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Aliases for DPM2 Gene

Aliases for DPM2 Gene

  • Dolichyl-Phosphate Mannosyltransferase Polypeptide 2, Regulatory Subunit 2 3
  • Dolichol-Phosphate Mannose Synthase Subunit 2 3 4
  • DPM Synthase Complex Subunit 2 3
  • DPM Synthase Subunit 2 3 4
  • CDG1U 3 6
  • Dolichol Phosphate-Mannose Biosynthesis Regulatory Protein 3

External Ids for DPM2 Gene

Summaries for DPM2 Gene

Entrez Gene Summary for DPM2 Gene

  • Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a hydrophobic protein that contains 2 predicted transmembrane domains and a putative ER localization signal near the C terminus. This protein associates with DPM1 in vivo and is required for the ER localization and stable expression of DPM1 and also enhances the binding of dolichol-phosphate to DPM1. [provided by RefSeq, Jul 2008]

GeneCards Summary for DPM2 Gene

DPM2 (Dolichyl-Phosphate Mannosyltransferase Polypeptide 2, Regulatory Subunit) is a Protein Coding gene. Diseases associated with DPM2 include congenital disorder of glycosylation, type iu and congenital disorder of glycosylation, type ie. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include enzyme regulator activity and dolichyl-phosphate beta-D-mannosyltransferase activity.

UniProtKB/Swiss-Prot for DPM2 Gene

  • Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.

Gene Wiki entry for DPM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DPM2 Gene

Genomics for DPM2 Gene

Genomic Location for DPM2 Gene

Start:
127,935,095 bp from pter
End:
127,938,484 bp from pter
Size:
3,390 bases
Orientation:
Minus strand

Genomic View for DPM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DPM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DPM2 Gene

Regulatory Elements for DPM2 Gene

Proteins for DPM2 Gene

  • Protein details for DPM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94777-DPM2_HUMAN
    Recommended name:
    Dolichol phosphate-mannose biosynthesis regulatory protein
    Protein Accession:
    O94777
    Secondary Accessions:
    • Q5XKK9
    • Q6FGH3

    Protein attributes for DPM2 Gene

    Size:
    84 amino acids
    Molecular mass:
    9312 Da
    Quaternary structure:
    • Component of the dolichol-phosphate mannose (DPM) synthase complex composed of DPM1, DPM2 and DPM3; in the complex interacts directly with DPM3. Associates with the GPI-GlcNAc transferase (GPI-GnT) complex.

neXtProt entry for DPM2 Gene

Proteomics data for DPM2 Gene at MOPED

Post-translational modifications for DPM2 Gene

No Post-translational modifications

Other Protein References for DPM2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DPM2 Gene

Domains for DPM2 Gene

Protein Domains for DPM2 Gene

Graphical View of Domain Structure for InterPro Entry

O94777

UniProtKB/Swiss-Prot:

DPM2_HUMAN
Family:
  • Belongs to the DPM2 family.:
    • O94777
genes like me logo Genes that share domains with DPM2: view

No data available for Gene Families for DPM2 Gene

Function for DPM2 Gene

Molecular function for DPM2 Gene

UniProtKB/Swiss-Prot Function: Regulates the biosynthesis of dolichol phosphate-mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity.

Gene Ontology (GO) - Molecular Function for DPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004582 contributes_to dolichyl-phosphate beta-D-mannosyltransferase activity IDA 10835346
GO:0005515 protein binding IPI 10835346
GO:0030234 enzyme regulator activity IBA --
genes like me logo Genes that share ontologies with DPM2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DPM2 Gene

Localization for DPM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DPM2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DPM2 Gene COMPARTMENTS Subcellular localization image for DPM2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 2
lysosome 1

Gene Ontology (GO) - Cellular Components for DPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex TAS 16280320
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS 16280320
GO:0030176 integral component of endoplasmic reticulum membrane IEA --
GO:0033185 dolichol-phosphate-mannose synthase complex IDA 10835346
genes like me logo Genes that share ontologies with DPM2: view

Pathways for DPM2 Gene

genes like me logo Genes that share pathways with DPM2: view

UniProtKB/Swiss-Prot O94777-DPM2_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for DPM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006501 C-terminal protein lipidation TAS --
GO:0006506 GPI anchor biosynthetic process IDA 10835346
GO:0009059 macromolecule biosynthetic process --
GO:0016254 preassembly of GPI anchor in ER membrane TAS --
genes like me logo Genes that share ontologies with DPM2: view

Transcripts for DPM2 Gene

Unigene Clusters for DPM2 Gene

Dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DPM2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: -
SP4: -
SP5: -

Relevant External Links for DPM2 Gene

GeneLoc Exon Structure for
DPM2
ECgene alternative splicing isoforms for
DPM2

Expression for DPM2 Gene

mRNA expression in normal human tissues for DPM2 Gene

SOURCE GeneReport for Unigene cluster for DPM2 Gene Hs.108973

genes like me logo Genes that share expressions with DPM2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for DPM2 Gene

Orthologs for DPM2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DPM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DPM2 35
  • 99.21 (n)
  • 98.81 (a)
DPM2 36
  • 53 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DPM2 35
  • 89.29 (n)
  • 88.1 (a)
DPM2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DPM2 35
  • 93.25 (n)
  • 91.67 (a)
DPM2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dpm2 35
  • 86.9 (n)
  • 88.1 (a)
Dpm2 16
Dpm2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DPM2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DPM2 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dpm2 35
  • 88.89 (n)
  • 88.1 (a)
chicken
(Gallus gallus)
Aves DPM2 35
  • 67.06 (n)
  • 65.48 (a)
DPM2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dpm2 35
  • 61.11 (n)
  • 58.33 (a)
zebrafish
(Danio rerio)
Actinopterygii dpm2 35
  • 59.67 (n)
  • 60.49 (a)
dpm2 36
  • 58 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G74340 35
  • 60.61 (n)
  • 59.74 (a)
rice
(Oryza sativa)
Liliopsida Os02g0140101 35
  • 61.84 (n)
  • 56.58 (a)
Species with no ortholog for DPM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DPM2 Gene

ENSEMBL:
Gene Tree for DPM2 (if available)
TreeFam:
Gene Tree for DPM2 (if available)

Paralogs for DPM2 Gene

No data available for Paralogs for DPM2 Gene

Variants for DPM2 Gene

Sequence variations from dbSNP and Humsavar for DPM2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6781 Benign 127,935,764(-) TCCTA(C/T)GTGAT synonymous-codon, reference
rs7997 Benign, - 127,935,750(-) GAAGA(C/G)CAAGA reference, missense
rs1801824 -- 127,937,443(-) TGGGT(G/T)ATTCT reference, synonymous-codon
rs2274424 -- 127,937,638(+) GTAGA(A/G)GGCTG intron-variant
rs2274425 -- 127,937,806(+) CACGG(C/T)GCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DPM2 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
dgv8291n71 CNV Loss 21882294
dgv8293n71 CNV Loss 21882294
nsv466577 CNV Loss 19166990
nsv6722 CNV Insertion 18451855
nsv831727 CNV Loss 17160897

Relevant External Links for DPM2 Gene

HapMap Linkage Disequilibrium report
DPM2
Human Gene Mutation Database (HGMD)
DPM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DPM2 Gene

Disorders for DPM2 Gene

(1) OMIM Diseases for DPM2 Gene (603564)

UniProtKB/Swiss-Prot

DPM2_HUMAN
  • Congenital disorder of glycosylation 1U (CDG1U) [MIM:615042]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Some CDG1U patients have dystrophic changes seen on muscle biopsy and reduced O-mannosyl glycans on alpha-dystroglycan. {ECO:0000269 PubMed:23109149}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with DPM2: view

Publications for DPM2 Gene

  1. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. (PMID: 9724629) Maeda Y. … Kinoshita T. (EMBO J. 1998) 2 3 4
  2. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. (PMID: 10835346) Maeda Y. … Kinoshita T. (EMBO J. 2000) 3 4 23
  3. DPM2-CDG: a muscular dystrophy-dystroglycanopathy syndrome with severe epilepsy. (PMID: 23109149) Barone R. … Lefeber D.J. (Ann. Neurol. 2012) 3 4
  4. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. (PMID: 10944123) Watanabe R. … Kinoshita T. (EMBO J. 2000) 3 4
  5. Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis. (PMID: 11102867) Kinoshita T. … Inoue N. (Curr Opin Chem Biol 2000) 3

Products for DPM2 Gene

Sources for DPM2 Gene

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