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Aliases for IL1RL2 Gene

Aliases for IL1RL2 Gene

  • Interleukin 1 Receptor-Like 2 2 3
  • IL1RRP2 3 4 6
  • Interleukin-1 Receptor-Related Protein 2 3 4
  • IL-36 Receptor 3 4
  • IL-1Rrp2 3 4
  • IL1R-Rp2 3 4
  • IL-36R 3 4
  • IL-1 Receptor-Related Protein 2 3
  • Interleukin-1 Receptor-Like 2 3

External Ids for IL1RL2 Gene

Previous GeneCards Identifiers for IL1RL2 Gene

  • GC02P100667
  • GC02P101256
  • GC02P102408
  • GC02P102424
  • GC02P102803
  • GC02P096567

Summaries for IL1RL2 Gene

Entrez Gene Summary for IL1RL2 Gene

  • The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL1RL2 Gene

IL1RL2 (Interleukin 1 Receptor-Like 2) is a Protein Coding gene. Among its related pathways are NOD-like Receptor Signaling Pathways. GO annotations related to this gene include interleukin-1 receptor activity and interleukin-1, Type I, activating receptor activity. An important paralog of this gene is IL1RAP.

UniProtKB/Swiss-Prot for IL1RL2 Gene

  • Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Gene Wiki entry for IL1RL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL1RL2 Gene

Genomics for IL1RL2 Gene

Regulatory Elements for IL1RL2 Gene

Genomic Location for IL1RL2 Gene

Start:
102,186,973 bp from pter
End:
102,240,002 bp from pter
Size:
53,030 bases
Orientation:
Plus strand

Genomic View for IL1RL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IL1RL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL1RL2 Gene

Proteins for IL1RL2 Gene

  • Protein details for IL1RL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB29-ILRL2_HUMAN
    Recommended name:
    Interleukin-1 receptor-like 2
    Protein Accession:
    Q9HB29
    Secondary Accessions:
    • A4FU63
    • Q13525
    • Q45H74
    • Q53TU8
    • Q587I8

    Protein attributes for IL1RL2 Gene

    Size:
    575 amino acids
    Molecular mass:
    65405 Da
    Quaternary structure:
    • Interacts with IL1RAP; the association is enhanced by IL36B indicative for an functional signaling complex and inhibited by IL36RN (By similarity).
    SequenceCaution:
    • Sequence=AAB53237.1; Type=Frameshift; Positions=556; Evidence={ECO:0000305};

    Alternative splice isoforms for IL1RL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL1RL2 Gene

Proteomics data for IL1RL2 Gene at MOPED

Post-translational modifications for IL1RL2 Gene

  • Glycosylation at Asn41, Asn59, Asn109, Asn127, Asn184, Asn234, Asn250, Asn266, and Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for IL1RL2 Gene

No data available for DME Specific Peptides for IL1RL2 Gene

Domains for IL1RL2 Gene

Gene Families for IL1RL2 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • IL :Interleukins and interleukin receptors
IUPHAR :

Suggested Antigen Peptide Sequences for IL1RL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB29

UniProtKB/Swiss-Prot:

ILRL2_HUMAN :
  • Q9HB29
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 TIR domain.
Family:
  • Belongs to the interleukin-1 receptor family.
genes like me logo Genes that share domains with IL1RL2: view

Function for IL1RL2 Gene

Molecular function for IL1RL2 Gene

GENATLAS Biochemistry: interleukin 1 receptor related protein 2,not binding IL1
UniProtKB/Swiss-Prot Function: Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Gene Ontology (GO) - Molecular Function for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004908 interleukin-1 receptor activity TAS 1833184
GO:0004909 interleukin-1, Type I, activating receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with IL1RL2: view
genes like me logo Genes that share phenotypes with IL1RL2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IL1RL2 Gene

Localization for IL1RL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL1RL2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IL1RL2 Gene COMPARTMENTS Subcellular localization image for IL1RL2 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 1833184
genes like me logo Genes that share ontologies with IL1RL2: view

Pathways for IL1RL2 Gene

genes like me logo Genes that share pathways with IL1RL2: view

Pathways by source for IL1RL2 Gene

1 R&D Systems pathway for IL1RL2 Gene

Interacting Proteins for IL1RL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000264257%0d%0a9606.ENSP00000280357%0d%0a
Selected Interacting proteins: ENSP00000264257 Q9HB29-ILRL2_HUMAN for IL1RL2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for IL1RL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006968 cellular defense response TAS 8332913
GO:0007165 signal transduction TAS 1833184
GO:0019221 cytokine-mediated signaling pathway TAS 1833184
GO:0032755 positive regulation of interleukin-6 production IEA --
genes like me logo Genes that share ontologies with IL1RL2: view

Transcripts for IL1RL2 Gene

mRNA/cDNA for IL1RL2 Gene

(14) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL1RL2 Gene

Interleukin 1 receptor-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IL1RL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1:
SP2: - -

Relevant External Links for IL1RL2 Gene

GeneLoc Exon Structure for
IL1RL2
ECgene alternative splicing isoforms for
IL1RL2

Expression for IL1RL2 Gene

mRNA expression in normal human tissues for IL1RL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL1RL2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (6.7), Skin - Not Sun Exposed (Suprapubic) (6.5), and Esophagus - Mucosa (5.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IL1RL2 Gene

SOURCE GeneReport for Unigene cluster for IL1RL2 Gene Hs.659863

mRNA Expression by UniProt/SwissProt for IL1RL2 Gene

Q9HB29-ILRL2_HUMAN
Tissue specificity: Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
genes like me logo Genes that share expressions with IL1RL2: view

Orthologs for IL1RL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL1RL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL1RL2 35
  • 98.96 (n)
  • 98.09 (a)
IL1RL2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IL1RL2 35
  • 77.46 (n)
  • 68.16 (a)
IL1RL2 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
IL1RL2 35
  • 81.16 (n)
  • 75.18 (a)
mouse
(Mus musculus)
Mammalia Il1rl2 35
  • 74.82 (n)
  • 67.2 (a)
Il1rl2 16
Il1rl2 36
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL1RL2 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL1RL2 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il1rl2 35
  • 74.8 (n)
  • 67.81 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 31 (a)
ManyToMany
IL1R1 36
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01054962.1 36
  • 24 (a)
ManyToMany
CABZ01054965.1 36
  • 22 (a)
ManyToMany
LOC799279 35
  • 47.36 (n)
  • 34.48 (a)
Species with no ortholog for IL1RL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL1RL2 Gene

ENSEMBL:
Gene Tree for IL1RL2 (if available)
TreeFam:
Gene Tree for IL1RL2 (if available)

Paralogs for IL1RL2 Gene

Paralogs for IL1RL2 Gene

Selected SIMAP similar genes for IL1RL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IL1RL2: view

Variants for IL1RL2 Gene

Sequence variations from dbSNP and Humsavar for IL1RL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs867770 -- 102,197,915(+) GTAGC(A/G)GCTCT intron-variant
rs870684 -- 102,198,482(-) GTGAT(A/G)GGGAC intron-variant
rs917994 -- 102,220,954(-) TGCCA(C/T)GCACA intron-variant
rs955754 -- 102,232,621(+) AGTCT(C/T)CTGCC intron-variant
rs995514 -- 102,222,996(-) CCTTC(A/G)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IL1RL2 Gene

Variant ID Type Subtype PubMed ID
nsv874735 CNV Gain 21882294
nsv874736 CNV Loss 21882294
nsv874737 CNV Gain 21882294
esv2720460 CNV Deletion 23290073
esv2564673 CNV Deletion 19546169
esv2720462 CNV Deletion 23290073
dgv4258n71 CNV Loss 21882294
dgv4259n71 CNV Loss 21882294
nsv874743 CNV Gain 21882294
nsv874744 CNV Loss 21882294
nsv874745 CNV Loss 21882294
dgv4260n71 CNV Loss 21882294
dgv4261n71 CNV Gain 21882294
nsv874752 CNV Loss 21882294
nsv874753 CNV Loss 21882294

Relevant External Links for IL1RL2 Gene

HapMap Linkage Disequilibrium report
IL1RL2
Human Gene Mutation Database (HGMD)
IL1RL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL1RL2 Gene

Disorders for IL1RL2 Gene

Relevant External Links for IL1RL2

Genetic Association Database (GAD)
IL1RL2
Human Genome Epidemiology (HuGE) Navigator
IL1RL2
genes like me logo Genes that share disorders with IL1RL2: view

No data available for UniProtKB/Swiss-Prot for IL1RL2 Gene

Publications for IL1RL2 Gene

  1. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. (PMID: 11466363) Debets R. … Kastelein R.A. (J. Immunol. 2001) 2 3 4 23
  2. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2). (PMID: 8898719) Lovenberg T.W. … Maki R.A. (J. Neuroimmunol. 1996) 2 3 4 23
  3. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. (PMID: 10191101) Dale M. … Nicklin M.J. (Genomics 1999) 2 3 23
  4. Association between interleukin 1 gene cluster polymorphisms and bilateral distal interphalangeal osteoarthritis. (PMID: 19684156) Solovieva S. … Leino-Arjas P. (J. Rheumatol. 2009) 3 23 48
  5. Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. (PMID: 10882729) Born T.L. … Sims J.E. (J. Biol. Chem. 2000) 3 4

Products for IL1RL2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IL1RL2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IL1RL2
    • Block miRNA regulation of IL1RL2 using miScript Target Protectors

    Sources for IL1RL2 Gene

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