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Aliases for TNFRSF18 Gene

Aliases for TNFRSF18 Gene

  • Tumor Necrosis Factor Receptor Superfamily Member 18 2 3 5
  • Tumor Necrosis Factor Receptor Superfamily, Member 18 2 3
  • Glucocorticoid-Induced TNFR-Related Protein 3 4
  • Activation-Inducible TNFR Family Receptor 3 4
  • AITR 3 4
  • GITR 3 4
  • TNF Receptor Superfamily Activation-Inducible Protein 3
  • CD357 Antigen 4
  • GITR-D 3
  • CD357 3

External Ids for TNFRSF18 Gene

Previous GeneCards Identifiers for TNFRSF18 Gene

  • GC01M000665
  • GC01M000890
  • GC01M001015
  • GC01M001044
  • GC01M001179
  • GC01M001128
  • GC01M000410

Summaries for TNFRSF18 Gene

Entrez Gene Summary for TNFRSF18 Gene

  • This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

GeneCards Summary for TNFRSF18 Gene

TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily Member 18) is a Protein Coding gene. Among its related pathways are TNF Signaling (sino) and ERK Signaling. GO annotations related to this gene include tumor necrosis factor-activated receptor activity.

UniProtKB/Swiss-Prot for TNFRSF18 Gene

  • Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Gene Wiki entry for TNFRSF18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFRSF18 Gene

Genomics for TNFRSF18 Gene

Regulatory Elements for TNFRSF18 Gene

Enhancers for TNFRSF18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TNFRSF18 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TNFRSF18 gene promoter:

Genomic Location for TNFRSF18 Gene

1,203,508 bp from pter
1,206,709 bp from pter
3,202 bases
Minus strand

Genomic View for TNFRSF18 Gene

Genes around TNFRSF18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNFRSF18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNFRSF18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFRSF18 Gene

Proteins for TNFRSF18 Gene

  • Protein details for TNFRSF18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor receptor superfamily member 18
    Protein Accession:
    Secondary Accessions:
    • B1AME1
    • O95851
    • Q5U0I4
    • Q9NYJ9

    Protein attributes for TNFRSF18 Gene

    241 amino acids
    Molecular mass:
    26000 Da
    Quaternary structure:
    • Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

    Alternative splice isoforms for TNFRSF18 Gene


neXtProt entry for TNFRSF18 Gene

Proteomics data for TNFRSF18 Gene at MOPED

Post-translational modifications for TNFRSF18 Gene

Other Protein References for TNFRSF18 Gene

Antibody Products

  • R&D Systems Antibodies for TNFRSF18 (GITR/TNFRSF18)

No data available for DME Specific Peptides for TNFRSF18 Gene

Domains & Families for TNFRSF18 Gene

Protein Domains for TNFRSF18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 TNFR-Cys repeats.
  • Contains 3 TNFR-Cys repeats.
genes like me logo Genes that share domains with TNFRSF18: view

Function for TNFRSF18 Gene

Molecular function for TNFRSF18 Gene

GENATLAS Biochemistry:
tumor necrosis factor receptor superfamily,member 18,expressed in normal T lymphocytes from thymus,spleen,lymphonodes,involved in regulation of T cell receptor-mediated cell death
UniProtKB/Swiss-Prot Function:
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
UniProtKB/Swiss-Prot Induction:
Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
genes like me logo Genes that share phenotypes with TNFRSF18: view

Animal Models for TNFRSF18 Gene

MGI Knock Outs for TNFRSF18:

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TNFRSF18 Gene

Localization for TNFRSF18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFRSF18 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

Jensen Localization Image for TNFRSF18 Gene COMPARTMENTS Subcellular localization image for TNFRSF18 gene
Compartment Confidence
extracellular 5
plasma membrane 5
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TNFRSF18 Gene

Pathways & Interactions for TNFRSF18 Gene

genes like me logo Genes that share pathways with TNFRSF18: view

Gene Ontology (GO) - Biological Process for TNFRSF18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002687 positive regulation of leukocyte migration IMP 23892569
GO:0007275 multicellular organism development IBA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IBA --
GO:0032496 response to lipopolysaccharide IBA --
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with TNFRSF18: view

No data available for SIGNOR curated interactions for TNFRSF18 Gene

Drugs & Compounds for TNFRSF18 Gene

(2) Drugs for TNFRSF18 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
TL6 Pharma 0
TRX518 Pharma 0
genes like me logo Genes that share compounds with TNFRSF18: view

Transcripts for TNFRSF18 Gene

Unigene Clusters for TNFRSF18 Gene

Tumor necrosis factor receptor superfamily, member 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF18 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP2: -

Relevant External Links for TNFRSF18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFRSF18 Gene

mRNA expression in normal human tissues for TNFRSF18 Gene

mRNA differential expression in normal tissues according to GTEx for TNFRSF18 Gene

This gene is overexpressed in Cervix - Endocervix (x7.1), Skin - Not Sun Exposed (Suprapubic) (x6.1), Whole Blood (x6.0), and Skin - Sun Exposed (Lower leg) (x4.9).

Protein differential expression in normal tissues from HIPED for TNFRSF18 Gene

This gene is overexpressed in Saliva (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TNFRSF18 Gene

SOURCE GeneReport for Unigene cluster for TNFRSF18 Gene Hs.212680

mRNA Expression by UniProt/SwissProt for TNFRSF18 Gene

Tissue specificity: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
genes like me logo Genes that share expression patterns with TNFRSF18: view

Protein tissue co-expression partners for TNFRSF18 Gene

Primer Products

Orthologs for TNFRSF18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFRSF18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFRSF18 35
  • 73.94 (n)
  • 66.81 (a)
  • 44 (a)
(Canis familiaris)
Mammalia TNFRSF18 35
  • 75.11 (n)
  • 66.81 (a)
  • 41 (a)
(Mus musculus)
Mammalia Tnfrsf18 35
  • 70.68 (n)
  • 61.26 (a)
Tnfrsf18 16
Tnfrsf18 36
  • 34 (a)
(Pan troglodytes)
Mammalia TNFRSF18 35
  • 98.62 (n)
  • 96.68 (a)
  • 48 (a)
(Rattus norvegicus)
Mammalia Tnfrsf18 35
  • 71.79 (n)
  • 64.62 (a)
(Monodelphis domestica)
Mammalia TNFRSF18 36
  • 26 (a)
(Ornithorhynchus anatinus)
Mammalia TNFRSF18 36
  • 17 (a)
(Gallus gallus)
Aves TNFRSF18 35
  • 47.41 (n)
  • 39.75 (a)
  • 18 (a)
(Anolis carolinensis)
Reptilia TNFRSF18 36
  • 23 (a)
(Danio rerio)
Actinopterygii tnfrsf18 36
  • 18 (a)
Species with no ortholog for TNFRSF18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFRSF18 Gene

Gene Tree for TNFRSF18 (if available)
Gene Tree for TNFRSF18 (if available)

Paralogs for TNFRSF18 Gene

No data available for Paralogs for TNFRSF18 Gene

Variants for TNFRSF18 Gene

Sequence variations from dbSNP and Humsavar for TNFRSF18 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11466676 - 1,206,444(-) TGGGA(C/G)GGGAA reference, missense
rs11466687 - 1,205,490(-) CAGGC(A/G)AGGAG reference, missense
rs11466688 - 1,205,433(-) GCGGA(A/G)ACCCT reference, missense
rs11466693 - 1,204,118(-) TGGCC(A/G)TGGCC intron-variant, reference, missense
rs946416 -- 1,204,310(+) CCTCC(A/G)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TNFRSF18 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
nsv428334 CNV Gain 18775914
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871107 CNV Loss 21882294
dgv23n71 CNV Loss 21882294
nsv870548 CNV Loss 21882294
nsv871427 CNV Loss 21882294
nsv871680 CNV Loss 21882294
nsv871133 CNV Loss 21882294
dgv24n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
dgv26n71 CNV Loss 21882294
nsv871512 CNV Loss 21882294

Variation tolerance for TNFRSF18 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TNFRSF18 Gene

Disorders for TNFRSF18 Gene

Relevant External Links for TNFRSF18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TNFRSF18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNFRSF18 Gene

Publications for TNFRSF18 Gene

  1. Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PMID: 10037686) Kwon B. … Kwon B.S. (J. Biol. Chem. 1999) 2 3 4 67
  2. Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans. (PMID: 19155305) Baessler T. … Salih H.R. (Cancer Res. 2009) 3 23
  3. Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes. (PMID: 19547759) A8uczyA8ski W. … GA^rska M. (Acta Biochim. Pol. 2009) 3 23
  4. Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking proliferative signals and increasing NK cell apoptosis. (PMID: 18230609) Liu B. … Nussenblatt R.B. (J. Biol. Chem. 2008) 3 23
  5. Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta. (PMID: 18924213) Satoguina J.S. … Hoerauf A. (Eur. J. Immunol. 2008) 3 23

Products for TNFRSF18 Gene

Sources for TNFRSF18 Gene