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Aliases for RIPK1 Gene

Aliases for RIPK1 Gene

  • Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1 2 3
  • Serine/Threonine-Protein Kinase RIP 3 4
  • Receptor-Interacting Protein 1 3 4
  • Cell Death Protein RIP 3 4
  • RIP-1 3 4
  • RIP1 3 4
  • RIP 3 4
  • Receptor-Interacting Serine/Threonine-Protein Kinase 1 3
  • Receptor Interacting Protein 3
  • EC 2.7.11.1 4

External Ids for RIPK1 Gene

Previous GeneCards Identifiers for RIPK1 Gene

  • GC06P003062
  • GC06P003022
  • GC06P002949

Summaries for RIPK1 Gene

GeneCards Summary for RIPK1 Gene

RIPK1 (Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is RIPK3.

UniProtKB/Swiss-Prot for RIPK1 Gene

  • Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via Lys-63-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Gene Wiki entry for RIPK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIPK1 Gene

Genomics for RIPK1 Gene

Regulatory Elements for RIPK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RIPK1 Gene

Start:
3,063,967 bp from pter
End:
3,115,187 bp from pter
Size:
51,221 bases
Orientation:
Plus strand

Genomic View for RIPK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RIPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPK1 Gene

Proteins for RIPK1 Gene

  • Protein details for RIPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13546-RIPK1_HUMAN
    Recommended name:
    Receptor-interacting serine/threonine-protein kinase 1
    Protein Accession:
    Q13546
    Secondary Accessions:
    • A0AV89
    • B2RAG1
    • B4E3F9
    • Q13180
    • Q59H33

    Protein attributes for RIPK1 Gene

    Size:
    671 amino acids
    Molecular mass:
    75931 Da
    Quaternary structure:
    • Interacts (via RIP homotypic interaction motif) with RIPK3 (via RIP homotypic interaction motif). Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity. Interacts (via the death domain) with TNFRSF6 (via the death domain) and TRADD (via the death domain). Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RNF216, EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interact with MAVS/IPS1. Interacts with ZFAND5. Interacts with RBCK1 (By similarity). Interacts with ZBP1 (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK3 and MLKL. Interacts (via kinase domain) with DAB2IP (via Ras-GAP domain); the interaction occurs in a TNF-alpha-dependent manner. Interacts with ARHGEF2. Interacts (via protein kinase domain) with RFFL; involved in RIPK1 ubiquitination. Interacts with RNF34; involved in RIPK1 ubiquitination.
    SequenceCaution:
    • Sequence=BAG65471.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RIPK1 Gene

    Alternative splice isoforms for RIPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPK1 Gene

Proteomics data for RIPK1 Gene at MOPED

Post-translational modifications for RIPK1 Gene

  • Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apoptotic signaling through the TRADD-FADD interaction.
  • RIPK1 and RIPK3 undergo reciprocal auto- and trans-phosphorylation. Phosphorylation of Ser-161 by RIPK3 is necessary for the formation of the necroptosis-inducing complex.
  • Ubiquitinated by Lys-11-, Lys-48-, Lys-63- and linear-linked type ubiquitin. Polyubiquitination with Lys-63-linked chains by TRAF2 induces association with the IKK complex. Deubiquitination of Lys-63-linked chains and polyubiquitination with Lys-48-linked chains by TNFAIP3 leads to RIPK1 proteasomal degradation and consequently down-regulates TNF-alpha-induced NFkappa-B signaling. Lys-48-linked polyubiquitination by RFFL or RNF34 also promotes proteasomal degradation and negatively regulates TNF-alpha-induced NFkappa-B signaling. Linear polyubiquitinated; the head-to-tail polyubiquitination is mediated by the LUBAC complex. LPS-mediated activation of NF-kappa-B. Also ubiquitinated with Lys-11-linked chains. Polyubiquitinated with Lys-48 and Lys-63-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B.
  • Ubiquitination at Lys377
  • Modification sites at PhosphoSitePlus

Other Protein References for RIPK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RIPK1 (RIPK1)

No data available for DME Specific Peptides for RIPK1 Gene

Domains for RIPK1 Gene

Suggested Antigen Peptide Sequences for RIPK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13546

UniProtKB/Swiss-Prot:

RIPK1_HUMAN :
  • Q13546
Domain:
  • Contains a C-terminal death domain (DD) that engages other DD-containing proteins as well as a central (intermediate) region important for NF-kB activation and RHIM-dependent signaling.
  • Contains 1 death domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with RIPK1: view

Function for RIPK1 Gene

Molecular function for RIPK1 Gene

GENATLAS Biochemistry:
receptor interacting serine-threonine kinase 1,expressed in brain,small intestine,testis,interacting weakly with TNFRSF1A,associating with the intracellular domain of TNFRSF6 (CD95,FAS)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by necrostatins, including necrostatin-1, necrostatin-3 and necrostatin-4.
UniProtKB/Swiss-Prot Function:
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at Ser-728 in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via Lys-63-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

Enzyme Numbers (IUBMB) for RIPK1 Gene

Gene Ontology (GO) - Molecular Function for RIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IMP 22817896
GO:0004674 protein serine/threonine kinase activity IDA 23473668
GO:0004713 protein tyrosine kinase activity --
GO:0005123 death receptor binding IPI 7538908
GO:0005515 protein binding IPI 10356400
genes like me logo Genes that share ontologies with RIPK1: view
genes like me logo Genes that share phenotypes with RIPK1: view

Animal Models for RIPK1 Gene

MGI Knock Outs for RIPK1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIPK1

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for RIPK1 Gene

Localization for RIPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIPK1 Gene

Cytoplasm. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RIPK1 Gene COMPARTMENTS Subcellular localization image for RIPK1 gene
Compartment Confidence
cytosol 4
mitochondrion 4
plasma membrane 4
nucleus 2
cytoskeleton 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 16507998
GO:0005829 cytosol TAS --
GO:0031264 death-inducing signaling complex IDA 11101870
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with RIPK1: view

Pathways for RIPK1 Gene

genes like me logo Genes that share pathways with RIPK1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for RIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 17389591
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation --
GO:0006915 apoptotic process TAS --
genes like me logo Genes that share ontologies with RIPK1: view

Compounds for RIPK1 Gene

Compound Products

(1) ApexBio Compounds for RIPK1 Gene

Compound Action Cas Number
Necrostatin-1 RIP1 inhibitor [4311-88-0]

(2) HMDB Compounds for RIPK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(15) Novoseek inferred chemical compound relationships for RIPK1 Gene

Compound -log(P) Hits PubMed IDs
tab-2 64 2
geldanamycin 57.1 4
cycloheximide 16.5 2
threonine 16.4 2
adriamycin 15.1 1
genes like me logo Genes that share compounds with RIPK1: view

Transcripts for RIPK1 Gene

Unigene Clusters for RIPK1 Gene

Receptor (TNFRSF)-interacting serine-threonine kinase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RIPK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIPK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for RIPK1 Gene

GeneLoc Exon Structure for
RIPK1
ECgene alternative splicing isoforms for
RIPK1

Expression for RIPK1 Gene

mRNA expression in normal human tissues for RIPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RIPK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.0) and Plasma (12.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RIPK1 Gene

SOURCE GeneReport for Unigene cluster for RIPK1 Gene Hs.519842

genes like me logo Genes that share expressions with RIPK1: view

Expression partners for RIPK1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RIPK1 Gene

Orthologs for RIPK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RIPK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RIPK1 35
  • 79.85 (n)
  • 75.19 (a)
RIPK1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RIPK1 35
  • 84.31 (n)
  • 79.19 (a)
RIPK1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ripk1 35
  • 79.08 (n)
  • 71.6 (a)
Ripk1 16
Ripk1 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RIPK1 35
  • 99.25 (n)
  • 99.4 (a)
RIPK1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ripk1 35
  • 79.08 (n)
  • 71.73 (a)
oppossum
(Monodelphis domestica)
Mammalia RIPK1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RIPK1 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves RIPK1 35
  • 60.05 (n)
  • 51.64 (a)
RIPK1 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RIPK1 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ripk1 35
  • 56 (n)
  • 48.73 (a)
zebrafish
(Danio rerio)
Actinopterygii ripk1l 35
  • 51.71 (n)
  • 43.09 (a)
ripk1l 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for RIPK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RIPK1 Gene

ENSEMBL:
Gene Tree for RIPK1 (if available)
TreeFam:
Gene Tree for RIPK1 (if available)

Paralogs for RIPK1 Gene

Paralogs for RIPK1 Gene

genes like me logo Genes that share paralogs with RIPK1: view

Variants for RIPK1 Gene

Sequence variations from dbSNP and Humsavar for RIPK1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs12478 -- 3,113,876(+) GTCAG(A/T)TTCTA utr-variant-3-prime
rs909966 -- 3,085,243(+) AAGAA(A/C)GTCTT intron-variant
rs1406820 -- 3,085,774(-) AGGAT(A/G)GGGGC intron-variant
rs1406821 -- 3,085,773(-) GGATA(A/G)GGGCT intron-variant
rs1983606 -- 3,114,726(-) CCCAG(C/G)CCGAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RIPK1 Gene

Variant ID Type Subtype PubMed ID
esv25797 CNV Gain 19812545
esv23861 CNV Loss 19812545
nsv883403 CNV Gain+Loss 21882294
nsv883404 CNV Loss 21882294
esv1036383 CNV Deletion 17803354

Relevant External Links for RIPK1 Gene

HapMap Linkage Disequilibrium report
RIPK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPK1 Gene

Disorders for RIPK1 Gene

(9) Novoseek inferred disease relationships for RIPK1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 72.4 30
tumors 54.4 27
colon cancer 23.7 1
inflammation 18.2 1
burkitt lymphoma 11.5 1

Relevant External Links for RIPK1

Genetic Association Database (GAD)
RIPK1
Human Genome Epidemiology (HuGE) Navigator
RIPK1
genes like me logo Genes that share disorders with RIPK1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for RIPK1 Gene

Publications for RIPK1 Gene

  1. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. (PMID: 8612133) Hsu H. … Goeddel D.V. (Immunity 1996) 2 3 4 23
  2. Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. (PMID: 9927690) Li Y. … Horwitz M.S. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4 23
  3. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. (PMID: 10356400) Sanz L. … Moscat J. (EMBO J. 1999) 3 4 23
  4. RIP3, a novel apoptosis-inducing kinase. (PMID: 10358032) Sun X. … Dixit V.M. (J. Biol. Chem. 1999) 3 4 23
  5. The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation. (PMID: 10409763) Izumi K.M. … Kieff E.D. (Mol. Cell. Biol. 1999) 3 4 23

Products for RIPK1 Gene

  • Addgene plasmids for RIPK1

Sources for RIPK1 Gene

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