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Aliases for IQGAP1 Gene

Aliases for IQGAP1 Gene

  • IQ Motif Containing GTPase Activating Protein 1 2 3
  • RasGAP-Like With IQ Motifs 2 3
  • SAR1 3 6
  • P195 3 4
  • Ras GTPase-Activating-Like Protein IQGAP1 3
  • HUMORFA01 3
  • KIAA0051 4

External Ids for IQGAP1 Gene

Summaries for IQGAP1 Gene

Entrez Gene Summary for IQGAP1 Gene

  • This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]

GeneCards Summary for IQGAP1 Gene

IQGAP1 (IQ Motif Containing GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with IQGAP1 include bullous skin disease and skin disease. Among its related pathways are Proteoglycans in cancer and Regulation of actin cytoskeleton. GO annotations related to this gene include calcium ion binding and calmodulin binding. An important paralog of this gene is IQGAP3.

UniProtKB/Swiss-Prot for IQGAP1 Gene

  • Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.

Gene Wiki entry for IQGAP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IQGAP1 Gene

Genomics for IQGAP1 Gene

Genomic Location for IQGAP1 Gene

Start:
90,388,218 bp from pter
End:
90,502,243 bp from pter
Size:
114,026 bases
Orientation:
Plus strand

Genomic View for IQGAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IQGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IQGAP1 Gene

Regulatory Elements for IQGAP1 Gene

Proteins for IQGAP1 Gene

  • Protein details for IQGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46940-IQGA1_HUMAN
    Recommended name:
    Ras GTPase-activating-like protein IQGAP1
    Protein Accession:
    P46940
    Secondary Accessions:
    • A7MBM3

    Protein attributes for IQGAP1 Gene

    Size:
    1657 amino acids
    Molecular mass:
    189252 Da
    Quaternary structure:
    • Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6.
    SequenceCaution:
    • Sequence=BAA06123.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IQGAP1 Gene

neXtProt entry for IQGAP1 Gene

Proteomics data for IQGAP1 Gene at MOPED

Post-translational modifications for IQGAP1 Gene

  • Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys88, Lys348, Lys811, Lys1027, Lys1088, Lys1144, Lys1155, Lys1165, Lys1230, Lys1477, and Lys1528

Other Protein References for IQGAP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IQGAP1 Gene

Domains for IQGAP1 Gene

Graphical View of Domain Structure for InterPro Entry

P46940

UniProtKB/Swiss-Prot:

IQGA1_HUMAN
Domain:
  • Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not phosphorylated, C1 and C2 interact, which prevents binding of nucleotide-free CDC42 and promotes binding of GTP-bound CDC42. Phosphorylation of Ser-1443 prevents interaction between C1 and C2, which opens the structure of the C-terminus and allows binding and sequestration of nucleotide-free CDC42 on both C1 and C2.:
    • P46940
  • Contains 1 CH (calponin-homology) domain.:
    • P46940
  • Contains 4 IQ domains.:
    • P46940
  • Contains 1 Ras-GAP domain.:
    • P46940
  • Contains 1 WW domain.:
    • P46940
genes like me logo Genes that share domains with IQGAP1: view

No data available for Gene Families for IQGAP1 Gene

Function for IQGAP1 Gene

Molecular function for IQGAP1 Gene

GENATLAS Biochemistry: IQ motif containing GTPase activating protein 1,S pombe RasGAP-like protein SAR1 homolog,potential effector for CDC42,may be involved in cell morphology
UniProtKB/Swiss-Prot Function: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.

Gene Ontology (GO) - Molecular Function for IQGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005095 GTPase inhibitor activity TAS 8670801
GO:0005096 GTPase activator activity TAS 8051149
GO:0005509 calcium ion binding TAS 18567582
GO:0005515 protein binding IPI 10793131
GO:0005516 calmodulin binding IPI 18567582
genes like me logo Genes that share ontologies with IQGAP1: view
genes like me logo Genes that share phenotypes with IQGAP1: view

Animal Models for IQGAP1 Gene

MGI Knock Outs for IQGAP1:

miRNA for IQGAP1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IQGAP1 Gene

Localization for IQGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IQGAP1 Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IQGAP1 Gene COMPARTMENTS Subcellular localization image for IQGAP1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for IQGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IQGAP1: view

Pathways for IQGAP1 Gene

genes like me logo Genes that share pathways with IQGAP1: view

Gene Ontology (GO) - Biological Process for IQGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IEA --
GO:0006112 energy reserve metabolic process TAS --
GO:0007165 signal transduction TAS 8051149
GO:0007173 epidermal growth factor receptor signaling pathway IMP 17563371
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with IQGAP1: view

Compounds for IQGAP1 Gene

(1) HMDB Compounds for IQGAP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(8) Novoseek inferred chemical compound relationships for IQGAP1 Gene

Compound -log(P) Hits PubMed IDs
zaldaride maleate 77.5 3
gtp 45.6 5
gdp 18.8 1
oxygen 0 5
calcium 0 14
genes like me logo Genes that share compounds with IQGAP1: view

Transcripts for IQGAP1 Gene

Unigene Clusters for IQGAP1 Gene

IQ motif containing GTPase activating protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IQGAP1 Gene

No ASD Table

Relevant External Links for IQGAP1 Gene

GeneLoc Exon Structure for
IQGAP1
ECgene alternative splicing isoforms for
IQGAP1

Expression for IQGAP1 Gene

mRNA expression in normal human tissues for IQGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IQGAP1 Gene

This gene is overexpressed in Whole Blood (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IQGAP1 Gene

SOURCE GeneReport for Unigene cluster for IQGAP1 Gene Hs.430551

mRNA Expression by UniProt/SwissProt for IQGAP1 Gene

P46940-IQGA1_HUMAN
Tissue specificity: Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas
genes like me logo Genes that share expressions with IQGAP1: view

Orthologs for IQGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IQGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IQGAP1 35
  • 99.74 (n)
  • 99.94 (a)
IQGAP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IQGAP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IQGAP1 35
  • 92.09 (n)
  • 97.04 (a)
IQGAP1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iqgap1 35
  • 88.57 (n)
  • 95.96 (a)
Iqgap1 16
Iqgap1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IQGAP1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Iqgap1 35
  • 88.39 (n)
  • 95.96 (a)
chicken
(Gallus gallus)
Aves IQGAP1 35
  • 79.11 (n)
  • 88.76 (a)
IQGAP1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IQGAP1 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia XIQGAP1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia iqgap1 35
  • 74.44 (n)
  • 83.02 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.515 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17687 35
iqgap1 35
  • 69.95 (n)
  • 76.37 (a)
iqgap1 36
  • 77 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pes-7 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IQG1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for IQGAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IQGAP1 Gene

ENSEMBL:
Gene Tree for IQGAP1 (if available)
TreeFam:
Gene Tree for IQGAP1 (if available)

Paralogs for IQGAP1 Gene

Paralogs for IQGAP1 Gene

Selected SIMAP similar genes for IQGAP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with IQGAP1: view

Variants for IQGAP1 Gene

Sequence variations from dbSNP and Humsavar for IQGAP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3539 -- 90,502,187(+) TTGTT(G/T)CTGCA utr-variant-3-prime
rs3540 -- 90,502,176(+) TGCCC(A/G)TCAGA utr-variant-3-prime
rs10307 -- 90,501,052(+) TAATG(C/T)ATCAA utr-variant-3-prime
rs11609 -- 90,500,533(+) ACACA(C/G)AACTA utr-variant-3-prime
rs14620 -- 90,502,153(+) TACTT(C/T)CTCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IQGAP1 Gene

Variant ID Type Subtype PubMed ID
nsv833087 CNV Loss 17160897
esv2751541 CNV Gain 17911159
nsv904493 CNV Gain 21882294
nsv457246 CNV Gain 19166990
nsv833088 CNV Loss 17160897
esv2658494 CNV Deletion 23128226

Relevant External Links for IQGAP1 Gene

HapMap Linkage Disequilibrium report
IQGAP1
Human Gene Mutation Database (HGMD)
IQGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IQGAP1 Gene

Disorders for IQGAP1 Gene

(10) Novoseek inferred disease relationships for IQGAP1 Gene

Disease -log(P) Hits PubMed IDs
familial adenomatous polyposis 54 3
colon carcinoma 34.3 2
gastric cancer 15.4 7
astrocytoma 13.4 2
tumors 9.57 13

Relevant External Links for IQGAP1

Human Genome Epidemiology (HuGE) Navigator
IQGAP1
genes like me logo Genes that share disorders with IQGAP1: view

No data available for UniProtKB/Swiss-Prot for IQGAP1 Gene

Publications for IQGAP1 Gene

  1. Identification of a human rasGAP-related protein containing calmodulin-binding motifs. (PMID: 8051149) Weissbach L. … Bernards A. (J. Biol. Chem. 1994) 2 3 4 23
  2. Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator. (PMID: 15355962) Grohmanova K. … Kroschewski R. (J. Biol. Chem. 2004) 3 4 23
  3. IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. (PMID: 15695813) Li Z. … Sacks D.B. (J. Biol. Chem. 2005) 3 4 23
  4. IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. (PMID: 8670801) Hart M.J. … Polakis P. (EMBO J. 1996) 2 3 4
  5. IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. (PMID: 19050761) Meyer R.D. … Rahimi N. (PLoS ONE 2008) 3 23

Products for IQGAP1 Gene

Sources for IQGAP1 Gene

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