Aliases for ADAM23 Gene
Aliases for ADAM23 Gene
External Ids for ADAM23 Gene
- HGNC: 202
- Entrez Gene: 8745
- Ensembl: ENSG00000114948
- OMIM: 603710
- UniProtKB: O75077
Previous GeneCards Identifiers for ADAM23 Gene
- GC02P205525
- GC02P206032
- GC02P207272
- GC02P207510
- GC02P207133
- GC02P207018
- GC02P199158
Summaries for ADAM23 Gene
-
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]
GeneCards Summary for ADAM23 Gene
ADAM23 (ADAM Metallopeptidase Domain 23) is a Protein Coding gene. Among its related pathways are LGI-ADAM interactions and Developmental Biology. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM11.
UniProtKB/Swiss-Prot for ADAM23 Gene
-
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
Additional gene information for ADAM23 Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM23 Gene
Genomics for ADAM23 Gene
GeneHancer (GH) Regulatory Elements for ADAM23 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02I206443 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE | 550.8 | +0.2 | 162 | 1 | CTCF MXI1 ZIC2 ZNF335 GLIS2 POLR2A PATZ1 SCRT2 PRDM10 ZNF600 | ADAM23 GC02P206607 | |
GH02I205729 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 4.5 | -710.9 | -710934 | 5.6 | FOXA2 BACH1 ZNF316 POLR2A FOSL2 NFE2 FOS MAFK EZH2 NFE2L2 | ENSG00000225216 NRP2 ADAM23 GC02P205736 | |
GH02I206368 | Enhancer | 0.5 | Ensembl ENCODE | 10.6 | -74.9 | -74903 | 1.2 | ATF2 | ADAM23 GPR1 GC02P206391 GC02P206342 | |
GH02I206246 | Enhancer | 0.5 | Ensembl | 10.1 | -197.2 | -197238 | 0.2 | NBN ATF7 ELF1 DPF2 IRF4 RUNX3 | GPR1 RN7SKP200 ZDBF2 SNORA41 EEF1B2 ADAM23 LOC100132849 HMGN1P6 GPR1-AS | |
GH02I206389 | Enhancer | 0.2 | ENCODE | 11.5 | -53.4 | -53422 | 1.4 | GC02P206391 ADAM23 GPR1 NDUFS1 GC02P206342 |
Regulatory Element Products
Genomic Locations for ADAM23 Gene
- chr2:206,443,539-206,621,130
- (GRCh38/hg38)
- Size:
- 177,592 bases
- Orientation:
- Plus strand
- chr2:207,308,263-207,485,851
- (GRCh37/hg19)
Genomic View for ADAM23 Gene
- Cytogenetic band:
-
- 2q33.3 by Ensembl
- 2q33.3 by Entrez Gene
- 2q33.3 by HGNC


RefSeq DNA sequence for ADAM23 Gene
Proteins for ADAM23 Gene
-
Protein details for ADAM23 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75077-ADA23_HUMAN
- Recommended name:
- Disintegrin and metalloproteinase domain-containing protein 23
- Protein Accession:
- O75077
- A2RU59
Protein attributes for ADAM23 Gene
- Size:
- 832 amino acids
- Molecular mass:
- 91926 Da
- Quaternary structure:
-
- Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3.
Protein Expression for ADAM23 Gene
Post-translational modifications for ADAM23 Gene
- Glycosylation at posLast=7676, posLast=9696, posLast=100100, Asn263, posLast=547547, posLast=548548, Asn664, and Asn732
Other Protein References for ADAM23 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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-
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Protein Products
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-
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Assay Products
- antibodies-online: Search results for 3 available Adam23 Elisa Kits ranked by validation data
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No data available for DME Specific Peptides for ADAM23 Gene
Domains & Families for ADAM23 Gene
Gene Families for ADAM23 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ADAM23 Gene
Suggested Antigen Peptide Sequences for ADAM23 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O75077UniProtKB/Swiss-Prot:
ADA23_HUMAN :- A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
- Domain:
-
- A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
Function for ADAM23 Gene
Molecular function for ADAM23 Gene
- GENATLAS Biochemistry:
- a disintegrin and metalloprotease domain 23,membrane anchored cell surface adhesion protein,expressed in the brain
- UniProtKB/Swiss-Prot Function:
- May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
Phenotypes From GWAS Catalog for ADAM23 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004222 | metalloendopeptidase activity | IEA | -- |
GO:0005178 | integrin binding | TAS | 9693107 |
GO:0005515 | protein binding | IPI | 20463223 |
GO:0008237 | metallopeptidase activity | TAS,IEA | 9693107 |
Phenotypes for ADAM23 Gene
- MGI mutant phenotypes for ADAM23:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ADAM23:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAM23 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for ADAM23
- genomics-online: gRNA clones - Search results for 89 available Adam23 gene related products
- Overview of 89 available Adam23 gene related products
- Applied Biological Materials CRISPR for ADAM23
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM23
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miRNA for ADAM23 Gene
- miRTarBase miRNAs that target ADAM23
miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM23
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-
ViGene Biosciences ready-to-package AAV shRNAs for ADAM23 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADAM23
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ADAM23
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ADAM23
-
ViGene Biosciences adenoviral particle packaged cDNA for ADAM23 gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM23 Gene
Localization for ADAM23 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAM23 Gene
- Cell membrane; Single-pass type I membrane protein.
- Isoform Gamma: Secreted.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 9693107 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAM23 Gene
Pathways & Interactions for ADAM23 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Developmental Biology | ||
2 | LGI-ADAM interactions |
Pathways by source for ADAM23 Gene
2 Reactome pathways for ADAM23 Gene
Interacting Proteins for ADAM23 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006508 | proteolysis | IEA | -- |
GO:0007155 | cell adhesion | IEA | -- |
GO:0007417 | central nervous system development | TAS | 9693107 |
GO:1990830 | cellular response to leukemia inhibitory factor | IEA | -- |
No data available for SIGNOR curated interactions for ADAM23 Gene
Transcripts for ADAM23 Gene
mRNA/cDNA for ADAM23 Gene
- (3) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (62) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ADAM23 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ADAM23
- genomics-online: gRNA clones - Search results for 89 available Adam23 gene related products
- Overview of 89 available Adam23 gene related products
- Applied Biological Materials CRISPR for ADAM23
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAM23
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miRNA Products
- Search ViGene Biosciences for ADAM23
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ADAM23
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- Overview of 89 available Adam23 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for ADAM23 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADAM23
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ADAM23
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ADAM23 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Mesenchymal Stem Cells (Uncategorized)
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- T Helper Cells Thymus
- Umbilical Cord (Extraembryonic Tissues)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
-
Tooth
- Dental Mesenchymal Cells Branchial Arch 1
- Eye (Sensory Organs)
- Ovary (Reproductive System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ADAM23 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAM23 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADAM23 Gene:
ADAM23SOURCE GeneReport for Unigene cluster for ADAM23 Gene:
Hs.591643mRNA Expression by UniProt/SwissProt for ADAM23 Gene:
O75077-ADA23_HUMANEvidence on tissue expression from TISSUES for ADAM23 Gene
- Nervous system(4.6)
Primer Products
-
OriGene qPCR primer pairs for ADAM23
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAM23 Gene
Orthologs for ADAM23 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ADAM23 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ADAM23 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | ADAM23 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | ADAM23 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Adam23 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Adam23 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | ADAM23 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ADAM23 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | ADAM23 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | adam23 33 |
|
||
Str.12051 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | ADAM23 (2 of 2) 34 |
|
OneToMany | |
wu:fj40f01 33 |
|
||||
adam23a 34 |
|
OneToMany | |||
fruit fly (Drosophila melanogaster) |
Insecta | mmd 35 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | adm-1 35 |
|
|
|
unc-71 34 |
|
OneToMany |
- Species where no ortholog for ADAM23 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADAM23 Gene
Paralogs for ADAM23 Gene
(14) SIMAP similar genes for ADAM23 Gene using alignment to 7 proteins:
Variants for ADAM23 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000002980 | -- | 206,483,157(+) | A/G | intron_variant | |
rs1000006541 | -- | 206,500,604(+) | C/T | intron_variant | |
rs1000029130 | -- | 206,615,308(+) | G/T | intron_variant | |
rs1000032401 | -- | 206,613,839(+) | T/G | intron_variant | |
rs1000033702 | -- | 206,604,582(+) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3344531 | CNV | insertion | 20981092 |
esv3594069 | CNV | loss | 21293372 |
nsv1011347 | CNV | gain | 25217958 |
nsv1072485 | CNV | deletion | 25765185 |
nsv1116823 | CNV | deletion | 24896259 |
nsv1126576 | CNV | deletion | 24896259 |
nsv1153377 | CNV | insertion | 26484159 |
nsv472414 | CNV | novel sequence insertion | 20440878 |
nsv477754 | CNV | novel sequence insertion | 20440878 |
nsv478360 | CNV | novel sequence insertion | 20440878 |
nsv584247 | CNV | gain | 21841781 |
nsv954823 | CNV | duplication | 24416366 |
nsv954824 | CNV | duplication | 24416366 |
Additional Variant Information for ADAM23 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADAM23
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAM23 Gene
Disorders for ADAM23 Gene
Additional Disease Information for ADAM23
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ADAM23 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM23 Gene
Publications for ADAM23 Gene
- Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K … Tanaka I (The Biochemical journal 1998) 2 3 4 22 58
- Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. (PMID: 14697522) Sun YP … Zhao S (Gene 2004) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Association and interaction analyses of eight genes under asthma linkage peaks. (PMID: 19824886) Ferreira MA … Duffy DL (Allergy 2009) 3 44 58
- ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism. (PMID: 10749942) Cal S … López-Otín C (Molecular biology of the cell 2000) 3 4 58
Products for ADAM23 Gene
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- VectorBuilder custom plasmid, inducible vectors for ADAM23
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAM23
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 75 available Adam23 Antibodies ranked by validation data
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- antibodies-online: Search results for 4 available Adam23 Proteins ranked by validation data
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- Quality Products:
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- Overview of 89 available Adam23 gene related products
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- Overview of 89 available Adam23 gene related products
Sources for ADAM23 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
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