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Aliases for CDS2 Gene

Aliases for CDS2 Gene

  • CDP-Diacylglycerol Synthase 2 2 3 4 5
  • EC 4 58
  • CTP:Phosphatidate Cytidylyltransferase 2 4
  • Phosphatidate Cytidylyltransferase 2 2
  • CDP-Diglyceride Pyrophosphorylase 2 4
  • CDP-Diglyceride Synthase 2 4
  • CDP-DAG Synthase 2 4
  • CDP-DG Synthase 2 4
  • EC 2.7.7 58
  • CDS 2 4

External Ids for CDS2 Gene

Previous GeneCards Identifiers for CDS2 Gene

  • GC20P005095
  • GC20P005102
  • GC20P005055
  • GC20P005107

Summaries for CDS2 Gene

Entrez Gene Summary for CDS2 Gene

  • Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDS2 Gene

CDS2 (CDP-Diacylglycerol Synthase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphatidate cytidylyltransferase activity. An important paralog of this gene is CDS1.

UniProtKB/Swiss-Prot for CDS2 Gene

  • Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.

Gene Wiki entry for CDS2 Gene

Additional gene information for CDS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDS2 Gene

Genomics for CDS2 Gene

Regulatory Elements for CDS2 Gene

Enhancers for CDS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H005168 1.5 Ensembl ENCODE dbSUPER 26.8 +44.3 44253 5.2 PKNOX1 FOXA2 MLX ARID4B YY1 TCF12 SLC30A9 ZNF143 RUNX3 MXD4 CDS2 PCNA ENSG00000212517 TMEM230 UBE2D3P1 GC20P005167 PIR42702 GC20P005196
GH20H005152 1.2 ENCODE dbSUPER 24.1 +26.6 26607 2.5 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 REST PPARG CDS2 PCNA ENSG00000212517 TMEM230 LOC100421361 PRNT GC20P005167 PIR42702
GH20H005179 0.6 ENCODE dbSUPER 28.6 +53.8 53839 1.4 NFE2 CDS2 PCNA ENSG00000212517 TMEM230 UBE2D3P1 GC20P005167 GC20P005196 PIR42702
GH20H005174 0.7 ENCODE dbSUPER 23.3 +49.1 49058 1.7 USF2 SPI1 CDS2 PCNA ENSG00000212517 TMEM230 UBE2D3P1 GC20P005167 PIR42702 GC20P005196
GH20H005163 0.6 dbSUPER 25.7 +38.9 38868 3.5 ZSCAN16 ZNF366 ZNF341 GLIS1 ZNF600 ATF7 ATF2 CDS2 PCNA ENSG00000212517 TMEM230 UBE2D3P1 GC20P005167 PIR42702
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDS2 on UCSC Golden Path with GeneCards custom track

Promoters for CDS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for CDS2 Gene

Genomic Locations for CDS2 Gene
71,127 bases
Plus strand

Genomic View for CDS2 Gene

Genes around CDS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDS2 Gene

Proteins for CDS2 Gene

  • Protein details for CDS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidate cytidylyltransferase 2
    Protein Accession:
    Secondary Accessions:
    • B2RDC6
    • D3DW04
    • Q5TDY2
    • Q5TDY3
    • Q5TDY4
    • Q5TDY5
    • Q9BYK5
    • Q9NTT2

    Protein attributes for CDS2 Gene

    445 amino acids
    Molecular mass:
    51418 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDS2 Gene


neXtProt entry for CDS2 Gene

Selected DME Specific Peptides for CDS2 Gene


Post-translational modifications for CDS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDS2 Gene

Domains & Families for CDS2 Gene

Gene Families for CDS2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for CDS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CDS family.
  • Belongs to the CDS family.
genes like me logo Genes that share domains with CDS2: view

Function for CDS2 Gene

Molecular function for CDS2 Gene

GENATLAS Biochemistry:
CDP-diacylglycerol synthase (CDS) 2,photoreceptor specific,highly expressed in the differentiating neuroblasts of the neural retina and central nervous system embryo,regulator of cellular phosphatidylinositol content,involved in phosphoinositide mediated signaling pathway
UniProtKB/Swiss-Prot CatalyticActivity:
CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
UniProtKB/Swiss-Prot Function:
Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.

Enzyme Numbers (IUBMB) for CDS2 Gene

Gene Ontology (GO) - Molecular Function for CDS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004605 phosphatidate cytidylyltransferase activity TAS --
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with CDS2: view
genes like me logo Genes that share phenotypes with CDS2: view

Animal Models for CDS2 Gene

MGI Knock Outs for CDS2:
  • Cds2 tm1a(KOMP)Wtsi

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CDS2 Gene

Localization for CDS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDS2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDS2 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 4
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IDA,IEA 19946888
genes like me logo Genes that share ontologies with CDS2: view

Pathways & Interactions for CDS2 Gene

genes like me logo Genes that share pathways with CDS2: view

UniProtKB/Swiss-Prot O95674-CDS2_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Gene Ontology (GO) - Biological Process for CDS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006655 phosphatidylglycerol biosynthetic process TAS --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0016024 CDP-diacylglycerol biosynthetic process IEA,IBA --
genes like me logo Genes that share ontologies with CDS2: view

No data available for SIGNOR curated interactions for CDS2 Gene

Drugs & Compounds for CDS2 Gene

(2) Drugs for CDS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Cytidine triphosphate Experimental Pharma 0

(58) Additional Compounds for CDS2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1,2-Dihexadecanoyl-rac-glycero-3-CDP
  • 1,2-Dipalmitoyl-rac-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/16:0)
  • CDP-DG(32:0)
  • CDP-Diacylglycerol(16:0/16:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-CDP
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:0)
  • CDP-DG(34:0)
  • CDP-Diacylglycerol(16:0/18:0)
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n7)
  • CDP-DG(16:0/18:1w7)
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:1)
  • CDP-DG(16:0/18:1n9)
  • CDP-DG(16:0/18:1w9)
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-CDP
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-cytidine-5'-diphosphate
  • CDP-DG(16:0/18:2)
  • CDP-DG(16:0/18:2n6)
  • CDP-DG(16:0/18:2w6)
genes like me logo Genes that share compounds with CDS2: view

Transcripts for CDS2 Gene

Unigene Clusters for CDS2 Gene

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDS2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7: - - - -
SP8: - -
SP9: -

Relevant External Links for CDS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDS2 Gene

Protein differential expression in normal tissues from HIPED for CDS2 Gene

This gene is overexpressed in Nasal epithelium (12.8) and Retina (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDS2 Gene

Protein tissue co-expression partners for CDS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDS2 Gene:


SOURCE GeneReport for Unigene cluster for CDS2 Gene:


mRNA Expression by UniProt/SwissProt for CDS2 Gene:

Tissue specificity: Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for CDS2 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Blood(4.2)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with CDS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CDS2 Gene

Orthologs for CDS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CDS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CDS2 34
  • 100 (a)
(Monodelphis domestica)
Mammalia CDS2 34
  • 93 (a)
(Bos Taurus)
Mammalia CDS2 33 34
  • 92.21 (n)
(Canis familiaris)
Mammalia CDS2 33 34
  • 91.91 (n)
(Mus musculus)
Mammalia Cds2 33 16 34
  • 88.74 (n)
(Rattus norvegicus)
Mammalia Cds2 33
  • 88.49 (n)
(Ornithorhynchus anatinus)
Mammalia CDS2 34
  • 72 (a)
(Gallus gallus)
Aves CDS2 33 34
  • 81 (n)
(Anolis carolinensis)
Reptilia CDS2 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cds2 33
  • 78.64 (n)
(Danio rerio)
Actinopterygii cds2 33 34
  • 76.46 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta CdsA 35 34
  • 58 (a)
(Caenorhabditis elegans)
Secernentea C33H5.18a 35
  • 51 (a)
C33H5.18b 35
  • 51 (a)
cdgs-1 34
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDS1 34
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CDS1 33
  • 49.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
Species where no ortholog for CDS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDS2 Gene

Gene Tree for CDS2 (if available)
Gene Tree for CDS2 (if available)

Paralogs for CDS2 Gene

Paralogs for CDS2 Gene

(1) SIMAP similar genes for CDS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CDS2: view

Variants for CDS2 Gene

Sequence variations from dbSNP and Humsavar for CDS2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000006799 -- 5,126,851(+) GCTCT(C/G)GGGTC upstream-variant-2KB, utr-variant-5-prime
rs1000030624 -- 5,140,082(+) CAGGC(A/G)TGAAC intron-variant
rs1000125279 -- 5,132,926(+) CCAGC(A/C/G)CTTTG intron-variant
rs1000129024 -- 5,191,968(+) AGCAA(A/G)TTCAT utr-variant-3-prime
rs1000175222 -- 5,182,605(+) AGGTT(C/T)AATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDS2 Gene

Variant ID Type Subtype PubMed ID
nsv428375 CNV loss 18775914
nsv1066860 CNV gain 25217958
esv3645092 CNV loss 21293372
esv2656923 CNV deletion 23128226

Variation tolerance for CDS2 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDS2 Gene

Disorders for CDS2 Gene

Relevant External Links for CDS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CDS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDS2 Gene

Publications for CDS2 Gene

  1. Identification and characterization of CDS2, a mammalian homolog of the Drosophila CDP-diacylglycerol synthase gene. (PMID: 9889000) Volta M … Franco B (Genomics 1999) 2 3 4 22 60
  2. Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes. (PMID: 9806839) Halford S … Hunt DM (Genomics 1998) 2 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60

Products for CDS2 Gene

Sources for CDS2 Gene

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