Aliases for PABPC4 Gene
External Ids for PABPC4 Gene
Previous GeneCards Identifiers for PABPC4 Gene
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for PABPC4 Gene
PABPC4 (Poly(A) Binding Protein Cytoplasmic 4) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PABPC1.
UniProtKB/Swiss-Prot for PABPC4 Gene
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).