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Aliases for DLEU2 Gene

Subcategory (RNA class) for DLEU2 Gene

lncRNA

Quality Score for this RNA gene is

13

Aliases for DLEU2 Gene

  • Deleted In Lymphocytic Leukemia 2 (Non-Protein Coding) 2 3
  • Mir-15a-16-1 Cluster Host Gene (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 22 2 3
  • Ret Finger Protein 2 Opposite Strand 2 3
  • Deleted In Lymphocytic Leukemia, 2 2 3
  • BCMSUN 3 6
  • Leu2 3 6
  • Leukemia Associated Gene 2 3
  • Non-Protein Coding RNA 22 2
  • NCRNA00022 3
  • LINC00022 3
  • MIR15AHG 3
  • TRIM13OS 3
  • RFP2OS 3
  • DLB2 3
  • 1B4 3

External Ids for DLEU2 Gene

ORGUL Members for DLEU2 Gene

Previous HGNC Symbols for DLEU2 Gene

  • DLB2
  • BCMSUN
  • RFP2OS

Previous GeneCards Identifiers for DLEU2 Gene

  • GC13M048617
  • GC13M044605
  • GC13M049554
  • GC13M048415
  • GC13M049515
  • GC13M050558
  • GC13M031351

Summaries for DLEU2 Gene

GeneCards Summary for DLEU2 Gene

DLEU2 (Deleted In Lymphocytic Leukemia 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DLEU2 include chronic lymphocytic leukemia.

Gene Wiki entry for DLEU2 Gene

fRNAdb sequence ontologies for DLEU2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • antisense_RNA: Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.

  • ncRNA: An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for DLEU2 Gene

Genomics for DLEU2 Gene

Regulatory Elements for DLEU2 Gene

Genomic Location for DLEU2 Gene

Start:
49,982,552 bp from pter
End:
50,125,720 bp from pter
Size:
143,169 bases
Orientation:
Minus strand

Genomic View for DLEU2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLEU2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLEU2 Gene

Proteins for DLEU2 Gene

Post-translational modifications for DLEU2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DLEU2 Gene

Domains for DLEU2 Gene

Suggested Antigen Peptide Sequences for DLEU2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains and UniProtKB/Swiss-Prot for DLEU2 Gene

Function for DLEU2 Gene

Phenotypes for DLEU2 Gene

GenomeRNAi human phenotypes for DLEU2:
genes like me logo Genes that share phenotypes with DLEU2: view

miRNA for DLEU2 Gene

miRTarBase miRNAs that target DLEU2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for DLEU2 Gene

Localization for DLEU2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DLEU2 Gene

Pathways for DLEU2 Gene

SuperPathways for DLEU2 Gene

No Data Available

Interacting Proteins for DLEU2 Gene

Gene Ontology (GO) - Biological Process for DLEU2 Gene

None

No data available for Pathways by source for DLEU2 Gene

Transcripts for DLEU2 Gene

Unigene Clusters for DLEU2 Gene

Deleted in lymphocytic leukemia 2 (non-protein coding):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLEU2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLEU2 Gene

No ASD Table

Relevant External Links for DLEU2 Gene

GeneLoc Exon Structure for
DLEU2
ECgene alternative splicing isoforms for
DLEU2

Expression for DLEU2 Gene

mRNA expression in normal human tissues for DLEU2 Gene

SOURCE GeneReport for Unigene cluster for DLEU2 Gene Hs.547964

genes like me logo Genes that share expressions with DLEU2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for DLEU2 Gene

Orthologs for DLEU2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for DLEU2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Dleu2 16
Species with no ortholog for DLEU2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DLEU2 Gene

ENSEMBL:
Gene Tree for DLEU2 (if available)
TreeFam:
Gene Tree for DLEU2 (if available)

Paralogs for DLEU2 Gene

No data available for Paralogs for DLEU2 Gene

Variants for DLEU2 Gene

Sequence variations from dbSNP and Humsavar for DLEU2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs790937 -- 50,077,820(-) TGTCT(A/G)ATGAA intron-variant
rs790941 -- 50,055,271(-) actta(C/T)gtaca intron-variant
rs790942 -- 50,060,530(-) tgtgc(C/T)aacta intron-variant
rs790943 -- 50,063,651(-) AAATT(A/C)ATAAA intron-variant
rs790944 -- 50,070,345(+) AACAA(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DLEU2 Gene

Variant ID Type Subtype PubMed ID
esv2747402 CNV Deletion 23290073
esv2661834 CNV Deletion 23128226
esv2580955 CNV Deletion 19546169
esv2085992 CNV Deletion 18987734
esv2666533 CNV Deletion 23128226
esv2747403 CNV Deletion 23290073
esv2747404 CNV Deletion 23290073
nsv64412 CNV Loss 16902084
esv2747405 CNV Deletion 23290073
esv1970441 CNV Deletion 18987734
nsv832608 CNV Gain 17160897

Relevant External Links for DLEU2 Gene

HapMap Linkage Disequilibrium report
DLEU2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLEU2 Gene

Disorders for DLEU2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DLEU2 Gene including...

Search for DLEU2 Gene in MalaCards »

Relevant External Links for DLEU2

Genetic Association Database (GAD)
DLEU2
Human Genome Epidemiology (HuGE) Navigator
DLEU2
genes like me logo Genes that share disorders with DLEU2: view

No data available for UniProtKB/Swiss-Prot for DLEU2 Gene

Publications for DLEU2 Gene

  1. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia. (PMID: 9395242) Liu Y. … Oscier D. (Oncogene 1997) 2 3 23
  2. BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22-p31, BCMSUN-like. (PMID: 11072235) Mertens D. … Lichter P. (Int. J. Cancer 2000) 2 3 23
  3. Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. (PMID: 11161783) Kapanadze B. … Sangfelt O. (Genomics 2000) 3 23
  4. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. (PMID: 20451256) Djurovic S. … Andreassen O.A. (J Affect Disord 2010) 3 48
  5. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3

Products for DLEU2 Gene

Sources for DLEU2 Gene

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