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Aliases for TNFRSF18 Gene

Aliases for TNFRSF18 Gene

  • Tumor Necrosis Factor Receptor Superfamily, Member 18 2 3
  • AITR 3 4 6
  • GITR 3 4 6
  • Glucocorticoid-Induced TNFR-Related Protein 3 4
  • Activation-Inducible TNFR Family Receptor 3 4
  • TNF Receptor Superfamily Activation-Inducible Protein 3
  • Tumor Necrosis Factor Receptor Superfamily Member 18 3
  • CD357 Antigen 4
  • GITR-D 3
  • CD357 3

External Ids for TNFRSF18 Gene

Summaries for TNFRSF18 Gene

Entrez Gene Summary for TNFRSF18 Gene

  • This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFRSF18 Gene

TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18) is a Protein Coding gene. Diseases associated with TNFRSF18 include diverticulitis. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot for TNFRSF18 Gene

  • Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway

Gene Wiki entry for TNFRSF18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF18 Gene

Genomics for TNFRSF18 Gene

Genomic Location for TNFRSF18 Gene

1,203,508 bp from pter
1,206,709 bp from pter
3,202 bases
Minus strand

Genomic View for TNFRSF18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFRSF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF18 Gene

Regulatory Elements for TNFRSF18 Gene

Transcription factor binding sites by QIAGEN in the TNFRSF18 gene promoter:

Proteins for TNFRSF18 Gene

  • Protein details for TNFRSF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 18
    Protein Accession:
    Secondary Accessions:
    • B1AME1
    • O95851
    • Q5U0I4
    • Q9NYJ9

    Protein attributes for TNFRSF18 Gene

    241 amino acids
    Molecular mass:
    26000 Da
    Quaternary structure:
    • Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA

    Alternative splice isoforms for TNFRSF18 Gene


neXtProt entry for TNFRSF18 Gene

Proteomics data for TNFRSF18 Gene at MOPED

Post-translational modifications for TNFRSF18 Gene

Other Protein References for TNFRSF18 Gene

No data available for DME Specific Peptides for TNFRSF18 Gene

Domains for TNFRSF18 Gene

Gene Families for TNFRSF18 Gene

  • CD :CD molecules
  • TNFRSF :Tumor necrosis factor receptor superfamily

Protein Domains for TNFRSF18 Gene


  • Contains 3 TNFR-Cys repeats.:
    • Q9Y5U5
genes like me logo Genes that share domains with TNFRSF18: view

Function for TNFRSF18 Gene

Molecular function for TNFRSF18 Gene

GENATLAS Biochemistry: tumor necrosis factor receptor superfamily,member 18,expressed in normal T lymphocytes from thymus,spleen,lymphonodes,involved in regulation of T cell receptor-mediated cell death
UniProtKB/Swiss-Prot Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway
UniProtKB/Swiss-Prot Induction: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation

Gene Ontology (GO) - Molecular Function for TNFRSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005031 tumor necrosis factor-activated receptor activity TAS 10074428
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFRSF18: view
genes like me logo Genes that share phenotypes with TNFRSF18: view

Animal Models for TNFRSF18 Gene

MGI Knock Outs for TNFRSF18:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TNFRSF18 Gene

Localization for TNFRSF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF18 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Jensen Localization Image for TNFRSF18 Gene COMPARTMENTS Subcellular localization image for TNFRSF18 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for TNFRSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with TNFRSF18: view

Pathways for TNFRSF18 Gene

genes like me logo Genes that share pathways with TNFRSF18: view

Pathways by source for TNFRSF18 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TNFRSF18 Gene
3 Sino Biological pathways for TNFRSF18 Gene

Gene Ontology (GO) - Biological Process for TNFRSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 10074428
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS 10074428
GO:0043066 negative regulation of apoptotic process TAS 10074428
genes like me logo Genes that share ontologies with TNFRSF18: view

Compounds for TNFRSF18 Gene

(1) IUPHAR Ligand for TNFRSF18 Gene

Ligand Type Action Affinity Pubmed IDs
TL6 None None
genes like me logo Genes that share compounds with TNFRSF18: view

Transcripts for TNFRSF18 Gene

Unigene Clusters for TNFRSF18 Gene

Tumor necrosis factor receptor superfamily, member 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF18 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP2: -

Relevant External Links for TNFRSF18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF18 Gene

mRNA expression in normal human tissues for TNFRSF18 Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF18 Gene

This gene is overexpressed in Cervix - Endocervix (7.1), Skin - Not Sun Exposed (Suprapubic) (6.1), Whole Blood (6.0), and Skin - Sun Exposed (Lower leg) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFRSF18 Gene

SOURCE GeneReport for Unigene cluster for TNFRSF18 Gene Hs.212680

mRNA Expression by UniProt/SwissProt for TNFRSF18 Gene

Tissue specificity: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen
genes like me logo Genes that share expressions with TNFRSF18: view

Orthologs for TNFRSF18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TNFRSF18 36
  • 98.62 (n)
  • 96.68 (a)
  • 48 (a)
(Bos Taurus)
Mammalia TNFRSF18 36
  • 73.94 (n)
  • 66.81 (a)
  • 44 (a)
(Canis familiaris)
Mammalia TNFRSF18 36
  • 75.11 (n)
  • 66.81 (a)
  • 41 (a)
(Mus musculus)
Mammalia Tnfrsf18 36
  • 70.68 (n)
  • 61.26 (a)
Tnfrsf18 16
Tnfrsf18 37
  • 34 (a)
(Monodelphis domestica)
Mammalia TNFRSF18 37
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF18 37
  • 17 (a)
(Rattus norvegicus)
Mammalia Tnfrsf18 36
  • 71.79 (n)
  • 64.62 (a)
(Gallus gallus)
Aves TNFRSF18 36
  • 47.41 (n)
  • 39.75 (a)
  • 18 (a)
(Anolis carolinensis)
Reptilia TNFRSF18 37
  • 23 (a)
(Danio rerio)
Actinopterygii tnfrsf18 37
  • 18 (a)
Species with no ortholog for TNFRSF18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF18 Gene

Gene Tree for TNFRSF18 (if available)
Gene Tree for TNFRSF18 (if available)

Paralogs for TNFRSF18 Gene

No data available for Paralogs for TNFRSF18 Gene

Variants for TNFRSF18 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs946416 -- 1,204,310(+) CCTCC(A/G)TGCTG intron-variant
rs1815606 -- 1,205,055(+) AGTAT(G/T)TGGTG intron-variant
rs2298213 -- 1,203,822(-) GGGCC(A/G)CCGAC utr-variant-3-prime, reference, synonymous-codon
rs3753344 -- 1,206,770(+) CTGGC(A/G)GGGAT upstream-variant-2KB
rs3753345 -- 1,207,713(+) AGGCC(A/G)CCCCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF18 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871107 CNV Loss 21882294
dgv23n71 CNV Loss 21882294
nsv870548 CNV Loss 21882294
nsv871427 CNV Loss 21882294
nsv871680 CNV Loss 21882294
nsv871133 CNV Loss 21882294
dgv24n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
dgv26n71 CNV Loss 21882294
nsv871512 CNV Loss 21882294

Relevant External Links for TNFRSF18 Gene

HapMap Linkage Disequilibrium report

Disorders for TNFRSF18 Gene

(1) MalaCards Diseases for TNFRSF18 Gene

Search for TNFRSF18 Gene in MalaCards »

(13) Novoseek inferred disease relationships for TNFRSF18 Gene

Disease -log(P) Hits PubMed IDs
necrosis 62.9 55
autoimmune diseases 53.4 6
autoimmunity 49 1
tumors 45.7 44
graft-versus-host disease 42.6 2

Relevant External Links for TNFRSF18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFRSF18: view

No data available for UniProtKB/Swiss-Prot for TNFRSF18 Gene

Publications for TNFRSF18 Gene

  1. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PMID: 10037686) Kwon B. … Kwon B.S. (J. Biol. Chem. 1999) 2 3 4 23
  2. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PMID: 10074428) Gurney A.L. … Ashkenazi A. (Curr. Biol. 1999) 3 4 23
  3. Identification of three novel mRNA splice variants of GITR. (PMID: 10836847) Nocentini G. … Riccardi C. (Cell Death Differ. 2000) 3 4 23
  4. Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis. (PMID: 16955181) Baumgartner-Nielsen J. … Deleuran B. (Acta Derm. Venereol. 2006) 3 23
  5. Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking proliferative signals and increasing NK cell apoptosis. (PMID: 18230609) Liu B. … Nussenblatt R.B. (J. Biol. Chem. 2008) 3 23

Products for TNFRSF18 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TNFRSF18
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TNFRSF18
    • Block miRNA regulation of TNFRSF18 using miScript Target Protectors

    Sources for TNFRSF18 Gene

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