Aliases for ADAM9 Gene
External Ids for ADAM9 Gene
Previous HGNC Symbols for ADAM9 Gene
Previous GeneCards Identifiers for ADAM9 Gene
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ADAM9 Gene
ADAM9 (ADAM Metallopeptidase Domain 9) is a Protein Coding gene. Diseases associated with ADAM9 include Cone-Rod Dystrophy 9 and Retinitis Pigmentosa. Among its related pathways are Notch Signaling Pathway (sino) and A-beta Signaling Pathways. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM33.
UniProtKB/Swiss-Prot for ADAM9 Gene
Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.