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Aliases for TNFSF13 Gene

Aliases for TNFSF13 Gene

  • Tumor Necrosis Factor (Ligand) Superfamily, Member 13 2 3
  • TNF- And APOL-Related Leukocyte Expressed Ligand 2 3 4
  • A Proliferation-Inducing Ligand 3 4
  • TALL-2 3 4
  • TRDL-1 3 4
  • APRIL 3 4
  • TALL2 3 4
  • ZTNF2 3 4
  • Tumor Necrosis Factor Ligand Superfamily Member 13 3
  • Tumor Necrosis Factor-Related Death Ligand-1 3
  • Tumor Necrosis Factor-Like Protein ZTNF2 3
  • TNF-Related Death Ligand 1 4
  • UNQ383/PRO715 3
  • CD256 Antigen 4
  • CD256 3

External Ids for TNFSF13 Gene

Previous GeneCards Identifiers for TNFSF13 Gene

  • GC17P007876
  • GC17P008201
  • GC17P007396
  • GC17P007653
  • GC17P007654
  • GC17P007397
  • GC17P007398
  • GC17P007399
  • GC17P007402
  • GC17P007392
  • GC17P007461
  • GC17P007355

Summaries for TNFSF13 Gene

Entrez Gene Summary for TNFSF13 Gene

  • The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

GeneCards Summary for TNFSF13 Gene

TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13) is a Protein Coding gene. Diseases associated with TNFSF13 include brain glioblastoma multiforme and glioblastoma multiforme. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and tumor necrosis factor receptor binding. An important paralog of this gene is TNFSF13B.

UniProtKB/Swiss-Prot for TNFSF13 Gene

  • Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.

Gene Wiki entry for TNFSF13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNFSF13 Gene

Genomics for TNFSF13 Gene

Regulatory Elements for TNFSF13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TNFSF13 Gene

7,558,292 bp from pter
7,561,608 bp from pter
3,317 bases
Plus strand

Genomic View for TNFSF13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TNFSF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNFSF13 Gene

Proteins for TNFSF13 Gene

  • Protein details for TNFSF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor necrosis factor ligand superfamily member 13
    Protein Accession:
    Secondary Accessions:
    • A8MYD5
    • B4DVT2
    • Q541E1
    • Q5U0G8
    • Q96HV6
    • Q9P1M8
    • Q9P1M9

    Protein attributes for TNFSF13 Gene

    250 amino acids
    Molecular mass:
    27433 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for TNFSF13 Gene

neXtProt entry for TNFSF13 Gene

Proteomics data for TNFSF13 Gene at MOPED

Post-translational modifications for TNFSF13 Gene

Antibody Products

  • R&D Systems Antibodies for TNFSF13 (APRIL/TNFSF13)

Protein Products

  • Cloud-Clone Corp. Proteins for TNFSF13

No data available for DME Specific Peptides for TNFSF13 Gene

Domains for TNFSF13 Gene

Gene Families for TNFSF13 Gene

  • CD :CD molecules
  • TNFSF :Tumor necrosis factor (ligand) superfamily

Protein Domains for TNFSF13 Gene

Graphical View of Domain Structure for InterPro Entry



  • O75888
  • Belongs to the tumor necrosis factor family.
genes like me logo Genes that share domains with TNFSF13: view

Function for TNFSF13 Gene

Molecular function for TNFSF13 Gene

GENATLAS Biochemistry:
tumor necrosis factor,ligand,superfamily,member 13,highly expressed in transformed cell lines and in diverse human cancers putative regulator of tumor cell growth
UniProtKB/Swiss-Prot Function:
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
UniProtKB/Swiss-Prot Induction:
Down-regulated by phorbol myristate acetate/ionomycin treatment

Gene Ontology (GO) - Molecular Function for TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 9743536
GO:0005125 cytokine activity IEA --
GO:0005164 tumor necrosis factor receptor binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TNFSF13: view

Phenotypes for TNFSF13 Gene

genes like me logo Genes that share phenotypes with TNFSF13: view

Animal Models for TNFSF13 Gene

MGI Knock Outs for TNFSF13:

Animal Model Products

CRISPR Products

miRNA for TNFSF13 Gene

miRTarBase miRNAs that target TNFSF13

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TNFSF13 Gene

Localization for TNFSF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNFSF13 Gene


Subcellular locations from

Jensen Localization Image for TNFSF13 Gene COMPARTMENTS Subcellular localization image for TNFSF13 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 4
plasma membrane 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 19828625
GO:0005829 cytosol TAS --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with TNFSF13: view

Pathways for TNFSF13 Gene

genes like me logo Genes that share pathways with TNFSF13: view

PCR Array Products

Gene Ontology (GO) - Biological Process for TNFSF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002426 immunoglobulin production in mucosal tissue IEA --
GO:0002636 positive regulation of germinal center formation IEA --
GO:0006955 immune response --
GO:0007165 signal transduction TAS 9743536
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TNFSF13: view

Compounds for TNFSF13 Gene

(1) ApexBio Compounds for TNFSF13 Gene

Compound Action Cas Number
Pomalidomide (CC-4047) "Immunomodulator,antumor/anti-angiogenic" [19171-19-8]

(3) Novoseek inferred chemical compound relationships for TNFSF13 Gene

Compound -log(P) Hits PubMed IDs
bcma 97.6 52
blys 93.8 57
monopril 88 4
genes like me logo Genes that share compounds with TNFSF13: view

Transcripts for TNFSF13 Gene

Unigene Clusters for TNFSF13 Gene

Tumor necrosis factor (ligand) superfamily, member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TNFSF13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNFSF13 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^
SP1: - - - - - - - - - - - - -
SP2: -
SP4: - -
SP5: - -
SP6: - - -
SP8: -
SP9: - - - - -
SP10: - - - -
SP11: - - - -
SP12: -

ExUns: 16a · 16b ^ 17a · 17b · 17c · 17d
SP3: -

Relevant External Links for TNFSF13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TNFSF13 Gene

mRNA expression in normal human tissues for TNFSF13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TNFSF13 Gene

This gene is overexpressed in Milk (27.1), Peripheral blood mononuclear cells (26.5), and Saliva (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TNFSF13 Gene

SOURCE GeneReport for Unigene cluster for TNFSF13 Gene Hs.54673

mRNA Expression by UniProt/SwissProt for TNFSF13 Gene

Tissue specificity: Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages
genes like me logo Genes that share expressions with TNFSF13: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for TNFSF13 Gene

Orthologs for TNFSF13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNFSF13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TNFSF13 35
  • 86.67 (n)
  • 83.6 (a)
TNFSF13 36
  • 84 (a)
(Canis familiaris)
Mammalia TNFSF13 35
  • 88.67 (n)
  • 87.2 (a)
TNFSF12 36
  • 18 (a)
(Mus musculus)
Mammalia Tnfsf13 35
  • 82.22 (n)
  • 81.25 (a)
Tnfsf13 16
Tnfsf13 36
  • 80 (a)
(Pan troglodytes)
Mammalia TNFSF13 35
  • 99.87 (n)
  • 99.6 (a)
TNFSF13 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tnfsf13 35
  • 82.43 (n)
  • 79.92 (a)
(Monodelphis domestica)
Mammalia TNFSF13 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730941 35
  • 49.3 (n)
  • 38.6 (a)
(Danio rerio)
Actinopterygii tnfsf13 36
  • 32 (a)
Species with no ortholog for TNFSF13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNFSF13 Gene

Gene Tree for TNFSF13 (if available)
Gene Tree for TNFSF13 (if available)

Paralogs for TNFSF13 Gene

Paralogs for TNFSF13 Gene

Selected SIMAP similar genes for TNFSF13 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TNFSF13: view

Variants for TNFSF13 Gene

Sequence variations from dbSNP and Humsavar for TNFSF13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_052586 -
VAR_052587 -

Structural Variations from Database of Genomic Variants (DGV) for TNFSF13 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
nsv907651 CNV Loss 21882294

Relevant External Links for TNFSF13 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNFSF13 Gene

Disorders for TNFSF13 Gene

(12) Novoseek inferred disease relationships for TNFSF13 Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 61.5 7
autoimmunity 60.3 3
necrosis 59.7 34
lupus erythematosus systemic 43.5 11
leukemia lymphocytic chronic 42.7 5

Relevant External Links for TNFSF13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TNFSF13: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for TNFSF13 Gene

Publications for TNFSF13 Gene

  1. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. (PMID: 9743536) Hahne M. … Tschopp J. (J. Exp. Med. 1998) 2 3 4 23
  2. APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. (PMID: 10706119) Kelly K.A. … Jones D.A. (Cancer Res. 2000) 3 4 23
  3. An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. (PMID: 12411489) Pradet-Balade B. … Hahne M. (EMBO J. 2002) 3 4 23
  4. A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus. (PMID: 12730512) Koyama T. … Horiuchi T. (Rheumatology (Oxford) 2003) 3 23 48
  5. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. (PMID: 17307753) Kawasaki A. … Tokunaga K. (Rheumatology (Oxford) 2007) 3 23 48

Products for TNFSF13 Gene

Sources for TNFSF13 Gene

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