Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CCKBR Gene

Aliases for CCKBR Gene

  • Cholecystokinin B Receptor 2 3
  • Cholecystokinin-2 Receptor 3 4
  • CCK-B Receptor 3 4
  • CCK-BR 3 4
  • CCK2-R 3 4
  • GASR 3 6
  • Gastrin/Cholecystokinin Type B Receptor 3
  • Gastrin Receptor 3
  • CCK2 Receptor 3
  • CCK-B 3
  • CCK2R 3
  • CCKRB 4

External Ids for CCKBR Gene

Previous GeneCards Identifiers for CCKBR Gene

  • GC11P007024
  • GC11P006741
  • GC11P006240
  • GC11P006245
  • GC11P006237
  • GC11P005940

Summaries for CCKBR Gene

Entrez Gene Summary for CCKBR Gene

  • This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCKBR Gene

CCKBR (Cholecystokinin B Receptor) is a Protein Coding gene. Diseases associated with CCKBR include duodenal gastrinoma and agoraphobia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include phosphatidylinositol phospholipase C activity and cholecystokinin receptor activity. An important paralog of this gene is GPR19.

UniProtKB/Swiss-Prot for CCKBR Gene

  • Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

  • Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism

Tocris Summary for CCKBR Gene

  • The cholecystokinin2 receptor (CCK1 receptor, CCK-B receptor) is a member of the cholecystokinin receptor group of G-protein-coupled receptors that also includes CCK1. They are located primarily in the brain, spinal cord and stomach where they play a role in anxiety, nociception, neuroleptic activity, gastric acid release, gastric mucosal cell growth and histamine release. The human CCK2 receptor gene has been localized to chromosome 11 (11p15.4).

Gene Wiki entry for CCKBR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCKBR Gene

Genomics for CCKBR Gene

Regulatory Elements for CCKBR Gene

Genomic Location for CCKBR Gene

Start:
6,259,611 bp from pter
End:
6,272,127 bp from pter
Size:
12,517 bases
Orientation:
Plus strand

Genomic View for CCKBR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CCKBR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCKBR Gene

Proteins for CCKBR Gene

  • Protein details for CCKBR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32239-GASR_HUMAN
    Recommended name:
    Gastrin/cholecystokinin type B receptor
    Protein Accession:
    P32239
    Secondary Accessions:
    • A8K7P9
    • O75824
    • Q16144
    • Q92492
    • Q96LC6
    • Q9NYK7
    • Q9UBV1

    Protein attributes for CCKBR Gene

    Size:
    447 amino acids
    Molecular mass:
    48419 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CCKBR Gene

    Alternative splice isoforms for CCKBR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CCKBR Gene

Proteomics data for CCKBR Gene at MOPED

Post-translational modifications for CCKBR Gene

  • Glycosylation at Asn7, Asn30, and Asn36
  • Modification sites at PhosphoSitePlus

Other Protein References for CCKBR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CCKBR Gene

Domains for CCKBR Gene

Gene Families for CCKBR Gene

HGNC:
  • CCKNR :GPCR / Class A : Cholecystokinin receptors
IUPHAR :

Protein Domains for CCKBR Gene

Graphical View of Domain Structure for InterPro Entry

P32239

UniProtKB/Swiss-Prot:

GASR_HUMAN :
  • P32239
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with CCKBR: view

Function for CCKBR Gene

Molecular function for CCKBR Gene

GENATLAS Biochemistry: cholecystokinin B/gastrin receptor, G protein coupled receptor superfamily,stimulating the phosphatidylinositol cycle,expressed in brain,pancreas and stomach
UniProtKB/Swiss-Prot Function: Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
UniProtKB/Swiss-Prot Function: Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism

Gene Ontology (GO) - Molecular Function for CCKBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity TAS 7681836
GO:0004930 G-protein coupled receptor activity --
GO:0004951 cholecystokinin receptor activity TAS 7681836
GO:0005515 protein binding IPI 16963136
GO:0015054 gastrin receptor activity IDA 10913157
genes like me logo Genes that share ontologies with CCKBR: view
genes like me logo Genes that share phenotypes with CCKBR: view

Animal Models for CCKBR Gene

MGI Knock Outs for CCKBR:

miRNA for CCKBR Gene

miRTarBase miRNAs that target CCKBR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CCKBR Gene

Localization for CCKBR Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCKBR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCKBR Gene COMPARTMENTS Subcellular localization image for CCKBR gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CCKBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 10913157
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with CCKBR: view

Pathways for CCKBR Gene

genes like me logo Genes that share pathways with CCKBR: view

Gene Ontology (GO) - Biological Process for CCKBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001696 gastric acid secretion IEA --
GO:0007166 cell surface receptor signaling pathway NAS 10913157
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8455720
GO:0007204 positive regulation of cytosolic calcium ion concentration IDA 10913157
genes like me logo Genes that share ontologies with CCKBR: view

Compounds for CCKBR Gene

(5) Tocris Compounds for CCKBR Gene

Compound Action Cas Number
L-365,260 Selective CCK2 antagonist [118101-09-0]
CI 988 Potent and selective CCK2 antagonist [130332-27-3]
Gastrin I (human) Selective CCK2 agonist [10047-33-3]
PD 135158 Potent and selective CCK2 antagonist [130285-87-9]
YM 022 Highly potent, selective non-peptide CCK2 antagonist [145084-28-2]

(1) HMDB Compounds for CCKBR Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for CCKBR Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pentagastrin
5534-95-2 target agonist

(23) IUPHAR Ligand for CCKBR Gene

Ligand Type Action Affinity Pubmed IDs
CCK-8 Agonist Full agonist 10
YF-476 Antagonist Antagonist 9.6
[125I]PD142308 Antagonist Antagonist 9.6
GV150013 Antagonist Antagonist 9.4
Z-360 Antagonist Antagonist 9.3
L-740093 Antagonist Antagonist 9.2
YM-022 Antagonist Antagonist 9.2
CI-988 Antagonist Antagonist 9.1
[3H]gastrin Agonist Full agonist 9
[125I]gastrin Agonist Full agonist 9
PD-135158 Antagonist Antagonist 8.9
CCK-33 Agonist Full agonist 8.8
CCK-8 (desulphated) Agonist Full agonist 8.7
[3H]L365260 Antagonist Antagonist 8.5
L-365260 Antagonist Antagonist 8.4
AG-041R Antagonist Antagonist 8.3
GW-5823 Agonist Full agonist 7.6
CCK-4 Agonist Full agonist 7.5
LY-288513 Antagonist Antagonist 7
devazepide Antagonist Antagonist 6.8
tetronothiodin Antagonist Antagonist 6.7
A-71378 Agonist Full agonist 6.5
lorglumide Antagonist Antagonist 5.5

(78) Novoseek inferred chemical compound relationships for CCKBR Gene

Compound -log(P) Hits PubMed IDs
gastrin 17 92.6 6
ym022 90.3 14
minigastrin 90.3 4
gv 150013 88 1
l365260 87.6 10
genes like me logo Genes that share compounds with CCKBR: view

Transcripts for CCKBR Gene

Unigene Clusters for CCKBR Gene

Cholecystokinin B receptor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCKBR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for CCKBR Gene

GeneLoc Exon Structure for
CCKBR
ECgene alternative splicing isoforms for
CCKBR

Expression for CCKBR Gene

mRNA expression in normal human tissues for CCKBR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCKBR Gene

This gene is overexpressed in Stomach (10.7), Brain - Cortex (7.5), Brain - Frontal Cortex (BA9) (6.3), and Brain - Anterior cingulate cortex (BA24) (6.1).

SOURCE GeneReport for Unigene cluster for CCKBR Gene Hs.203

mRNA Expression by UniProt/SwissProt for CCKBR Gene

P32239-GASR_HUMAN
Tissue specificity: Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
genes like me logo Genes that share expressions with CCKBR: view

No data available for Protein expression for CCKBR Gene

Orthologs for CCKBR Gene

This gene was present in the common ancestor of animals.

Orthologs for CCKBR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCKBR 35
  • 99.11 (n)
  • 99.11 (a)
CCKBR 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCKBR 35
  • 87.7 (n)
  • 91.05 (a)
CCKBR 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCKBR 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cckbr 35
  • 85.54 (n)
  • 89.66 (a)
Cckbr 16
Cckbr 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cckbr 35
  • 85.62 (n)
  • 90.11 (a)
chicken
(Gallus gallus)
Aves CCKBR 35
  • 65.79 (n)
  • 61.96 (a)
CCKBR 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCKBR 36
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CCKBR (1 of 2) 36
  • 49 (a)
OneToMany
CCKBR (2 of 2) 36
  • 54 (a)
OneToMany
LOC100331465 35
  • 58.41 (n)
  • 55.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CCKLR-17D1 35
  • 50.26 (n)
  • 40.87 (a)
CCKLR-17D1 36
  • 20 (a)
ManyToMany
CCKLR-17D3 36
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ckr-1 36
  • 24 (a)
ManyToMany
ckr-2 36
  • 20 (a)
ManyToMany
Y39A3B.5 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
Species with no ortholog for CCKBR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CCKBR Gene

ENSEMBL:
Gene Tree for CCKBR (if available)
TreeFam:
Gene Tree for CCKBR (if available)

Paralogs for CCKBR Gene

Paralogs for CCKBR Gene

Selected SIMAP similar genes for CCKBR Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CCKBR: view

Variants for CCKBR Gene

Sequence variations from dbSNP and Humsavar for CCKBR Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs906895 -- 6,259,018(-) TTGGG(A/G)GTGGT upstream-variant-2KB
rs1042043 -- 6,259,940(+) CTGCT(A/C)AAGCT reference, synonymous-codon
rs1042045 -- 6,271,135(+) GCTCC(A/T)GGGCC synonymous-codon, reference
rs1042047 -- 6,271,952(+) CAGTG(A/C)CCCTT utr-variant-3-prime
rs1042048 -- 6,271,980(+) ATACC(A/C/G)TCAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CCKBR Gene

Variant ID Type Subtype PubMed ID
nsv7656 CNV Loss 18451855

Relevant External Links for CCKBR Gene

HapMap Linkage Disequilibrium report
CCKBR
Human Gene Mutation Database (HGMD)
CCKBR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCKBR Gene

Disorders for CCKBR Gene

MalaCards: The human disease database

MalaCards: The human disease database. (12) Diseases for CCKBR Gene including...

Search for CCKBR Gene in MalaCards »

(5) University of Copenhagen DISEASES for CCKBR Gene

(70) Novoseek inferred disease relationships for CCKBR Gene

Disease -log(P) Hits PubMed IDs
ovarian stromal cancer 89 5
panic attacks 70.2 6
thyroid carcinoma medullary 68.7 19
panic disorder 64.5 26
panic 62.5 9

Relevant External Links for CCKBR

Genetic Association Database (GAD)
CCKBR
Human Genome Epidemiology (HuGE) Navigator
CCKBR
genes like me logo Genes that share disorders with CCKBR: view

No data available for UniProtKB/Swiss-Prot for CCKBR Gene

Publications for CCKBR Gene

  1. Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. (PMID: 1280419) Pisegna J.R. … Wank S.A. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. A truncated isoform of human CCK-B/gastrin receptor generated by alternative usage of a novel exon. (PMID: 7887934) Miyake A. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  3. The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. (PMID: 7681836) Lee Y.-M. … Kopin A.S. (J. Biol. Chem. 1993) 3 4 23
  4. Cholecystokinin stimulates Ca2+ mobilization and clonal growth in small cell lung cancer through CCKA and CCKB/gastrin receptors. (PMID: 8185170) Herget T. … Rozengurt E. (Ann. N. Y. Acad. Sci. 1994) 3 4 23
  5. Functional characterization of two cholecystokinin-B/gastrin receptor isoforms: a preferential splice donor site in the human receptor gene. (PMID: 7848914) Ito M. … Matsui T. (Cell Growth Differ. 1994) 3 4 23

Products for CCKBR Gene

  • Addgene plasmids for CCKBR

Sources for CCKBR Gene

Back to Top

Content