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Aliases for ZPR1 Gene

Aliases for ZPR1 Gene

  • ZPR1 Zinc Finger 2 3
  • Zinc Finger Protein 259 2 3 4
  • ZNF259 3 4
  • Zinc Finger Protein ZPR1 3
  • ZNF259, 6

External Ids for ZPR1 Gene

Previous Symbols for ZPR1 Gene

  • ZNF259

Summaries for ZPR1 Gene

GeneCards Summary for ZPR1 Gene

ZPR1 (ZPR1 Zinc Finger) is a Protein Coding gene. Among its related pathways are Translational Control and EGFR1 Signaling Pathway.

UniProtKB/Swiss-Prot for ZPR1 Gene

  • Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.

Gene Wiki entry for ZPR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZPR1 Gene

Genomics for ZPR1 Gene

Genomic Location for ZPR1 Gene

Start:
116,777,720 bp from pter
End:
116,788,050 bp from pter
Size:
10,331 bases
Orientation:
Minus strand

Genomic View for ZPR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZPR1 Gene

No data available for Regulatory Elements for ZPR1 Gene

Proteins for ZPR1 Gene

  • Protein details for ZPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75312-ZPR1_HUMAN
    Recommended name:
    Zinc finger protein ZPR1
    Protein Accession:
    O75312
    Secondary Accessions:
    • Q2TAA0

    Protein attributes for ZPR1 Gene

    Size:
    459 amino acids
    Molecular mass:
    50925 Da
    Quaternary structure:
    • Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Interacts (via C-terminal region) with SMN1 (via C-terminal region); the interaction occurs after treatment with serum. Interacts with elongation factor 1-alpha EEF1A1; the interaction occurs in a epidermal growth factor (EGF)-dependent manner. Interacts (via zinc fingers) with EGFR (via C-terminal cytoplasmic kinase domain); the interaction is negatively regulated in response to epidermal growth factor (EGF) stimulation and the EGFR kinase activity. May also bind to the PDGFR receptor.

neXtProt entry for ZPR1 Gene

Proteomics data for ZPR1 Gene at MOPED

Post-translational modifications for ZPR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZPR1 Gene

No data available for DME Specific Peptides for ZPR1 Gene

Domains for ZPR1 Gene

Protein Domains for ZPR1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75312

UniProtKB/Swiss-Prot:

ZPR1_HUMAN
Family:
  • Belongs to the ZPR1 family.:
    • O75312
genes like me logo Genes that share domains with ZPR1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ZPR1 Gene

Function for ZPR1 Gene

Molecular function for ZPR1 Gene

UniProtKB/Swiss-Prot Function: Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death.

Gene Ontology (GO) - Molecular Function for ZPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11283611
GO:0008270 zinc ion binding IEA --
GO:0030971 receptor tyrosine kinase binding IEA --
GO:0031369 translation initiation factor binding IPI 9852145
genes like me logo Genes that share ontologies with ZPR1: view

Phenotypes for ZPR1 Gene

MGI mutant phenotypes for ZPR1:
inferred from 1 alleles
GenomeRNAi human phenotypes for ZPR1:
genes like me logo Genes that share phenotypes with ZPR1: view

Animal Models for ZPR1 Gene

MGI Knock Outs for ZPR1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ZPR1 Gene

Localization for ZPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZPR1 Gene

Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon. Cell projection, growth cone. Note=Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized throughout the cell during mitosis. Colocalized with NPAT and SMN1 in nuclear bodies including gems (Gemini of coiled bodies) and Cajal bodies in a cell cycle-dependent manner. Translocates together with EEF1A1 from the cytoplasm to the nucleolus after treatment with mitogens. Colocalized with EGFR in the cytoplasm of quiescent cells. Translocates from the cytoplasm to the nucleus in a epidermal growth factor (EGF)-dependent manner. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ZPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11283611
GO:0005654 nucleoplasm IDA 17068332
GO:0005730 nucleolus IDA 9852145
GO:0005737 cytoplasm IDA 11283611
GO:0015030 Cajal body IDA 11283611
genes like me logo Genes that share ontologies with ZPR1: view

No data available for Subcellular locations from COMPARTMENTS for ZPR1 Gene

Pathways for ZPR1 Gene

genes like me logo Genes that share pathways with ZPR1: view

Pathways by source for ZPR1 Gene

1 Cell Signaling Technology pathway for ZPR1 Gene
1 BioSystems pathway for ZPR1 Gene

Gene Ontology (GO) - Biological Process for ZPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization ISS --
GO:0001833 inner cell mass cell proliferation IEA --
GO:0001834 trophectodermal cell proliferation ISS --
GO:0006397 mRNA processing IEA --
GO:0007165 signal transduction TAS 8650580
genes like me logo Genes that share ontologies with ZPR1: view

Compounds for ZPR1 Gene

(1) Novoseek inferred chemical compound relationships for ZPR1 Gene

Compound -log(P) Hits PubMed IDs
zinc 55.5 8
genes like me logo Genes that share compounds with ZPR1: view

Transcripts for ZPR1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZPR1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -
SP3:

Relevant External Links for ZPR1 Gene

GeneLoc Exon Structure for
ZPR1
ECgene alternative splicing isoforms for
ZPR1

Expression for ZPR1 Gene

mRNA expression in normal human tissues for ZPR1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ZPR1 Gene

mRNA Expression by UniProt/SwissProt for ZPR1 Gene

O75312-ZPR1_HUMAN
Tissue specificity: Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients.
genes like me logo Genes that share expressions with ZPR1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ZPR1 Gene

Orthologs for ZPR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ZPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF259 35
  • 99.56 (n)
  • 99.35 (a)
ZNF259 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF259 35
  • 89.69 (n)
  • 91.29 (a)
ZNF259 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF259 35
  • 88.89 (n)
  • 89.98 (a)
ZNF259 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp259 35
  • 87.15 (n)
  • 90.41 (a)
Zfp259 16
Zfp259 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF259 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp259 35
  • 86.93 (n)
  • 89.11 (a)
chicken
(Gallus gallus)
Aves ZNF259 35
  • 73.66 (n)
  • 76.89 (a)
ZNF259 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF259 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6633 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4088 35
znf259 35
  • 69.98 (n)
  • 73.7 (a)
zebrafish
(Danio rerio)
Actinopterygii wufc17g09 35
znf259 36
  • 70 (a)
OneToOne
zpr1 35
  • 68.01 (n)
  • 72.45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004417 35
  • 55.85 (n)
  • 51.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Zpr1 35
  • 56.56 (n)
  • 50.36 (a)
Zpr1 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_W03F9.1 35
  • 50.36 (n)
  • 41.81 (a)
W03F9.1 36
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL137C 35
  • 53.95 (n)
  • 48.66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZPR1 35
  • 53.38 (n)
  • 50.37 (a)
ZPR1 36
  • 43 (a)
OneToOne
ZPR1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16215g 35
  • 51.29 (n)
  • 45.61 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G22480 35
  • 53.1 (n)
  • 44.12 (a)
corn
(Zea mays)
Liliopsida Zm.4971 35
rice
(Oryza sativa)
Liliopsida Os.27108 35
Os08g0471900 35
  • 52.04 (n)
  • 42.89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08507 35
  • 53.63 (n)
  • 44.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes zpr1 35
  • 50.12 (n)
  • 46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.639 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5185 36
  • 50 (a)
OneToOne
Species with no ortholog for ZPR1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZPR1 Gene

ENSEMBL:
Gene Tree for ZPR1 (if available)
TreeFam:
Gene Tree for ZPR1 (if available)

Paralogs for ZPR1 Gene

Pseudogenes.org Pseudogenes for ZPR1 Gene

genes like me logo Genes that share paralogs with ZPR1: view

No data available for Paralogs for ZPR1 Gene

Variants for ZPR1 Gene

Sequence variations from dbSNP and Humsavar for ZPR1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs603446 -- 116,783,719(+) TAGGG(C/T)CATTA intron-variant
rs618923 -- 116,783,443(+) TGAAC(A/G)TTATT intron-variant
rs620801 -- 116,783,856(+) AATTT(A/C)CCTTa intron-variant
rs641169 -- 116,778,184(+) ccatc(C/T)gatgt downstream-variant-500B
rs964184 -- 116,778,201(+) TTCCT(C/G)ATCTG downstream-variant-500B

Relevant External Links for ZPR1 Gene

HapMap Linkage Disequilibrium report
ZPR1
Human Gene Mutation Database (HGMD)
ZPR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZPR1 Gene

Disorders for ZPR1 Gene

No disorders were found for ZPR1 Gene.

No data available for UniProtKB/Swiss-Prot for ZPR1 Gene

Publications for ZPR1 Gene

  1. Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor. (PMID: 8650580) Galcheva-Gargova Z. … Davis R.J. (Science 1996) 2 3 4 23
  2. The cytoplasmic zinc finger protein ZPR1 accumulates in the nucleolus of proliferating cells. (PMID: 9763455) Galcheva-Gargova Z. … Davis R.J. (Mol. Biol. Cell 1998) 2 3 4 23
  3. Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein. (PMID: 11283611) Gangwani L. … Davis R.J. (Nat. Cell Biol. 2001) 3 4 23
  4. Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression. (PMID: 17068332) Gangwani L. (J. Biol. Chem. 2006) 3 4 23
  5. The zinc finger protein ZPR1 is a potential modifier of spinal muscular atrophy. (PMID: 22422766) Ahmad S. … Gangwani L. (Hum. Mol. Genet. 2012) 2 3 4

Products for ZPR1 Gene

Sources for ZPR1 Gene

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