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Aliases for SNAP23 Gene

Aliases for SNAP23 Gene

  • Synaptosomal-Associated Protein, 23kDa 2 3
  • Vesicle-Membrane Fusion Protein SNAP-23 3 4
  • Synaptosomal-Associated Protein, 23kD 2 3
  • SNAP-23 3 4
  • Synaptosomal-Associated Protein 23 3
  • HsT17016 3
  • SNAP23A 3
  • SNAP23B 3

External Ids for SNAP23 Gene

Previous GeneCards Identifiers for SNAP23 Gene

  • GC15P038155
  • GC15P035683
  • GC15P040366
  • GC15P040503
  • GC15P040575
  • GC15P042787
  • GC15P019635

Summaries for SNAP23 Gene

Entrez Gene Summary for SNAP23 Gene

  • Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNAP23 Gene

SNAP23 (Synaptosomal-Associated Protein, 23kDa) is a Protein Coding gene. Diseases associated with SNAP23 include botulism. Among its related pathways are Clathrin derived vesicle budding and Insulin Signaling. An important paralog of this gene is SNAP25.

UniProtKB/Swiss-Prot for SNAP23 Gene

  • Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion

Gene Wiki entry for SNAP23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAP23 Gene

Genomics for SNAP23 Gene

Regulatory Elements for SNAP23 Gene

Transcription factor binding sites by QIAGEN in the SNAP23 gene promoter:

Genomic Location for SNAP23 Gene

Start:
42,491,233 bp from pter
End:
42,545,356 bp from pter
Size:
54,124 bases
Orientation:
Plus strand

Genomic View for SNAP23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SNAP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAP23 Gene

Proteins for SNAP23 Gene

  • Protein details for SNAP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00161-SNP23_HUMAN
    Recommended name:
    Synaptosomal-associated protein 23
    Protein Accession:
    O00161
    Secondary Accessions:
    • O00162
    • Q13602
    • Q6IAE3

    Protein attributes for SNAP23 Gene

    Size:
    211 amino acids
    Molecular mass:
    23354 Da
    Quaternary structure:
    • Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3. Binds simultaneously to SNAPIN and SYN4. Found in a complex with VAMP8 and STX4 in pancreas. Interacts with STX1A and STX12 (By similarity). Binds tightly to multiple syntaxins and synaptobrevins/VAMPs. Found in a complex with VAMP8 and STX1A.

    Three dimensional structures from OCA and Proteopedia for SNAP23 Gene

    Alternative splice isoforms for SNAP23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAP23 Gene

Proteomics data for SNAP23 Gene at MOPED

Post-translational modifications for SNAP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNAP23 Gene

Domains for SNAP23 Gene

Protein Domains for SNAP23 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAP23 Gene

Graphical View of Domain Structure for InterPro Entry

O00161

UniProtKB/Swiss-Prot:

SNP23_HUMAN :
  • O00161
Domain:
  • Contains 2 t-SNARE coiled-coil homology domains.
Family:
  • Belongs to the SNAP-25 family.
genes like me logo Genes that share domains with SNAP23: view

No data available for Gene Families for SNAP23 Gene

Function for SNAP23 Gene

Molecular function for SNAP23 Gene

UniProtKB/Swiss-Prot Function: Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion

Gene Ontology (GO) - Molecular Function for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005484 SNAP receptor activity IBA --
GO:0005515 protein binding IPI 12773094
GO:0019905 syntaxin binding IPI 16677249
genes like me logo Genes that share ontologies with SNAP23: view
genes like me logo Genes that share phenotypes with SNAP23: view

Animal Models for SNAP23 Gene

MGI Knock Outs for SNAP23:

miRNA for SNAP23 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SNAP23 Gene

Localization for SNAP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAP23 Gene

Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Mainly localized to the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAP23 Gene COMPARTMENTS Subcellular localization image for SNAP23 gene
Compartment Confidence
lysosome 5
plasma membrane 5
vacuole 5
golgi apparatus 4
nucleus 4
cytosol 3
endosome 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 18457912
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with SNAP23: view

Pathways for SNAP23 Gene

genes like me logo Genes that share pathways with SNAP23: view

Gene Ontology (GO) - Biological Process for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002553 histamine secretion by mast cell IMP 18253931
GO:0006887 exocytosis --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0006903 vesicle targeting TAS 8663154
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with SNAP23: view

Compounds for SNAP23 Gene

(9) Novoseek inferred chemical compound relationships for SNAP23 Gene

Compound -log(P) Hits PubMed IDs
n-ethylmaleimide 54.1 3
lipid 14.8 10
cysteine 14.5 7
glucose 9.4 7
sucrose 5.95 1
genes like me logo Genes that share compounds with SNAP23: view

Transcripts for SNAP23 Gene

Unigene Clusters for SNAP23 Gene

Synaptosomal-associated protein, 23kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAP23 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - -
SP9:
SP10: -
SP11: - - -

Relevant External Links for SNAP23 Gene

GeneLoc Exon Structure for
SNAP23
ECgene alternative splicing isoforms for
SNAP23

Expression for SNAP23 Gene

mRNA expression in normal human tissues for SNAP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAP23 Gene

This gene is overexpressed in Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAP23 Gene

SOURCE GeneReport for Unigene cluster for SNAP23 Gene Hs.511149

mRNA Expression by UniProt/SwissProt for SNAP23 Gene

O00161-SNP23_HUMAN
Tissue specificity: Ubiquitous. Highest levels where found in placenta
genes like me logo Genes that share expressions with SNAP23: view

Orthologs for SNAP23 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAP23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAP23 35
  • 99.84 (n)
  • 100 (a)
SNAP23 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SNAP23 35
  • 89.26 (n)
  • 86.26 (a)
SNAP23 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAP23 35
  • 91 (n)
  • 88.63 (a)
SNAP23 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snap23 35
  • 88.41 (n)
  • 87.62 (a)
Snap23 16
Snap23 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNAP23 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAP23 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snap23 35
  • 87.78 (n)
  • 87.62 (a)
chicken
(Gallus gallus)
Aves SNAP23 35
  • 75.76 (n)
  • 77.03 (a)
SNAP23 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia snap23 35
  • 70.41 (n)
  • 70.73 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
SNAP23 (1 of 2) 36
  • 54 (a)
OneToMany
SNAP23 (2 of 2) 36
  • 38 (a)
OneToMany
zgc:56072 35
  • 63.64 (n)
  • 63.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta Snap24 36
  • 45 (a)
ManyToMany
Snap25 36
  • 48 (a)
ManyToMany
Snap25 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea aex-4 36
  • 21 (a)
ManyToMany
ric-4 36
  • 41 (a)
ManyToMany
Y22F5A.3 37
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6593 36
  • 57 (a)
OneToMany
Species with no ortholog for SNAP23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAP23 Gene

ENSEMBL:
Gene Tree for SNAP23 (if available)
TreeFam:
Gene Tree for SNAP23 (if available)

Paralogs for SNAP23 Gene

Paralogs for SNAP23 Gene

Pseudogenes.org Pseudogenes for SNAP23 Gene

genes like me logo Genes that share paralogs with SNAP23: view

Variants for SNAP23 Gene

Sequence variations from dbSNP and Humsavar for SNAP23 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs11022 -- 42,532,380(-) CAGCC(A/G)GGCAC utr-variant-3-prime
rs1060265 -- 42,532,384(+) CTGGC(C/T)GAGTT utr-variant-3-prime
rs1060291 -- 42,528,391(+) ACAAC(A/G)GGAGC synonymous-codon, reference, intron-variant
rs1871156 -- 42,524,533(-) ATCTC(G/T)CACAT intron-variant
rs1900921 -- 42,494,946(+) TGCCC(A/C)TAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SNAP23 Gene

Variant ID Type Subtype PubMed ID
nsv832987 CNV Gain 17160897
nsv528725 CNV Gain 19592680
nsv1508 CNV Insertion 18451855

Relevant External Links for SNAP23 Gene

HapMap Linkage Disequilibrium report
SNAP23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAP23 Gene

Disorders for SNAP23 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SNAP23 Gene including...

Search for SNAP23 Gene in MalaCards »

(3) University of Copenhagen DISEASES for SNAP23 Gene

(2) Novoseek inferred disease relationships for SNAP23 Gene

Disease -log(P) Hits PubMed IDs
tetanus 42.8 2
insulin resistance 8.93 2

Relevant External Links for SNAP23

Genetic Association Database (GAD)
SNAP23
Human Genome Epidemiology (HuGE) Navigator
SNAP23
genes like me logo Genes that share disorders with SNAP23: view

No data available for UniProtKB/Swiss-Prot for SNAP23 Gene

Publications for SNAP23 Gene

  1. Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. (PMID: 9070898) Mollinedo F. … Lazo P.A. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. (PMID: 8663154) Ravichandran V. … Roche P.A. (J. Biol. Chem. 1996) 2 3 4 23
  3. Genomic organization, chromosomal localization, alternative splicing, and isoforms of human Synaptosome associated protein-23 gene implicated in vesicle-membrane fusion. (PMID: 11354632) Lazo P.A. … Estivill X. (Hum. Genet. 2001) 3 4 23
  4. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. (PMID: 12556468) Freedman S.J. … Eck M.J. (J. Biol. Chem. 2003) 3 4 23
  5. The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23. (PMID: 12475239) Diefenbach R.J. … Cunningham A.L. (Biochemistry 2002) 3 23

Products for SNAP23 Gene

Sources for SNAP23 Gene

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