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Aliases for KSR1 Gene

Aliases for KSR1 Gene

  • Kinase Suppressor Of Ras 1 2 3 5
  • KSR 3 4
  • Kinase Suppressor Of Ras 2
  • RSU2 3

External Ids for KSR1 Gene

Previous HGNC Symbols for KSR1 Gene

  • KSR

Previous GeneCards Identifiers for KSR1 Gene

  • GC17P022899
  • GC17P025799
  • GC17P022092
  • GC17P025783

Summaries for KSR1 Gene

GeneCards Summary for KSR1 Gene

KSR1 (Kinase Suppressor Of Ras 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for KSR1 Gene

  • Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Gene Wiki entry for KSR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KSR1 Gene

Genomics for KSR1 Gene

Regulatory Elements for KSR1 Gene

Promoters for KSR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KSR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KSR1 Gene

Chromosome:
17
Start:
27,456,464 bp from pter
End:
27,626,441 bp from pter
Size:
169,978 bases
Orientation:
Plus strand

Genomic View for KSR1 Gene

Genes around KSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KSR1 Gene

Proteins for KSR1 Gene

  • Protein details for KSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVT5-KSR1_HUMAN
    Recommended name:
    Kinase suppressor of Ras 1
    Protein Accession:
    Q8IVT5
    Secondary Accessions:
    • F8WEA9
    • H7BYU0
    • Q13476

    Protein attributes for KSR1 Gene

    Size:
    923 amino acids
    Molecular mass:
    102160 Da
    Quaternary structure:
    • Interacts with HSP90AA1/HSP90, YWHAE/14-3-3, CDC37, MAP2K1/MEK-1 and MAP2K2/MEK-2 (PubMed:10409742). Interacts with MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization (By similarity). Interacts with isoform 1 of VRK2 (PubMed:20679487).

    Alternative splice isoforms for KSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KSR1 Gene

Proteomics data for KSR1 Gene at MOPED

Post-translational modifications for KSR1 Gene

  • Phosphorylated on Ser-311 and, to a higher extent, on Ser-406 by MARK3. Dephosphorylated on Ser-406 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KSR1 (KSR)

No data available for DME Specific Peptides for KSR1 Gene

Domains & Families for KSR1 Gene

Gene Families for KSR1 Gene

Suggested Antigen Peptide Sequences for KSR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVT5

UniProtKB/Swiss-Prot:

KSR1_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1 and MAP2K2 membrane localization. The domain is required but not sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation (PubMed:10409742).
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1 and MAP2K2 membrane localization. The domain is required but not sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation (PubMed:10409742).
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with KSR1: view

Function for KSR1 Gene

Molecular function for KSR1 Gene

UniProtKB/Swiss-Prot Function:
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Gene Ontology (GO) - Molecular Function for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031434 mitogen-activated protein kinase kinase binding IEA --
genes like me logo Genes that share ontologies with KSR1: view
genes like me logo Genes that share phenotypes with KSR1: view

Animal Models for KSR1 Gene

MGI Knock Outs for KSR1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KSR1 Gene

Localization for KSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KSR1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Endoplasmic reticulum membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305 PubMed:12007434}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KSR1 Gene COMPARTMENTS Subcellular localization image for KSR1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KSR1: view

Pathways & Interactions for KSR1 Gene

SuperPathways for KSR1 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 Negative regulation of MAPK pathway
genes like me logo Genes that share pathways with KSR1: view

Interacting Proteins for KSR1 Gene

SIGNOR curated interactions for KSR1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with KSR1: view

Drugs & Compounds for KSR1 Gene

(4) Additional Compounds for KSR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with KSR1: view

Transcripts for KSR1 Gene

Unigene Clusters for KSR1 Gene

Kinase suppressor of ras 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KSR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7: - -

ExUns: 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KSR1 Gene

GeneLoc Exon Structure for
KSR1
ECgene alternative splicing isoforms for
KSR1

Expression for KSR1 Gene

mRNA expression in normal human tissues for KSR1 Gene

mRNA differential expression in normal tissues according to GTEx for KSR1 Gene

This gene is overexpressed in Pancreas (x6.5).

Protein differential expression in normal tissues from HIPED for KSR1 Gene

This gene is overexpressed in Heart (25.0), Plasma (15.5), and Peripheral blood mononuclear cells (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KSR1 Gene



SOURCE GeneReport for Unigene cluster for KSR1 Gene Hs.133534

genes like me logo Genes that share expression patterns with KSR1: view

Protein tissue co-expression partners for KSR1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KSR1 Gene

Orthologs for KSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KSR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KSR1 35
  • 90.59 (n)
  • 93.87 (a)
KSR1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KSR1 35
  • 90.12 (n)
  • 93.5 (a)
KSR1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ksr1 35
  • 87 (n)
  • 90.74 (a)
Ksr1 16
Ksr1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KSR1 35
  • 97.68 (n)
  • 97.37 (a)
rat
(Rattus norvegicus)
Mammalia Ksr1 35
  • 88.35 (n)
  • 94.34 (a)
oppossum
(Monodelphis domestica)
Mammalia KSR1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KSR1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves KSR1 35
  • 70.98 (n)
  • 76.6 (a)
KSR1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KSR1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ksr1 35
  • 69.55 (n)
  • 77.23 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16325 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-174l22.2 35
  • 67.43 (n)
  • 66.04 (a)
KSR1 (1 of 2) 36
  • 47 (a)
OneToMany
KSR1 (2 of 2) 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ksr 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ksr-1 36
  • 25 (a)
ManyToMany
ksr-2 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11620 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for KSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KSR1 Gene

ENSEMBL:
Gene Tree for KSR1 (if available)
TreeFam:
Gene Tree for KSR1 (if available)

Paralogs for KSR1 Gene

genes like me logo Genes that share paralogs with KSR1: view

Variants for KSR1 Gene

Sequence variations from dbSNP and Humsavar for KSR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_040658 -
VAR_046048 -
VAR_046049 -
rs878028 -- 27,522,291(-) TAGGA(C/T)CAAGT intron-variant
rs883127 -- 27,458,716(+) CCCAC(C/T)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KSR1 Gene

Variant ID Type Subtype PubMed ID
esv2422193 CNV Duplication 17116639
dgv943e1 CNV Complex 17122850
esv6766 CNV Gain 19470904

Variation tolerance for KSR1 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KSR1 Gene

HapMap Linkage Disequilibrium report
KSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KSR1 Gene

Disorders for KSR1 Gene

Relevant External Links for KSR1

Genetic Association Database (GAD)
KSR1
Human Genome Epidemiology (HuGE) Navigator
KSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KSR1

No disorders were found for KSR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KSR1 Gene

Publications for KSR1 Gene

  1. KSR, a novel protein kinase required for RAS signal transduction. (PMID: 8521512) Therrien M. … Rubin G.M. (Cell 1995) 2 3 4 67
  2. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. (PMID: 14724641) Matheny S.A. … White M.A. (Nature 2004) 3 23
  3. Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton. (PMID: 15090600) Harrison R.E. … Jongstra J. (J. Cell. Sci. 2004) 3 23
  4. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PMID: 11741534) MA1ller J. … Morrison D.K. (Mol. Cell 2001) 3 23
  5. Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. (PMID: 9858547) Cacace A.M. … Morrison D.K. (Mol. Cell. Biol. 1999) 3 23

Products for KSR1 Gene

Sources for KSR1 Gene

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