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Aliases for FADD Gene

Aliases for FADD Gene

  • Fas (TNFRSF6)-Associated Via Death Domain 2 3
  • Growth-Inhibiting Gene 3 Protein 2 3 4
  • Fas-Associating Death Domain-Containing Protein 2 3
  • Fas-Associating Protein With Death Domain 2 3
  • Mediator Of Receptor-Induced Toxicity 2 3
  • Mediator Of Receptor Induced Toxicity 3 4
  • MORT1 3 4
  • FAS-Associating Death Domain-Containing Protein 4
  • Protein FADD 4
  • GIG3 3

External Ids for FADD Gene

Previous GeneCards Identifiers for FADD Gene

  • GC11P072381
  • GC11P071572
  • GC11P070271
  • GC11P069775
  • GC11P069726
  • GC11P070049
  • GC11P066308

Summaries for FADD Gene

Entrez Gene Summary for FADD Gene

  • The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

GeneCards Summary for FADD Gene

FADD (Fas (TNFRSF6)-Associated Via Death Domain) is a Protein Coding gene. Diseases associated with FADD include fadd-related immunodeficiency and infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include identical protein binding and protease binding.

UniProtKB/Swiss-Prot for FADD Gene

  • Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Gene Wiki entry for FADD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FADD Gene

Genomics for FADD Gene

Regulatory Elements for FADD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FADD Gene

Chromosome:
11
Start:
70,203,163 bp from pter
End:
70,207,402 bp from pter
Size:
4,240 bases
Orientation:
Plus strand

Genomic View for FADD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FADD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FADD Gene

Proteins for FADD Gene

  • Protein details for FADD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13158-FADD_HUMAN
    Recommended name:
    FAS-associated death domain protein
    Protein Accession:
    Q13158
    Secondary Accessions:
    • Q14866
    • Q6IBR4

    Protein attributes for FADD Gene

    Size:
    208 amino acids
    Molecular mass:
    23279 Da
    Quaternary structure:
    • Can self-associate. Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and PIDD1. Interacts (via death domain) with FAS (via death domain). Interacts with CASP8. Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).

    Three dimensional structures from OCA and Proteopedia for FADD Gene

neXtProt entry for FADD Gene

Proteomics data for FADD Gene at MOPED

Post-translational modifications for FADD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FADD Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FADD (FADD)

No data available for DME Specific Peptides for FADD Gene

Domains & Families for FADD Gene

Gene Families for FADD Gene

Protein Domains for FADD Gene

Suggested Antigen Peptide Sequences for FADD Gene

Graphical View of Domain Structure for InterPro Entry

Q13158

UniProtKB/Swiss-Prot:

FADD_HUMAN :
  • Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
Domain:
  • Contains a death domain involved in the binding of the corresponding domain within Fas receptor.
  • The interaction between the FAS and FADD death domains is crucial for the formation of the death-inducing signaling complex (DISC).
  • Contains 1 death domain.
  • Contains 1 DED (death effector) domain.
genes like me logo Genes that share domains with FADD: view

Function for FADD Gene

Molecular function for FADD Gene

GENATLAS Biochemistry:
Fas-associated DEATH domain protein (FADD/MORT1),23kDa,intracellular mediator of lymphocyte apoptosis,associating with the DEATH domain of TNFRSF6 and CASP8
UniProtKB/Swiss-Prot Function:
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

Gene Ontology (GO) - Molecular Function for FADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 9208847
GO:0005123 death receptor binding IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding IPI 7536190
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with FADD: view
genes like me logo Genes that share phenotypes with FADD: view

Animal Models for FADD Gene

MGI Knock Outs for FADD:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FADD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FADD Gene

Localization for FADD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FADD Gene COMPARTMENTS Subcellular localization image for FADD gene
Compartment Confidence
cytosol 5
plasma membrane 5
nucleus 3
golgi apparatus 2
mitochondrion 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22510408
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 22510408
GO:0031264 death-inducing signaling complex TAS 18309324
GO:0031265 CD95 death-inducing signaling complex IDA 20935634
genes like me logo Genes that share ontologies with FADD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FADD Gene

Pathways & Interactions for FADD Gene

SuperPathways for FADD Gene

Superpath Contained pathways
1 TWEAK Pathway
2 CASP8 activity is inhibited
3 MyD88 cascade initiated on plasma membrane
4 Toll-like receptor signaling pathway
5 Apoptosis and survival Caspase cascade
genes like me logo Genes that share pathways with FADD: view

PCR Array Products

SIGNOR curated interactions for FADD Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FADD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity ISS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0002821 positive regulation of adaptive immune response ISS --
GO:0006915 apoptotic process TAS --
genes like me logo Genes that share ontologies with FADD: view

Drugs & Compounds for FADD Gene

(13) Drugs for FADD Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Doxorubicin Approved, Investigational Pharma Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1525
Ethanol Approved Pharma 1708
Mitomycin Approved Pharma Inhibits DNA synthesis,antibiotic and antitumor agent 0
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2505

(8) Additional Compounds for FADD Gene - From: NovoSeek

genes like me logo Genes that share compounds with FADD: view

Transcripts for FADD Gene

mRNA/cDNA for FADD Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(318) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FADD Gene

Fas (TNFRSF6)-associated via death domain:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FADD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FADD Gene

No ASD Table

Relevant External Links for FADD Gene

GeneLoc Exon Structure for
FADD
ECgene alternative splicing isoforms for
FADD

Expression for FADD Gene

mRNA expression in normal human tissues for FADD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FADD Gene

This gene is overexpressed in Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for FADD Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (22.0), Bone marrow stromal cell (15.6), and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FADD Gene



SOURCE GeneReport for Unigene cluster for FADD Gene Hs.86131

mRNA Expression by UniProt/SwissProt for FADD Gene

Q13158-FADD_HUMAN
Tissue specificity: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes
genes like me logo Genes that share expression patterns with FADD: view

Protein tissue co-expression partners for FADD Gene

Primer Products

In Situ Assay Products

Orthologs for FADD Gene

This gene was present in the common ancestor of chordates.

Orthologs for FADD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FADD 35
  • 76.86 (n)
  • 66.99 (a)
FADD 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fadd 35
  • 75.98 (n)
  • 69.12 (a)
Fadd 16
Fadd 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FADD 35
  • 98.88 (n)
  • 98.08 (a)
FADD 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fadd 35
  • 75.24 (n)
  • 68.93 (a)
dog
(Canis familiaris)
Mammalia FADD 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FADD 36
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves FADD 35
  • 55.49 (n)
  • 45.81 (a)
FADD 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FADD 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fadd 35
  • 56.21 (n)
  • 43.14 (a)
zebrafish
(Danio rerio)
Actinopterygii fadd 35
  • 50 (n)
  • 39.61 (a)
fadd 36
  • 34 (a)
OneToOne
Species with no ortholog for FADD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FADD Gene

ENSEMBL:
Gene Tree for FADD (if available)
TreeFam:
Gene Tree for FADD (if available)

Paralogs for FADD Gene

No data available for Paralogs for FADD Gene

Variants for FADD Gene

Sequence variations from dbSNP and Humsavar for FADD Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4197 -- 70,207,017(-) CCACA(-/ACA)GCACC utr-variant-3-prime
rs1051422 -- 70,207,029(+) GGGGA(A/G)AGGCA utr-variant-3-prime
rs1131677 -- 70,203,417(+) GGCGC(A/G)CGGAG utr-variant-5-prime
rs1131715 -- 70,207,381(+) CCATA(C/T)TACAA utr-variant-3-prime
rs2230821 -- 70,206,245(+) AGATA(C/T)CCCCG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FADD Gene

Variant ID Type Subtype PubMed ID
esv268477 CNV Insertion 20981092

Variation tolerance for FADD Gene

Residual Variation Intolerance Score: 29.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FADD Gene

HapMap Linkage Disequilibrium report
FADD
Human Gene Mutation Database (HGMD)
FADD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FADD Gene

Disorders for FADD Gene

MalaCards: The human disease database

(9) MalaCards diseases for FADD Gene - From: OMIM, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
fadd-related immunodeficiency
infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations
  • recurrent infections, encephalopathy, hepatic dysfunction and cardiovascular malformations
oculootodental syndrome
  • ood
systemic lupus erythematosus 4
  • systemic lupus erythematosus, susceptibility to, 4
oral cavity cancer
  • malignant tumor of the floor of the mouth
- elite association
Search FADD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FADD_HUMAN
  • Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations (IEHDCM) [MIM:613759]: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV). {ECO:0000269 PubMed:21109225}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FADD

Genetic Association Database (GAD)
FADD
Human Genome Epidemiology (HuGE) Navigator
FADD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FADD
genes like me logo Genes that share disorders with FADD: view

No data available for Genatlas for FADD Gene

Publications for FADD Gene

  1. Cryptocaryone, a natural dihydrochalcone, induces apoptosis in human androgen independent prostate cancer cells by death receptor clustering in lipid raft and nonraft compartments. (PMID: 20403609) Chen Y.C. … Guh J.H. (J. Urol. 2010) 23 67
  2. Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells. (PMID: 20202822) Rebillard A. … Dimanche-Boitrel M.T. (Eur. J. Cancer 2010) 23 67
  3. Overexpression of FADD enhances 5-fluorouracil-induced apoptosis in colorectal adenocarcinoma cells. (PMID: 19415536) Yin A. … Luo H. (Med. Oncol. 2010) 23 67
  4. Lack of Fas-pathway gene mutations in primary resected esophageal squamous cell carcinoma. (PMID: 20438666) Ko C.L. … Hsia J.Y. (Chang Gung Med J 2010) 23 67
  5. Death receptor 5-recruited raft components contributes to the sensitivity of Jurkat leukemia cell lines to TRAIL-induced cell death. (PMID: 19242990) Min Y. … Zheng D. (IUBMB Life 2009) 23 67

Products for FADD Gene

Sources for FADD Gene

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