Aliases for SUCLG1 Gene
Aliases for SUCLG1 Gene
- Succinate-CoA Ligase Alpha Subunit 2 3 5
- Succinyl-CoA Synthetase Subunit Alpha 3 4
- EC 6.2.1.4 4 56
- SCS-Alpha 3 4
- Succinate--CoA Ligase [ADP/GDP-Forming] Subunit Alpha, Mitochondrial 3
- Succinyl-CoA Ligase [ADP/GDP-Forming] Subunit Alpha, Mitochondrial 3
- Succinyl-CoA Ligase [GDP-Forming] Subunit Alpha, Mitochondrial 3
- Succinate-CoA Ligase, GDP-Forming, Alpha Subunit 2
External Ids for SUCLG1 Gene
- HGNC: 11449
- Entrez Gene: 8802
- Ensembl: ENSG00000163541
- OMIM: 611224
- UniProtKB: P53597
Previous GeneCards Identifiers for SUCLG1 Gene
- GC02M084632
- GC02M084944
- GC02M084625
- GC02M084562
Summaries for SUCLG1 Gene
-
This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
GeneCards Summary for SUCLG1 Gene
SUCLG1 (Succinate-CoA Ligase Alpha Subunit) is a Protein Coding gene. Diseases associated with SUCLG1 include Mitochondrial Dna Depletion Syndrome 9 and Succinate-Coa Ligase Deficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Pyruvate metabolism and Citric Acid (TCA) cycle. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is ACLY.
UniProtKB/Swiss-Prot for SUCLG1 Gene
-
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Additional gene information for SUCLG1 Gene
- Monarch Initiative
- Search for SUCLG1 at DataMed
- Search for SUCLG1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SUCLG1 Gene
Genomics for SUCLG1 Gene
GeneHancer (GH) Regulatory Elements for SUCLG1 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02I084456 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 557.3 | +0.3 | 254 | 6.6 | HDGF PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 | DNAH6 SUCLG1 LOC100996506 ELMOD3 | |
GH02I084485 | Enhancer | 0.7 | ENCODE | 17.3 | -26.7 | -26746 | 2.9 | SOX13 FOXA2 SAP130 CEBPG FEZF1 THRB RAD21 TEAD3 HNF4G NR2F6 | SUCLG1 TRABD2A RPS2P17 DNAH6 PIR55247 GC02P084502 | |
GH02I084740 | Enhancer | 0.8 | Ensembl ENCODE | 6 | -281.4 | -281400 | 1.2 | CTCF STAT1 ESRRA ZNF792 MNT ZIC2 RAD21 CTBP1 SMC3 | SUCLG1 TRABD2A DUXAP1 GC02P084565 DNAH6 | |
GH02I084493 | Enhancer | 0.5 | ENCODE | 5.5 | -33.7 | -33666 | 1.2 | SP1 JUND JUN FOSL2 FOS | TRABD2A SUCLG1 GC02P084502 PIR55247 DNAH6 | |
GH02I084701 | Enhancer | 0.4 | ENCODE | 6 | -242.1 | -242066 | 2.2 | CEBPB FOS | DNAH6 SUCLG1 DUXAP1 GC02P084565 |
Regulatory Element Products
Genomic Locations for SUCLG1 Gene
- chr2:84,423,523-84,460,045
- (GRCh38/hg38)
- Size:
- 36,523 bases
- Orientation:
- Minus strand
- chr2:84,650,647-84,687,169
- (GRCh37/hg19)
Genomic View for SUCLG1 Gene
- Cytogenetic band:
-
- 2p11.2 by Ensembl
- 2p11.2 by Entrez Gene
- 2p11.2 by HGNC


RefSeq DNA sequence for SUCLG1 Gene
Proteins for SUCLG1 Gene
-
Protein details for SUCLG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P53597-SUCA_HUMAN
- Recommended name:
- Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
- Protein Accession:
- P53597
- Q9BWB0
- Q9UNP6
Protein attributes for SUCLG1 Gene
- Size:
- 346 amino acids
- Molecular mass:
- 36250 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
- SequenceCaution:
-
- Sequence=AAD17940.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH00504.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA92426.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for SUCLG1 Gene
Selected DME Specific Peptides for SUCLG1 Gene
- P53597:
-
- GPNCPGVI
- ECKIGIMPG
- GIVSRSGTLTYEAV
- SSGLAAARLLSR
- VCITEGIP
- IGIVSRSGTLTYEA
- MGHAGAI
- QGFTGKQGTFH
- KPVVSFIAG
- VSRSGTLTYEAVHQ
- LPVFNTV
- ASVIYVP
- IGPNCPG
- VGIGGDP
- ICQGFTG
- AEENAAEFLK
- GIGGDPFNGT
- VSMSPAQLGT
Post-translational modifications for SUCLG1 Gene
- Ubiquitination at isoforms=66 and posLast=280280
Other Protein References for SUCLG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for SUCLG1 (SUCLG1)
-
Custom Antibody ServicesOriGene Antibodies for SUCLG1
- Novus Biologicals Antibodies for SUCLG1
-
Abcam antibodies for SUCLG1
- Invitrogen Antibodies for SUCLG1
- GeneTex SUCLG1 antibody for SUCLG1
Protein Products
-
OriGene Purified Proteins for SUCLG1
- Search Origene for MassSpec and Protein Over-expression Lysates for SUCLG1
- Origene Custom Protein Services for SUCLG1
- antibodies-online: Search results for 7 available SUCLG1 Proteins ranked by validation data
- Compare Top SUCLG1 Proteins
-
Quality Products:
- GeneTex Proteins for SUCLG1
-
Abcam proteins for SUCLG1
Assay Products
Domains & Families for SUCLG1 Gene
Gene Families for SUCLG1 Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted secreted proteins
Protein Domains for SUCLG1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SUCLG1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P53597- Family:
-
- Belongs to the succinate/malate CoA ligase alpha subunit family.
Function for SUCLG1 Gene
Molecular function for SUCLG1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
- UniProtKB/Swiss-Prot CatalyticActivity:
- GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
- UniProtKB/Swiss-Prot Function:
- Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Enzyme Numbers (IUBMB) for SUCLG1 Gene
Phenotypes From GWAS Catalog for SUCLG1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003723 | RNA binding | HDA,IDA | 22658674 |
GO:0003824 | catalytic activity | IEA | -- |
GO:0004775 | succinate-CoA ligase (ADP-forming) activity | IEA | -- |
GO:0004776 | succinate-CoA ligase (GDP-forming) activity | IBA | -- |
Phenotypes for SUCLG1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SUCLG1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUCLG1 gene
- Search ViGene Biosciences for SUCLG1
CRISPR Products
-
OriGene CRISPR knockouts for SUCLG1
- genomics-online: gRNA clones - Search results for available SUCLG1 gene related products
- Applied Biological Materials CRISPR for SUCLG1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUCLG1
- GenScript: Design CRISPR guide RNA sequences for SUCLG1
miRNA for SUCLG1 Gene
- miRTarBase miRNAs that target SUCLG1
miRNA Products
- Search ViGene Biosciences for SUCLG1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SUCLG1
- Browse OriGene Inhibitory RNA Products For SUCLG1
- genomics-online: shRNA clones - Search results for available SUCLG1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SUCLG1 gene
Clone Products
- Sino Biological Human cDNA Clone for SUCLG1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available SUCLG1 gene related products
- orf clones - Search results for available SUCLG1 gene related products
- Applied Biological Materials Clones for SUCLG1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SUCLG1
-
ViGene Biosciences adenoviral particle packaged cDNA for SUCLG1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SUCLG1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SUCLG1 gene
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for SUCLG1 Gene
Localization for SUCLG1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SUCLG1 Gene
- Mitochondrion.
- Mitochondria (3)
- Plasma membrane (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IDA,TAS | -- |
GO:0005743 | mitochondrial inner membrane | IEA | -- |
GO:0005759 | mitochondrial matrix | IBA,TAS | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for SUCLG1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Citrate cycle (TCA cycle) |
.01
|
|
2 | Pyruvate metabolism and Citric Acid (TCA) cycle |
.01
|
|
3 | Metabolism |
.37
|
|
4 | Carbon metabolism | ||
5 | Propanoate metabolism |
Pathways by source for SUCLG1 Gene
1 Cell Signaling Technology pathway for SUCLG1 Gene
4 BioSystems pathways for SUCLG1 Gene
4 Reactome pathways for SUCLG1 Gene
1 PharmGKB pathway for SUCLG1 Gene
4 KEGG pathways for SUCLG1 Gene
UniProtKB/Swiss-Prot P53597-SUCA_HUMAN
- Pathway: Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
Interacting Proteins for SUCLG1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006099 | tricarboxylic acid cycle | TAS | -- |
GO:0008152 | metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for SUCLG1 Gene
Drugs & Compounds for SUCLG1 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
ADP |
|
Full agonist, Agonist | 58-64-0 |
|
||
IDP |
|
86-04-4 |
|
|||
inosine triphosphate |
|
132-06-9 |
|
|||
Itaconic acid |
|
97-65-4 |
|
|||
Itaconyl-CoA |
|
6008-93-1 |
|
Transcripts for SUCLG1 Gene
mRNA/cDNA for SUCLG1 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (482) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SUCLG1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SUCLG1
- genomics-online: gRNA clones - Search results for available SUCLG1 gene related products
- Applied Biological Materials CRISPR for SUCLG1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SUCLG1
- GenScript: Design CRISPR guide RNA sequences for SUCLG1
miRNA Products
- Search ViGene Biosciences for SUCLG1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SUCLG1
- Browse OriGene Inhibitory RNA Products For SUCLG1
- genomics-online: shRNA clones - Search results for available SUCLG1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SUCLG1 gene
Clone Products
- Sino Biological Human cDNA Clone for SUCLG1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- genomics-online: cdna clones - Search results for available SUCLG1 gene related products
- orf clones - Search results for available SUCLG1 gene related products
- Applied Biological Materials Clones for SUCLG1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||
SP7: | - |
Expression for SUCLG1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Intestine (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
-
Colon (Gastrointestinal Tract)
-
Thyroid (Endocrine System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for SUCLG1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SUCLG1 Gene
NURSA nuclear receptor signaling pathways regulating expression of SUCLG1 Gene:
SUCLG1SOURCE GeneReport for Unigene cluster for SUCLG1 Gene:
Hs.270428Evidence on tissue expression from TISSUES for SUCLG1 Gene
- Nervous system(4.8)
- Lung(4.6)
- Liver(4.5)
- Muscle(4.5)
- Kidney(4)
- Intestine(3.1)
- Adrenal gland(2.5)
- Gall bladder(2.5)
- Lymph node(2.5)
- Pancreas(2.5)
- Stomach(2.5)
- Thyroid gland(2.5)
- Skin(2.2)
- Blood(2)
- Heart(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for SUCLG1 Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- endocrine
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
- urinary
- brain
- cerebellum
- ear
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
- chest wall
- clavicle
- diaphragm
- heart
- lung
- rib
- rib cage
- scapula
- sternum
- adrenal gland
- kidney
- pelvis
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
- blood
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal column
- sweat gland
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for SUCLG1
-
OriGene qPCR primer pairs and template standards for SUCLG1
- genomics-online: primer clones - Search results for available SUCLG1 gene related products
No data available for mRNA Expression by UniProt/SwissProt for SUCLG1 Gene
Orthologs for SUCLG1 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SUCLG1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | SUCLG1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | SUCLG1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Suclg1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Suclg1 33 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | SUCLG1 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | SUCLG1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | SUCLG1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SUCLG1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | suclg1 33 |
|
||
Str.7116 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | suclg1 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Scsalpha 35 33 34 |
|
||
CG6255 35 34 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001312 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | F23H11.3 35 |
|
|
|
C05G5.4 35 |
|
|
|||
sucl-2 34 |
|
OneToMany | |||
sucl-1 33 34 |
|
||||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LSC1 33 34 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E03235g 33 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR134C 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G08300 33 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7530 33 |
|
||
barley (Hordeum vulgare) |
Liliopsida | Hv.319 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os.38799 33 |
|
||
wheat (Triticum aestivum) |
Liliopsida | Ta.5528 33 |
|
||
corn (Zea mays) |
Liliopsida | Zm.6083 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU01227 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC16E8.17c 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2200 33 |
|
- Species where no ortholog for SUCLG1 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for SUCLG1 Gene
Variants for SUCLG1 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs113840224 | benign, uncertain-significance, not specified, Mitochondrial DNA depletion syndrome, Mitochondrial DNA depletion syndrome 9 (encephalomyopathic with methylmalonic aciduria) | 84,425,529(-) | G/A | coding_sequence_variant, synonymous_variant | |
rs116492610 | benign, likely-benign, not specified, Mitochondrial DNA depletion syndrome 9 (encephalomyopathic with methylmalonic aciduria), Mitochondrial DNA depletion syndrome | 84,449,640(-) | T/C | intron_variant | |
rs12621740 | likely-benign, Mitochondrial DNA depletion syndrome 9 (encephalomyopathic with methylmalonic aciduria), Mitochondrial DNA depletion syndrome | 84,459,402(-) | G/A | 5_prime_UTR_variant | |
rs140936198 | uncertain-significance, Mitochondrial DNA depletion syndrome, Mitochondrial DNA depletion syndrome 9 (encephalomyopathic with methylmalonic aciduria) | 84,459,376(-) | T/C | 5_prime_UTR_variant | |
rs141973418 | benign, uncertain-significance, not specified, Mitochondrial DNA depletion syndrome, Mitochondrial DNA depletion syndrome 9 (encephalomyopathic with methylmalonic aciduria) | 84,443,404(-) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2677941 | CNV | deletion | 23128226 |
esv3591513 | CNV | loss | 21293372 |
nsv1002072 | CNV | gain | 25217958 |
Additional Variant Information for SUCLG1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SUCLG1 Gene
Disorders for SUCLG1 Gene

(6) MalaCards diseases for SUCLG1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
mitochondrial dna depletion syndrome 9 |
|
|
succinate-coa ligase deficiency |
|
|
lactic acidosis |
|
|
hemorrhoid |
|
|
methylmalonic aciduria, cblb type |
|
|
UniProtKB/Swiss-Prot
SUCA_HUMAN- Mitochondrial DNA depletion syndrome 9 (MTDPS9) [MIM:245400]: A severe disorder due to mitochondrial dysfunction. It is characterized by infantile onset of hypotonia, lactic acidosis, severe psychomotor retardation, progressive neurologic deterioration, and excretion of methylmalonic acid. {ECO:0000269 PubMed:17668387, ECO:0000269 PubMed:19526370, ECO:0000269 PubMed:20453710, ECO:0000269 PubMed:20693550}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for SUCLG1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for SUCLG1 Gene
Publications for SUCLG1 Gene
- Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion. (PMID: 17668387) Ostergaard E … Wibrand F (American journal of human genetics 2007) 3 4 25 58
- The molecular basis for cross-reaction of an anti-dystrophin antibody with alpha-actinin. (PMID: 9128182) James M … Morris GE (Biochimica et biophysica acta 1997) 2 3 4 58
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Marked mitochondrial DNA depletion associated with a novel SUCLG1 gene mutation resulting in lethal neonatal acidosis, multi-organ failure, and interrupted aortic arch. (PMID: 20227526) Rivera H … Martin MA (Mitochondrion 2010) 3 22 58
- A novel missense mutation in SUCLG1 associated with mitochondrial DNA depletion, encephalomyopathic form, with methylmalonic aciduria. (PMID: 19526370) Ostergaard E … Holme E (European journal of pediatrics 2010) 3 4 58
Products for SUCLG1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for SUCLG1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SUCLG1
- Search Origene for MassSpec and Protein Over-expression Lysates for SUCLG1
- Origene Custom Protein Services for SUCLG1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SUCLG1
- Browse OriGene Inhibitory RNA Products For SUCLG1
- OriGene qPCR primer pairs and template standards for SUCLG1
- OriGene qPCR primer pairs for SUCLG1
- OriGene CRISPR knockouts for SUCLG1
- OriGene ORF clones in human for SUCLG1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SUCLG1
- GenScript: Next-day shipping of latest version cDNA ORF clones for SUCLG1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for SUCLG1
- GenScript Custom Assay Services for SUCLG1
- GenScript Custom overexpressing Cell Line Services for SUCLG1
- GenScript: Design CRISPR guide RNA sequences for SUCLG1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for SUCLG1
- Cell Signaling Technology (CST) Antibodies for SUCLG1 (SUCLG1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for SUCLG1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for SUCLG1
- Novus Biologicals proteins and lysates for SUCLG1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for SUCLG1
- Abcam proteins for SUCLG1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for SUCLG1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for 24 available SUCLG1 Antibodies ranked by validation data
- Compare Top SUCLG1 Antibodies
- antibodies-online: Search results for available SUCLG1 related products ranked by validation data
- antibodies-online: Search results for 7 available SUCLG1 Proteins ranked by validation data
- Compare Top SUCLG1 Proteins
- Quality Products:
- GeneTex SUCLG1 antibody for SUCLG1
- GeneTex Proteins for SUCLG1
- ViGene Biosciences adenoviral particle packaged cDNA for SUCLG1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SUCLG1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SUCLG1 gene
- Search ViGene Biosciences for SUCLG1
- Horizon Cell Lines for SUCLG1
- genomics-online: cdna clones - Search results for available SUCLG1 gene related products
- orf clones - Search results for available SUCLG1 gene related products
- genomics-online: gRNA clones - Search results for available SUCLG1 gene related products
- genomics-online: primer clones - Search results for available SUCLG1 gene related products
- genomics-online: shRNA clones - Search results for available SUCLG1 gene related products
Sources for SUCLG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew