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Aliases for KSR1 Gene

Aliases for KSR1 Gene

  • Kinase Suppressor Of Ras 1 2 3
  • KSR 3 4
  • Kinase Suppressor Of Ras 2
  • RSU2 3
  • KSR, 6

External Ids for KSR1 Gene

Previous HGNC Symbols for KSR1 Gene

  • KSR

Previous GeneCards Identifiers for KSR1 Gene

  • GC17P022899
  • GC17P025799
  • GC17P022092
  • GC17P025783

Summaries for KSR1 Gene

GeneCards Summary for KSR1 Gene

KSR1 (Kinase Suppressor Of Ras 1) is a Protein Coding gene. Diseases associated with KSR1 include scarlet fever and bronchopneumonia. Among its related pathways are Ras signaling pathway and ErbB1 downstream signaling. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for KSR1 Gene

  • Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity

Gene Wiki entry for KSR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KSR1 Gene

Genomics for KSR1 Gene

Regulatory Elements for KSR1 Gene

Genomic Location for KSR1 Gene

Start:
27,456,464 bp from pter
End:
27,626,441 bp from pter
Size:
169,978 bases
Orientation:
Plus strand

Genomic View for KSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KSR1 Gene

Proteins for KSR1 Gene

  • Protein details for KSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVT5-KSR1_HUMAN
    Recommended name:
    Kinase suppressor of Ras 1
    Protein Accession:
    Q8IVT5
    Secondary Accessions:
    • F8WEA9
    • H7BYU0
    • Q13476

    Protein attributes for KSR1 Gene

    Size:
    923 amino acids
    Molecular mass:
    102160 Da
    Quaternary structure:
    • Interacts with HSPCA/HSP90, YWHAB/14-3-3, CDC37, MAP2K/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. Interacts with isoform 1 of VRK2.

    Alternative splice isoforms for KSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KSR1 Gene

Proteomics data for KSR1 Gene at MOPED

Post-translational modifications for KSR1 Gene

  • Phosphorylated on Ser-311 and, to a higher extent, on Ser-406 by MARK3. Dephosphorylated on Ser-406 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KSR1 Gene

Domains for KSR1 Gene

Gene Families for KSR1 Gene

Suggested Antigen Peptide Sequences for KSR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVT5

UniProtKB/Swiss-Prot:

KSR1_HUMAN :
  • Q8IVT5
Domain:
  • The protein kinase domain is predicted to be catalytically inactive
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with KSR1: view

Function for KSR1 Gene

Molecular function for KSR1 Gene

UniProtKB/Swiss-Prot Function: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity

Gene Ontology (GO) - Molecular Function for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity NAS 8521512
GO:0004674 protein serine/threonine kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0005078 MAP-kinase scaffold activity IEA --
GO:0005515 protein binding IPI 20679487
genes like me logo Genes that share ontologies with KSR1: view
genes like me logo Genes that share phenotypes with KSR1: view

Animal Models for KSR1 Gene

MGI Knock Outs for KSR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KSR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for KSR1 Gene

Localization for KSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KSR1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Endoplasmic reticulum membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KSR1 Gene COMPARTMENTS Subcellular localization image for KSR1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 22572157
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0043234 protein complex IDA 22572157
genes like me logo Genes that share ontologies with KSR1: view

Pathways for KSR1 Gene

genes like me logo Genes that share pathways with KSR1: view

Pathways by source for KSR1 Gene

1 Cell Signaling Technology pathway for KSR1 Gene
2 KEGG pathways for KSR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for KSR1 Gene

Gene Ontology (GO) - Biological Process for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007265 Ras protein signal transduction NAS 8521512
GO:0035556 intracellular signal transduction --
GO:0043410 positive regulation of MAPK cascade IEA --
genes like me logo Genes that share ontologies with KSR1: view

Compounds for KSR1 Gene

(843) HMDB Compounds for KSR1 Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with KSR1: view

Transcripts for KSR1 Gene

Unigene Clusters for KSR1 Gene

Kinase suppressor of ras 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KSR1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KSR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KSR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7: - -

ExUns: 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KSR1 Gene

GeneLoc Exon Structure for
KSR1
ECgene alternative splicing isoforms for
KSR1

Expression for KSR1 Gene

mRNA expression in normal human tissues for KSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KSR1 Gene

This gene is overexpressed in Pancreas (6.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KSR1 Gene

SOURCE GeneReport for Unigene cluster for KSR1 Gene Hs.133534

genes like me logo Genes that share expressions with KSR1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KSR1 Gene

Orthologs for KSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KSR1 35
  • 97.68 (n)
  • 97.37 (a)
cow
(Bos Taurus)
Mammalia KSR1 35
  • 90.59 (n)
  • 93.87 (a)
KSR1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KSR1 35
  • 90.12 (n)
  • 93.5 (a)
KSR1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ksr1 35
  • 87 (n)
  • 90.74 (a)
Ksr1 16
Ksr1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KSR1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KSR1 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ksr1 35
  • 88.35 (n)
  • 94.34 (a)
chicken
(Gallus gallus)
Aves KSR1 35
  • 70.98 (n)
  • 76.6 (a)
KSR1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KSR1 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16325 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ksr1 35
  • 69.55 (n)
  • 77.23 (a)
zebrafish
(Danio rerio)
Actinopterygii KSR1 (1 of 2) 36
  • 47 (a)
OneToMany
KSR1 (2 of 2) 36
  • 48 (a)
OneToMany
si:dkey-174l22.2 35
  • 67.43 (n)
  • 66.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta ksr 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ksr-1 36
  • 25 (a)
ManyToMany
ksr-2 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11620 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToMany
Species with no ortholog for KSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KSR1 Gene

ENSEMBL:
Gene Tree for KSR1 (if available)
TreeFam:
Gene Tree for KSR1 (if available)

Paralogs for KSR1 Gene

genes like me logo Genes that share paralogs with KSR1: view

Variants for KSR1 Gene

Sequence variations from dbSNP and Humsavar for KSR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs745221 -- 27,589,074(-) AGTTG(C/T)GATCC intron-variant
rs749529 -- 27,624,618(+) AAACT(C/G)TTAAC utr-variant-3-prime
rs869670 -- 27,546,265(+) CCTGC(A/C)CTGAT intron-variant
rs869671 -- 27,546,285(+) TAGGG(A/G)GATCT intron-variant
rs878028 -- 27,522,291(-) TAGGA(C/T)CAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KSR1 Gene

Variant ID Type Subtype PubMed ID
esv2422193 CNV Duplication 17116639
dgv943e1 CNV Complex 17122850
esv6766 CNV Gain 19470904

Relevant External Links for KSR1 Gene

HapMap Linkage Disequilibrium report
KSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KSR1 Gene

Disorders for KSR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for KSR1 Gene including...

Search for KSR1 Gene in MalaCards »

(4) University of Copenhagen DISEASES for KSR1 Gene

Relevant External Links for KSR1

Genetic Association Database (GAD)
KSR1
Human Genome Epidemiology (HuGE) Navigator
KSR1
genes like me logo Genes that share disorders with KSR1: view

No data available for UniProtKB/Swiss-Prot for KSR1 Gene

Publications for KSR1 Gene

  1. KSR, a novel protein kinase required for RAS signal transduction. (PMID: 8521512) Therrien M. … Rubin G.M. (Cell 1995) 2 3 4
  2. MAP kinase module: the Ksr connection. (PMID: 12007434) Roy F. … Therrien M. (Curr. Biol. 2002) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PMID: 11741534) MA1ller J. … Morrison D.K. (Mol. Cell 2001) 3 23
  5. Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. (PMID: 9858547) Cacace A.M. … Morrison D.K. (Mol. Cell. Biol. 1999) 3 23

Products for KSR1 Gene

  • Addgene plasmids for KSR1

Sources for KSR1 Gene

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