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Aliases for PABPC4 Gene

Aliases for PABPC4 Gene

  • Poly(A) Binding Protein Cytoplasmic 4 2 3
  • Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) 2 3 5
  • Inducible Poly(A)-Binding Protein 2 3 4
  • Activated-Platelet Protein 1 2 3 4
  • Poly(A)-Binding Protein 4 3 4
  • PABP-4 3 4
  • PABP4 3 4
  • APP-1 3 4
  • IPABP 3 4
  • APP1 3 4
  • Poly(A)-Binding Protein, Cytoplasmic 4 (Inducible Form) 2

External Ids for PABPC4 Gene

Previous GeneCards Identifiers for PABPC4 Gene

  • GC01M039944
  • GC01M039030
  • GC01M039490
  • GC01M039439
  • GC01M039422
  • GC01M039695
  • GC01M039799
  • GC01M040026
  • GC01M038145

Summaries for PABPC4 Gene

Entrez Gene Summary for PABPC4 Gene

  • Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for PABPC4 Gene

PABPC4 (Poly(A) Binding Protein Cytoplasmic 4) is a Protein Coding gene. Among its related pathways are RNA transport and mRNA surveillance pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PABPC1L2A.

UniProtKB/Swiss-Prot for PABPC4 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Gene Wiki entry for PABPC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC4 Gene

Genomics for PABPC4 Gene

Regulatory Elements for PABPC4 Gene

Promoters for PABPC4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PABPC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PABPC4 Gene

Chromosome:
1
Start:
39,560,813 bp from pter
End:
39,576,849 bp from pter
Size:
16,037 bases
Orientation:
Minus strand

Genomic View for PABPC4 Gene

Genes around PABPC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC4 Gene

Proteins for PABPC4 Gene

  • Protein details for PABPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13310-PABP4_HUMAN
    Recommended name:
    Polyadenylate-binding protein 4
    Protein Accession:
    Q13310
    Secondary Accessions:
    • B1ANQ8
    • Q4VC03
    • Q6P0N3

    Protein attributes for PABPC4 Gene

    Size:
    644 amino acids
    Molecular mass:
    70783 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1.

    Alternative splice isoforms for PABPC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC4 Gene

Proteomics data for PABPC4 Gene at MOPED

Post-translational modifications for PABPC4 Gene

  • Arg-518 is dimethylated, probably to asymmetric dimethylarginine.
  • Ubiquitination at Lys 196, Lys 216, Lys 299, Lys 312, Lys 361, and Lys 375
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for PABPC4 Gene

Domains & Families for PABPC4 Gene

Gene Families for PABPC4 Gene

Graphical View of Domain Structure for InterPro Entry

Q13310

UniProtKB/Swiss-Prot:

PABP4_HUMAN :
  • Contains 1 PABC domain.
  • Belongs to the polyadenylate-binding protein type-1 family.
Domain:
  • Contains 1 PABC domain.
  • Contains 4 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC4: view

Function for PABPC4 Gene

Molecular function for PABPC4 Gene

GENATLAS Biochemistry:
poly (A) binding nuclear protein,cytoplasmic 4,inducible,detected in activated human T cells and activated platelets,PABPC1 homolog
UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Gene Ontology (GO) - Molecular Function for PABPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11369516
GO:0008143 poly(A) binding IDA 8524242
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PABPC4: view
genes like me logo Genes that share phenotypes with PABPC4: view

Animal Models for PABPC4 Gene

MGI Knock Outs for PABPC4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PABPC4 Gene

Localization for PABPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC4 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC4 Gene COMPARTMENTS Subcellular localization image for PABPC4 gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for PABPC4 Gene

Pathways & Interactions for PABPC4 Gene

genes like me logo Genes that share pathways with PABPC4: view

Pathways by source for PABPC4 Gene

3 KEGG pathways for PABPC4 Gene

Gene Ontology (GO) - Biological Process for PABPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 8524242
genes like me logo Genes that share ontologies with PABPC4: view

No data available for SIGNOR curated interactions for PABPC4 Gene

Drugs & Compounds for PABPC4 Gene

No Compound Related Data Available

Transcripts for PABPC4 Gene

Unigene Clusters for PABPC4 Gene

Poly(A) binding protein, cytoplasmic 4 (inducible form):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6: - -
SP7: - -
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

ExUns: 12d · 12e ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11: -
SP12:
SP13: - - -
SP14:
SP15:

Relevant External Links for PABPC4 Gene

GeneLoc Exon Structure for
PABPC4
ECgene alternative splicing isoforms for
PABPC4

Expression for PABPC4 Gene

mRNA expression in normal human tissues for PABPC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PABPC4 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1) and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for PABPC4 Gene

This gene is overexpressed in Pancreas (9.1) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PABPC4 Gene



SOURCE GeneReport for Unigene cluster for PABPC4 Gene Hs.169900

mRNA Expression by UniProt/SwissProt for PABPC4 Gene

Q13310-PABP4_HUMAN
Tissue specificity: Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.
genes like me logo Genes that share expression patterns with PABPC4: view

Protein tissue co-expression partners for PABPC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PABPC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PABPC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PABPC4 35
  • 93.63 (n)
  • 98.29 (a)
PABPC4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PABPC4 35
  • 94.42 (n)
  • 99.08 (a)
PABPC4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pabpc4 35
  • 90.51 (n)
  • 97.88 (a)
Pabpc4 16
Gm10110 36
  • 98 (a)
OneToMany
Pabpc4 36
  • 98 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia PABPC4 35
  • 99.8 (n)
  • 100 (a)
PABPC4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pabpc4 35
  • 90.84 (n)
  • 97.98 (a)
oppossum
(Monodelphis domestica)
Mammalia PABPC4 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PABPC4 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PABPC4 35
  • 82.7 (n)
  • 91.75 (a)
PABPC4 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PABPC4 36
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 35
pabpc4 35
  • 75.64 (n)
  • 86.31 (a)
pabpc4 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4612 37
  • 50 (a)
pAbp 37
  • 59 (a)
pAbp 35
  • 61.31 (n)
  • 62.38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011092 35
  • 62.97 (n)
  • 67.7 (a)
worm
(Caenorhabditis elegans)
Secernentea pab-1 37
  • 53 (a)
pab-2 37
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PES4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PAB5 35
  • 52.48 (n)
  • 48.99 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.291 35
wheat
(Triticum aestivum)
Liliopsida Ta.130 35
Species with no ortholog for PABPC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for PABPC4 Gene

ENSEMBL:
Gene Tree for PABPC4 (if available)
TreeFam:
Gene Tree for PABPC4 (if available)

Paralogs for PABPC4 Gene

Pseudogenes.org Pseudogenes for PABPC4 Gene

genes like me logo Genes that share paralogs with PABPC4: view

Variants for PABPC4 Gene

Sequence variations from dbSNP and Humsavar for PABPC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_054048 -
rs1358330 -- 39,574,504(+) CAAAA(A/G)TCAGT intron-variant
rs1804943 -- 39,561,712(-) TTGCT(A/G)CTGCT reference, missense
rs4660293 -- 39,562,508(+) TGACT(A/G)TGTGA intron-variant
rs6680838 -- 39,574,963(+) CATTC(C/G)TTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC4 Gene

Variant ID Type Subtype PubMed ID
nsv870829 CNV Gain 21882294
nsv7177 OTHER Inversion 18451855
nsv508160 CNV Loss 20534489
nsv829649 CNV Loss 17160897

Variation tolerance for PABPC4 Gene

Residual Variation Intolerance Score: 2.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PABPC4 Gene

HapMap Linkage Disequilibrium report
PABPC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC4 Gene

Disorders for PABPC4 Gene

Relevant External Links for PABPC4

Genetic Association Database (GAD)
PABPC4
Human Genome Epidemiology (HuGE) Navigator
PABPC4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PABPC4

No disorders were found for PABPC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC4 Gene

Publications for PABPC4 Gene

  1. Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets. (PMID: 9030741) Houng A.K. … Reed G.L. (Eur. J. Biochem. 1997) 3 4 23 67
  2. Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PMID: 10543404) FAcral C. … GuellaAn G. (Hum. Genet. 1999) 2 3 23
  3. iPABP, an inducible poly(A)-binding protein detected in activated human T cells. (PMID: 8524242) Yang H. … Lindsten T. (Mol. Cell. Biol. 1995) 3 23
  4. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  5. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3

Products for PABPC4 Gene

Sources for PABPC4 Gene

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