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Aliases for SIGLEC5 Gene

Aliases for SIGLEC5 Gene

  • Sialic Acid Binding Ig Like Lectin 5 2 3 5
  • Obesity-Binding Protein 2 3 4
  • OB-Binding Protein 2 3 4
  • CD33 Antigen-Like 2 3 4
  • SIGLEC-5 3 4
  • CD33L2 3 4
  • OB-BP2 3 4
  • OBBP2 3 4
  • Sialic Acid-Binding Immunoglobulin-Like Lectin 5 3
  • Sialic Acid Binding Ig-Like Lectin 5 2
  • Sialic Acid-Binding Ig-Like Lectin 5 3
  • CD170 Antigen 4
  • CD170 3

External Ids for SIGLEC5 Gene

Previous HGNC Symbols for SIGLEC5 Gene

  • CD33L2

Previous GeneCards Identifiers for SIGLEC5 Gene

  • GC19M052745
  • GC19M052476
  • GC19M056791
  • GC19M056806
  • GC19M052114

Summaries for SIGLEC5 Gene

Entrez Gene Summary for SIGLEC5 Gene

  • This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]

GeneCards Summary for SIGLEC5 Gene

SIGLEC5 (Sialic Acid Binding Ig Like Lectin 5) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is ENSG00000268500.

UniProtKB/Swiss-Prot for SIGLEC5 Gene

  • Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Gene Wiki entry for SIGLEC5 Gene

Additional gene information for SIGLEC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SIGLEC5 Gene

Genomics for SIGLEC5 Gene

GeneHancer (GH) Regulatory Elements for SIGLEC5 Gene

Promoters and enhancers for SIGLEC5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I051628 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 560.2 +15.8 15779 3.1 SOX6 SUZ12 ZSCAN4 YBX1 MNT ZKSCAN1 FOXA1 TCF12 ZNF658 FOXK2 SIGLEC5 SIGLEC14 ENSG00000268970 RPL9P33 ENSG00000273837 ENSG00000268500
GH19I051644 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.3 -330 3.1 BCOR IKZF1 ZFP36 ZMYM3 KDM1A REST SPI1 SIGLEC14 ENSG00000268500 SIGLEC5 IGLON5
GH19I051570 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +73.3 73318 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B ZNF2 IRF4 YY1 POLR2B ZNF766 ZNF175 ZNF766 ZNF701 ZNF350 ZNF616 ZNF808 ZNF841 SIGLEC14 SIGLEC5 RPL7P51
GH19I051360 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10 +280.6 280602 8.5 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A MEF2D ETFB CLDND2 ENSG00000268520 ZNF616 POLD1 ZNF766 ZNF836 ZNF841 ZNF577 ZNF175
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -44.9 -44946 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SIGLEC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SIGLEC5 gene promoter:

Genomic Locations for SIGLEC5 Gene

Genomic Locations for SIGLEC5 Gene
chr19:51,610,957-51,645,545
(GRCh38/hg38)
Size:
34,589 bases
Orientation:
Minus strand
chr19:52,114,781-52,150,151
(GRCh37/hg19)

Genomic View for SIGLEC5 Gene

Genes around SIGLEC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SIGLEC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SIGLEC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SIGLEC5 Gene

Proteins for SIGLEC5 Gene

  • Protein details for SIGLEC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15389-SIGL5_HUMAN
    Recommended name:
    Sialic acid-binding Ig-like lectin 5
    Protein Accession:
    O15389

    Protein attributes for SIGLEC5 Gene

    Size:
    551 amino acids
    Molecular mass:
    60715 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SIGLEC5 Gene

neXtProt entry for SIGLEC5 Gene

Post-translational modifications for SIGLEC5 Gene

  • Glycosylation at isoforms=100, posLast=210210, posLast=231231, posLast=253253, isoforms=328, isoforms=375, posLast=384384, and isoforms=393

Other Protein References for SIGLEC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SIGLEC5 (Siglec-5/Siglec-14)
  • R&D Systems Antibodies for SIGLEC5 (Siglec-5/CD170)
  • Abcam antibodies for SIGLEC5

No data available for DME Specific Peptides for SIGLEC5 Gene

Domains & Families for SIGLEC5 Gene

Gene Families for SIGLEC5 Gene

Protein Domains for SIGLEC5 Gene

Suggested Antigen Peptide Sequences for SIGLEC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15389

UniProtKB/Swiss-Prot:

SIGL5_HUMAN :
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Domain:
  • Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
Family:
  • Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
genes like me logo Genes that share domains with SIGLEC5: view

Function for SIGLEC5 Gene

Molecular function for SIGLEC5 Gene

GENATLAS Biochemistry:
sialic acid binding Ig-like lectin 5,expressed in neutrophils,with alternatively spliced transcripts,sialoadhesin family,Ig superfamily
UniProtKB/Swiss-Prot Function:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Phenotypes From GWAS Catalog for SIGLEC5 Gene

Gene Ontology (GO) - Molecular Function for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with SIGLEC5: view

Phenotypes for SIGLEC5 Gene

genes like me logo Genes that share phenotypes with SIGLEC5: view

miRNA for SIGLEC5 Gene

miRTarBase miRNAs that target SIGLEC5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SIGLEC5 Gene

Localization for SIGLEC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SIGLEC5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SIGLEC5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytosol 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030667 secretory granule membrane TAS --
GO:0070821 tertiary granule membrane TAS --
genes like me logo Genes that share ontologies with SIGLEC5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SIGLEC5 Gene

Pathways & Interactions for SIGLEC5 Gene

genes like me logo Genes that share pathways with SIGLEC5: view

Interacting Proteins for SIGLEC5 Gene

Gene Ontology (GO) - Biological Process for SIGLEC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with SIGLEC5: view

No data available for SIGNOR curated interactions for SIGLEC5 Gene

Drugs & Compounds for SIGLEC5 Gene

(1) Drugs for SIGLEC5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SIGLEC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SIGLEC5: view

Transcripts for SIGLEC5 Gene

mRNA/cDNA for SIGLEC5 Gene

Unigene Clusters for SIGLEC5 Gene

Sialic acid binding Ig-like lectin 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SIGLEC5 Gene

No ASD Table

Relevant External Links for SIGLEC5 Gene

GeneLoc Exon Structure for
SIGLEC5
ECgene alternative splicing isoforms for
SIGLEC5

Expression for SIGLEC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SIGLEC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SIGLEC5 Gene

This gene is overexpressed in Whole Blood (x21.3), Testis (x9.2), Spleen (x7.6), and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for SIGLEC5 Gene

This gene is overexpressed in Neutrophil (39.5), Monocytes (13.6), and Peripheral blood mononuclear cells (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SIGLEC5 Gene



Protein tissue co-expression partners for SIGLEC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of SIGLEC5 Gene:

SIGLEC5

SOURCE GeneReport for Unigene cluster for SIGLEC5 Gene:

Hs.310333

mRNA Expression by UniProt/SwissProt for SIGLEC5 Gene:

O15389-SIGL5_HUMAN
Tissue specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

Evidence on tissue expression from TISSUES for SIGLEC5 Gene

  • Nervous system(4.9)
  • Lung(4)
  • Blood(3.7)
  • Pancreas(2.9)
  • Kidney(2.8)
  • Bone marrow(2.4)
  • Eye(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with SIGLEC5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SIGLEC5 Gene

Orthologs for SIGLEC5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SIGLEC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SIGLEC5 33
  • 76.05 (n)
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 57 (a)
ManyToMany
-- 34
  • 55 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia SIGLEC5 33
  • 75.74 (n)
-- 34
  • 62 (a)
ManyToMany
-- 34
  • 57 (a)
ManyToMany
Species where no ortholog for SIGLEC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SIGLEC5 Gene

ENSEMBL:
Gene Tree for SIGLEC5 (if available)
TreeFam:
Gene Tree for SIGLEC5 (if available)

Paralogs for SIGLEC5 Gene

(8) SIMAP similar genes for SIGLEC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SIGLEC5: view

Variants for SIGLEC5 Gene

Sequence variations from dbSNP and Humsavar for SIGLEC5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000008137 -- 51,614,605(-) T/C intron_variant
rs1000075807 -- 51,614,352(-) C/T intron_variant
rs1000310556 -- 51,623,509(-) G/A intron_variant
rs1000366982 -- 51,628,855(-) G/A intron_variant
rs1000476607 -- 51,626,881(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SIGLEC5 Gene

Variant ID Type Subtype PubMed ID
dgv1061e212 CNV loss 25503493
dgv1062e212 CNV loss 25503493
dgv1063e212 CNV gain 25503493
dgv3623n100 CNV loss 25217958
dgv424n27 CNV loss 19166990
dgv593n67 CNV loss 20364138
dgv6517n54 CNV loss 21841781
dgv6518n54 CNV loss 21841781
dgv6519n54 CNV loss 21841781
dgv6520n54 CNV gain+loss 21841781
dgv6521n54 CNV loss 21841781
dgv656e199 CNV deletion 23128226
esv2516533 CNV deletion 19546169
esv2659920 CNV deletion 23128226
esv27396 CNV loss 19812545
esv2758767 CNV gain+loss 17122850
esv2760513 CNV gain+loss 21179565
esv3644675 CNV loss 21293372
nsv1056611 CNV loss 25217958
nsv1058762 CNV gain 25217958
nsv1072362 CNV deletion 25765185
nsv1140251 OTHER inversion 24896259
nsv1150213 CNV duplication 26484159
nsv1160656 CNV deletion 26073780
nsv181 CNV deletion 15895083
nsv2532 CNV deletion 18451855
nsv2534 CNV insertion 18451855
nsv458725 CNV loss 19166990
nsv469584 CNV loss 16826518
nsv510771 CNV deletion 20534489
nsv579966 CNV loss 21841781
nsv579967 CNV loss 21841781
nsv579968 CNV loss 21841781
nsv9741 CNV loss 18304495

Variation tolerance for SIGLEC5 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.71; 83.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SIGLEC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SIGLEC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SIGLEC5 Gene

Disorders for SIGLEC5 Gene

Additional Disease Information for SIGLEC5

No disorders were found for SIGLEC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SIGLEC5 Gene

Publications for SIGLEC5 Gene

  1. Structural implications of Siglec-5-mediated sialoglycan recognition. (PMID: 18022638) Zhuravleva MA … Sun PD (Journal of molecular biology 2008) 3 4 22 58
  2. Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. (PMID: 10343116) Kim HS (Cytogenetics and cell genetics 1999) 2 3 22 58
  3. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. (PMID: 9731071) Cornish AL … Crocker PR (Blood 1998) 3 4 22 58
  4. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. (PMID: 17012248) Angata T … Nakamura M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 3 22 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58

Products for SIGLEC5 Gene

Sources for SIGLEC5 Gene

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