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Aliases for RIPK1 Gene

Aliases for RIPK1 Gene

  • Receptor Interacting Serine/Threonine Kinase 1 2 3 5
  • Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1 2 3
  • Receptor-Interacting Protein Kinase 1 2 3
  • Serine/Threonine-Protein Kinase RIP 3 4
  • Receptor-Interacting Protein 1 3 4
  • Cell Death Protein RIP 3 4
  • RIP-1 3 4
  • RIP1 3 4
  • RIP 3 4
  • Receptor-Interacting Serine/Threonine-Protein Kinase 1 3
  • EC 2.7.11.1 4

External Ids for RIPK1 Gene

Previous GeneCards Identifiers for RIPK1 Gene

  • GC06P003062
  • GC06P003022
  • GC06P002949

Summaries for RIPK1 Gene

GeneCards Summary for RIPK1 Gene

RIPK1 (Receptor Interacting Serine/Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are TRAF Pathway and Apoptosis and survival Caspase cascade. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is ANKK1.

UniProtKB/Swiss-Prot for RIPK1 Gene

  • Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via Lys-63-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Gene Wiki entry for RIPK1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPK1 Gene

Genomics for RIPK1 Gene

Regulatory Elements for RIPK1 Gene

Enhancers for RIPK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G002979 2.1 FANTOM5 Ensembl ENCODE dbSUPER 28.7 -77.8 -77848 13.6 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 RIPK1 ENSG00000272320 NQO2 PSMG4 LOC105374888 SERPINB9 SERPINB6 ENSG00000232999 WRNIP1 ENSG00000228170
GH06G004017 1.5 ENCODE dbSUPER 39.1 +956.6 956560 7.0 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF548 RIPK1 PSMG4 FAM50B ENSG00000230648 LYRM4-AS1 C6orf201 ENSG00000272248
GH06G003156 2 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +98.1 98141 11.6 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 TUBB2A TUBB2B TUBB2BP1 PSMG4 RIPK1 BPHL LOC105374889
GH06G003052 1.6 Ensembl ENCODE dbSUPER 15.3 -10.0 -9967 2.4 HDGF FOXA2 PKNOX1 CREB3L1 ARNT AGO1 SIN3A ARID4B DMAP1 CBX5 ENSG00000272277 RIPK1 ENSG00000229282 SERPINB8P1
GH06G002845 1.5 Ensembl ENCODE dbSUPER 15 -217.4 -217394 1.7 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B DMAP1 ZNF2 YY1 GTF3C2 SERPINB9 RIPK1 ENSG00000232999 NQO2 LINC01011 SERPINB6 WRNIP1 MYLK4 SERPINB1 MIR4645
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RIPK1 on UCSC Golden Path with GeneCards custom track

Promoters for RIPK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000192172 233 1601 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 CBX5 ZNF263

Genomic Location for RIPK1 Gene

Chromosome:
6
Start:
3,063,967 bp from pter
End:
3,115,187 bp from pter
Size:
51,221 bases
Orientation:
Plus strand

Genomic View for RIPK1 Gene

Genes around RIPK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPK1 Gene

Proteins for RIPK1 Gene

  • Protein details for RIPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13546-RIPK1_HUMAN
    Recommended name:
    Receptor-interacting serine/threonine-protein kinase 1
    Protein Accession:
    Q13546
    Secondary Accessions:
    • A0AV89
    • B2RAG1
    • B4E3F9
    • Q13180
    • Q59H33

    Protein attributes for RIPK1 Gene

    Size:
    671 amino acids
    Molecular mass:
    75931 Da
    Quaternary structure:
    • Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif). Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1 (By similarity). Interacts with ZBP1 (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK3 and MLKL. Interacts (via kinase domain) with DAB2IP (via Ras-GAP domain); the interaction occurs in a TNF-alpha-dependent manner. Interacts with ARHGEF2. Interacts (via protein kinase domain) with RFFL; involved in RIPK1 ubiquitination. Interacts with RNF34; involved in RIPK1 ubiquitination. Interacts with TICAM1 and this interaction is enhanced in the presence of WDFY1 (PubMed:25736436).
    SequenceCaution:
    • Sequence=BAG65471.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIPK1 Gene

    Alternative splice isoforms for RIPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPK1 Gene

Post-translational modifications for RIPK1 Gene

  • Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apoptotic signaling through the TRADD-FADD interaction.
  • RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-161 by RIPK3 is necessary for the formation of the necroptosis-inducing complex.
  • Ubiquitinated by Lys-11-, Lys-48-, Lys-63- and linear-linked type ubiquitin. Polyubiquitination with Lys-63-linked chains by TRAF2 induces association with the IKK complex. Deubiquitination of Lys-63-linked chains and polyubiquitination with Lys-48-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and consequently down-regulates TNF-alpha-induced NFkappa-B signaling. Lys-48-linked polyubiquitination by RFFL or RNF34 also promotes proteasomal degradation and negatively regulates TNF-alpha-induced NFkappa-B signaling. Linear polyubiquitinated; the head-to-tail polyubiquitination is mediated by the LUBAC complex. LPS-mediated activation of NF-kappa-B. Also ubiquitinated with Lys-11-linked chains. Polyubiquitinated with Lys-48 and Lys-63-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
  • Ubiquitination at isoforms=2377
  • Modification sites at PhosphoSitePlus

Other Protein References for RIPK1 Gene

No data available for DME Specific Peptides for RIPK1 Gene

Domains & Families for RIPK1 Gene

Suggested Antigen Peptide Sequences for RIPK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13546

UniProtKB/Swiss-Prot:

RIPK1_HUMAN :
  • Contains a C-terminal death domain (DD) that engages other DD-containing proteins as well as a central (intermediate) region important for NF-kB activation and RHIM-dependent signaling.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • Contains a C-terminal death domain (DD) that engages other DD-containing proteins as well as a central (intermediate) region important for NF-kB activation and RHIM-dependent signaling.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with RIPK1: view

Function for RIPK1 Gene

Molecular function for RIPK1 Gene

GENATLAS Biochemistry:
receptor interacting serine-threonine kinase 1,expressed in brain,small intestine,testis,interacting weakly with TNFRSF1A,associating with the intracellular domain of TNFRSF6 (CD95,FAS)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by necrostatins, including necrostatin-1, necrostatin-3 and necrostatin-4.
UniProtKB/Swiss-Prot Function:
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via Lys-63-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Enzyme Numbers (IUBMB) for RIPK1 Gene

Gene Ontology (GO) - Molecular Function for RIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IMP 22817896
GO:0004674 protein serine/threonine kinase activity IDA,IEA 8612133
GO:0004871 signal transducer activity IBA --
GO:0005123 death receptor binding IPI 7538908
GO:0005515 protein binding IPI 10356400
genes like me logo Genes that share ontologies with RIPK1: view
genes like me logo Genes that share phenotypes with RIPK1: view

Animal Models for RIPK1 Gene

MGI Knock Outs for RIPK1:

Animal Model Products

CRISPR Products

miRNA for RIPK1 Gene

miRTarBase miRNAs that target RIPK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RIPK1 Gene

Localization for RIPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPK1 Gene

Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPK1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
cytosol 5
nucleus 4
extracellular 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA 16507998
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RIPK1: view

Pathways & Interactions for RIPK1 Gene

SuperPathways for RIPK1 Gene

SuperPathway Contained pathways
1 TNFR1 Pathway
2 Dimerization of procaspase-8
3 Activated TLR4 signalling
4 Apoptosis Modulation and Signaling
.41
.33
5 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
genes like me logo Genes that share pathways with RIPK1: view

Pathways by source for RIPK1 Gene

SIGNOR curated interactions for RIPK1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 17389591
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IMP 21737330
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS --
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with RIPK1: view

Drugs & Compounds for RIPK1 Gene

(11) Drugs for RIPK1 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Necrostatin-1 Pharma RIP1 inhibitor 0

(7) Additional Compounds for RIPK1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for RIPK1 Gene

Compound Action Cas Number
Necrostatin-1 RIP1 inhibitor 4311-88-0
genes like me logo Genes that share compounds with RIPK1: view

Drug Products

Transcripts for RIPK1 Gene

Unigene Clusters for RIPK1 Gene

Receptor (TNFRSF)-interacting serine-threonine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RIPK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for RIPK1 Gene

GeneLoc Exon Structure for
RIPK1
ECgene alternative splicing isoforms for
RIPK1

Expression for RIPK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RIPK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.0) and Plasma (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RIPK1 Gene



Protein tissue co-expression partners for RIPK1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RIPK1 Gene:

RIPK1

SOURCE GeneReport for Unigene cluster for RIPK1 Gene:

Hs.519842

Evidence on tissue expression from TISSUES for RIPK1 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Heart(4.4)
  • Adrenal gland(4.2)
  • Blood(2.1)
  • Intestine(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with RIPK1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPK1 Gene

Orthologs for RIPK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RIPK1 34 35
  • 99.25 (n)
dog
(Canis familiaris)
Mammalia RIPK1 34 35
  • 84.31 (n)
cow
(Bos Taurus)
Mammalia RIPK1 34 35
  • 79.85 (n)
mouse
(Mus musculus)
Mammalia Ripk1 34 16 35
  • 79.08 (n)
rat
(Rattus norvegicus)
Mammalia Ripk1 34
  • 79.08 (n)
oppossum
(Monodelphis domestica)
Mammalia RIPK1 35
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIPK1 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIPK1 34 35
  • 60.05 (n)
lizard
(Anolis carolinensis)
Reptilia RIPK1 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ripk1 34
  • 56 (n)
zebrafish
(Danio rerio)
Actinopterygii ripk1l 34 35
  • 51.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToOne
Species where no ortholog for RIPK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIPK1 Gene

ENSEMBL:
Gene Tree for RIPK1 (if available)
TreeFam:
Gene Tree for RIPK1 (if available)

Paralogs for RIPK1 Gene

Paralogs for RIPK1 Gene

genes like me logo Genes that share paralogs with RIPK1: view

Variants for RIPK1 Gene

Sequence variations from dbSNP and Humsavar for RIPK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs758268804 A colorectal adenocarcinoma sample 3,077,855(+) TGGGC(A/G)TCATC reference, missense, utr-variant-5-prime
rs759012409 A colorectal adenocarcinoma sample 3,083,284(+) CTGGG(C/T)GATAT reference, missense
rs774996232 A colorectal adenocarcinoma sample 3,077,805(+) GGAGG(C/T)GAAGA reference, missense, utr-variant-5-prime
rs1000095415 -- 3,068,930(+) CGGGG(G/T)GCGCG intron-variant
rs1000126978 -- 3,109,862(+) GGTAC(C/G)TCATG intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for RIPK1 Gene

Variant ID Type Subtype PubMed ID
esv1036383 CNV deletion 17803354
esv23861 CNV loss 19812545
esv25797 CNV gain 19812545
nsv1126743 CNV deletion 24896259
nsv600834 CNV loss 21841781
nsv950762 CNV deletion 24416366

Variation tolerance for RIPK1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RIPK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPK1 Gene

Disorders for RIPK1 Gene

Relevant External Links for RIPK1

Genetic Association Database (GAD)
RIPK1
Human Genome Epidemiology (HuGE) Navigator
RIPK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RIPK1

No disorders were found for RIPK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIPK1 Gene

Publications for RIPK1 Gene

  1. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PMID: 8612133) Hsu H. … Goeddel D.V. (Immunity 1996) 2 3 4 22 64
  2. CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation. (PMID: 18450452) Liao W. … Srinivasula S.M. (Curr. Biol. 2008) 3 4 22 64
  3. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1- triggered NF-kappaB activation by targeting TAB2/3 for degradation. (PMID: 17449468) Tian Y. … Shu H.B. (J. Biol. Chem. 2007) 3 4 22 64
  4. Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. (PMID: 11734559) Sun X. … Dixit V.M. (J. Biol. Chem. 2002) 3 4 22 64
  5. The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome. (PMID: 11116146) Habib A.A. … Vartanian T. (J. Biol. Chem. 2001) 3 4 22 64

Products for RIPK1 Gene

Sources for RIPK1 Gene

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