF2B2 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | EIF2B2 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | eif2b2 35 |
|
||
| Str.5710 35 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.4626 35 |
|
||
| eif2b2 35 |
|
||||
| eif2b2 36 |
|
OneToOne | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3346 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | eIF2B-bgr 37 |
|
|
|
| eIF2B-beta 35 |
|
||||
| eIF2B-beta 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007097 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y47H9C.7 36 |
|
OneToOne | |
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR292C 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A04433g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GCD7 35 |
|
||
| GCD7 36 |
|
OneToOne | |||
| GCD7 38 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G07300 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os10g0392700 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5793 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC343.14c 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToOne |
- Species with no ortholog for EIF2B2:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for EIF2B2 Gene
No data available for Paralogs for EIF2B2 Gene
Variants for EIF2B2 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_012289 | Leukodystrophy with vanishing white matter (VWM) | ||||
| VAR_012290 | Leukodystrophy with vanishing white matter (VWM) | ||||
| VAR_012321 | Leukodystrophy with vanishing white matter (VWM) | ||||
| VAR_012322 | Leukodystrophy with vanishing white matter (VWM) | ||||
| VAR_016842 | Leukodystrophy with vanishing white matter (VWM) |
Residual Variation Intolerance Score:
27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.31;
25.98% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for EIF2B2 Gene
- Human Gene Mutation Database (HGMD)
- EIF2B2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EIF2B2 Gene
Disorders for EIF2B2 Gene
(9) MalaCards diseases for EIF2B2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukoencephalopathy with vanishing white matter |
|
|
| late infantile cach syndrome |
|
|
| juvenile or adult cach syndrome |
|
|
| congenital or early infantile cach syndrome |
|
|
| eif2b2-related childhood ataxia with central nervous system hypomyelination/vanishing white matter |
|
|
Search EIF2B2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
EI2BB_HUMAN- Leukodystrophy with vanishing white matter (VWM) [MIM:603896]: A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. {ECO:0000269 PubMed:11704758, ECO:0000269 PubMed:12707859, ECO:0000269 PubMed:15776425, ECO:0000269 PubMed:21484434, ECO:0000269 PubMed:22285377, ECO:0000269 PubMed:22729508}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for EIF2B2
No data available for Genatlas for EIF2B2 Gene
Publications for EIF2B2 Gene
- Identification of ten novel mutations in patients with eIF2B-related disorders. (PMID: 15776425) Ohlenbusch A. … Gartner J. (Hum. Mutat. 2005) 3 4 23 67
- Ovarian failure related to eukaryotic initiation factor 2B mutations. (PMID: 12707859) Fogli A. … Boespflug-Tanguy O. (Am. J. Hum. Genet. 2003) 3 23
- Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein. (PMID: 11323413) Williams D.D. … Proud C.G. (J. Biol. Chem. 2001) 3 23
- Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter. (PMID: 11704758) Leegwater P.A.J. … van der Knaap M.S. (Nat. Genet. 2001) 3 23
- Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2. (PMID: 8887689) Yang W. … Hinnebusch A.G. (Mol. Cell. Biol. 1996) 2 3
Products for EIF2B2 Gene
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- antibodies-online Antibodies for EIF2B2: See all 35
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- antibodies-online Proteins for EIF2B2: See all 9
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- Search ViGene Biosciences for EIF2B2
- Search ViGene Biosciences for EIF2B2
- Santa Cruz Biotechnology (SCBT) Antibodies for EIF2B2
- Search Santa Cruz Biotechnology (SCBT) for EIF2B2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for EIF2B2
Sources for EIF2B2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon