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Aliases for SNAP23 Gene

Aliases for SNAP23 Gene

  • Synaptosome Associated Protein 23kDa 2 3 5
  • Vesicle-Membrane Fusion Protein SNAP-23 3 4
  • Synaptosomal-Associated Protein, 23kDa 2 3
  • Synaptosomal-Associated Protein, 23kD 2 3
  • SNAP-23 3 4
  • HsT17016 3
  • SNAP23A 3
  • SNAP23B 3

External Ids for SNAP23 Gene

Previous GeneCards Identifiers for SNAP23 Gene

  • GC15P038155
  • GC15P035683
  • GC15P040366
  • GC15P040503
  • GC15P040575
  • GC15P042787
  • GC15P019635

Summaries for SNAP23 Gene

Entrez Gene Summary for SNAP23 Gene

  • Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNAP23 Gene

SNAP23 (Synaptosome Associated Protein 23kDa) is a Protein Coding gene. Diseases associated with SNAP23 include Tetanus and Hemophagocytic Lymphohistiocytosis. Among its related pathways are Platelet activation and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is SNAP25.

UniProtKB/Swiss-Prot for SNAP23 Gene

  • Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

Gene Wiki entry for SNAP23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAP23 Gene

Genomics for SNAP23 Gene

Regulatory Elements for SNAP23 Gene

Enhancers for SNAP23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SNAP23 on UCSC Golden Path with GeneCards custom track

Promoters for SNAP23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SNAP23 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SNAP23 gene promoter:

Genomic Location for SNAP23 Gene

Chromosome:
15
Start:
42,491,233 bp from pter
End:
42,545,356 bp from pter
Size:
54,124 bases
Orientation:
Plus strand

Genomic View for SNAP23 Gene

Genes around SNAP23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAP23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAP23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAP23 Gene

Proteins for SNAP23 Gene

  • Protein details for SNAP23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00161-SNP23_HUMAN
    Recommended name:
    Synaptosomal-associated protein 23
    Protein Accession:
    O00161
    Secondary Accessions:
    • O00162
    • Q13602
    • Q6IAE3

    Protein attributes for SNAP23 Gene

    Size:
    211 amino acids
    Molecular mass:
    23354 Da
    Quaternary structure:
    • Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3. Binds simultaneously to SNAPIN and SYN4. Found in a complex with VAMP8 and STX4 in pancreas. Interacts with STX1A and STX12 (By similarity). Binds tightly to multiple syntaxins and synaptobrevins/VAMPs. Found in a complex with VAMP8 and STX1A.

    Three dimensional structures from OCA and Proteopedia for SNAP23 Gene

    Alternative splice isoforms for SNAP23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAP23 Gene

Proteomics data for SNAP23 Gene at MOPED

Post-translational modifications for SNAP23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SNAP23 Gene

Domains & Families for SNAP23 Gene

Gene Families for SNAP23 Gene

Protein Domains for SNAP23 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAP23 Gene

Graphical View of Domain Structure for InterPro Entry

O00161

UniProtKB/Swiss-Prot:

SNP23_HUMAN :
  • Contains 2 t-SNARE coiled-coil homology domains.
  • Belongs to the SNAP-25 family.
Domain:
  • Contains 2 t-SNARE coiled-coil homology domains.
Family:
  • Belongs to the SNAP-25 family.
genes like me logo Genes that share domains with SNAP23: view

Function for SNAP23 Gene

Molecular function for SNAP23 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
genes like me logo Genes that share phenotypes with SNAP23: view

Animal Models for SNAP23 Gene

MGI Knock Outs for SNAP23:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNAP23 Gene

Localization for SNAP23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAP23 Gene

Cell membrane; Peripheral membrane protein. Cell membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note=Mainly localized to the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SNAP23 Gene COMPARTMENTS Subcellular localization image for SNAP23 gene
Compartment Confidence
extracellular 5
lysosome 5
nucleus 5
plasma membrane 5
vacuole 5
cytosol 3
cytoskeleton 2
endosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0042629 mast cell granule IMP 18253931
GO:0043005 neuron projection IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SNAP23: view

Pathways & Interactions for SNAP23 Gene

genes like me logo Genes that share pathways with SNAP23: view

Gene Ontology (GO) - Biological Process for SNAP23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061024 membrane organization TAS --
genes like me logo Genes that share ontologies with SNAP23: view

No data available for SIGNOR curated interactions for SNAP23 Gene

Drugs & Compounds for SNAP23 Gene

(6) Drugs for SNAP23 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for SNAP23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNAP23: view

Transcripts for SNAP23 Gene

Unigene Clusters for SNAP23 Gene

Synaptosomal-associated protein, 23kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SNAP23 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - -
SP9:
SP10: -
SP11: - - -

Relevant External Links for SNAP23 Gene

GeneLoc Exon Structure for
SNAP23
ECgene alternative splicing isoforms for
SNAP23

Expression for SNAP23 Gene

mRNA expression in normal human tissues for SNAP23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAP23 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for SNAP23 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.4) and Platelet (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SNAP23 Gene



SOURCE GeneReport for Unigene cluster for SNAP23 Gene Hs.511149

mRNA Expression by UniProt/SwissProt for SNAP23 Gene

O00161-SNP23_HUMAN
Tissue specificity: Ubiquitous. Highest levels where found in placenta.
genes like me logo Genes that share expression patterns with SNAP23: view

Protein tissue co-expression partners for SNAP23 Gene

- Elite partner

Primer Products

Orthologs for SNAP23 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAP23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SNAP23 35
  • 89.26 (n)
  • 86.26 (a)
SNAP23 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNAP23 35
  • 91 (n)
  • 88.63 (a)
SNAP23 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Snap23 35
  • 88.41 (n)
  • 87.62 (a)
Snap23 16
Snap23 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SNAP23 35
  • 99.84 (n)
  • 100 (a)
SNAP23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snap23 35
  • 87.78 (n)
  • 87.62 (a)
oppossum
(Monodelphis domestica)
Mammalia SNAP23 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAP23 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAP23 35
  • 75.76 (n)
  • 77.03 (a)
SNAP23 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
OneToMany
-- 36
  • 52 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia snap23 35
  • 70.41 (n)
  • 70.73 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
zgc:56072 35
  • 63.64 (n)
  • 63.16 (a)
SNAP23 (1 of 2) 36
  • 54 (a)
OneToMany
SNAP23 (2 of 2) 36
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Snap25 37
  • 51 (a)
Snap24 36
  • 45 (a)
ManyToMany
Snap25 36
  • 48 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y22F5A.3 37
  • 51 (a)
aex-4 36
  • 21 (a)
ManyToMany
ric-4 36
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6593 36
  • 57 (a)
OneToMany
Species with no ortholog for SNAP23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNAP23 Gene

ENSEMBL:
Gene Tree for SNAP23 (if available)
TreeFam:
Gene Tree for SNAP23 (if available)

Paralogs for SNAP23 Gene

Paralogs for SNAP23 Gene

Pseudogenes.org Pseudogenes for SNAP23 Gene

genes like me logo Genes that share paralogs with SNAP23: view

Variants for SNAP23 Gene

Sequence variations from dbSNP and Humsavar for SNAP23 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs4924684 -- 42,504,244(+) GACTG(A/G)GGAAG intron-variant
rs4924686 -- 42,510,055(+) CAGAG(C/T)GAGAC intron-variant
rs5812222 -- 42,503,387(+) TTTTT(-/T)GAGAT intron-variant
rs5812223 -- 42,508,262(+) GCCTC(-/A)AAAAA intron-variant
rs5812224 -- 42,512,396(+) CTTAC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SNAP23 Gene

Variant ID Type Subtype PubMed ID
nsv832987 CNV Gain 17160897
nsv528725 CNV Gain 19592680
nsv1508 CNV Insertion 18451855

Variation tolerance for SNAP23 Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SNAP23 Gene

Disorders for SNAP23 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SNAP23 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
tetanus
  • clostridial tetanus
hemophagocytic lymphohistiocytosis
  • haemophagocytic syndrome
alcohol-related birth defect
  • fetal alcohol syndrome
chief cell adenoma
  • chief cell adenoma of parathyroid gland
myopathy, myofibrillar, 3
  • myofibrillar myopathy 3
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SNAP23

Genetic Association Database (GAD)
SNAP23
Human Genome Epidemiology (HuGE) Navigator
SNAP23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SNAP23
genes like me logo Genes that share disorders with SNAP23: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNAP23 Gene

Publications for SNAP23 Gene

  1. Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells. (PMID: 9070898) Mollinedo F. … Lazo P.A. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. (PMID: 8663154) Ravichandran V. … Roche P.A. (J. Biol. Chem. 1996) 2 3 23
  3. VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. (PMID: 19910495) Kean M.J. … Coppolino M.G. (J. Cell. Sci. 2009) 3 23
  4. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. (PMID: 18253931) Sander L.E. … Lorentz A. (Eur. J. Immunol. 2008) 3 23
  5. Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. (PMID: 18457912) Lu M. … BrAonstrAPm R. (Mol. Cell. Endocrinol. 2008) 3 23

Products for SNAP23 Gene

Sources for SNAP23 Gene

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