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Aliases for NRP1 Gene

Aliases for NRP1 Gene

  • Neuropilin 1 2 3
  • VEGF165R 3 4 6
  • NRP 3 4 6
  • Vascular Endothelial Cell Growth Factor 165 Receptor 3 4
  • Transmembrane Receptor 3
  • CD304 Antigen 4
  • Neuropilin-1 3
  • BDCA4 3
  • CD304 3
  • NP1 3

External Ids for NRP1 Gene

Summaries for NRP1 Gene

Entrez Gene Summary for NRP1 Gene

  • This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for NRP1 Gene

NRP1 (Neuropilin 1) is a Protein Coding gene. Diseases associated with NRP1 include acute hemorrhagic leukoencephalitis and retinal vascular disease. Among its related pathways are Signaling by GPCR and L1CAM interactions. GO annotations related to this gene include heparin binding and coreceptor activity. An important paralog of this gene is NRP2.

UniProtKB/Swiss-Prot for NRP1 Gene

  • The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis

  • The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity

Gene Wiki entry for NRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NRP1 Gene

Genomics for NRP1 Gene

Genomic Location for NRP1 Gene

Start:
33,177,491 bp from pter
End:
33,336,262 bp from pter
Size:
158,772 bases
Orientation:
Minus strand

Genomic View for NRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NRP1 Gene

Regulatory Elements for NRP1 Gene

Proteins for NRP1 Gene

  • Protein details for NRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14786-NRP1_HUMAN
    Recommended name:
    Neuropilin-1
    Protein Accession:
    O14786
    Secondary Accessions:
    • B0LPG9
    • O60461
    • Q5T7F1
    • Q5T7F2
    • Q5T7F3
    • Q86T59
    • Q96I90
    • Q96IH5

    Protein attributes for NRP1 Gene

    Size:
    923 amino acids
    Molecular mass:
    103134 Da
    Quaternary structure:
    • Homodimer, and heterodimer with NRP2. Interacts with FER (By similarity). Binds PLXNB1.

    Three dimensional structures from OCA and Proteopedia for NRP1 Gene

    Alternative splice isoforms for NRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NRP1 Gene

Proteomics data for NRP1 Gene at MOPED

Post-translational modifications for NRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys53 and Lys106
  • Glycosylation at Asn150, Asn261, Asn300, Asn522, Ser612, Thr827, Ser829, Thr830, Asn842, and Ser844

No data available for DME Specific Peptides for NRP1 Gene

Domains for NRP1 Gene

Gene Families for NRP1 Gene

HGNC:
  • CD :CD molecules

Graphical View of Domain Structure for InterPro Entry

O14786

UniProtKB/Swiss-Prot:

NRP1_HUMAN
Domain:
  • The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding:
    • O14786
  • Contains 2 CUB domains.:
    • O14786
  • Contains 2 F5/8 type C domains.:
    • O14786
  • Contains 1 MAM domain.:
    • O14786
Family:
  • Belongs to the neuropilin family.:
    • O14786
genes like me logo Genes that share domains with NRP1: view

Function for NRP1 Gene

Molecular function for NRP1 Gene

GENATLAS Biochemistry: neuropilin 1,cell surface glycoprotein,expressed by the developing nervous system, complexing with plexin 1(PLXN1),implicated in repulsive axon guidance,also expressed by endothelial and tumor cells,vascular endothelial growth factor-165 receptor,with dominant negative form resulting from the deletion of an extracellular domain,necessary component of receptor complexes for some,but not all,secreted semaphorin family members
UniProtKB/Swiss-Prot Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis
UniProtKB/Swiss-Prot Function: The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity

Gene Ontology (GO) - Molecular Function for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005021 vascular endothelial growth factor-activated receptor activity NAS 19909241
GO:0005515 protein binding IPI 16763549
GO:0008201 heparin binding IEA --
GO:0015026 coreceptor activity TAS 21245381
GO:0017154 semaphorin receptor activity NAS 19909241
genes like me logo Genes that share ontologies with NRP1: view
genes like me logo Genes that share phenotypes with NRP1: view

Animal Models for NRP1 Gene

MGI Knock Outs for NRP1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NRP1 Gene

Localization for NRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NRP1 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NRP1 Gene COMPARTMENTS Subcellular localization image for NRP1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002116 semaphorin receptor complex NAS 19909241
GO:0005615 extracellular space IDA 16502470
GO:0005769 early endosome ISS 23639442
GO:0005829 cytosol IDA 21245381
GO:0005883 neurofilament IEA --
genes like me logo Genes that share ontologies with NRP1: view

Pathways for NRP1 Gene

genes like me logo Genes that share pathways with NRP1: view

Pathways by source for NRP1 Gene

1 R&D Systems pathway for NRP1 Gene
1 Sino Biological pathway for NRP1 Gene
1 Cell Signaling Technology pathway for NRP1 Gene
1 PharmGKB pathway for NRP1 Gene
2 KEGG pathways for NRP1 Gene

Gene Ontology (GO) - Biological Process for NRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS 24401374
GO:0001569 patterning of blood vessels ISS --
GO:0001764 neuron migration ISS --
GO:0001938 positive regulation of endothelial cell proliferation TAS 21245381
GO:0002040 sprouting angiogenesis ISS 24401374
genes like me logo Genes that share ontologies with NRP1: view

Compounds for NRP1 Gene

(2) Drugbank Compounds for NRP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Palifermin
  • FGF-7
162394-19-6 target
Pegaptanib
222716-86-1 target

(44) Novoseek inferred chemical compound relationships for NRP1 Gene

Compound -log(P) Hits PubMed IDs
vegf 83.1 185
tyrosine 66.1 81
matrigel 36.2 4
bcma 30.6 2
gp 130 23.4 3
genes like me logo Genes that share compounds with NRP1: view

Transcripts for NRP1 Gene

Unigene Clusters for NRP1 Gene

Neuropilin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NRP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - -
SP7: - - -
SP8: - - - -
SP9: - - - - -
SP10:
SP11:

ExUns: 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NRP1 Gene

GeneLoc Exon Structure for
NRP1
ECgene alternative splicing isoforms for
NRP1

Expression for NRP1 Gene

mRNA expression in normal human tissues for NRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NRP1 Gene

SOURCE GeneReport for Unigene cluster for NRP1 Gene Hs.131704

mRNA Expression by UniProt/SwissProt for NRP1 Gene

O14786-NRP1_HUMAN
Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules
genes like me logo Genes that share expressions with NRP1: view

No data available for mRNA differential expression in normal tissues for NRP1 Gene

Orthologs for NRP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NRP1 35
  • 99.39 (n)
  • 99.67 (a)
NRP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NRP1 35
  • 90.58 (n)
  • 95.68 (a)
NRP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NRP1 35
  • 91.57 (n)
  • 96.56 (a)
NRP1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nrp1 35
  • 87.36 (n)
  • 93.28 (a)
Nrp1 16
Nrp1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NRP1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NRP1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nrp1 35
  • 87.74 (n)
  • 93.38 (a)
chicken
(Gallus gallus)
Aves NRP1 35
  • 78.21 (n)
  • 83.18 (a)
NRP1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NRP1 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397804 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nrp1 35
  • 71.99 (n)
  • 73.84 (a)
zebrafish
(Danio rerio)
Actinopterygii nrp1 35
nrp1a 35
  • 66.25 (n)
  • 67.72 (a)
nrp1a 36
  • 65 (a)
OneToMany
nrp1b 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7396 36
  • 23 (a)
OneToMany
Species with no ortholog for NRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NRP1 Gene

ENSEMBL:
Gene Tree for NRP1 (if available)
TreeFam:
Gene Tree for NRP1 (if available)

Paralogs for NRP1 Gene

Paralogs for NRP1 Gene

genes like me logo Genes that share paralogs with NRP1: view

Variants for NRP1 Gene

Sequence variations from dbSNP and Humsavar for NRP1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10080 -- 33,178,180(-) ATAGA(C/T)GAGAC utr-variant-3-prime, nc-transcript-variant
rs13324 -- 33,178,722(-) TAATA(C/T)AAATT utr-variant-3-prime, nc-transcript-variant
rs725328 -- 33,247,609(-) TATTC(A/G)GAGAA intron-variant
rs734186 -- 33,195,901(-) TCAAT(C/T)CAAAC intron-variant
rs734187 -- 33,195,768(-) AAGTG(C/T)TCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NRP1 Gene

Variant ID Type Subtype PubMed ID
nsv831829 CNV Loss 17160897
esv27085 CNV Loss 19812545
esv4611 CNV Deletion 18987735
esv2735262 CNV Deletion 23290073
esv2678844 CNV Deletion 23128226
nsv24782 CNV Loss 16902084
esv8432 CNV Loss 19470904
nsv825336 CNV Loss 20364138
nsv6299 CNV Insertion 18451855
nsv528133 CNV Loss 19592680
esv268350 CNV Insertion 20981092
esv2662402 CNV Deletion 23128226

Relevant External Links for NRP1 Gene

HapMap Linkage Disequilibrium report
NRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NRP1 Gene

Disorders for NRP1 Gene

(2) University of Copenhagen DISEASES for NRP1 Gene

(68) Novoseek inferred disease relationships for NRP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 50.7 115
neovascularization 45.7 4
cancer 37.4 26
metastasis 33.5 15
cadasil 33.1 1

Relevant External Links for NRP1

Genetic Association Database (GAD)
NRP1
Human Genome Epidemiology (HuGE) Navigator
NRP1
genes like me logo Genes that share disorders with NRP1: view

No data available for UniProtKB/Swiss-Prot for NRP1 Gene

Publications for NRP1 Gene

  1. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. (PMID: 9529250) Soker S. … Klagsbrun M. (Cell 1998) 2 3 4 23
  2. The altered expression of syndecan 4 in the uninvolved skin of venous leg ulcer patients may predispose to venous leg ulcer. (PMID: 18638267) Nagy N. … SzAcll M. (Wound Repair Regen 2008) 3 23 48
  3. Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes. (PMID: 18785001) Schneider B.P. … Sledge G.W. (Breast Cancer Res. Treat. 2009) 3 23 48
  4. Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. (PMID: 18922901) Castro-Rivera E. … Minna J.D. (Cancer Res. 2008) 3 23
  5. Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway. (PMID: 18704117) Frankel P. … Zachary I.C. (EMBO Rep. 2008) 3 23

Products for NRP1 Gene

Sources for NRP1 Gene

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