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Aliases for DLK1 Gene

Aliases for DLK1 Gene

  • Delta-Like 1 Homolog (Drosophila) 2 3
  • PREF1 3 6
  • DLK-1 3 4
  • FA1 3 6
  • DLK 3 4
  • PG2 3 4
  • Delta-Like Homolog (Drosophila) 2
  • Protein Delta Homolog 1 3
  • Preadipocyte Factor 1 3
  • Fetal Antigen 1 3
  • Secredeltin 3
  • DELTA1 3
  • Pref-1 3
  • ZOG 3

External Ids for DLK1 Gene

Previous GeneCards Identifiers for DLK1 Gene

  • GC14P098584
  • GC14P095008
  • GC14P099183
  • GC14P100263
  • GC14P101193
  • GC14P081373
  • GC14P101197

Summaries for DLK1 Gene

Entrez Gene Summary for DLK1 Gene

  • This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]

GeneCards Summary for DLK1 Gene

DLK1 (Delta-Like 1 Homolog (Drosophila)) is a Protein Coding gene. Diseases associated with DLK1 include temple syndrome and uniparental disomy, paternal, chromosome 14. Among its related pathways are Signaling by GPCR and Disease. An important paralog of this gene is NOTCH2.

UniProtKB/Swiss-Prot for DLK1 Gene

  • May have a role in neuroendocrine differentiation

Gene Wiki entry for DLK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DLK1 Gene

Genomics for DLK1 Gene

Regulatory Elements for DLK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DLK1 Gene

100,725,705 bp from pter
100,738,224 bp from pter
12,520 bases
Plus strand

Genomic View for DLK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DLK1 Gene

Proteins for DLK1 Gene

  • Protein details for DLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein delta homolog 1
    Protein Accession:
    Secondary Accessions:
    • P15803
    • Q96DW5

    Protein attributes for DLK1 Gene

    383 amino acids
    Molecular mass:
    41300 Da
    Quaternary structure:
    • Monomer
    • Sequence=CAA35582.1; Type=Frameshift; Positions=22, 108, 199; Evidence={ECO:0000305};

    Alternative splice isoforms for DLK1 Gene


neXtProt entry for DLK1 Gene

Proteomics data for DLK1 Gene at MOPED

Post-translational modifications for DLK1 Gene

  • N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Ser94, Asn100, Thr143, Ser163, Asn165, Asn172, Ser214, Thr222, Ser251, Thr256, Ser260, and Thr269
  • Modification sites at PhosphoSitePlus

Other Protein References for DLK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for DLK1 (Pref-1/DLK1/FA1)
  • Cell Signaling Technology (CST) Antibodies for DLK1 (DLK1)

No data available for DME Specific Peptides for DLK1 Gene

Domains for DLK1 Gene

Suggested Antigen Peptide Sequences for DLK1 Gene

Graphical View of Domain Structure for InterPro Entry



  • P80370
  • Contains 6 EGF-like domains.
genes like me logo Genes that share domains with DLK1: view

No data available for Gene Families for DLK1 Gene

Function for DLK1 Gene

Molecular function for DLK1 Gene

GENATLAS Biochemistry:
delta (Drosophila)-like 1,member of the EGF-like homeotic family,involved in cell differentiation in a justacrine/paracrine manner and in the pathogenesis of NF1,participating in the control of cell differentiation of several cell type,including small cell lung cancer lines,immune stem cells,B cells and adrenal glumerulose cells
UniProtKB/Swiss-Prot Function:
May have a role in neuroendocrine differentiation

Gene Ontology (GO) - Molecular Function for DLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005509 calcium ion binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DLK1: view
genes like me logo Genes that share phenotypes with DLK1: view

Animal Models for DLK1 Gene

MGI Knock Outs for DLK1:

Animal Model Products

miRNA for DLK1 Gene

miRTarBase miRNAs that target DLK1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLK1

Clone Products

  • Addgene plasmids for DLK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DLK1 Gene

Localization for DLK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DLK1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for DLK1 Gene COMPARTMENTS Subcellular localization image for DLK1 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 7925474
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DLK1: view

Pathways for DLK1 Gene

genes like me logo Genes that share pathways with DLK1: view

Pathways by source for DLK1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for DLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway TAS --
GO:0007275 multicellular organismal development TAS 8500166
GO:0009791 post-embryonic development IEA --
GO:0010468 regulation of gene expression IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DLK1: view

Compounds for DLK1 Gene

(7) Novoseek inferred chemical compound relationships for DLK1 Gene

Compound -log(P) Hits PubMed IDs
ibmx 50.8 7
dexamethasone 31.2 15
lipid 17 2
cyclic amp 15.8 2
glucose 0 1
genes like me logo Genes that share compounds with DLK1: view

Transcripts for DLK1 Gene

Unigene Clusters for DLK1 Gene

Delta-like 1 homolog (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DLK1

Clone Products

  • Addgene plasmids for DLK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DLK1 Gene

No ASD Table

Relevant External Links for DLK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DLK1 Gene

mRNA expression in normal human tissues for DLK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DLK1 Gene

This gene is overexpressed in Adrenal Gland (27.7), Pituitary (17.2), and Ovary (4.8).

Protein differential expression in normal tissues for DLK1 Gene

This gene is overexpressed in Fetal Brain (24.4), Urine (22.5), and Fetal ovary (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DLK1 Gene

SOURCE GeneReport for Unigene cluster for DLK1 Gene Hs.533717

mRNA Expression by UniProt/SwissProt for DLK1 Gene

Tissue specificity: Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue
genes like me logo Genes that share expressions with DLK1: view

In Situ Assay Products

No data available for Expression partners for DLK1 Gene

Orthologs for DLK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DLK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia DLK1 35
  • 90.1 (n)
  • 87.74 (a)
DLK1 36
  • 87 (a)
(Mus musculus)
Mammalia Dlk1 35
  • 87.03 (n)
  • 86.16 (a)
Dlk1 16
Dlk1 36
  • 85 (a)
(Pan troglodytes)
Mammalia DLK1 35
  • 99.22 (n)
  • 99.48 (a)
DLK1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dlk1 35
  • 87.03 (n)
  • 85.38 (a)
(Bos Taurus)
Mammalia DLK 36
  • 83 (a)
(Monodelphis domestica)
Mammalia DLK1 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia DLK1 36
  • 50 (a)
(Gallus gallus)
Aves DLK1 35
  • 58.57 (n)
  • 55.65 (a)
DLK1 36
  • 52 (a)
(Anolis carolinensis)
Reptilia DLK1 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dlk1 35
  • 54.85 (n)
  • 51.95 (a)
(Danio rerio)
Actinopterygii LOC101883341 35
  • 55.9 (n)
  • 41.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta wry 36
  • 7 (a)
Species with no ortholog for DLK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DLK1 Gene

Gene Tree for DLK1 (if available)
Gene Tree for DLK1 (if available)

Paralogs for DLK1 Gene

Selected SIMAP similar genes for DLK1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DLK1: view

Variants for DLK1 Gene

Sequence variations from dbSNP and Humsavar for DLK1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7501 -- 100,734,936(+) GTTCC(A/G/T)CAGAG utr-variant-3-prime
rs12975 -- 100,734,851(+) AAGAT(C/T)GACAT reference, synonymous-codon
rs1058006 - 100,732,102(+) GGACG(A/G)TGGCC reference, missense
rs1058009 - 100,734,523(+) GCCCA(A/G)CGGCT missense, reference
rs1135716 -- 100,728,943(+) GCCAG(C/T)CTGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DLK1 Gene

Variant ID Type Subtype PubMed ID
nsv521690 CNV Loss 19592680
esv2751158 CNV Gain 17911159
nsv525723 CNV Loss 19592680
nsv832876 CNV Loss 17160897
nsv456428 CNV Loss 19166990
nsv470668 CNV Loss 18288195
nsv1425 CNV Insertion 18451855

Relevant External Links for DLK1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DLK1 Gene

Disorders for DLK1 Gene

(6) Novoseek inferred disease relationships for DLK1 Gene

Disease -log(P) Hits PubMed IDs
neuroendocrine tumors 57.1 3
pheochromocytoma 38.4 3
myelodysplastic syndromes 33.2 5
tumors 6.86 14
obesity 3.74 6

Relevant External Links for DLK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DLK1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for DLK1 Gene

Publications for DLK1 Gene

  1. Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2. (PMID: 7925474) Jensen C.H. … Teisner B. (Eur. J. Biochem. 1994) 2 3 4 23
  2. Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2. (PMID: 8501199) Jensen C.H. … Skjoedt K. (Hum. Reprod. 1993) 3 4 23
  3. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. (PMID: 8095043) Laborda J. … Notario V. (J. Biol. Chem. 1993) 2 3 4
  4. dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the EGF-like superfamily. Identification of polymorphic variants of this RNA. (PMID: 7711066) Lee Y.L. … Laborda J. (Biochim. Biophys. Acta 1995) 3 4 23
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48

Products for DLK1 Gene

  • Addgene plasmids for DLK1

Sources for DLK1 Gene

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