Aliases for TNFRSF14 Gene
- TNF Receptor Superfamily Member 14 2 3 5
- Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator) 2 3
- Herpes Virus Entry Mediator A 3 4
- HVEA 3 4
- HVEM 3 4
- TR2 3 4
- Tumor Necrosis Factor Receptor Superfamily, Member 14 2
- Tumor Necrosis Factor Receptor Superfamily Member 14 3
- Tumor Necrosis Factor Receptor-Like Gene2 3
External Ids for TNFRSF14 Gene
Previous GeneCards Identifiers for TNFRSF14 Gene
This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for TNFRSF14 Gene
TNFRSF14 (TNF Receptor Superfamily Member 14) is a Protein Coding gene. Diseases associated with TNFRSF14 include Herpes Simplex and Cleft Lip/Palate-Ectodermal Dysplasia Syndrome. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Akt Signaling. GO annotations related to this gene include ubiquitin protein ligase binding and tumor necrosis factor-activated receptor activity. An important paralog of this gene is TNFRSF6B.
UniProtKB/Swiss-Prot for TNFRSF14 Gene
Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1 and herpes simplex virus 1/HHV-2.