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Aliases for ZPR1 Gene

Aliases for ZPR1 Gene

  • ZPR1 Zinc Finger 2 3 5
  • Zinc Finger Protein 259 2 3 4
  • ZNF259 3 4

External Ids for ZPR1 Gene

Previous HGNC Symbols for ZPR1 Gene

  • ZNF259

Previous GeneCards Identifiers for ZPR1 Gene

  • GC11M116649

Summaries for ZPR1 Gene

Entrez Gene Summary for ZPR1 Gene

  • The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for ZPR1 Gene

ZPR1 (ZPR1 Zinc Finger) is a Protein Coding gene. Diseases associated with ZPR1 include spinal muscular atrophy and muscular atrophy. Among its related pathways are Translational Control and EGFR1 Signaling Pathway. GO annotations related to this gene include receptor tyrosine kinase binding and translation initiation factor binding.

UniProtKB/Swiss-Prot for ZPR1 Gene

  • Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.

Gene Wiki entry for ZPR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPR1 Gene

Genomics for ZPR1 Gene

Regulatory Elements for ZPR1 Gene

Enhancers for ZPR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ZPR1 on UCSC Golden Path with GeneCards custom track

Promoters for ZPR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZPR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZPR1 Gene

Chromosome:
11
Start:
116,773,799 bp from pter
End:
116,788,050 bp from pter
Size:
14,252 bases
Orientation:
Minus strand

Genomic View for ZPR1 Gene

Genes around ZPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPR1 Gene

Proteins for ZPR1 Gene

  • Protein details for ZPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75312-ZPR1_HUMAN
    Recommended name:
    Zinc finger protein ZPR1
    Protein Accession:
    O75312
    Secondary Accessions:
    • Q2TAA0

    Protein attributes for ZPR1 Gene

    Size:
    459 amino acids
    Molecular mass:
    50925 Da
    Quaternary structure:
    • Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and the EGFR kinase activity. May also bind to the PDGFR receptor.

neXtProt entry for ZPR1 Gene

Proteomics data for ZPR1 Gene at MOPED

Post-translational modifications for ZPR1 Gene

  • Ubiquitination at Lys 66, Lys 119, and Lys 299
  • Modification sites at PhosphoSitePlus

Other Protein References for ZPR1 Gene

No data available for DME Specific Peptides for ZPR1 Gene

Domains & Families for ZPR1 Gene

Gene Families for ZPR1 Gene

Protein Domains for ZPR1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ZPR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75312

UniProtKB/Swiss-Prot:

ZPR1_HUMAN :
  • Belongs to the ZPR1 family.
Family:
  • Belongs to the ZPR1 family.
genes like me logo Genes that share domains with ZPR1: view

Function for ZPR1 Gene

Molecular function for ZPR1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.

Gene Ontology (GO) - Molecular Function for ZPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11283611
genes like me logo Genes that share ontologies with ZPR1: view
genes like me logo Genes that share phenotypes with ZPR1: view

Animal Models for ZPR1 Gene

MGI Knock Outs for ZPR1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZPR1 Gene

Localization for ZPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPR1 Gene

Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon. Cell projection, growth cone. Note=Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ZPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9852145
genes like me logo Genes that share ontologies with ZPR1: view

No data available for Subcellular locations from COMPARTMENTS for ZPR1 Gene

Pathways & Interactions for ZPR1 Gene

genes like me logo Genes that share pathways with ZPR1: view

Pathways by source for ZPR1 Gene

1 Cell Signaling Technology pathway for ZPR1 Gene
1 BioSystems pathway for ZPR1 Gene

Gene Ontology (GO) - Biological Process for ZPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization ISS --
GO:0001833 inner cell mass cell proliferation IEA --
GO:0006397 mRNA processing IEA --
GO:0007165 signal transduction TAS 8650580
GO:0030576 Cajal body organization IEA,ISS --
genes like me logo Genes that share ontologies with ZPR1: view

No data available for SIGNOR curated interactions for ZPR1 Gene

Drugs & Compounds for ZPR1 Gene

(1) Drugs for ZPR1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZPR1: view

Transcripts for ZPR1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZPR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -
SP3:

Relevant External Links for ZPR1 Gene

GeneLoc Exon Structure for
ZPR1
ECgene alternative splicing isoforms for
ZPR1

Expression for ZPR1 Gene

mRNA expression in normal human tissues for ZPR1 Gene

Protein differential expression in normal tissues from HIPED for ZPR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1) and Lymph node (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZPR1 Gene



mRNA Expression by UniProt/SwissProt for ZPR1 Gene

O75312-ZPR1_HUMAN
Tissue specificity: Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients.
genes like me logo Genes that share expression patterns with ZPR1: view

Protein tissue co-expression partners for ZPR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZPR1 Gene

Orthologs for ZPR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZPR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF259 35
  • 89.69 (n)
  • 91.29 (a)
ZNF259 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF259 35
  • 88.89 (n)
  • 89.98 (a)
ZNF259 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp259 35
  • 87.15 (n)
  • 90.41 (a)
Zpr1 16
Zfp259 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF259 35
  • 99.56 (n)
  • 99.35 (a)
ZNF259 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp259 35
  • 86.93 (n)
  • 89.11 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF259 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF259 35
  • 73.66 (n)
  • 76.89 (a)
ZNF259 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF259 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4088 35
znf259 35
  • 69.98 (n)
  • 73.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6633 35
zebrafish
(Danio rerio)
Actinopterygii wufc17g09 35
zpr1 35
  • 68.01 (n)
  • 72.45 (a)
znf259 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004417 35
  • 55.85 (n)
  • 51.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Zpr1 35
  • 56.56 (n)
  • 50.36 (a)
Zpr1 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_W03F9.1 35
  • 50.36 (n)
  • 41.81 (a)
W03F9.1 36
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL137C 35
  • 53.95 (n)
  • 48.66 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16215g 35
  • 51.29 (n)
  • 45.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZPR1 35
  • 53.38 (n)
  • 50.37 (a)
ZPR1 36
  • 43 (a)
OneToOne
ZPR1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G22480 35
  • 53.1 (n)
  • 44.12 (a)
rice
(Oryza sativa)
Liliopsida Os.27108 35
Os08g0471900 35
  • 52.04 (n)
  • 42.89 (a)
corn
(Zea mays)
Liliopsida Zm.4971 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.639 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08507 35
  • 53.63 (n)
  • 44.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes zpr1 35
  • 50.12 (n)
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5185 36
  • 50 (a)
OneToOne
Species with no ortholog for ZPR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZPR1 Gene

ENSEMBL:
Gene Tree for ZPR1 (if available)
TreeFam:
Gene Tree for ZPR1 (if available)

Paralogs for ZPR1 Gene

Pseudogenes.org Pseudogenes for ZPR1 Gene

genes like me logo Genes that share paralogs with ZPR1: view

No data available for Paralogs for ZPR1 Gene

Variants for ZPR1 Gene

Sequence variations from dbSNP and Humsavar for ZPR1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35120633 - 116,784,884(+) CGGGG(A/C/G)CATTG reference, missense
rs603446 -- 116,783,719(+) TAGGG(C/T)CATTA intron-variant
rs618923 -- 116,783,443(+) TGAAC(A/G)TTATT intron-variant
rs641169 -- 116,778,184(+) ccatc(C/T)gatgt downstream-variant-500B
rs964184 -- 116,778,201(+) TTCCT(C/G)ATCTG downstream-variant-500B

Variation tolerance for ZPR1 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZPR1 Gene

HapMap Linkage Disequilibrium report
ZPR1
Human Gene Mutation Database (HGMD)
ZPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZPR1 Gene

Disorders for ZPR1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ZPR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinal muscular atrophy
  • juvenile spinal muscular atrophy
muscular atrophy
  • amyotrophia nos
survival motor neuron spinal muscular atrophy
  • spinal muscular atrophies of childhood
spinal muscular atrophy-1
  • werdnig-hoffmann disease
- elite association - COSMIC cancer census association via MalaCards
Search ZPR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ZPR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZPR1
genes like me logo Genes that share disorders with ZPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZPR1 Gene

Publications for ZPR1 Gene

  1. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. (PMID: 9763455) Galcheva-Gargova Z. … Davis R.J. (Mol. Biol. Cell 1998) 2 3 4 23 67
  2. Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. (PMID: 8650580) Galcheva-Gargova Z. … Davis R.J. (Science 1996) 2 3 23
  3. The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. (PMID: 22422766) Ahmad S. … Gangwani L. (Hum. Mol. Genet. 2012) 2 3
  4. Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha. (PMID: 19966453) Yanaka N. … Kato N. (Biosci. Biotechnol. Biochem. 2009) 3 23
  5. Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. (PMID: 17068332) Gangwani L. (J. Biol. Chem. 2006) 3 23

Products for ZPR1 Gene

Sources for ZPR1 Gene

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