Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDS2 Gene

Aliases for CDS2 Gene

  • CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 2 2 3
  • EC 2.7.7.41 4 64
  • CTP:Phosphatidate Cytidylyltransferase 2 4
  • CDP-Diglyceride Pyrophosphorylase 2 4
  • CDP-Diacylglycerol Synthase 2 4
  • CDP-Diglyceride Synthase 2 4
  • CDP-DAG Synthase 2 4
  • CDP-DG Synthase 2 4
  • EC 2.7.7 64
  • CDS 2 4

External Ids for CDS2 Gene

Summaries for CDS2 Gene

Entrez Gene Summary for CDS2 Gene

  • Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDS2 Gene

CDS2 (CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include phosphatidate cytidylyltransferase activity. An important paralog of this gene is CDS1.

UniProtKB/Swiss-Prot for CDS2 Gene

  • Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin

Gene Wiki entry for CDS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDS2 Gene

Genomics for CDS2 Gene

Genomic Location for CDS2 Gene

Start:
5,126,761 bp from pter
End:
5,197,887 bp from pter
Size:
71,127 bases
Orientation:
Plus strand

Genomic View for CDS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDS2 Gene

Proteins for CDS2 Gene

  • Protein details for CDS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95674-CDS2_HUMAN
    Recommended name:
    Phosphatidate cytidylyltransferase 2
    Protein Accession:
    O95674
    Secondary Accessions:
    • B2RDC6
    • D3DW04
    • Q5TDY2
    • Q5TDY3
    • Q5TDY4
    • Q5TDY5
    • Q9BYK5
    • Q9NTT2

    Protein attributes for CDS2 Gene

    Size:
    445 amino acids
    Molecular mass:
    51418 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDS2 Gene

Proteomics data for CDS2 Gene at MOPED

Post-translational modifications for CDS2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys367

Other Protein References for CDS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for CDS2 Gene

Protein Domains for CDS2 Gene

UniProtKB/Swiss-Prot:

CDS2_HUMAN
Family:
  • Belongs to the CDS family.:
    • O95674
genes like me logo Genes that share domains with CDS2: view

No data available for Gene Families for CDS2 Gene

Function for CDS2 Gene

Molecular function for CDS2 Gene

GENATLAS Biochemistry: CDP-diacylglycerol synthase (CDS) 2,photoreceptor specific,highly expressed in the differentiating neuroblasts of the neural retina and central nervous system embryo,regulator of cellular phosphatidylinositol content,involved in phosphoinositide mediated signaling pathway
UniProtKB/Swiss-Prot CatalyticActivity: CTP + phosphatidate = diphosphate + CDP-diacylglycerol
UniProtKB/Swiss-Prot Function: Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin

Enzyme Numbers (IUBMB) for CDS2 Gene

Gene Ontology (GO) - Molecular Function for CDS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004605 phosphatidate cytidylyltransferase activity NAS 9806839
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with CDS2: view
genes like me logo Genes that share phenotypes with CDS2: view

miRNA for CDS2 Gene

miRTarBase miRNAs that target CDS2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CDS2 Gene

Localization for CDS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDS2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDS2 Gene COMPARTMENTS Subcellular localization image for CDS2 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CDS2: view

Pathways for CDS2 Gene

genes like me logo Genes that share pathways with CDS2: view

UniProtKB/Swiss-Prot O95674-CDS2_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3

Gene Ontology (GO) - Biological Process for CDS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006655 phosphatidylglycerol biosynthetic process TAS --
GO:0016024 CDP-diacylglycerol biosynthetic process IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0046474 glycerophospholipid biosynthetic process TAS --
genes like me logo Genes that share ontologies with CDS2: view

Compounds for CDS2 Gene

(898) HMDB Compounds for CDS2 Gene

Compound Synonyms Cas Number PubMed IDs
CDP-DG(16:0/16:0)
  • CDP-DG(16:0/16:0)
Not Available
CDP-DG(16:0/18:0)
  • CDP-DG(34:0)
Not Available
CDP-DG(16:0/18:1(11Z))
  • CDP-Diacylglycerol(16:0/18:1w7)
Not Available
CDP-DG(16:0/18:1(9Z))
  • 1-palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate
Not Available
CDP-DG(16:0/18:2(9Z,12Z))
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP
Not Available

(1) Novoseek inferred chemical compound relationships for CDS2 Gene

Compound -log(P) Hits PubMed IDs
cdpdiacylglycerol 96.8 4
genes like me logo Genes that share compounds with CDS2: view

Transcripts for CDS2 Gene

Unigene Clusters for CDS2 Gene

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: - - - -
SP8: - -
SP9: -
SP10:

Relevant External Links for CDS2 Gene

GeneLoc Exon Structure for
CDS2
ECgene alternative splicing isoforms for
CDS2

Expression for CDS2 Gene

mRNA expression in normal human tissues for CDS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDS2 Gene

SOURCE GeneReport for Unigene cluster for CDS2 Gene Hs.126857

mRNA Expression by UniProt/SwissProt for CDS2 Gene

O95674-CDS2_HUMAN
Tissue specificity: Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with CDS2: view

Orthologs for CDS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDS2 36
  • 92.21 (n)
  • 95.73 (a)
CDS2 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDS2 36
  • 91.91 (n)
  • 96.63 (a)
CDS2 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cds2 36
  • 88.74 (n)
  • 96.4 (a)
Cds2 16
Cds2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDS2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CDS2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cds2 36
  • 88.49 (n)
  • 95.03 (a)
chicken
(Gallus gallus)
Aves CDS2 36
  • 81 (n)
  • 91.4 (a)
CDS2 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDS2 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cds2 36
  • 78.64 (n)
  • 87.73 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
cds2 36
  • 76.46 (n)
  • 84.28 (a)
cds2 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CdsA 37
  • 56 (a)
OneToMany
CdsA 38
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea cdgs-1 37
  • 48 (a)
OneToMany
C33H5.18a 38
  • 51 (a)
C33H5.18b 38
  • 51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDS1 37
  • 34 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CDS1 36
  • 49.58 (n)
  • 42.89 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 59 (a)
OneToMany
Species with no ortholog for CDS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDS2 Gene

ENSEMBL:
Gene Tree for CDS2 (if available)
TreeFam:
Gene Tree for CDS2 (if available)

Paralogs for CDS2 Gene

Paralogs for CDS2 Gene

Selected SIMAP similar genes for CDS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDS2: view

Variants for CDS2 Gene

Sequence variations from dbSNP and Humsavar for CDS2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs261343 -- 5,136,818(-) atgta(C/T)cccct intron-variant
rs261344 -- 5,135,976(-) ACAAA(A/G)GAGCT intron-variant
rs261345 -- 5,135,294(-) AGAAA(C/T)AGTAA intron-variant
rs732817 -- 5,194,591(+) CCCAA(C/T)GCACT utr-variant-3-prime
rs1040757 -- 5,174,259(+) CTCCA(A/G)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDS2 Gene

Variant ID Type Subtype PubMed ID
nsv912629 CNV Gain 21882294
nsv428375 CNV Loss 18775914
nsv912632 CNV Gain 21882294
esv2656923 CNV Deletion 23128226

Relevant External Links for CDS2 Gene

HapMap Linkage Disequilibrium report
CDS2

Disorders for CDS2 Gene

Relevant External Links for CDS2

Genetic Association Database (GAD)
CDS2
Human Genome Epidemiology (HuGE) Navigator
CDS2
genes like me logo Genes that share disorders with CDS2: view

No data available for UniProtKB/Swiss-Prot for CDS2 Gene

Publications for CDS2 Gene

  1. Isolation and chromosomal localization of two human CDP- diacylglycerol synthase (CDS) genes. (PMID: 9806839) Halford S. … Hunt D.M. (Genomics 1998) 2 3 4 23
  2. Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. (PMID: 9889000) Volta M. … Franco B. (Genomics 1999) 2 3 4 23
  3. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. (PMID: 9407135) Lykidis A. … Jackowski S. (J. Biol. Chem. 1997) 3 23
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for CDS2 Gene

Sources for CDS2 Gene

Back to Top

Content