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Aliases for CREG1 Gene

Aliases for CREG1 Gene

  • Cellular Repressor Of E1A-Stimulated Genes 1 2 3 4
  • CREG 3 4
  • Cellular Repressor Of E1A-Stimulated Genes 2
  • Protein CREG1 3

External Ids for CREG1 Gene

Previous HGNC Symbols for CREG1 Gene

  • CREG

Previous GeneCards Identifiers for CREG1 Gene

  • GC01M164241
  • GC01M165776
  • GC01M138756

Summaries for CREG1 Gene

Entrez Gene Summary for CREG1 Gene

  • The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for CREG1 Gene

CREG1 (Cellular Repressor Of E1A-Stimulated Genes 1) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include transcription factor binding and oxidoreductase activity. An important paralog of this gene is CREG2.

UniProtKB/Swiss-Prot for CREG1 Gene

  • May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.

Gene Wiki entry for CREG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CREG1 Gene

Genomics for CREG1 Gene

Regulatory Elements for CREG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CREG1 Gene

Start:
167,529,677 bp from pter
End:
167,553,819 bp from pter
Size:
24,143 bases
Orientation:
Minus strand

Genomic View for CREG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CREG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CREG1 Gene

Proteins for CREG1 Gene

  • Protein details for CREG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75629-CREG1_HUMAN
    Recommended name:
    Protein CREG1
    Protein Accession:
    O75629
    Secondary Accessions:
    • B2RDD4
    • Q8N9A3

    Protein attributes for CREG1 Gene

    Size:
    220 amino acids
    Molecular mass:
    24075 Da
    Quaternary structure:
    • Homodimer. Interacts with IGF2R; the interaction is dependent on glycosylation.

    Three dimensional structures from OCA and Proteopedia for CREG1 Gene

neXtProt entry for CREG1 Gene

Proteomics data for CREG1 Gene at MOPED

Post-translational modifications for CREG1 Gene

Other Protein References for CREG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CREG1 Gene

Domains for CREG1 Gene

Protein Domains for CREG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CREG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75629

UniProtKB/Swiss-Prot:

CREG1_HUMAN :
  • O75629
Family:
  • Belongs to the CREG family.
genes like me logo Genes that share domains with CREG1: view

No data available for Gene Families for CREG1 Gene

Function for CREG1 Gene

Molecular function for CREG1 Gene

UniProtKB/Swiss-Prot Function: May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.

Gene Ontology (GO) - Molecular Function for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity TAS 9710587
GO:0008134 transcription factor binding IEA --
GO:0010181 FMN binding IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with CREG1: view

Phenotypes for CREG1 Gene

GenomeRNAi human phenotypes for CREG1:
genes like me logo Genes that share phenotypes with CREG1: view

Animal Model Products

CRISPR Products

miRNA for CREG1 Gene

miRTarBase miRNAs that target CREG1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CREG1 Gene

Localization for CREG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CREG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CREG1 Gene COMPARTMENTS Subcellular localization image for CREG1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005667 transcription factor complex IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with CREG1: view

Pathways for CREG1 Gene

SuperPathways for CREG1 Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with CREG1: view

Pathways by source for CREG1 Gene

1 BioSystems pathway for CREG1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CREG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9710587
GO:0007275 multicellular organismal development TAS 9710587
GO:0008283 cell proliferation TAS 9710587
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with CREG1: view

Transcripts for CREG1 Gene

mRNA/cDNA for CREG1 Gene

(472) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CREG1 Gene

Cellular repressor of E1A-stimulated genes 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CREG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CREG1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for CREG1 Gene

GeneLoc Exon Structure for
CREG1
ECgene alternative splicing isoforms for
CREG1

Expression for CREG1 Gene

mRNA expression in normal human tissues for CREG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CREG1 Gene

SOURCE GeneReport for Unigene cluster for CREG1 Gene Hs.5710

genes like me logo Genes that share expressions with CREG1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CREG1 Gene

Orthologs for CREG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CREG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CREG1 35
  • 98.62 (n)
  • 98.17 (a)
CREG1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CREG1 35
  • 85.76 (n)
  • 80.91 (a)
CREG1 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CREG1 35
  • 88.21 (n)
  • 88.21 (a)
CREG1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Creg1 35
  • 82.05 (n)
  • 78.97 (a)
Creg1 16
Creg1 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CREG1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CREG1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Creg1 35
  • 81.03 (n)
  • 78.97 (a)
chicken
(Gallus gallus)
Aves CREG1 35
  • 74.56 (n)
  • 64.5 (a)
CREG1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CREG1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia creg1 35
  • 67.06 (n)
  • 66.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5415 35
zebrafish
(Danio rerio)
Actinopterygii creg1 35
  • 65.67 (n)
  • 58.68 (a)
creg1 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CREG 35
  • 47.65 (n)
  • 34.36 (a)
CREG 36
  • 29 (a)
OneToMany
Species with no ortholog for CREG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CREG1 Gene

ENSEMBL:
Gene Tree for CREG1 (if available)
TreeFam:
Gene Tree for CREG1 (if available)

Paralogs for CREG1 Gene

Paralogs for CREG1 Gene

Selected SIMAP similar genes for CREG1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CREG1: view

Variants for CREG1 Gene

Sequence variations from dbSNP and Humsavar for CREG1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9811 -- 167,541,270(-) GAGAA(G/T)ACACT utr-variant-3-prime
rs10405 -- 167,541,302(-) AACAT(G/T)GCATT utr-variant-3-prime
rs942082 -- 167,555,755(-) AAACC(A/G)CCGAC upstream-variant-2KB
rs1005299 -- 167,555,562(-) cactg(C/T)tggtg upstream-variant-2KB
rs1043310 -- 167,541,798(-) AGATA(C/G)ACAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CREG1 Gene

Variant ID Type Subtype PubMed ID
nsv831814 CNV Loss 17160897
nsv528710 CNV Gain 19592680
nsv819670 CNV Loss 19587683

Relevant External Links for CREG1 Gene

HapMap Linkage Disequilibrium report
CREG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CREG1 Gene

Disorders for CREG1 Gene

(1) University of Copenhagen DISEASES for CREG1 Gene

(1) Novoseek inferred disease relationships for CREG1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma embryonal 58.5 2

Relevant External Links for CREG1

Genetic Association Database (GAD)
CREG1
Human Genome Epidemiology (HuGE) Navigator
CREG1
genes like me logo Genes that share disorders with CREG1: view

No data available for UniProtKB/Swiss-Prot for CREG1 Gene

Publications for CREG1 Gene

  1. The secreted glycoprotein CREG enhances differentiation of NTERA-2 human embryonal carcinoma cells. (PMID: 10815803) Veal E. … Gill G. (Oncogene 2000) 3 4 23
  2. The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation. (PMID: 16344469) Sacher M. … Cygler M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 23
  3. A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. (PMID: 9710587) Veal E. … Gill G. (Mol. Cell. Biol. 1998) 2 3 4
  4. Cellular repressor of E1A-stimulated genes attenuates cardiac hypertrophy and fibrosis. (PMID: 19413895) Bian Z. … Li H. (J. Cell. Mol. Med. 2009) 3 23
  5. Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. (PMID: 20060003) Han Y. … Yan C. (J. Mol. Cell. Cardiol. 2010) 3 23

Products for CREG1 Gene

Sources for CREG1 Gene

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