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Aliases for ADAM18 Gene

Aliases for ADAM18 Gene

  • ADAM Metallopeptidase Domain 18 2 3
  • Transmembrane Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein III 3 4
  • A Disintegrin And Metalloproteinase Domain 18 2 3
  • Disintegrin And Metalloproteinase Domain-Containing Protein 18 3
  • Putative ADAM18 Gene Product 3
  • TMDC III 4
  • ADAM 18 4
  • ADAM27 3
  • TMDC3 4

External Ids for ADAM18 Gene

Previous GeneCards Identifiers for ADAM18 Gene

  • GC08P038838
  • GC08P039501
  • GC08P039182
  • GC08P039459
  • GC08P038983
  • GC08P039561
  • GC08P037975

Summaries for ADAM18 Gene

Entrez Gene Summary for ADAM18 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a sperm surface protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GeneCards Summary for ADAM18 Gene

ADAM18 (ADAM Metallopeptidase Domain 18) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM22.

UniProtKB/Swiss-Prot for ADAM18 Gene

  • Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).

Gene Wiki entry for ADAM18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM18 Gene

Genomics for ADAM18 Gene

Regulatory Elements for ADAM18 Gene

Transcription factor binding sites by QIAGEN in the ADAM18 gene promoter:

Genomic Location for ADAM18 Gene

39,584,489 bp from pter
39,730,064 bp from pter
145,576 bases
Plus strand

Genomic View for ADAM18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM18 Gene

Proteins for ADAM18 Gene

  • Protein details for ADAM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 18
    Protein Accession:
    Secondary Accessions:
    • B2R9Y0
    • Q0VAI4
    • Q6IRW9
    • Q6UXJ9

    Protein attributes for ADAM18 Gene

    739 amino acids
    Molecular mass:
    82856 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAM18 Gene


neXtProt entry for ADAM18 Gene

Proteomics data for ADAM18 Gene at MOPED

Post-translational modifications for ADAM18 Gene

  • The prodomain and the metalloprotease-like domain are cleaved during the epididymal maturation of the spermatozoa.
  • Glycosylation at Asn36, Asn76, Asn122, Asn149, Asn156, Asn177, Asn294, Asn359, Asn465, Asn561, Asn611, and Asn625
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM18 Gene

No data available for DME Specific Peptides for ADAM18 Gene

Domains for ADAM18 Gene

Gene Families for ADAM18 Gene

  • ADAM :ADAM metallopeptidase domain containing

Suggested Antigen Peptide Sequences for ADAM18 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y3Q7
  • A tripeptide motif (ECD) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM18: view

Function for ADAM18 Gene

Molecular function for ADAM18 Gene

UniProtKB/Swiss-Prot Function:
Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein (By similarity).

Gene Ontology (GO) - Molecular Function for ADAM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity TAS 10395895
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAM18: view

Phenotypes for ADAM18 Gene

MGI mutant phenotypes for ADAM18:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with ADAM18: view

Animal Models for ADAM18 Gene

MGI Knock Outs for ADAM18:

Animal Model Products

miRNA for ADAM18 Gene

miRTarBase miRNAs that target ADAM18

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADAM18 Gene

Localization for ADAM18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM18 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ADAM18 Gene COMPARTMENTS Subcellular localization image for ADAM18 gene
Compartment Confidence
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADAM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 10395895
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADAM18: view

Pathways for ADAM18 Gene

SuperPathways for ADAM18 Gene

No Data Available

Interacting Proteins for ADAM18 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000265707 for ADAM18 Gene via STRING

Gene Ontology (GO) - Biological Process for ADAM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ADAM18: view

No data available for Pathways by source for ADAM18 Gene

Transcripts for ADAM18 Gene

Unigene Clusters for ADAM18 Gene

ADAM metallopeptidase domain 18:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAM18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM18 Gene

No ASD Table

Relevant External Links for ADAM18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAM18 Gene

mRNA expression in normal human tissues for ADAM18 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM18 Gene

This gene is overexpressed in Testis (51.4).

Protein differential expression in normal tissues for ADAM18 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAM18 Gene

SOURCE GeneReport for Unigene cluster for ADAM18 Gene Hs.127930

mRNA Expression by UniProt/SwissProt for ADAM18 Gene

Tissue specificity: Expressed specifically in testis
genes like me logo Genes that share expressions with ADAM18: view

Expression partners for ADAM18 Gene

In Situ Assay Products

Orthologs for ADAM18 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ADAM18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAM18 35
  • 83.52 (n)
  • 74.15 (a)
ADAM18 36
  • 73 (a)
(Canis familiaris)
Mammalia ADAM18 35
  • 85.43 (n)
  • 75.91 (a)
ADAM18 36
  • 76 (a)
(Mus musculus)
Mammalia Adam18 35
  • 74.39 (n)
  • 63.6 (a)
Adam18 16
Adam18 36
  • 62 (a)
(Pan troglodytes)
Mammalia ADAM18 35
  • 98.1 (n)
  • 96.92 (a)
ADAM18 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Adam18 35
  • 74.27 (n)
  • 63.35 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
Species with no ortholog for ADAM18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADAM18 Gene

Gene Tree for ADAM18 (if available)
Gene Tree for ADAM18 (if available)

Paralogs for ADAM18 Gene

Paralogs for ADAM18 Gene

Selected SIMAP similar genes for ADAM18 Gene using alignment to 4 proteins: Pseudogenes for ADAM18 Gene

genes like me logo Genes that share paralogs with ADAM18: view

Variants for ADAM18 Gene

Sequence variations from dbSNP and Humsavar for ADAM18 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs201955 -- 39,708,416(+) TTACA(A/C)ACTCT intron-variant
rs201956 -- 39,712,754(+) ttcaa(A/G)aagaa intron-variant
rs201957 -- 39,706,475(+) TTTAA(A/G)AAATT intron-variant
rs201958 -- 39,706,527(+) ATTTT(G/T)TAAAG intron-variant
rs201959 -- 39,717,805(+) accat(A/G)tatct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAM18 Gene

Variant ID Type Subtype PubMed ID
dgv2227e1 CNV Complex 17122850
nsv890725 CNV Gain 21882294
dgv2230e1 CNV Complex 17122850
dgv2231e1 CNV Complex 17122850
dgv7781n71 CNV Loss 21882294
dgv7782n71 CNV Loss 21882294
dgv7783n71 CNV Loss 21882294
esv33750 CNV Loss 17666407
nsv890831 CNV Loss 21882294
nsv890833 CNV Loss 21882294
nsv890835 CNV Loss 21882294
nsv890836 CNV Loss 21882294
esv271607 CNV Insertion 20981092
nsv890837 CNV Loss 21882294
esv2660839 CNV Deletion 23128226
nsv522716 CNV Loss 19592680
nsv890838 CNV Loss 21882294
nsv510141 CNV Loss 20534489
nsv890839 CNV Loss 21882294
esv2225914 CNV Deletion 18987734
esv2736903 CNV Deletion 23290073

Relevant External Links for ADAM18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM18 Gene

Disorders for ADAM18 Gene

Relevant External Links for ADAM18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ADAM18 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAM18 Gene

Publications for ADAM18 Gene

  1. Human tMDC III: a sperm protein with a potential role in oocyte recognition. (PMID: 12200459) Frayne J. … Hall L. (Mol. Hum. Reprod. 2002) 2 3 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3 48
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ADAM18 Gene

Sources for ADAM18 Gene

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