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Aliases for ADAM15 Gene

Aliases for ADAM15 Gene

  • ADAM Metallopeptidase Domain 15 2 3 5
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 15 3 4
  • A Disintegrin And Metalloproteinase Domain 15 (Metargidin) 2 3
  • Metalloprotease RGD Disintegrin Protein 3 4
  • Metargidin 2 4
  • MDC-15 3 4
  • MDC15 3 4
  • Disintegrin And Metalloproteinase Domain-Containing Protein 15 3
  • EC 3.4.24.- 4
  • EC 3.4.24 61
  • ADAM 15 4

External Ids for ADAM15 Gene

Previous GeneCards Identifiers for ADAM15 Gene

  • GC01M148227
  • GC01P150754
  • GC01P151799
  • GC01P152240
  • GC01P151836
  • GC01P153290
  • GC01P126385

Summaries for ADAM15 Gene

Entrez Gene Summary for ADAM15 Gene

  • The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADAM15 Gene

ADAM15 (ADAM Metallopeptidase Domain 15) is a Protein Coding gene. Among its related pathways are Notch Signaling Pathway (sino) and Degradation of the extracellular matrix. GO annotations related to this gene include SH3 domain binding and integrin binding. An important paralog of this gene is ADAM12.

UniProtKB/Swiss-Prot for ADAM15 Gene

  • Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Gene Wiki entry for ADAM15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM15 Gene

Genomics for ADAM15 Gene

Regulatory Elements for ADAM15 Gene

Enhancers for ADAM15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F155015 1.1 Ensembl ENCODE 18.9 -32.7 -32710 4.3 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 KIAA0907 ENSG00000271267 MSTO2P LOC101928120 PYGO2 THBS3 ASH1L-AS1 RUSC1-AS1 ADAM15 ZBTB7B
GH01F155069 1 Ensembl ENCODE 18.4 +20.4 20353 3.0 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 GLIS2 ADAM15 GBAP1 THBS3 POU5F1P4 DCST1-AS1 EFNA3
GH01F155084 0.2 ENCODE 17.4 +34.7 34712 2.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ADAM15 ASH1L PYGO2 EFNA1 SLC50A1 KRTCAP2 MIR92B MUC1 MTX1 THBS3
GH01F155073 0.5 Ensembl 16 +23.2 23235 0.8 GLIS1 PRDM10 ZNF18 ADAM15 DCST1-AS1 EFNA3
GH01F155022 1.1 Ensembl ENCODE 12.5 -27.7 -27659 1.4 BMI1 RAD21 ZNF121 ZNF362 CEBPB ZEB2 REST SMARCA4 MYNN IKZF1 ZBTB7B ADAM15 DCST1-AS1 DCST2 FLAD1 PYGO2 UBE2Q1 CHRNB2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADAM15 on UCSC Golden Path with GeneCards custom track

Promoters for ADAM15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000545487 1234 2401 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207

Genomic Location for ADAM15 Gene

Chromosome:
1
Start:
155,050,566 bp from pter
End:
155,062,776 bp from pter
Size:
12,211 bases
Orientation:
Plus strand

Genomic View for ADAM15 Gene

Genes around ADAM15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM15 Gene

Proteins for ADAM15 Gene

  • Protein details for ADAM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13444-ADA15_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 15
    Protein Accession:
    Q13444
    Secondary Accessions:
    • B3KQU5
    • B4DLB5
    • B4DMH8
    • E9PN65
    • Q13493
    • Q53XQ0
    • Q5SR68
    • Q5SR69
    • Q6R267
    • Q71S61
    • Q71S62
    • Q71S63
    • Q71S64
    • Q71S65
    • Q71S66
    • Q71S67
    • Q71S68
    • Q71S69
    • Q96C78
    • U3KQL5

    Protein attributes for ADAM15 Gene

    Size:
    863 amino acids
    Molecular mass:
    92959 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Interacts with ITAGV-ITGB3 (vitronectin receptor). Interacts with SH3GL2 and SNX9; this interaction occurs preferentially with ADAM15 precursor, rather than the processed form, suggesting it occurs in a secretory pathway compartment prior to the medial Golgi. Interacts with ITAG9-ITGB1 (By similarity). Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A. Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC.

    Alternative splice isoforms for ADAM15 Gene

neXtProt entry for ADAM15 Gene

Selected DME Specific Peptides for ADAM15 Gene

Q13444:
  • SGGVNMDHS
  • EGWAPPDC
  • GHSLGLDH
  • KCHGHGVC

Post-translational modifications for ADAM15 Gene

  • Phosphorylation increases association with PTKs.
  • The precursor is cleaved by a furin endopeptidase.
  • Glycosylation at Asn 237, Asn 389, Asn 392, Asn 606, and Asn 611
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for ADAM15 Gene

Gene Families for ADAM15 Gene

Suggested Antigen Peptide Sequences for ADAM15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13444

UniProtKB/Swiss-Prot:

ADA15_HUMAN :
  • The cytoplasmic domain is required for SH3GL2- and SNX9-binding.
Domain:
  • The cytoplasmic domain is required for SH3GL2- and SNX9-binding.
  • Disintegrin domain binds to integrin alphaV-beta3.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM15: view

Function for ADAM15 Gene

Molecular function for ADAM15 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by hydroxamate-type metalloproteinase inhibitors such as marimastat. Inhibited by metalloproteinase inhibitor 2 (TIMP-2) and TIMP-3 at nanomolar concentrations. Not significantly inhibited by TIMP-1 at concentrations of up to 100 nM. Not activated by PMA or ionomycin.
UniProtKB/Swiss-Prot Function:
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.

Enzyme Numbers (IUBMB) for ADAM15 Gene

Gene Ontology (GO) - Molecular Function for ADAM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0005178 integrin binding IMP 22505472
GO:0005515 protein binding IPI 10531379
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IDA,TAS 12777399
genes like me logo Genes that share ontologies with ADAM15: view
genes like me logo Genes that share phenotypes with ADAM15: view

Animal Models for ADAM15 Gene

MGI Knock Outs for ADAM15:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAM15

miRNA for ADAM15 Gene

miRTarBase miRNAs that target ADAM15

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM15 Gene

Localization for ADAM15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM15 Gene

Endomembrane system; Single-pass type I membrane protein. Cell junction, adherens junction. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM15 Gene COMPARTMENTS Subcellular localization image for ADAM15 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005912 adherens junction IEA --
GO:0009986 cell surface IDA 22505472
genes like me logo Genes that share ontologies with ADAM15: view

Pathways & Interactions for ADAM15 Gene

genes like me logo Genes that share pathways with ADAM15: view

Pathways by source for ADAM15 Gene

1 Sino Biological pathway for ADAM15 Gene

SIGNOR curated interactions for ADAM15 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for ADAM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001953 negative regulation of cell-matrix adhesion IMP 22505472
GO:0006508 proteolysis IEA --
GO:0006915 NOT apoptotic process IDA 22505472
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with ADAM15: view

Drugs & Compounds for ADAM15 Gene

(3) Additional Compounds for ADAM15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM15: view

Transcripts for ADAM15 Gene

Unigene Clusters for ADAM15 Gene

ADAM metallopeptidase domain 15:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM15 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - - -
SP10: - - -
SP11: - - - - - - - - - - - - - - - -
SP12: - - - - -
SP13: - - - -
SP14: - - -
SP15:
SP16: - - - - - - - - - - - - - - - - - -
SP17: - -
SP18: - -
SP19: - - -
SP20:
SP21:

ExUns: 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP2: -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - - - -
SP9: - - - -
SP10: - - - - -
SP11: - - - - -
SP12:
SP13:
SP14:
SP15: - -
SP16: - - - - -
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ADAM15 Gene

GeneLoc Exon Structure for
ADAM15
ECgene alternative splicing isoforms for
ADAM15

Expression for ADAM15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAM15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADAM15 Gene

This gene is overexpressed in Breast (52.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADAM15 Gene



NURSA nuclear receptor signaling pathways regulating expression of ADAM15 Gene:

ADAM15

SOURCE GeneReport for Unigene cluster for ADAM15 Gene:

Hs.312098

mRNA Expression by UniProt/SwissProt for ADAM15 Gene:

Q13444-ADA15_HUMAN
Tissue specificity: Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
genes like me logo Genes that share expression patterns with ADAM15: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ADAM15 Gene

Orthologs for ADAM15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAM15 35 34
  • 99.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADAM15 34 35
  • 84.76 (n)
dog
(Canis familiaris)
Mammalia ADAM15 34 35
  • 83.45 (n)
mouse
(Mus musculus)
Mammalia Adam15 34 16 35
  • 82.53 (n)
rat
(Rattus norvegicus)
Mammalia Adam15 34
  • 82.44 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAM15 35
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC795199 34
  • 53.29 (n)
adam15 35
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mmd 36
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea adm-1 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
Species where no ortholog for ADAM15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAM15 Gene

ENSEMBL:
Gene Tree for ADAM15 (if available)
TreeFam:
Gene Tree for ADAM15 (if available)

Paralogs for ADAM15 Gene

(11) SIMAP similar genes for ADAM15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADAM15: view

Variants for ADAM15 Gene

Sequence variations from dbSNP and Humsavar for ADAM15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs483352774 Uncertain significance 155,061,444(+) GCCCC(A/C/G/T)CCTTC intron-variant, nc-transcript-variant, reference, synonymous-codon, missense
rs10158328 -- 155,055,287(+) gtggc(A/G)tgatc intron-variant
rs1051908 -- 155,062,549(+) TTCAA(A/G)AGGCG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1051917 -- 155,062,628(+) GCACC(C/G)CCACG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111294050 -- 155,062,204(+) TGACA(-/C)CCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADAM15 Gene

Variant ID Type Subtype PubMed ID
esv3587615 CNV gain 21293372
esv3587616 CNV gain 21293372
nsv509502 CNV insertion 20534489
nsv524157 CNV loss 19592680
nsv952212 CNV deletion 24416366

Variation tolerance for ADAM15 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAM15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM15 Gene

Disorders for ADAM15 Gene

Relevant External Links for ADAM15

Genetic Association Database (GAD)
ADAM15
Human Genome Epidemiology (HuGE) Navigator
ADAM15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM15

No disorders were found for ADAM15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM15 Gene

Publications for ADAM15 Gene

  1. Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. (PMID: 9516430) Zhang X.P. … Takada Y. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins. (PMID: 19718658) Kleino I. … Saksela K. (J. Cell. Biochem. 2009) 3 4 22 64
  3. Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays. (PMID: 19207106) Maretzky T. … Blobel C.P. (Biochem. J. 2009) 3 4 22 64
  4. Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. (PMID: 18296648) Zhong J.L. … Edwards D.R. (Mol. Cancer Res. 2008) 3 4 22 64
  5. ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation. (PMID: 18387333) Chen Q. … Ding J. (Int. J. Biochem. Cell Biol. 2008) 3 4 22 64

Products for ADAM15 Gene

Sources for ADAM15 Gene

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