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Aliases for ADAM9 Gene

Aliases for ADAM9 Gene

  • ADAM Metallopeptidase Domain 9 2 3
  • MCMP 3 4 6
  • MDC9 3 4 6
  • Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 3 4
  • Cellular Disintegrin-Related Protein 3 4
  • Myeloma Cell Metalloproteinase 3 4
  • Cone Rod Dystrophy 9 2 3
  • Mltng 3 4
  • CORD9 3 6
  • Disintegrin And Metalloproteinase Domain-Containing Protein 9 3
  • A Disintegrin And Metalloproteinase Domain 9 (Meltrin Gamma) 2
  • ADAM Metallopeptidase Domain 9 (Meltrin Gamma) 3
  • Meltrin Gamma 2
  • Meltrin-Gamma 4
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • KIAA0021 4
  • ADAM 9 4

External Ids for ADAM9 Gene

Previous HGNC Symbols for ADAM9 Gene

  • CORD9

Previous GeneCards Identifiers for ADAM9 Gene

  • GC08P038441
  • GC08P039068
  • GC08P038595
  • GC08P038871
  • GC08P038974
  • GC08P037387

Summaries for ADAM9 Gene

Entrez Gene Summary for ADAM9 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ADAM9 Gene

ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include cone-rod dystrophy 9 and myeloma. Among its related pathways are Degradation of the extracellular matrix and Cytoskeletal Signaling. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM33.

UniProtKB/Swiss-Prot for ADAM9 Gene

  • Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.

Gene Wiki entry for ADAM9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM9 Gene

Genomics for ADAM9 Gene

Regulatory Elements for ADAM9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADAM9 Gene

Start:
38,996,869 bp from pter
End:
39,105,261 bp from pter
Size:
108,393 bases
Orientation:
Plus strand

Genomic View for ADAM9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM9 Gene

Proteins for ADAM9 Gene

  • Protein details for ADAM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13443-ADAM9_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 9
    Protein Accession:
    Q13443
    Secondary Accessions:
    • B7ZLN7
    • Q10718
    • Q8NFM6

    Protein attributes for ADAM9 Gene

    Size:
    819 amino acids
    Molecular mass:
    90556 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with SH3GL2 and SNX9 through its cytoplasmic tail.

    Three dimensional structures from OCA and Proteopedia for ADAM9 Gene

    Alternative splice isoforms for ADAM9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM9 Gene

Proteomics data for ADAM9 Gene at MOPED

Selected DME Specific Peptides for ADAM9 Gene

Post-translational modifications for ADAM9 Gene

  • Glycosylation at Asn125, Asn144, Asn154, Asn231, Asn381, and Asn487
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM9 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ADAM9 (ADAM9)

Domains for ADAM9 Gene

Gene Families for ADAM9 Gene

HGNC:
  • ADAM :ADAM metallopeptidase domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for ADAM9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13443

UniProtKB/Swiss-Prot:

ADAM9_HUMAN :
  • Q13443
Domain:
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM9: view

Function for ADAM9 Gene

Molecular function for ADAM9 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease (active) domain 9,membrane anchored cell surface adhesion protein,widely expressed,also expressed in meyloma cells
UniProtKB/Swiss-Prot Function:
Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.

Enzyme Numbers (IUBMB) for ADAM9 Gene

Gene Ontology (GO) - Molecular Function for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IMP 22480688
GO:0005080 protein kinase C binding ISS 8647900
GO:0005178 integrin binding IPI 17704059
GO:0005515 protein binding IPI 10527948
GO:0005518 collagen binding IMP 15361064
genes like me logo Genes that share ontologies with ADAM9: view
genes like me logo Genes that share phenotypes with ADAM9: view

Animal Models for ADAM9 Gene

MGI Knock Outs for ADAM9:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM9

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for ADAM9 Gene

Localization for ADAM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM9 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM9 Gene COMPARTMENTS Subcellular localization image for ADAM9 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space ISS 8647900
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ADAM9: view

Pathways for ADAM9 Gene

genes like me logo Genes that share pathways with ADAM9: view

Pathways by source for ADAM9 Gene

1 Sino Biological pathway for ADAM9 Gene
2 Cell Signaling Technology pathways for ADAM9 Gene
1 GeneGo (Thomson Reuters) pathway for ADAM9 Gene
1 R&D Systems pathway for ADAM9 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADAM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IDA 17704059
GO:0006508 proteolysis --
GO:0006509 membrane protein ectodomain proteolysis IMP 22480688
GO:0007155 cell adhesion IMP 11162558
GO:0007160 cell-matrix adhesion IMP 15361064
genes like me logo Genes that share ontologies with ADAM9: view

Compounds for ADAM9 Gene

(1) HMDB Compounds for ADAM9 Gene

Compound Synonyms Cas Number PubMed IDs
Clotrimazole
  • (Chlorotrityl)imidazole
23593-75-1

(2) Novoseek inferred chemical compound relationships for ADAM9 Gene

Compound -log(P) Hits PubMed IDs
oxygen 0 2
h2o2 0 6
genes like me logo Genes that share compounds with ADAM9: view

Transcripts for ADAM9 Gene

Unigene Clusters for ADAM9 Gene

ADAM metallopeptidase domain 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM9 Gene

No ASD Table

Relevant External Links for ADAM9 Gene

GeneLoc Exon Structure for
ADAM9
ECgene alternative splicing isoforms for
ADAM9

Expression for ADAM9 Gene

mRNA expression in normal human tissues for ADAM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ADAM9 Gene

This gene is overexpressed in Amniocyte (35.5) and Adrenal (17.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAM9 Gene

SOURCE GeneReport for Unigene cluster for ADAM9 Gene Hs.591852

mRNA Expression by UniProt/SwissProt for ADAM9 Gene

Q13443-ADAM9_HUMAN
Tissue specificity: Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
genes like me logo Genes that share expressions with ADAM9: view

Expression partners for ADAM9 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADAM9 Gene

Orthologs for ADAM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM9 35
  • 87.3 (n)
  • 85.59 (a)
ADAM-9 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM9 35
  • 92.23 (n)
  • 92.55 (a)
ADAM9 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam9 35
  • 83.97 (n)
  • 87.06 (a)
Adam9 16
Adam9 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM9 35
  • 99.76 (n)
  • 99.76 (a)
ADAM9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam9 35
  • 83.84 (n)
  • 86.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM9 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM9 35
  • 70.25 (n)
  • 68.95 (a)
ADAM9 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM9 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam9 35
  • 67.54 (n)
  • 70.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia adam9-A 35
zebrafish
(Danio rerio)
Actinopterygii adam9 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 35 (a)
Neu3 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 27 (a)
adm-2 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
Species with no ortholog for ADAM9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM9 Gene

ENSEMBL:
Gene Tree for ADAM9 (if available)
TreeFam:
Gene Tree for ADAM9 (if available)

Paralogs for ADAM9 Gene

genes like me logo Genes that share paralogs with ADAM9: view

Variants for ADAM9 Gene

Sequence variations from dbSNP and Humsavar for ADAM9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1126850 -- 39,104,853(+) TAAGC(A/C)CTAAA utr-variant-3-prime, nc-transcript-variant
rs1802884 -- 39,104,819(+) TACTA(C/T)GGCAG utr-variant-3-prime, nc-transcript-variant
rs3208797 -- 39,078,171(+) TGTTT(C/T)TCACT intron-variant
rs4075849 -- 39,077,064(+) TCTGC(C/T)GTATT intron-variant
rs4128871 -- 39,002,475(+) CACCA(C/T)GCCCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM9 Gene

Variant ID Type Subtype PubMed ID
nsv515080 CNV Complex 21397061
esv270261 CNV Insertion 20981092
esv272925 CNV Insertion 20981092
esv1147428 CNV Insertion 17803354
esv9208 CNV Gain 19470904
nsv524818 CNV Loss 19592680
esv2795 CNV Deletion 18987735
esv2736897 CNV Deletion 23290073
esv2659169 CNV Deletion 23128226
nsv6162 CNV Insertion 18451855

Relevant External Links for ADAM9 Gene

HapMap Linkage Disequilibrium report
ADAM9
Human Gene Mutation Database (HGMD)
ADAM9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM9 Gene

Disorders for ADAM9 Gene

(1) OMIM Diseases for ADAM9 Gene (602713)

UniProtKB/Swiss-Prot

ADAM9_HUMAN
  • Cone-rod dystrophy 9 (CORD9) [MIM:612775]: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. {ECO:0000269 PubMed:19409519}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ADAM9 Gene

(10) Novoseek inferred disease relationships for ADAM9 Gene

Disease -log(P) Hits PubMed IDs
metastasis 26.6 3
tumors 24.1 10
prostate cancer 23.6 17
aggressiveness 22.4 2
liver metastases 18.4 2

Relevant External Links for ADAM9

Genetic Association Database (GAD)
ADAM9
Human Genome Epidemiology (HuGE) Navigator
ADAM9
genes like me logo Genes that share disorders with ADAM9: view

No data available for Genatlas for ADAM9 Gene

Publications for ADAM9 Gene

  1. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. (PMID: 8647900) Weskamp G. … Blobel C.P. (J. Cell Biol. 1996) 2 3 4 23
  2. Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. (PMID: 19409519) Parry D.A. … Inglehearn C.F. (Am. J. Hum. Genet. 2009) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4
  4. Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease. (PMID: 19237226) Cong L. … Jia J. (Neurobiol. Aging 2011) 3 48
  5. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2-beta. (PMID: 10527948) Nelson K.K. … Blobel C.P. (Biochem. J. 1999) 3 23

Products for ADAM9 Gene

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