Aliases for GGH Gene
External Ids for GGH Gene
Previous GeneCards Identifiers for GGH Gene
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]
GeneCards Summary for GGH Gene
GGH (Gamma-Glutamyl Hydrolase (Conjugase, Folylpolygammaglutamyl Hydrolase)) is a Protein Coding gene. Diseases associated with GGH include methotrexate dose selection and tropical sprue. Among its related pathways are Folate biosynthesis and Pyrimidine metabolism. GO annotations related to this gene include omega peptidase activity and gamma-glutamyl-peptidase activity.
UniProtKB/Swiss-Prot for GGH Gene
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates