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Aliases for RAB11A Gene

Aliases for RAB11A Gene

  • RAB11A, Member RAS Oncogene Family 2 3
  • Rab-11 3 4
  • YL8 3 4
  • RAB 11A, Member Oncogene Family 3
  • Ras-Related Protein Rab-11A 3
  • RAB11 4

External Ids for RAB11A Gene

Summaries for RAB11A Gene

Entrez Gene Summary for RAB11A Gene

  • The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for RAB11A Gene

RAB11A (RAB11A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB11A include esophagus squamous cell carcinoma. Among its related pathways are Endocytosis and Thromboxane A2 receptor signaling. GO annotations related to this gene include GTP binding and syntaxin binding. An important paralog of this gene is RAB42.

UniProtKB/Swiss-Prot for RAB11A Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Gene Wiki entry for RAB11A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB11A Gene

Genomics for RAB11A Gene

Genomic Location for RAB11A Gene

Start:
65,726,054 bp from pter
End:
65,891,991 bp from pter
Size:
165,938 bases
Orientation:
Plus strand

Genomic View for RAB11A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAB11A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB11A Gene

Regulatory Elements for RAB11A Gene

Proteins for RAB11A Gene

  • Protein details for RAB11A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62491-RB11A_HUMAN
    Recommended name:
    Ras-related protein Rab-11A
    Protein Accession:
    P62491
    Secondary Accessions:
    • B2R4B6
    • B4DT13
    • P24410
    • Q5TZN9
    • Q9JLX1

    Protein attributes for RAB11A Gene

    Size:
    216 amino acids
    Molecular mass:
    24394 Da
    Quaternary structure:
    • Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3 (By similarity). Interacts with EXOC6 in a GTP-dependent manner (By similarity). Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner.

    Three dimensional structures from OCA and Proteopedia for RAB11A Gene

    Alternative splice isoforms for RAB11A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB11A Gene

Proteomics data for RAB11A Gene at MOPED

Post-translational modifications for RAB11A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys24, Lys61, Lys179, and Lys207

Other Protein References for RAB11A Gene

No data available for DME Specific Peptides for RAB11A Gene

Domains for RAB11A Gene

Gene Families for RAB11A Gene

HGNC:
  • RAB :RAB, member RAS oncogene

UniProtKB/Swiss-Prot:

RB11A_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rab family.:
    • P62491
genes like me logo Genes that share domains with RAB11A: view

Function for RAB11A Gene

Molecular function for RAB11A Gene

GENATLAS Biochemistry: RAS related GTP-binding protein,branch rab,member 11,widely expressed with two transcripts small and large,putatively involved in secretory pathway
UniProtKB/Swiss-Prot Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Gene Ontology (GO) - Molecular Function for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 15837192
GO:0005515 protein binding IPI 12470645
GO:0005525 GTP binding IEA --
GO:0008017 microtubule binding IDA 24561039
GO:0019905 syntaxin binding NAS 12145319
genes like me logo Genes that share ontologies with RAB11A: view

Phenotypes for RAB11A Gene

GenomeRNAi human phenotypes for RAB11A:
genes like me logo Genes that share phenotypes with RAB11A: view

miRNA for RAB11A Gene

miRTarBase miRNAs that target RAB11A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAB11A Gene

Localization for RAB11A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB11A Gene

Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAB11A Gene COMPARTMENTS Subcellular localization image for RAB11A gene
Compartment Confidence
endosome 5
plasma membrane 5
cytoskeleton 3
cytosol 3
golgi apparatus 2
mitochondrion 2
vacuole 1

Gene Ontology (GO) - Cellular Components for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 24561039
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005771 multivesicular body IDA 15634213
genes like me logo Genes that share ontologies with RAB11A: view

Pathways for RAB11A Gene

genes like me logo Genes that share pathways with RAB11A: view

Gene Ontology (GO) - Biological Process for RAB11A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IMP 15601896
GO:0003091 renal water homeostasis TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0006833 water transport TAS --
GO:0006886 intracellular protein transport IBA --
genes like me logo Genes that share ontologies with RAB11A: view

Compounds for RAB11A Gene

(2) Drugbank Compounds for RAB11A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
5'-Guanosine-Diphosphate-Monothiophosphate
target
Guanosine-5'-Diphosphate
146-91-8 target

(3) Novoseek inferred chemical compound relationships for RAB11A Gene

Compound -log(P) Hits PubMed IDs
gtp 52.3 13
gdp 40.2 4
glucose 0 1
genes like me logo Genes that share compounds with RAB11A: view

Transcripts for RAB11A Gene

mRNA/cDNA for RAB11A Gene

(2) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB11A Gene

RAB11A, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAB11A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -

Relevant External Links for RAB11A Gene

GeneLoc Exon Structure for
RAB11A
ECgene alternative splicing isoforms for
RAB11A

Expression for RAB11A Gene

mRNA expression in normal human tissues for RAB11A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAB11A Gene

SOURCE GeneReport for Unigene cluster for RAB11A Gene Hs.321541

genes like me logo Genes that share expressions with RAB11A: view

Orthologs for RAB11A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB11A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB11A 36
  • 99.69 (n)
  • 100 (a)
RAB11A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAB11A 36
  • 95.83 (n)
  • 99.54 (a)
RAB11A 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB11A 36
  • 96.3 (n)
  • 100 (a)
RAB11A 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rab11a 36
  • 95.83 (n)
  • 100 (a)
Rab11a 16
Rab11a 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB11A 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB11A 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab11a 36
  • 94.91 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RAB11A 36
  • 86.42 (n)
  • 99.07 (a)
RAB11A 37
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB11A 37
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab11a 36
  • 80.25 (n)
  • 98.15 (a)
Str.6874 36
zebrafish
(Danio rerio)
Actinopterygii rab11a 36
  • 78.29 (n)
  • 95.81 (a)
rab11a 37
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004559 36
  • 69.18 (n)
  • 86.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab11 36
  • 66.98 (n)
  • 85.51 (a)
Rab11 37
  • 86 (a)
OneToMany
Rab11 38
  • 85 (a)
worm
(Caenorhabditis elegans)
Secernentea rab-11.1 36
  • 66.83 (n)
  • 82.3 (a)
rab-11.1 37
  • 81 (a)
ManyToMany
rab-11.2 37
  • 70 (a)
ManyToMany
rab-11.1 38
  • 80 (a)
C33D12.6 38
  • 37 (a)
F11A5.3 38
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER434C 36
  • 55.83 (n)
  • 64.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 36
  • 60.09 (n)
  • 63.38 (a)
YPT31 37
  • 59 (a)
ManyToMany
YPT31 39
YPT32 37
  • 59 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B00671g 36
  • 60.78 (n)
  • 64.22 (a)
soybean
(Glycine max)
eudicotyledons Gma.15815 36
thale cress
(Arabidopsis thaliana)
eudicotyledons RABA1f 36
  • 60.66 (n)
  • 69.67 (a)
rice
(Oryza sativa)
Liliopsida Os05g0564400 36
  • 60.51 (n)
  • 67.3 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01523 36
  • 64.27 (n)
  • 76.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ypt3 36
  • 65.71 (n)
  • 71.15 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3887 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
ManyToMany
Species with no ortholog for RAB11A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB11A Gene

ENSEMBL:
Gene Tree for RAB11A (if available)
TreeFam:
Gene Tree for RAB11A (if available)

Paralogs for RAB11A Gene

Pseudogenes.org Pseudogenes for RAB11A Gene

genes like me logo Genes that share paralogs with RAB11A: view

Variants for RAB11A Gene

Sequence variations from dbSNP and Humsavar for RAB11A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4920 -- 65,887,810(+) AACAA(G/T)CCAAA utr-variant-3-prime, reference, missense
rs1130813 -- 65,888,006(+) CACTT(C/G)TCCCG utr-variant-3-prime
rs1130814 -- 65,888,722(+) CTTAG(A/G)ACCTT utr-variant-3-prime
rs1130815 -- 65,888,779(+) GGCAT(C/G)GATAA utr-variant-3-prime
rs1130816 -- 65,888,780(+) GCATG(C/G)ATAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAB11A Gene

Variant ID Type Subtype PubMed ID
nsv833044 CNV Loss 17160897
nsv904323 CNV Loss 21882294
dgv751e1 CNV Complex 17122850
nsv471684 CNV Gain 15918152

Relevant External Links for RAB11A Gene

HapMap Linkage Disequilibrium report
RAB11A

Disorders for RAB11A Gene

(1) University of Copenhagen DISEASES for RAB11A Gene

(3) Novoseek inferred disease relationships for RAB11A Gene

Disease -log(P) Hits PubMed IDs
barrett esophagus 24 1
dysplasia 0 6
adenocarcinoma 0 1

Relevant External Links for RAB11A

Genetic Association Database (GAD)
RAB11A
Human Genome Epidemiology (HuGE) Navigator
RAB11A
genes like me logo Genes that share disorders with RAB11A: view

No data available for UniProtKB/Swiss-Prot for RAB11A Gene

Publications for RAB11A Gene

  1. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. (PMID: 11786538) Lindsay A.J. … McCaffrey M.W. (J. Biol. Chem. 2002) 3 4 23
  2. Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins. (PMID: 15173169) Junutula J.R. … Prekeris R. (J. Biol. Chem. 2004) 3 4 23
  3. The RCP-Rab11 complex regulates endocytic protein sorting. (PMID: 15181150) Peden A.A. … Prekeris R. (Mol. Biol. Cell 2004) 3 4 23
  4. Crystallographic evidence for substrate-assisted GTP hydrolysis by a small GTP binding protein. (PMID: 15837192) Pasqualato S. … Cherfils J. (Structure 2005) 3 4 23
  5. Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1. (PMID: 17030804) Shiba T. … Wakatsuki S. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23

Products for RAB11A Gene

Sources for RAB11A Gene

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