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Aliases for IER3 Gene

Aliases for IER3 Gene

  • Immediate Early Response 3 2 3
  • PRG1 3 4 6
  • DIF2 3 4 6
  • IEX1 3 4 6
  • Differentiation-Dependent Gene 2 Protein 3 4
  • Immediate Early Response 3 Protein 3 4
  • PACAP-Responsive Gene 1 Protein 3 4
  • Immediate Early Protein GLY96 3 4
  • Protein DIF-2 3 4
  • GLY96 3 6
  • Radiation-Inducible Immediate-Early Gene IEX-1 3
  • Expressed In Pancreatic Carcinoma 3
  • Immediately Early Gene X-1 3
  • Gly96, Mouse, Homolog Of 3
  • Anti-Death Protein 3
  • Protein PRG1 4
  • IEX-1L 3
  • DIF-2 3
  • IEX-1 3

External Ids for IER3 Gene

Previous GeneCards Identifiers for IER3 Gene

  • GC06M030766
  • GC06M030481
  • GC06M030817
  • GC06M030818

Summaries for IER3 Gene

Entrez Gene Summary for IER3 Gene

  • This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for IER3 Gene

IER3 (Immediate Early Response 3) is a Protein Coding gene. Diseases associated with IER3 include juvenile hyaline fibromatosis.

UniProtKB/Swiss-Prot for IER3 Gene

  • May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.

Gene Wiki entry for IER3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IER3 Gene

Genomics for IER3 Gene

Regulatory Elements for IER3 Gene

Transcription factor binding sites by QIAGEN in the IER3 gene promoter:

Genomic Location for IER3 Gene

Start:
30,743,199 bp from pter
End:
30,744,554 bp from pter
Size:
1,356 bases
Orientation:
Minus strand

Genomic View for IER3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for IER3 Gene

  • Protein details for IER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46695-IEX1_HUMAN
    Recommended name:
    Radiation-inducible immediate-early gene IEX-1
    Protein Accession:
    P46695
    Secondary Accessions:
    • Q5SU30
    • Q92691
    • Q93044

    Protein attributes for IER3 Gene

    Size:
    156 amino acids
    Molecular mass:
    16903 Da
    Quaternary structure:
    • Interacts with the PPP2R5C-PP2A holoenzyme and ERK kinases; regulates ERK dephosphorylation.

neXtProt entry for IER3 Gene

Proteomics data for IER3 Gene at MOPED

Post-translational modifications for IER3 Gene

  • Glycosylated
  • Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli.
  • Glycosylation at Asn133
  • Modification sites at PhosphoSitePlus

Other Protein References for IER3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IER3 Gene

Domains for IER3 Gene

Protein Domains for IER3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P46695

UniProtKB/Swiss-Prot:

IEX1_HUMAN :
  • P46695
Family:
  • Belongs to the IER3 family.
genes like me logo Genes that share domains with IER3: view

No data available for Gene Families for IER3 Gene

Function for IER3 Gene

Molecular function for IER3 Gene

GENATLAS Biochemistry: immediate early gene induced by ionizing radiation and activators of PRKC,including a shorter (IEX-S) and a larger non spliced isoform (IEX-L) the later inhibiting apoptosis involved in NFKB mediate survival cell
UniProtKB/Swiss-Prot Function: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
UniProtKB/Swiss-Prot Induction: By radiation, 12-O-tetradecanoyl phorbol-13 acetate (TPA), okadaic acid, TNF and NUPR1.

Gene Ontology (GO) - Molecular Function for IER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15451437
genes like me logo Genes that share ontologies with IER3: view
genes like me logo Genes that share phenotypes with IER3: view

Animal Models for IER3 Gene

MGI Knock Outs for IER3:

miRNA for IER3 Gene

miRTarBase miRNAs that target IER3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IER3 Gene

Localization for IER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IER3 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IER3 Gene COMPARTMENTS Subcellular localization image for IER3 gene
Compartment Confidence
nucleus 5
mitochondrion 2
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20467439
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IER3: view

Pathways for IER3 Gene

SuperPathways for IER3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001562 response to protozoan IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0006282 regulation of DNA repair IEA --
GO:0006915 apoptotic process TAS 9196025
GO:0007095 mitotic G2 DNA damage checkpoint IEA --
genes like me logo Genes that share ontologies with IER3: view

No data available for Pathways by source for IER3 Gene

Compounds for IER3 Gene

(4) Novoseek inferred chemical compound relationships for IER3 Gene

Compound -log(P) Hits PubMed IDs
calcitriol 20.2 2
cycloheximide 10.7 1
etoposide 9.13 1
estrogen 0 2
genes like me logo Genes that share compounds with IER3: view

Transcripts for IER3 Gene

mRNA/cDNA for IER3 Gene

(21) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IER3 Gene

Immediate early response 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IER3 Gene

No ASD Table

Relevant External Links for IER3 Gene

GeneLoc Exon Structure for
IER3
ECgene alternative splicing isoforms for
IER3

Expression for IER3 Gene

mRNA expression in normal human tissues for IER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for IER3 Gene Hs.76095

genes like me logo Genes that share expressions with IER3: view

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for IER3 Gene

Orthologs for IER3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IER3 35
  • 99.57 (n)
  • 98.72 (a)
IER3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IER3 35
  • 85.9 (n)
  • 80.77 (a)
IER3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IER3 35
  • 83.97 (n)
  • 78.21 (a)
IER3 36
  • 43 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ier3 35
  • 78.14 (n)
  • 75.32 (a)
Ier3 16
Ier3 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IER3 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ier3 35
  • 79.06 (n)
  • 76.28 (a)
lizard
(Anolis carolinensis)
Reptilia IER3 36
  • 41 (a)
OneToOne
Species with no ortholog for IER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IER3 Gene

ENSEMBL:
Gene Tree for IER3 (if available)
TreeFam:
Gene Tree for IER3 (if available)

Paralogs for IER3 Gene

Selected SIMAP similar genes for IER3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IER3 Gene

genes like me logo Genes that share paralogs with IER3: view

No data available for Paralogs for IER3 Gene

Variants for IER3 Gene

Sequence variations from dbSNP and Humsavar for IER3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2284173 -- 30,745,519(+) GATGC(A/G)GCTGG upstream-variant-2KB
rs2284174 -- 30,745,803(+) AGAAT(C/T)TAAAA upstream-variant-2KB
rs3130662 -- 30,746,031(+) GAATG(A/C)AATCC upstream-variant-2KB
rs3757338 -- 30,744,991(+) gcacg(C/T)gccac upstream-variant-2KB
rs6931296 -- 30,745,554(+) ctcag(C/G)aacag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IER3 Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
esv2670269 CNV Deletion 23128226
nsv830626 CNV Loss 17160897
dgv1917e1 CNV Complex 17122850
nsv884100 CNV Gain 21882294
nsv884101 CNV Gain 21882294
nsv884102 CNV Gain 21882294

Relevant External Links for IER3 Gene

HapMap Linkage Disequilibrium report
IER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IER3 Gene

Disorders for IER3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IER3 Gene including...

Search for IER3 Gene in MalaCards »

(6) Novoseek inferred disease relationships for IER3 Gene

Disease -log(P) Hits PubMed IDs
tumors 17.2 15
necrosis 9.24 7
breast cancer 0 2
prostate cancer 0 1
cancer 0 3

Relevant External Links for IER3

Genetic Association Database (GAD)
IER3
Human Genome Epidemiology (HuGE) Navigator
IER3
genes like me logo Genes that share disorders with IER3: view

No data available for UniProtKB/Swiss-Prot for IER3 Gene

Publications for IER3 Gene

  1. Identification and characterization of a radiation-inducible glycosylated human early-response gene. (PMID: 8603392) Kondratyev A.D. … Jung M.O. (Cancer Res. 1996) 2 3 4 23
  2. IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. (PMID: 12356731) Garcia J. … Porteu F. (EMBO J. 2002) 3 4 23
  3. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. (PMID: 16456541) Letourneux C. … Porteu F. (EMBO J. 2006) 3 4 23
  4. Immediate early gene X1 (IEX-1) is organized in subnuclear structures and partially co-localizes with promyelocytic leukemia protein in HeLa cells. (PMID: 15855159) Kruse M.L. … SchAofer H. (J. Biol. Chem. 2005) 3 23
  5. Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1. (PMID: 11844788) Im H.J. … Kumar R. (J. Biol. Chem. 2002) 3 23

Products for IER3 Gene

Sources for IER3 Gene

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