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Aliases for RAB11A Gene

Aliases for RAB11A Gene

  • RAB11A, Member RAS Oncogene Family 2 3 5
  • Rab-11 3 4
  • YL8 3 4
  • RAB 11A, Member Oncogene Family 3
  • Ras-Related Protein Rab-11A 3
  • RAB11 4

External Ids for RAB11A Gene

Previous GeneCards Identifiers for RAB11A Gene

  • GC15P061897
  • GC15P059260
  • GC15P063740
  • GC15P063877
  • GC15P063948
  • GC15P066161
  • GC15P042986
  • GC15P066018
  • GC15P065784
  • GC15P066280
  • GC15P066274
  • GC15P066340
  • GC15P066869
  • GC15P067397
  • GC15P067919

Summaries for RAB11A Gene

Entrez Gene Summary for RAB11A Gene

  • The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for RAB11A Gene

RAB11A (RAB11A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11A include Autosomal Dominant Non-Syndromic Intellectual Disability and Barrett Esophagus. Among its related pathways are Organelle biogenesis and maintenance and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and microtubule binding. An important paralog of this gene is RAB11B.

UniProtKB/Swiss-Prot for RAB11A Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Gene Wiki entry for RAB11A Gene

Additional gene information for RAB11A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11A Gene

Genomics for RAB11A Gene

GeneHancer (GH) Regulatory Elements for RAB11A Gene

Promoters and enhancers for RAB11A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I065868 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 550.1 +144.5 144526 3.7 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 TRQ-CTG1-4 RAB11A PDCD7 PARP16 SLC24A1 INTS14 MTFMT UBAP1L TIPIN SNAPC5
GH15I065722 Enhancer 0.4 ENCODE 550.8 -1.6 -1581 3.2 FOXA2 CEBPB CEBPG RAB11A SNORD13E DENND4A HACD3 MIR4511
GH15I065817 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +94.1 94079 4.7 HDGF PKNOX1 SMAD1 ARNT IRF4 TCF12 GATA2 ATF7 RUNX3 KDM4B DENND4A ZWILCH INTS14 PDCD7 SLC24A1 ENSG00000260773 TIPIN MTFMT RAB11A SNORD13E
GH15I065831 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.5 +107.2 107239 3.8 PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 INTS14 SLC24A1 DENND4A ENSG00000260773 PDCD7 PARP16 LOC646358 RAB11A HACD3 IGDCC4
GH15I065827 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +102.4 102413 2.9 DRAP1 CTCF PKNOX1 ETV1 MZF1 RAD21 RFX5 GATA3 FOXK2 ZBTB48 DENND4A RAB11A IGDCC4 DPP8 DIS3L HNRNPA1P44 ENSG00000283249 LOC105370866
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB11A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB11A gene promoter:

Genomic Locations for RAB11A Gene

Genomic Locations for RAB11A Gene
chr15:65,726,054-65,891,991
(GRCh38/hg38)
Size:
165,938 bases
Orientation:
Plus strand
chr15:66,018,392-66,184,329
(GRCh37/hg19)

Genomic View for RAB11A Gene

Genes around RAB11A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB11A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11A Gene

Proteins for RAB11A Gene

  • Protein details for RAB11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62491-RB11A_HUMAN
    Recommended name:
    Ras-related protein Rab-11A
    Protein Accession:
    P62491
    Secondary Accessions:
    • B2R4B6
    • B4DT13
    • P24410
    • Q5TZN9
    • Q9JLX1

    Protein attributes for RAB11A Gene

    Size:
    216 amino acids
    Molecular mass:
    24394 Da
    Quaternary structure:
    • Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27 (PubMed:21976701, PubMed:17082457). Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5 (PubMed:26506309). Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner (PubMed:21976701).

    Three dimensional structures from OCA and Proteopedia for RAB11A Gene

    Alternative splice isoforms for RAB11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11A Gene

Post-translational modifications for RAB11A Gene

  • Ubiquitination at Lys179 and Lys207

Other Protein References for RAB11A Gene

No data available for DME Specific Peptides for RAB11A Gene

Domains & Families for RAB11A Gene

Gene Families for RAB11A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAB11A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62491

UniProtKB/Swiss-Prot:

RB11A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB11A: view

Function for RAB11A Gene

Molecular function for RAB11A Gene

GENATLAS Biochemistry:
RAS related GTP-binding protein,branch rab,member 11,widely expressed with two transcripts small and large,putatively involved in secretory pathway
UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Phenotypes From GWAS Catalog for RAB11A Gene

Gene Ontology (GO) - Molecular Function for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA,IEA 15837192
GO:0005515 protein binding IPI 12470645
GO:0005525 GTP binding IEA --
GO:0008017 microtubule binding IDA 24561039
GO:0019905 syntaxin binding NAS 12145319
genes like me logo Genes that share ontologies with RAB11A: view
genes like me logo Genes that share phenotypes with RAB11A: view

Animal Models for RAB11A Gene

MGI Knock Outs for RAB11A:

miRNA for RAB11A Gene

miRTarBase miRNAs that target RAB11A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB11A Gene

Localization for RAB11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11A Gene

Cell membrane; Lipid-anchor. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:11994279, ECO:0000269 PubMed:15601896, ECO:0000269 PubMed:20890297, ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB11A gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
golgi apparatus 5
endosome 5
plasma membrane 4
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 24561039
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IEA --
GO:0005771 multivesicular body IDA 15634213
genes like me logo Genes that share ontologies with RAB11A: view

Pathways & Interactions for RAB11A Gene

genes like me logo Genes that share pathways with RAB11A: view

Gene Ontology (GO) - Biological Process for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 15601896
GO:0003091 renal water homeostasis TAS --
GO:0006810 transport IEA --
GO:0007049 cell cycle IEA --
GO:0007080 mitotic metaphase plate congression IMP 24561039
genes like me logo Genes that share ontologies with RAB11A: view

No data available for SIGNOR curated interactions for RAB11A Gene

Drugs & Compounds for RAB11A Gene

(3) Drugs for RAB11A Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5'-Guanosine-Diphosphate-Monothiophosphate Experimental Pharma Target 0
Guanosine diphosphate Experimental Pharma Target 0

(2) Additional Compounds for RAB11A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB11A: view

Transcripts for RAB11A Gene

mRNA/cDNA for RAB11A Gene

(2) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB11A Gene

RAB11A, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -

Relevant External Links for RAB11A Gene

GeneLoc Exon Structure for
RAB11A
ECgene alternative splicing isoforms for
RAB11A

Expression for RAB11A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB11A Gene

Protein differential expression in normal tissues from HIPED for RAB11A Gene

This gene is overexpressed in Adipocyte (22.6), Monocytes (10.2), Bone (7.4), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB11A Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB11A Gene:

RAB11A

SOURCE GeneReport for Unigene cluster for RAB11A Gene:

Hs.321541

Evidence on tissue expression from TISSUES for RAB11A Gene

  • Nervous system(5)
  • Blood(4.5)
  • Skin(3.8)
  • Kidney(3.5)
  • Pancreas(3.3)
  • Intestine(3.2)
  • Eye(2.8)
  • Lung(2.8)
  • Stomach(2.7)
  • Adrenal gland(2.6)
  • Heart(2.5)
  • Muscle(2.5)
  • Liver(2.3)
  • Gall bladder(2.1)
  • Spleen(2.1)
  • Lymph node(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with RAB11A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB11A Gene

Orthologs for RAB11A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB11A Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia RAB11A 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB11A 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia RAB11A 33 34
  • 96.3 (n)
cow
(Bos Taurus)
Mammalia RAB11A 33 34
  • 95.83 (n)
mouse
(Mus musculus)
Mammalia Rab11a 33 16 34
  • 95.83 (n)
rat
(Rattus norvegicus)
Mammalia Rab11a 33
  • 94.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11A 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB11A 33 34
  • 86.42 (n)
lizard
(Anolis carolinensis)
Reptilia RAB11A 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11a 33
  • 80.25 (n)
Str.6874 33
zebrafish
(Danio rerio)
Actinopterygii rab11a 33 34
  • 78.29 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004559 33
  • 69.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab11 35 33 34
  • 66.98 (n)
worm
(Caenorhabditis elegans)
Secernentea rab-11.2 34
  • 70 (a)
ManyToMany
rab-11.1 35 33 34
  • 66.83 (n)
F11A5.3 35
  • 51 (a)
C33D12.6 35
  • 37 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00671g 33
  • 60.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 33 34 36
  • 60.09 (n)
YPT32 34
  • 59 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER434C 33
  • 55.83 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RABA1f 33
  • 60.66 (n)
soybean
(Glycine max)
eudicotyledons Gma.15815 33
rice
(Oryza sativa)
Liliopsida Os05g0564400 33
  • 60.51 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ypt3 33
  • 65.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01523 33
  • 64.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3887 33
Species where no ortholog for RAB11A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB11A Gene

ENSEMBL:
Gene Tree for RAB11A (if available)
TreeFam:
Gene Tree for RAB11A (if available)

Paralogs for RAB11A Gene

Pseudogenes.org Pseudogenes for RAB11A Gene

genes like me logo Genes that share paralogs with RAB11A: view

Variants for RAB11A Gene

Sequence variations from dbSNP and Humsavar for RAB11A Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000100561 -- 65,870,114(+) C/A/G intron_variant
rs1000132479 -- 65,889,407(+) T/C 3_prime_UTR_variant
rs1000171212 -- 65,892,461(+) C/T downstream_transcript_variant
rs1000173967 -- 65,889,884(+) G/A 3_prime_UTR_variant
rs1000394359 -- 65,885,054(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB11A Gene

Variant ID Type Subtype PubMed ID
esv2760035 CNV loss 17122850
nsv471684 CNV gain 15918152
nsv833044 CNV loss 17160897

Variation tolerance for RAB11A Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB11A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB11A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB11A Gene

Disorders for RAB11A Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAB11A Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
autosomal dominant non-syndromic intellectual disability
  • autosomal dominant mental retardation
barrett esophagus
  • barrett metaplasia
functional diarrhea
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAB11A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAB11A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB11A Gene

Publications for RAB11A Gene

  1. Requirement of myosin Vb.Rab11a.Rab11-FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. (PMID: 19542231) Chu BB … Song BL (The Journal of biological chemistry 2009) 3 4 22 58
  2. Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. (PMID: 17462998) Swiatecka-Urban A … Stanton BA (The Journal of biological chemistry 2007) 3 4 22 58
  3. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PMID: 17030804) Shiba T … Wakatsuki S (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 58
  4. Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein. (PMID: 15837192) Pasqualato S … Cherfils J (Structure (London, England : 1993) 2005) 3 4 22 58
  5. Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. (PMID: 15173169) Junutula JR … Prekeris R (The Journal of biological chemistry 2004) 3 4 22 58

Products for RAB11A Gene

Sources for RAB11A Gene

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