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Aliases for CDK5R1 Gene

Aliases for CDK5R1 Gene

  • Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (P35) 2 3
  • Cyclin-Dependent Kinase 5 Regulatory Subunit 1 3 4
  • TPKII Regulatory Subunit 3 4
  • CDK5 Activator 1 3 4
  • CDK5R 3 4
  • NCK5A 3 4
  • Cyclin-Dependent Kinase 5 Activator 1 3
  • Tau Protein Kinase II 23kDa Subunit 3
  • Regulatory Partner For CDK5 Kinase 3
  • Neuronal CDK5 Activator 3
  • P35nck5a 3
  • CDK5P35 3
  • P25 3
  • P23 3
  • P35 3

External Ids for CDK5R1 Gene

Previous GeneCards Identifiers for CDK5R1 Gene

  • GC17P030580
  • GC17P032848
  • GC17P030959
  • GC17P027838
  • GC17P030813
  • GC17P027000

Summaries for CDK5R1 Gene

Entrez Gene Summary for CDK5R1 Gene

  • The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDK5R1 Gene

CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (P35)) is a Protein Coding gene. Diseases associated with CDK5R1 include tauopathy. Among its related pathways are L1CAM interactions and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include calcium ion binding and protein kinase activity. An important paralog of this gene is CDK5R2.

UniProtKB/Swiss-Prot for CDK5R1 Gene

  • p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Gene Wiki entry for CDK5R1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDK5R1 Gene

Genomics for CDK5R1 Gene

Regulatory Elements for CDK5R1 Gene

Genomic Location for CDK5R1 Gene

Start:
32,486,619 bp from pter
End:
32,491,256 bp from pter
Size:
4,638 bases
Orientation:
Plus strand

Genomic View for CDK5R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDK5R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDK5R1 Gene

Proteins for CDK5R1 Gene

  • Protein details for CDK5R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15078-CD5R1_HUMAN
    Recommended name:
    Cyclin-dependent kinase 5 activator 1
    Protein Accession:
    Q15078
    Secondary Accessions:
    • E1P664
    • Q5U0G3

    Protein attributes for CDK5R1 Gene

    Size:
    307 amino acids
    Molecular mass:
    34060 Da
    Quaternary structure:
    • Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 (By similarity). Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.
    Miscellaneous:
    • Cleavage of p35 to p25 may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases. The p25 form accumulates in neurons in the brain of patients with Alzheimer disease, but not in normal brain. This accumulation correlates with an increase in CDK5 kinase activity. Application of amyloid beta peptide A-beta(1-42) induced the conversion of p35 to p25 in primary cortical neurons. Expression of the p25/Cdk5 complex in cultured primary neurons induces cytoskeletal disruption, morphological degeneration and apoptosis

    Three dimensional structures from OCA and Proteopedia for CDK5R1 Gene

neXtProt entry for CDK5R1 Gene

Proteomics data for CDK5R1 Gene at MOPED

Post-translational modifications for CDK5R1 Gene

  • Myristoylated. A proper myristoylation signal is essential for the proper distribution of p35.
  • Phosphorylation at Ser-8 and Thr-138 by CDK5 prevents calpain-mediated proteolysis.
  • The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).
  • Ubiquitinated. Degradation of p35 by proteasome results in down-regulation of CDK5 activity. During this process, CDK5 phosphorylates p35 and induces its ubiquitination and subsequent degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDK5R1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CDK5R1 Gene

Domains for CDK5R1 Gene

Protein Domains for CDK5R1 Gene

Graphical View of Domain Structure for InterPro Entry

Q15078

UniProtKB/Swiss-Prot:

CD5R1_HUMAN :
  • Q15078
Family:
  • Belongs to the cyclin-dependent kinase 5 activator family.
genes like me logo Genes that share domains with CDK5R1: view

No data available for Gene Families for CDK5R1 Gene

Function for CDK5R1 Gene

Molecular function for CDK5R1 Gene

GENATLAS Biochemistry: cyclin-dependent kinase 5 regulatory subunit1,short lived molecule specifically expressed in neuronal cells,constitutively expressed after cleavage,associating and activating the CDK5 p25 complex with a resulting hyperphorylation of tau,which reduces taus ability to associate with microtubules,and may be involved in the pathogenesis of neurodegenerative diseases
UniProtKB/Swiss-Prot Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at Thr-451 and Thr-461 and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Gene Ontology (GO) - Molecular Function for CDK5R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 7592934
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IPI 10721722
GO:0016301 kinase activity ISS --
genes like me logo Genes that share ontologies with CDK5R1: view
genes like me logo Genes that share phenotypes with CDK5R1: view

Animal Models for CDK5R1 Gene

MGI Knock Outs for CDK5R1:

miRNA for CDK5R1 Gene

miRTarBase miRNAs that target CDK5R1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CDK5R1 Gene

Localization for CDK5R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDK5R1 Gene

Cyclin-dependent kinase 5 activator 1, p35: Cell membrane; Lipid-anchor; Cytoplasmic side. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
Cyclin-dependent kinase 5 activator 1, p25: Nucleus. Cytoplasm, perinuclear region. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDK5R1 Gene COMPARTMENTS Subcellular localization image for CDK5R1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytoskeleton 4
cytosol 4
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CDK5R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with CDK5R1: view

Pathways for CDK5R1 Gene

genes like me logo Genes that share pathways with CDK5R1: view

Gene Ontology (GO) - Biological Process for CDK5R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7592934
GO:0001764 neuron migration ISS --
GO:0006468 protein phosphorylation --
GO:0007158 neuron cell-cell adhesion ISS --
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with CDK5R1: view

Compounds for CDK5R1 Gene

(2) Drugbank Compounds for CDK5R1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
target
Indirubin-3'-Monoxime
target

(13) Novoseek inferred chemical compound relationships for CDK5R1 Gene

Compound -log(P) Hits PubMed IDs
roscovitine 87.3 3
olomoucine 64.7 1
glycogen 40.2 5
threonine 37.4 3
serine 22.3 3
genes like me logo Genes that share compounds with CDK5R1: view

Transcripts for CDK5R1 Gene

mRNA/cDNA for CDK5R1 Gene

Unigene Clusters for CDK5R1 Gene

Cyclin-dependent kinase 5, regulatory subunit 1 (p35):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDK5R1 Gene

No ASD Table

Relevant External Links for CDK5R1 Gene

GeneLoc Exon Structure for
CDK5R1
ECgene alternative splicing isoforms for
CDK5R1

Expression for CDK5R1 Gene

mRNA expression in normal human tissues for CDK5R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDK5R1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (6.8), Brain - Anterior cingulate cortex (BA24) (5.9), Brain - Cortex (5.2), and Brain - Hippocampus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDK5R1 Gene

SOURCE GeneReport for Unigene cluster for CDK5R1 Gene Hs.500015

mRNA Expression by UniProt/SwissProt for CDK5R1 Gene

Q15078-CD5R1_HUMAN
Tissue specificity: Brain and neuron specific
genes like me logo Genes that share expressions with CDK5R1: view

Orthologs for CDK5R1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDK5R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDK5R1 35
  • 100 (n)
  • 100 (a)
CDK5R1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDK5R1 35
  • 94.68 (n)
  • 98.7 (a)
CDK5R1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDK5R1 35
  • 95.33 (n)
  • 99.02 (a)
CDK5R1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdk5r1 35
  • 92.51 (n)
  • 98.37 (a)
Cdk5r1 16
Cdk5r1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDK5R1 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdk5r1 35
  • 92.51 (n)
  • 98.37 (a)
lizard
(Anolis carolinensis)
Reptilia CDK5R1 36
  • 56 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cdk5r1-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cdk5r1 35
  • 69.86 (n)
  • 76.03 (a)
zebrafish
(Danio rerio)
Actinopterygii CDK5R1 (1 of 3) 36
  • 58 (a)
OneToMany
cdk5r1a 36
  • 67 (a)
OneToMany
cdk5r1b 35
  • 76.63 (n)
  • 81.73 (a)
cdk5r1b 36
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cdk5alpha 36
  • 29 (a)
OneToMany
Cdk5alpha 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea cdka-1 36
  • 29 (a)
OneToMany
T23F11.3 37
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for CDK5R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDK5R1 Gene

ENSEMBL:
Gene Tree for CDK5R1 (if available)
TreeFam:
Gene Tree for CDK5R1 (if available)

Paralogs for CDK5R1 Gene

Paralogs for CDK5R1 Gene

Selected SIMAP similar genes for CDK5R1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CDK5R1: view

Variants for CDK5R1 Gene

Sequence variations from dbSNP and Humsavar for CDK5R1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs15560 -- 32,491,103(+) TCTCA(A/T)TTTGT utr-variant-3-prime
rs731880 -- 32,491,691(-) GCCCA(A/T)GTGGA downstream-variant-500B
rs735555 -- 32,490,432(-) GACAC(A/G)CAACT utr-variant-3-prime
rs756785 -- 32,485,827(-) CTGGG(A/G)AACAG upstream-variant-2KB
rs1042845 -- 32,487,830(+) CAGCC(C/T)AACAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CDK5R1 Gene

Variant ID Type Subtype PubMed ID
nsv519839 CNV Loss 19592680
nsv908070 CNV Loss 21882294
esv21464 CNV Loss 19812545

Relevant External Links for CDK5R1 Gene

HapMap Linkage Disequilibrium report
CDK5R1
Human Gene Mutation Database (HGMD)
CDK5R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDK5R1 Gene

Disorders for CDK5R1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDK5R1 Gene including...

Search for CDK5R1 Gene in MalaCards »

(14) Novoseek inferred disease relationships for CDK5R1 Gene

Disease -log(P) Hits PubMed IDs
neurofibrillary tangles 61.4 1
neurodegeneration 59.3 6
alzheimers disease 58 15
neurodegenerative diseases 49.8 6
memory impairment 22.7 3

Relevant External Links for CDK5R1

Genetic Association Database (GAD)
CDK5R1
Human Genome Epidemiology (HuGE) Navigator
CDK5R1
genes like me logo Genes that share disorders with CDK5R1: view

No data available for UniProtKB/Swiss-Prot for CDK5R1 Gene

Publications for CDK5R1 Gene

  1. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. (PMID: 10604467) Patrick G.N. … Tsai L.H. (Nature 1999) 3 4 23
  2. Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PMID: 16425041) Venturin M. … Riva P. (Neurogenetics 2006) 3 23 48
  3. Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk. (PMID: 19154537) Mateo I. … Combarros O. (Acta Neurol. Scand. 2009) 3 23 48
  4. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. (PMID: 8090221) Tsai L.-H. … Harlow E. (Nature 1994) 2 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for CDK5R1 Gene

  • antibodies-online proteins for CDK5R1
  • antibodies-online antibodies for CDK5R1
  • antibodies-online kits for CDK5R1

Sources for CDK5R1 Gene

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