Aliases for CD164 Gene
External Ids for CD164 Gene
Previous GeneCards Identifiers for CD164 Gene
This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]
GeneCards Summary for CD164 Gene
CD164 (CD164 Molecule) is a Protein Coding gene. Diseases associated with CD164 include Autosomal Dominant Nonsyndromic Deafness 66 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Lysosome. An important paralog of this gene is CD164L2.
UniProtKB/Swiss-Prot for CD164 Gene
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).