External Ids for ZPR1 Gene
Previous HGNC Symbols for ZPR1 Gene
Previous GeneCards Identifiers for ZPR1 Gene
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for ZPR1 Gene
ZPR1 (ZPR1 Zinc Finger) is a Protein Coding gene. Diseases associated with ZPR1 include survival motor neuron spinal muscular atrophy and muscular atrophy. Among its related pathways are Translational Control and EGFR1 Signaling Pathway. GO annotations related to this gene include receptor tyrosine kinase binding and translation initiation factor binding.
UniProtKB/Swiss-Prot for ZPR1 Gene
Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.