Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAM23 Gene

Aliases for ADAM23 Gene

  • ADAM Metallopeptidase Domain 23 2 3 5
  • Metalloproteinase-Like, Disintegrin-Like, And Cysteine-Rich Protein 3 3 4
  • MDC-3 3 4
  • MDC3 3 4
  • A Disintegrin And Metalloproteinase Domain 23 2
  • ADAM 23 4

External Ids for ADAM23 Gene

Previous GeneCards Identifiers for ADAM23 Gene

  • GC02P205525
  • GC02P206032
  • GC02P207272
  • GC02P207510
  • GC02P207133
  • GC02P207018
  • GC02P199158

Summaries for ADAM23 Gene

Entrez Gene Summary for ADAM23 Gene

  • This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]

GeneCards Summary for ADAM23 Gene

ADAM23 (ADAM Metallopeptidase Domain 23) is a Protein Coding gene. Among its related pathways are Developmental Biology and LGI-ADAM interactions. GO annotations related to this gene include metalloendopeptidase activity and metallopeptidase activity. An important paralog of this gene is ADAM18.

UniProtKB/Swiss-Prot for ADAM23 Gene

  • May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.

Gene Wiki entry for ADAM23 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAM23 Gene

Genomics for ADAM23 Gene

Regulatory Elements for ADAM23 Gene

Promoters for ADAM23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAM23 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAM23 Gene

Chromosome:
2
Start:
206,443,539 bp from pter
End:
206,621,130 bp from pter
Size:
177,592 bases
Orientation:
Plus strand

Genomic View for ADAM23 Gene

Genes around ADAM23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAM23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAM23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAM23 Gene

Proteins for ADAM23 Gene

  • Protein details for ADAM23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75077-ADA23_HUMAN
    Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 23
    Protein Accession:
    O75077
    Secondary Accessions:
    • A2RU59

    Protein attributes for ADAM23 Gene

    Size:
    832 amino acids
    Molecular mass:
    91926 Da
    Quaternary structure:
    • Can bind to LGI1 and LGI4 (By similarity). Ligand for integrin alpha-V/beta-3.

    Alternative splice isoforms for ADAM23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAM23 Gene

Proteomics data for ADAM23 Gene at MOPED

Post-translational modifications for ADAM23 Gene

  • Glycosylation at Asn 76, Asn 96, Asn 100, Asn 263, Asn 547, Asn 548, Asn 664, and Asn 732
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAM23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAM23 Gene

Domains & Families for ADAM23 Gene

Gene Families for ADAM23 Gene

Suggested Antigen Peptide Sequences for ADAM23 Gene

Graphical View of Domain Structure for InterPro Entry

O75077

UniProtKB/Swiss-Prot:

ADA23_HUMAN :
  • A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
Domain:
  • A conserved motif AVN[ED]CD within the disintegrin-like domain could be involved in the binding to the integrin receptor.
  • Contains 1 disintegrin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 peptidase M12B domain.
genes like me logo Genes that share domains with ADAM23: view

Function for ADAM23 Gene

Molecular function for ADAM23 Gene

GENATLAS Biochemistry:
a disintegrin and metalloprotease domain 23,membrane anchored cell surface adhesion protein,expressed in the brain
UniProtKB/Swiss-Prot Function:
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.

Gene Ontology (GO) - Molecular Function for ADAM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
genes like me logo Genes that share ontologies with ADAM23: view
genes like me logo Genes that share phenotypes with ADAM23: view

Animal Models for ADAM23 Gene

MGI Knock Outs for ADAM23:

Animal Model Products

miRNA for ADAM23 Gene

miRTarBase miRNAs that target ADAM23

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADAM23 Gene

Localization for ADAM23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAM23 Gene

Cell membrane; Single-pass type I membrane protein.
Isoform Gamma: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAM23 Gene COMPARTMENTS Subcellular localization image for ADAM23 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ADAM23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ADAM23: view

Pathways & Interactions for ADAM23 Gene

genes like me logo Genes that share pathways with ADAM23: view

Pathways by source for ADAM23 Gene

2 Reactome pathways for ADAM23 Gene

Gene Ontology (GO) - Biological Process for ADAM23 Gene

None

No data available for SIGNOR curated interactions for ADAM23 Gene

Drugs & Compounds for ADAM23 Gene

(1) Additional Compounds for ADAM23 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAM23: view

Transcripts for ADAM23 Gene

Unigene Clusters for ADAM23 Gene

ADAM metallopeptidase domain 23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAM23 Gene

No ASD Table

Relevant External Links for ADAM23 Gene

GeneLoc Exon Structure for
ADAM23
ECgene alternative splicing isoforms for
ADAM23

Expression for ADAM23 Gene

mRNA expression in normal human tissues for ADAM23 Gene

mRNA differential expression in normal tissues according to GTEx for ADAM23 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6), Brain - Nucleus accumbens (basal ganglia) (x4.5), Heart - Left Ventricle (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for ADAM23 Gene

This gene is overexpressed in Frontal cortex (50.8), Brain (8.8), and Spinal cord (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAM23 Gene



SOURCE GeneReport for Unigene cluster for ADAM23 Gene Hs.591643

mRNA Expression by UniProt/SwissProt for ADAM23 Gene

O75077-ADA23_HUMAN
Tissue specificity: Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.
genes like me logo Genes that share expression patterns with ADAM23: view

Protein tissue co-expression partners for ADAM23 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ADAM23 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAM23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAM23 35
  • 92.31 (n)
  • 94.23 (a)
ADAM23 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAM23 35
  • 92.95 (n)
  • 95.28 (a)
ADAM23 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adam23 35
  • 88.77 (n)
  • 93.84 (a)
Adam23 16
Adam23 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAM23 35
  • 99.88 (n)
  • 100 (a)
ADAM23 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adam23 35
  • 87.6 (n)
  • 91.91 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAM23 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAM23 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAM23 35
  • 77.97 (n)
  • 81.02 (a)
ADAM23 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAM23 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adam23 35
  • 71.57 (n)
  • 74.09 (a)
Str.12051 35
zebrafish
(Danio rerio)
Actinopterygii wu:fj40f01 35
  • 65.73 (n)
  • 66.06 (a)
ADAM23 (2 of 2) 36
  • 67 (a)
OneToMany
adam23a 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mmd 37
  • 32 (a)
mmd 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea adm-1 37
  • 30 (a)
unc-71 36
  • 19 (a)
OneToMany
Species with no ortholog for ADAM23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAM23 Gene

ENSEMBL:
Gene Tree for ADAM23 (if available)
TreeFam:
Gene Tree for ADAM23 (if available)

Paralogs for ADAM23 Gene

Paralogs for ADAM23 Gene

genes like me logo Genes that share paralogs with ADAM23: view

Variants for ADAM23 Gene

Sequence variations from dbSNP and Humsavar for ADAM23 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs759844 -- 206,564,144(-) ATATA(G/T)AGAGA intron-variant
rs759845 -- 206,531,504(-) AGATA(C/T)CCAAG intron-variant
rs733237 -- 206,522,979(-) GTTTC(A/G)TTTCT intron-variant
rs918800 -- 206,529,224(-) CAGTA(C/T)TTAAC intron-variant
rs1013475 -- 206,562,949(-) GTCTT(C/T)CTATC intron-variant

Variation tolerance for ADAM23 Gene

Residual Variation Intolerance Score: 9.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 31.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAM23 Gene

HapMap Linkage Disequilibrium report
ADAM23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADAM23 Gene

Disorders for ADAM23 Gene

Relevant External Links for ADAM23

Genetic Association Database (GAD)
ADAM23
Human Genome Epidemiology (HuGE) Navigator
ADAM23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAM23

No disorders were found for ADAM23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAM23 Gene

Publications for ADAM23 Gene

  1. Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain. (PMID: 9693107) Sagane K. … Tanaka I. (Biochem. J. 1998) 2 3 4 23 67
  2. Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains. (PMID: 14697522) Sun Y.P. … Zhao S. (Gene 2004) 3 23
  3. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. (PMID: 24662834) Costa E.T. … Camargo A.A. (Oncogene 2015) 3
  4. CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers. (PMID: 25620615) Fridrichova I. … Danihel L. (Transl Res 2015) 3
  5. Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome. (PMID: 25740824) Yamanoi K. … Kanai Y. (Carcinogenesis 2015) 3

Products for ADAM23 Gene

Sources for ADAM23 Gene

Back to Top

Content