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Aliases for PABPC4 Gene

Aliases for PABPC4 Gene

  • Poly(A) Binding Protein Cytoplasmic 4 2 3 5
  • Inducible Poly(A)-Binding Protein 2 3 4
  • Activated-Platelet Protein 1 2 3 4
  • Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) 2 3
  • Poly(A)-Binding Protein 4 3 4
  • PABP-4 3 4
  • PABP4 3 4
  • APP-1 3 4
  • IPABP 3 4
  • APP1 3 4
  • Poly(A)-Binding Protein, Cytoplasmic 4 (Inducible Form) 2
  • Polyadenylate-Binding Protein 4 3

External Ids for PABPC4 Gene

Previous GeneCards Identifiers for PABPC4 Gene

  • GC01M039944
  • GC01M039030
  • GC01M039490
  • GC01M039439
  • GC01M039422
  • GC01M039695
  • GC01M039799
  • GC01M040026
  • GC01M038145

Summaries for PABPC4 Gene

Entrez Gene Summary for PABPC4 Gene

  • Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for PABPC4 Gene

PABPC4 (Poly(A) Binding Protein Cytoplasmic 4) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for PABPC4 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Gene Wiki entry for PABPC4 Gene

Additional gene information for PABPC4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC4 Gene

Genomics for PABPC4 Gene

GeneHancer (GH) Regulatory Elements for PABPC4 Gene

Promoters and enhancers for PABPC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I039573 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 564.5 +1.4 1436 4.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A YY1 POLR2B ZNF766 ZNF213 PABPC4 OXCT2P1 PPIE OXCT2 RRAGC GC01M039569 GC01M039576 SNORA55 GC01M039568
GH01I040372 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.3 -799.0 -799004 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 SMAP2 PPIEL EXO5 PPIE TRIT1 ENSG00000259943 ENSG00000182109 NFYC-AS1 RLF NFYC
GH01I040256 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 12.3 -681.0 -680964 3.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ENSG00000259943 ZMPSTE24 PPIE PPIEL EXO5 TRIT1 RLF NFYC-AS1 NFYC LOC105378672
GH01I040096 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.3 -520.3 -520290 1.5 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 PPT1 PPIE EXO5 TRIT1 NFYC PPIEL PABPC4 RLF LOC101929516 CAP1
GH01I040530 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.3 -955.3 -955276 2.9 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF684 EXO5 LOC105378672 PPIE ZFP69 NFYC PABPC4 RLF LOC101929516 TRIT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PABPC4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PABPC4 gene promoter:

Genomic Locations for PABPC4 Gene

Genomic Locations for PABPC4 Gene
chr1:39,560,813-39,576,849
(GRCh38/hg38)
Size:
16,037 bases
Orientation:
Minus strand
chr1:40,026,485-40,042,521
(GRCh37/hg19)

Genomic View for PABPC4 Gene

Genes around PABPC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC4 Gene

Proteins for PABPC4 Gene

  • Protein details for PABPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13310-PABP4_HUMAN
    Recommended name:
    Polyadenylate-binding protein 4
    Protein Accession:
    Q13310
    Secondary Accessions:
    • B1ANQ8
    • Q4VC03
    • Q6P0N3

    Protein attributes for PABPC4 Gene

    Size:
    644 amino acids
    Molecular mass:
    70783 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1. Interacts with ZFC3H1 in a RNase-sensitive manner (PubMed:27871484).

    Alternative splice isoforms for PABPC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC4 Gene

Post-translational modifications for PABPC4 Gene

  • Arg-518 is dimethylated, probably to asymmetric dimethylarginine.
  • Ubiquitination at isoforms=2, 3196, isoforms=2, 3216, isoforms=2, 3299, Lys312, isoforms=2, 3361, and isoforms=2, 3375

No data available for DME Specific Peptides for PABPC4 Gene

Domains & Families for PABPC4 Gene

Gene Families for PABPC4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q13310

UniProtKB/Swiss-Prot:

PABP4_HUMAN :
  • Belongs to the polyadenylate-binding protein type-1 family.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC4: view

Function for PABPC4 Gene

Molecular function for PABPC4 Gene

GENATLAS Biochemistry:
poly (A) binding nuclear protein,cytoplasmic 4,inducible,detected in activated human T cells and activated platelets,PABPC1 homolog
UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Phenotypes From GWAS Catalog for PABPC4 Gene

Gene Ontology (GO) - Molecular Function for PABPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,HDA 22658674
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 11369516
GO:0008143 poly(A) binding IDA,TAS 8524242
GO:0008266 poly(U) RNA binding IDA 8524242
genes like me logo Genes that share ontologies with PABPC4: view
genes like me logo Genes that share phenotypes with PABPC4: view

Animal Models for PABPC4 Gene

MGI Knock Outs for PABPC4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PABPC4 Gene

Localization for PABPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC4 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PABPC4 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PABPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21940797
GO:0005737 cytoplasm IEA,IDA 8524242
GO:0005829 cytosol IDA --
GO:0010494 cytoplasmic stress granule IDA 21940797
GO:0030529 intracellular ribonucleoprotein complex IDA 17289661
genes like me logo Genes that share ontologies with PABPC4: view

Pathways & Interactions for PABPC4 Gene

genes like me logo Genes that share pathways with PABPC4: view

Pathways by source for PABPC4 Gene

3 KEGG pathways for PABPC4 Gene

Gene Ontology (GO) - Biological Process for PABPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 8524242
GO:0006401 RNA catabolic process TAS 8524242
GO:0006412 translation TAS 8524242
GO:0007596 blood coagulation TAS 9030741
GO:0043488 regulation of mRNA stability IEA --
genes like me logo Genes that share ontologies with PABPC4: view

No data available for SIGNOR curated interactions for PABPC4 Gene

Drugs & Compounds for PABPC4 Gene

No Compound Related Data Available

Transcripts for PABPC4 Gene

Unigene Clusters for PABPC4 Gene

Poly(A) binding protein, cytoplasmic 4 (inducible form):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6: - -
SP7: - -
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

ExUns: 12d · 12e ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11: -
SP12:
SP13: - - -
SP14:
SP15:

Relevant External Links for PABPC4 Gene

GeneLoc Exon Structure for
PABPC4
ECgene alternative splicing isoforms for
PABPC4

Expression for PABPC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PABPC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PABPC4 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1) and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for PABPC4 Gene

This gene is overexpressed in Pancreas (9.1) and Lymph node (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PABPC4 Gene



Protein tissue co-expression partners for PABPC4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PABPC4 Gene:

PABPC4

SOURCE GeneReport for Unigene cluster for PABPC4 Gene:

Hs.169900

mRNA Expression by UniProt/SwissProt for PABPC4 Gene:

Q13310-PABP4_HUMAN
Tissue specificity: Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated.

Evidence on tissue expression from TISSUES for PABPC4 Gene

  • Skin(4.7)
  • Liver(4.4)
  • Nervous system(3.8)
  • Intestine(3.3)
  • Muscle(2.4)
  • Pancreas(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with PABPC4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PABPC4 Gene

Orthologs for PABPC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PABPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC4 33 34
  • 99.8 (n)
mouse
(Mus musculus)
Mammalia Gm10110 34
  • 98 (a)
OneToMany
Pabpc4 33 16 34
  • 90.51 (n)
dog
(Canis familiaris)
Mammalia PABPC4 33 34
  • 94.42 (n)
cow
(Bos Taurus)
Mammalia PABPC4 33 34
  • 93.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PABPC4 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pabpc4 33
  • 90.84 (n)
oppossum
(Monodelphis domestica)
Mammalia PABPC4 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PABPC4 33 34
  • 82.7 (n)
lizard
(Anolis carolinensis)
Reptilia PABPC4 34
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pabpc4 33 34
  • 75.64 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011092 33
  • 62.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta pAbp 35 33
  • 61.31 (n)
CG4612 35
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea pab-2 35
  • 60 (a)
pab-1 35
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PES4 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PAB5 33
  • 52.48 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.291 33
wheat
(Triticum aestivum)
Liliopsida Ta.130 33
Species where no ortholog for PABPC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for PABPC4 Gene

ENSEMBL:
Gene Tree for PABPC4 (if available)
TreeFam:
Gene Tree for PABPC4 (if available)

Paralogs for PABPC4 Gene

Variants for PABPC4 Gene

Sequence variations from dbSNP and Humsavar for PABPC4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000057139 -- 39,570,119(-) CCACCACCA/CCACCA intron_variant
rs1000078619 -- 39,564,646(-) G/A intron_variant
rs1000385134 -- 39,565,276(-) C/A coding_sequence_variant, missense_variant
rs1000548596 -- 39,574,707(-) G/A intron_variant
rs1000693709 -- 39,564,037(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC4 Gene

Variant ID Type Subtype PubMed ID
nsv1116447 OTHER inversion 24896259
nsv508160 CNV deletion 20534489
nsv7177 OTHER inversion 18451855
nsv829649 CNV loss 17160897

Variation tolerance for PABPC4 Gene

Residual Variation Intolerance Score: 2.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PABPC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PABPC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC4 Gene

Disorders for PABPC4 Gene

Additional Disease Information for PABPC4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PABPC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC4 Gene

Publications for PABPC4 Gene

  1. Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PMID: 10543404) Féral C … Guellaën G (Human genetics 1999) 2 3 22 58
  2. Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets. (PMID: 9030741) Houng AK … Reed GL (European journal of biochemistry 1997) 3 4 22 58
  3. iPABP, an inducible poly(A)-binding protein detected in activated human T cells. (PMID: 8524242) Yang H … Lindsten T (Molecular and cellular biology 1995) 3 4 22 58
  4. Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts. (PMID: 27871484) Meola N … Jensen TH (Molecular cell 2016) 3 4 58
  5. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 44 58

Products for PABPC4 Gene

Sources for PABPC4 Gene

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