External Ids for CCNK Gene
Previous GeneCards Identifiers for CCNK Gene
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
GeneCards Summary for CCNK Gene
CCNK (Cyclin K) is a Protein Coding gene. Diseases associated with CCNK include Kaposi Sarcoma. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include protein kinase binding and RNA polymerase II carboxy-terminal domain kinase activity. An important paralog of this gene is CCNT2.
UniProtKB/Swiss-Prot for CCNK Gene
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).