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Aliases for TRIM24 Gene

Aliases for TRIM24 Gene

  • Tripartite Motif Containing 24 2 3 5
  • RING-Type E3 Ubiquitin Transferase TIF1-Alpha 3 4
  • Transcriptional Intermediary Factor 1 2 3
  • E3 Ubiquitin-Protein Ligase TRIM24 3 4
  • RING Finger Protein 82 3 4
  • TIF1-Alpha 3 4
  • RNF82 3 4
  • TIF1A 3 4
  • TIF1 3 4
  • Transcription Intermediary Factor 1-Alpha 3
  • Tripartite Motif-Containing Protein 24 4
  • Tripartite Motif-Containing 24 2
  • EC 2.3.2.27 4
  • TIF1ALPHA 3
  • EC 6.3.2 61
  • HTIF1 3
  • PTC6 3
  • TF1A 3

External Ids for TRIM24 Gene

Previous HGNC Symbols for TRIM24 Gene

  • TIF1

Previous GeneCards Identifiers for TRIM24 Gene

  • GC07P137603
  • GC07P137795
  • GC07P138144
  • GC07P132454

Summaries for TRIM24 Gene

Entrez Gene Summary for TRIM24 Gene

  • The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM24 Gene

TRIM24 (Tripartite Motif Containing 24) is a Protein Coding gene. Diseases associated with TRIM24 include Differentiated Thyroid Carcinoma and Cerebellar Agenesis. Among its related pathways are FGFR1 mutant receptor activation and HIV Life Cycle. GO annotations related to this gene include sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TRIM33.

UniProtKB/Swiss-Prot for TRIM24 Gene

  • Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at Lys-4 (H3K4me0) and acetylated at Lys-23 (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

Gene Wiki entry for TRIM24 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM24 Gene

Genomics for TRIM24 Gene

Regulatory Elements for TRIM24 Gene

Enhancers for TRIM24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G138349 1.7 FANTOM5 ENCODE dbSUPER 17.4 -107.8 -107775 4.9 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B DMAP1 SLC30A9 ZNF766 TRIM24 SVOPL CREB3L2 RPS17P12 GC07M138404
GH07G137974 2 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -475.4 -475410 21.0 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A TRIM24 CREB3L2 LOC100130880 GC07M137981
GH07G138313 1.5 FANTOM5 ENCODE 14.5 -144.7 -144717 4.3 CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TRIM24 TTC26 RPS17P12 GC07M138404
GH07G137995 2 FANTOM5 Ensembl ENCODE dbSUPER 7.6 -460.9 -460876 7.9 HDGF PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 CREB3L2 TRIM24 GC07M137981
GH07G138435 0.5 ENCODE 19.3 -24.8 -24836 0.2 PKNOX1 ZGPAT CBX3 ZBTB40 TRIM24 GC07M138431 GC07P138424
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM24 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000218861 684 3001 CREB3L1 ZFP64 YY1 SLC30A9 SP3 NFYC TBX21 SSRP1 ZNF610 GLIS1

Genomic Location for TRIM24 Gene

Chromosome:
7
Start:
138,460,216 bp from pter
End:
138,589,993 bp from pter
Size:
129,778 bases
Orientation:
Plus strand

Genomic View for TRIM24 Gene

Genes around TRIM24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM24 Gene

Proteins for TRIM24 Gene

  • Protein details for TRIM24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15164-TIF1A_HUMAN
    Recommended name:
    Transcription intermediary factor 1-alpha
    Protein Accession:
    O15164
    Secondary Accessions:
    • A4D1R7
    • A4D1R8
    • O95854

    Protein attributes for TRIM24 Gene

    Size:
    1050 amino acids
    Molecular mass:
    116831 Da
    Quaternary structure:
    • Interacts with CARM1, NCOA2/GRIP1, PML, KAT5/TIP60, BRD7, CBX1, CBX3 and CBX5. Part of a coactivator complex containing TRIM24, NCOA2 and CARM1 (By similarity). Interacts with NR3C2/MCR. Interacts with the ligand-binding domain of estrogen receptors (in vitro). Interaction with DNA-bound estrogen receptors requires the presence of estradiol. Interacts with AR and p53/TP53. Interacts (via bromo domain) with histone H3 (via N-terminus), provided that it is not methylated at Lys-4 (H3K4me0). Does not interact with histone H3 that is methylated at Lys-4 (H3K4me1, H3K4me2 or H3K4me3). Interacts (via bromo domain) with histone H3 (via N-terminus) that is acetylated at Lys-23 (H3K23ac). Has the highest affinity for histone H3 that is both unmodified at Lys-4 (H3K4me0) and acetylated at Lys-23 (H3K23ac). Has very low affinity for histone H3 that is methylated at Lys-9 (H3K9me), or acetylated at both Lys-9 (H3K9ac) and Lys-14 (H3K14ac), or acetylated at Lys-27 (H3K27ac) (in vitro).

    Three dimensional structures from OCA and Proteopedia for TRIM24 Gene

    Alternative splice isoforms for TRIM24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM24 Gene

Selected DME Specific Peptides for TRIM24 Gene

O15164:
  • GSSTALLYSKRLIT
  • DDPNEDWCAVCQNGG

Post-translational modifications for TRIM24 Gene

Other Protein References for TRIM24 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TRIM24 Gene

Suggested Antigen Peptide Sequences for TRIM24 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIM24: view

No data available for UniProtKB/Swiss-Prot for TRIM24 Gene

Function for TRIM24 Gene

Molecular function for TRIM24 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at Lys-4 (H3K4me0) and acetylated at Lys-23 (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in some cases of breast cancer.

Enzyme Numbers (IUBMB) for TRIM24 Gene

Gene Ontology (GO) - Molecular Function for TRIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 19556538
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 21164480
GO:0003713 transcription coactivator activity TAS,IDA 21164480
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with TRIM24: view
genes like me logo Genes that share phenotypes with TRIM24: view

Human Phenotype Ontology for TRIM24 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TRIM24 Gene

MGI Knock Outs for TRIM24:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for TRIM24 Gene

Localization for TRIM24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM24 Gene

Nucleus. Cytoplasm. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM24 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TRIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,TAS 21164480
GO:0005654 nucleoplasm IDA --
GO:0005719 nuclear euchromatin IEA --
GO:0005726 perichromatin fibrils IEA --
genes like me logo Genes that share ontologies with TRIM24: view

Pathways & Interactions for TRIM24 Gene

genes like me logo Genes that share pathways with TRIM24: view

Pathways by source for TRIM24 Gene

UniProtKB/Swiss-Prot O15164-TIF1A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRIM24 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for TRIM24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9115274
GO:0006468 protein phosphorylation IEA --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TRIM24: view

Drugs & Compounds for TRIM24 Gene

(3) Drugs for TRIM24 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TRIM24 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TRIM24: view

Transcripts for TRIM24 Gene

Unigene Clusters for TRIM24 Gene

Tripartite motif containing 24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TRIM24 Gene

GeneLoc Exon Structure for
TRIM24
ECgene alternative splicing isoforms for
TRIM24

Expression for TRIM24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM24 Gene

This gene is overexpressed in Bone marrow stromal cell (53.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM24 Gene



Protein tissue co-expression partners for TRIM24 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM24 Gene:

TRIM24

SOURCE GeneReport for Unigene cluster for TRIM24 Gene:

Hs.490287

Evidence on tissue expression from TISSUES for TRIM24 Gene

  • Liver(4.4)
  • Thyroid gland(4.4)
  • Nervous system(2.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM24 Gene

Germ Layers:
  • endoderm
Systems:
  • endocrine
Organs:
Head and neck:
  • neck
  • thyroid
genes like me logo Genes that share expression patterns with TRIM24: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM24 Gene

Orthologs for TRIM24 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM24 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 95 (a)
OneToMany
TRIM24 34
  • 93.9 (n)
-- 35
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TRIM24 34 35
  • 93.05 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM24 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim24 34 16 35
  • 89.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM24 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM24 34 35
  • 78.94 (n)
lizard
(Anolis carolinensis)
Reptilia TRIM24 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim24 34
  • 67.69 (n)
zebrafish
(Danio rerio)
Actinopterygii trim24 35
  • 39 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta mei-P26 35
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhl-2 35
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 35
  • 22 (a)
OneToMany
Species where no ortholog for TRIM24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM24 Gene

ENSEMBL:
Gene Tree for TRIM24 (if available)
TreeFam:
Gene Tree for TRIM24 (if available)

Paralogs for TRIM24 Gene

Paralogs for TRIM24 Gene

(1) SIMAP similar genes for TRIM24 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM24: view

Variants for TRIM24 Gene

Sequence variations from dbSNP and Humsavar for TRIM24 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_042382 An ovarian serous carcinoma sample
VAR_042383 A lung squamous cell carcinoma sample
rs1000000823 -- 138,543,345(+) TGATG(A/C/T)ATTTC intron-variant
rs1000023982 -- 138,543,305(+) TTAAC(C/T)AAATT intron-variant
rs1000038444 -- 138,494,309(+) AGACA(A/G)GGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM24 Gene

Variant ID Type Subtype PubMed ID
esv2292840 CNV deletion 18987734
esv2677536 CNV deletion 23128226
esv2735212 CNV deletion 23290073
esv34048 CNV loss 18971310
esv3615194 CNV loss 21293372
nsv1030956 CNV gain 25217958
nsv5968 CNV insertion 18451855
nsv831153 CNV loss 17160897
nsv981589 CNV duplication 23825009

Variation tolerance for TRIM24 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM24 Gene

Disorders for TRIM24 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRIM24 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
cerebellar agenesis
8p11 myeloproliferative syndrome
  • chromosome 8p11 myeloproliferative syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TIF1A_HUMAN
  • Note=A chromosomal aberration involving TRIM24/TIF1 is found in papillary thyroid carcinomas (PTCs). Translocation t(7;10)(q32;q11) with RET. The translocation generates the TRIM24/RET (PTC6) oncogene. {ECO:0000269 PubMed:10439047}.

Relevant External Links for TRIM24

Genetic Association Database (GAD)
TRIM24
Human Genome Epidemiology (HuGE) Navigator
TRIM24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM24
genes like me logo Genes that share disorders with TRIM24: view

No data available for Genatlas for TRIM24 Gene

Publications for TRIM24 Gene

  1. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. (PMID: 9115274) Thenot S. … Cavailles V. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Trim24 targets endogenous p53 for degradation. (PMID: 19556538) Allton K. … Barton M.C. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 22 64
  3. TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells. (PMID: 19909775) Kikuchi M. … Hatakeyama S. (Biochim. Biophys. Acta 2009) 3 4 22 64
  4. TIF1gamma, a novel member of the transcriptional intermediary factor 1 family. (PMID: 10022127) Venturini L. … De The H. (Oncogene 1999) 3 4 22 64
  5. The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. (PMID: 10439047) Klugbauer S. … Rabes H.M. (Oncogene 1999) 3 4 22 64

Products for TRIM24 Gene

Sources for TRIM24 Gene

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