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Aliases for CCK Gene

Aliases for CCK Gene

  • Cholecystokinin 2 3 5
  • Cholecystokinin Triacontatriapeptide 2 3
  • Prepro-Cholecystokinin 2 3

External Ids for CCK Gene

Previous GeneCards Identifiers for CCK Gene

  • GC03P041561
  • GC03U900036
  • GC03M9D0028

Summaries for CCK Gene

Entrez Gene Summary for CCK Gene

  • This gene encodes a member of the gastrin/cholecystokinin family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the peptide hormones cholecystokinin-8, -12, -33, and others. The encoded peptides have been shown to regulate gastric acid secretion and food intake. A sulfated form of cholecystokinin-8 may modulate neuronal activity in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

GeneCards Summary for CCK Gene

CCK (Cholecystokinin) is a Protein Coding gene. Diseases associated with CCK include Cholecystitis and Bulimia Nervosa. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include hormone activity and neuropeptide hormone activity.

UniProtKB/Swiss-Prot for CCK Gene

  • This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Tocris Summary for CCK Gene

  • Cholecystokinin (CCK) is a neuropeptide and gut hormone that regulates pancreatic enzyme secretion and gastrointestinal motility, and acts as a satiety signal. It is released simultaneously from intestinal cells and neurons in response to a meal. The precursor molecule prepro-CCK can be cleaved to generate a variety of biologically active forms of CCK including CCK-33, CCK-8 (CCK octapeptide), CCK-39 and CCK-58. Two CCK receptor subtypes, CCK1 and CCK2, mediate the physiological actions of CCK and the related peptide gastrin. The CCK1 receptor has a high affinity for sulfated CCK analogs, whereas the CCK2 receptor has similar affinity for sulfated and non-sulfated forms.

Gene Wiki entry for CCK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCK Gene

Genomics for CCK Gene

Regulatory Elements for CCK Gene

Enhancers for CCK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CCK on UCSC Golden Path with GeneCards custom track

Genomic Location for CCK Gene

Chromosome:
3
Start:
42,257,825 bp from pter
End:
42,266,207 bp from pter
Size:
8,383 bases
Orientation:
Minus strand

Genomic View for CCK Gene

Genes around CCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCK Gene

Proteins for CCK Gene

  • Protein details for CCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06307-CCKN_HUMAN
    Recommended name:
    Cholecystokinin
    Protein Accession:
    P06307

    Protein attributes for CCK Gene

    Size:
    115 amino acids
    Molecular mass:
    12669 Da
    Quaternary structure:
    • Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.

neXtProt entry for CCK Gene

Proteomics data for CCK Gene at MOPED

Post-translational modifications for CCK Gene

  • The precursor is cleaved by proteases to produce a number of active cholecystokinins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CCK Gene

Antibody Products

No data available for DME Specific Peptides for CCK Gene

Domains & Families for CCK Gene

Gene Families for CCK Gene

Protein Domains for CCK Gene

Suggested Antigen Peptide Sequences for CCK Gene

Graphical View of Domain Structure for InterPro Entry

P06307

UniProtKB/Swiss-Prot:

CCKN_HUMAN :
  • Belongs to the gastrin/cholecystokinin family.
Family:
  • Belongs to the gastrin/cholecystokinin family.
genes like me logo Genes that share domains with CCK: view

Function for CCK Gene

Molecular function for CCK Gene

GENATLAS Biochemistry:
cholecystokinin
UniProtKB/Swiss-Prot Function:
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
genes like me logo Genes that share phenotypes with CCK: view

Animal Models for CCK Gene

MGI Knock Outs for CCK:
  • Cck tm2b(EUCOMM)Hmgu
  • Cck tm1Lcs
  • Cck tm1Dgen

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CCK Gene

Localization for CCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCK Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CCK Gene COMPARTMENTS Subcellular localization image for CCK gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
vacuole 2
endosome 1
golgi apparatus 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0030424 axon ISS 15152034
GO:0030425 dendrite IEA --
GO:0043194 axon initial segment IEA --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with CCK: view

Pathways & Interactions for CCK Gene

genes like me logo Genes that share pathways with CCK: view

SIGNOR curated interactions for CCK Gene

Activates:

Gene Ontology (GO) - Biological Process for CCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0001836 release of cytochrome c from mitochondria IEA --
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 10320330
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with CCK: view

Drugs & Compounds for CCK Gene

(100) Drugs for CCK Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxine Approved Nutra 176,176
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 519
Caffeine Approved Nutra Antagonist 349
Esomeprazole Approved, Investigational Pharma Proton pump inhibitor 313
Hydrocortisone Approved Pharma Agonist 594

(85) Additional Compounds for CCK Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Butabindide oxalate
185213-03-0
CCK Octapeptide, non-sulfated
25679-24-7
CCK Octapeptide, sulfated
25126-32-3
Proglumide sodium salt
99247-33-3

(4) Tocris Compounds for CCK Gene

Compound Action Cas Number
Butabindide oxalate CCK-inactivating serine protease inhibitor 185213-03-0
CCK Octapeptide, non-sulfated Non-sulfated form of CCK octapeptide 25679-24-7
CCK Octapeptide, sulfated C-terminal octapeptide of CCK 25126-32-3
Proglumide sodium salt Non-selective CCK antagonist; orally active 99247-33-3
genes like me logo Genes that share compounds with CCK: view

Transcripts for CCK Gene

Unigene Clusters for CCK Gene

Cholecystokinin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CCK Gene

No ASD Table

Relevant External Links for CCK Gene

GeneLoc Exon Structure for
CCK
ECgene alternative splicing isoforms for
CCK

Expression for CCK Gene

mRNA expression in normal human tissues for CCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CCK Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x12.0), Brain - Cortex (x10.9), Brain - Anterior cingulate cortex (BA24) (x10.6), Brain - Amygdala (x7.3), and Brain - Hippocampus (x5.4).

Protein differential expression in normal tissues from HIPED for CCK Gene

This gene is overexpressed in Frontal cortex (49.9) and Brain (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCK Gene



SOURCE GeneReport for Unigene cluster for CCK Gene Hs.458426

genes like me logo Genes that share expression patterns with CCK: view

Protein tissue co-expression partners for CCK Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CCK Gene

Orthologs for CCK Gene

This gene was present in the common ancestor of chordates.

Orthologs for CCK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCK 35
  • 85.51 (n)
  • 80.87 (a)
CCK 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCK 35
  • 88.6 (n)
  • 87.72 (a)
CCK 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cck 35
  • 82.9 (n)
  • 80.87 (a)
Cck 16
Cck 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCK 35
  • 99.71 (n)
  • 99.13 (a)
CCK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cck 35
  • 81.45 (n)
  • 78.26 (a)
oppossum
(Monodelphis domestica)
Mammalia CCK 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCK 36
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCK 35
  • 66.96 (n)
  • 57.39 (a)
CCK 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCK 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497815 35
  • 55.65 (n)
  • 49.57 (a)
zebrafish
(Danio rerio)
Actinopterygii cck 36
  • 35 (a)
OneToMany
CCK (1 of 2) 36
  • 38 (a)
OneToMany
Species with no ortholog for CCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CCK Gene

ENSEMBL:
Gene Tree for CCK (if available)
TreeFam:
Gene Tree for CCK (if available)

Paralogs for CCK Gene

No data available for Paralogs for CCK Gene

Variants for CCK Gene

Sequence variations from dbSNP and Humsavar for CCK Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11571848 - 42,263,536(-) CTCCG(A/G)GCTGC reference, missense
rs3774395 - 42,258,163(+) GTCCC(A/G)GTCAC reference, missense
rs747455 -- 42,264,472(-) ATTAA(A/G)GGATG intron-variant, upstream-variant-2KB
rs747456 -- 42,264,266(-) TGCAC(A/G)GGGCT intron-variant, upstream-variant-2KB
rs754635 -- 42,263,639(+) TGTAG(C/G)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCK Gene

Variant ID Type Subtype PubMed ID
nsv834671 CNV Gain 17160897

Variation tolerance for CCK Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCK Gene

Human Gene Mutation Database (HGMD)
CCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCK Gene

Disorders for CCK Gene

MalaCards: The human disease database

(58) MalaCards diseases for CCK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cholecystitis
  • acute and chronic cholecystitis
bulimia nervosa
  • hyperorexia nervosa
biliary dyskinesia
  • sphincter of oddi dysfunction
acalculous cholecystitis
  • acute acalculous cholecystitis
gallbladder disease
  • gall bladder
- elite association - COSMIC cancer census association via MalaCards
Search CCK in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCK

Genetic Association Database (GAD)
CCK
Human Genome Epidemiology (HuGE) Navigator
CCK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCK
genes like me logo Genes that share disorders with CCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCK Gene

Publications for CCK Gene

  1. Molecular cloning of the human cholecystokinin gene by use of a synthetic probe containing deoxyinosine. (PMID: 3856870) Takahashi Y. … Matsubara K. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4 67
  2. Effect of age and frailty on ghrelin and cholecystokinin responses to a meal test. (PMID: 19339394) Serra-Prat M. … Puig-Domingo M. (Am. J. Clin. Nutr. 2009) 3 23
  3. Levels of serum leptin, cholecystokinin, plasma lipid and lipoprotein differ between patients with gallstone or/and those with hepatolithiasis. (PMID: 18234641) Lei Z.M. … Li J. (HBPD INT 2008) 3 23
  4. Effects of mid-jejunal compared to duodenal glucose infusion on peptide hormone release and appetite in healthy men. (PMID: 18396340) Chaikomin R. … Rayner C.K. (Regul. Pept. 2008) 3 23
  5. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. (PMID: 18555802) Murphy J.A. … Sutton R. (Gastroenterology 2008) 3 23

Products for CCK Gene

Sources for CCK Gene

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