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Aliases for SNAP23 Gene

Aliases for SNAP23 Gene

  • Synaptosome Associated Protein 23 2 3 5
  • Vesicle-Membrane Fusion Protein SNAP-23 3 4
  • Synaptosomal-Associated Protein, 23kDa 2 3
  • SNAP-23 3 4
  • Synaptosomal-Associated Protein, 23kD 3
  • Synaptosome Associated Protein 23kDa 3
  • Synaptosomal-Associated Protein 23 3
  • HsT17016 3
  • SNAP23A 3
  • SNAP23B 3

External Ids for SNAP23 Gene

Previous GeneCards Identifiers for SNAP23 Gene

  • GC15P038155
  • GC15P035683
  • GC15P040366
  • GC15P040503
  • GC15P040575
  • GC15P042787
  • GC15P019635

Summaries for SNAP23 Gene

Entrez Gene Summary for SNAP23 Gene

  • Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNAP23 Gene

SNAP23 (Synaptosome Associated Protein 23) is a Protein Coding gene. Diseases associated with SNAP23 include Tetanus and Hemophagocytic Lymphohistiocytosis. Among its related pathways are Clathrin derived vesicle budding and Innate Immune System. Gene Ontology (GO) annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is SNAP25.

UniProtKB/Swiss-Prot for SNAP23 Gene

  • Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

Gene Wiki entry for SNAP23 Gene

Additional gene information for SNAP23 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAP23 Gene

Genomics for SNAP23 Gene

GeneHancer (GH) Regulatory Elements for SNAP23 Gene

Promoters and enhancers for SNAP23 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I042493 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 553.8 +4.1 4072 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 SNAP23 LRRC57 GANC HAUS2 LOC105370795 VPS39 CDAN1 TMEM87A ZSCAN29 ADAL
GH15I042490 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.0 3 2.5 PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SNAP23 ZNF106 LRRC57 TMEM87A GANC HAUS2 RPS3AP47 ENSG00000261684
GH15I042489 Promoter 0.5 EPDnew 550.8 -1.9 -1949 0.1 SNAP23 ZNF106 HAUS2 LRRC57 GANC TMEM87A GC15P042438
GH15I043122 Promoter/Enhancer 1.4 Ensembl ENCODE 11.2 +631.8 631832 1.7 PKNOX1 ATF1 SIN3A BRCA1 YY1 GLIS2 ATF7 MCM3 SP3 RXRA TMEM62 LRRC57 RPS3AP47 GANC WDR76 LOC105370795 TMEM87A CDAN1 VPS39 SNAP23
GH15I042497 Enhancer 1.3 Ensembl ENCODE dbSUPER 8.8 +8.4 8374 4.3 HDGF PKNOX1 ARNT FEZF1 GTF3C2 TCF12 ATF7 FOS NCOA1 MEF2D TUBGCP4 LRRC57 HAUS2 ENSG00000260814 MGA LCMT2 MAPKBP1 CDAN1 GANC TMEM87A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNAP23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNAP23 gene promoter:

Genomic Locations for SNAP23 Gene

Genomic Locations for SNAP23 Gene
54,124 bases
Plus strand

Genomic View for SNAP23 Gene

Genes around SNAP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAP23 Gene

Proteins for SNAP23 Gene

  • Protein details for SNAP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Synaptosomal-associated protein 23
    Protein Accession:
    Secondary Accessions:
    • O00162
    • Q13602
    • Q6IAE3

    Protein attributes for SNAP23 Gene

    211 amino acids
    Molecular mass:
    23354 Da
    Quaternary structure:
    • Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (PubMed:12556468). Found in a complex with VAMP8 and STX1A (PubMed:12130530). Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).

    Three dimensional structures from OCA and Proteopedia for SNAP23 Gene

    Alternative splice isoforms for SNAP23 Gene


neXtProt entry for SNAP23 Gene

Post-translational modifications for SNAP23 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNAP23 Gene

Domains & Families for SNAP23 Gene

Gene Families for SNAP23 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SNAP23 Gene


Suggested Antigen Peptide Sequences for SNAP23 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SNAP-25 family.
  • Belongs to the SNAP-25 family.
genes like me logo Genes that share domains with SNAP23: view

Function for SNAP23 Gene

Molecular function for SNAP23 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

Phenotypes From GWAS Catalog for SNAP23 Gene

Gene Ontology (GO) - Molecular Function for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12773094
GO:0019905 syntaxin binding IPI 16677249
genes like me logo Genes that share ontologies with SNAP23: view
genes like me logo Genes that share phenotypes with SNAP23: view

Animal Models for SNAP23 Gene

MGI Knock Outs for SNAP23:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNAP23 Gene

Localization for SNAP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAP23 Gene

Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Mainly localized to the plasma membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAP23 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
lysosome 5
cytosol 3
endosome 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 18457912
GO:0005886 plasma membrane TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0005925 focal adhesion HDA,IDA 21423176
genes like me logo Genes that share ontologies with SNAP23: view

Pathways & Interactions for SNAP23 Gene

genes like me logo Genes that share pathways with SNAP23: view

Gene Ontology (GO) - Biological Process for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002553 histamine secretion by mast cell IMP 18253931
GO:0006810 transport IEA --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006903 vesicle targeting TAS 8663154
genes like me logo Genes that share ontologies with SNAP23: view

No data available for SIGNOR curated interactions for SNAP23 Gene

Drugs & Compounds for SNAP23 Gene

(7) Drugs for SNAP23 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for SNAP23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNAP23: view

Transcripts for SNAP23 Gene

Unigene Clusters for SNAP23 Gene

Synaptosomal-associated protein, 23kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAP23 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - -
SP10: -
SP11: - - -

Relevant External Links for SNAP23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNAP23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNAP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAP23 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for SNAP23 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4) and Platelet (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SNAP23 Gene

Protein tissue co-expression partners for SNAP23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SNAP23 Gene:


SOURCE GeneReport for Unigene cluster for SNAP23 Gene:


mRNA Expression by UniProt/SwissProt for SNAP23 Gene:

Tissue specificity: Ubiquitous. Highest levels where found in placenta.

Evidence on tissue expression from TISSUES for SNAP23 Gene

  • Blood(4.6)
  • Liver(4.3)
  • Nervous system(3.4)
  • Kidney(2.4)
  • Lung(2.4)
  • Spleen(2.4)
  • Muscle(2.3)
  • Intestine(2.2)
  • Adrenal gland(2.1)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with SNAP23: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAP23 Gene

Orthologs for SNAP23 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAP23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNAP23 33 34
  • 99.84 (n)
(Canis familiaris)
Mammalia SNAP23 33 34
  • 91 (n)
(Bos Taurus)
Mammalia SNAP23 33 34
  • 89.26 (n)
(Mus musculus)
Mammalia Snap23 33 16 34
  • 88.41 (n)
(Rattus norvegicus)
Mammalia Snap23 33
  • 87.78 (n)
(Monodelphis domestica)
Mammalia SNAP23 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia SNAP23 34
  • 78 (a)
(Gallus gallus)
Aves SNAP23 33 34
  • 75.76 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
-- 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snap23 33
  • 70.41 (n)
(Danio rerio)
Actinopterygii zgc:56072 33
  • 63.64 (n)
SNAP23 (1 of 2) 34
  • 54 (a)
SNAP23 (2 of 2) 34
  • 38 (a)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Snap25 35 34
  • 51 (a)
Snap24 34
  • 45 (a)
(Caenorhabditis elegans)
Secernentea Y22F5A.3 35
  • 51 (a)
ric-4 34
  • 41 (a)
aex-4 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6593 34
  • 57 (a)
Species where no ortholog for SNAP23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAP23 Gene

Gene Tree for SNAP23 (if available)
Gene Tree for SNAP23 (if available)

Paralogs for SNAP23 Gene

Paralogs for SNAP23 Gene Pseudogenes for SNAP23 Gene

genes like me logo Genes that share paralogs with SNAP23: view

Variants for SNAP23 Gene

Sequence variations from dbSNP and Humsavar for SNAP23 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000021467 -- 42,502,725(+) G/A intron_variant
rs1000063744 -- 42,493,242(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000123406 -- 42,500,000(+) C/G intron_variant
rs1000221779 -- 42,531,630(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000327909 -- 42,523,497(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNAP23 Gene

Variant ID Type Subtype PubMed ID
esv2761870 CNV loss 21179565
esv3636272 CNV loss 21293372
esv3636274 CNV loss 21293372
nsv1508 CNV insertion 18451855
nsv528725 CNV gain 19592680
nsv832987 CNV gain 17160897

Variation tolerance for SNAP23 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNAP23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAP23 Gene

Disorders for SNAP23 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SNAP23 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • clostridial tetanus
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SNAP23

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SNAP23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNAP23 Gene

Publications for SNAP23 Gene

  1. Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. (PMID: 9070898) Mollinedo F … Lazo PA (Biochemical and biophysical research communications 1997) 2 3 4 22 58
  2. Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. (PMID: 8663154) Ravichandran V … Roche PA (The Journal of biological chemistry 1996) 2 3 4 22 58
  3. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. (PMID: 12556468) Freedman SJ … Eck MJ (The Journal of biological chemistry 2003) 3 4 22 58
  4. Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes. (PMID: 11354632) Lazo PA … Estivill X (Human genetics 2001) 3 4 22 58
  5. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 44 58

Products for SNAP23 Gene

Sources for SNAP23 Gene

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