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Aliases for MARCO Gene

Aliases for MARCO Gene

  • Macrophage Receptor With Collagenous Structure 2 3 4 5
  • SCARA2 3 4
  • Scavenger Receptor Class A, Member 2 3
  • Scavenger Receptor Class A Member 2 4
  • Scavenger Receptor Class A 2
  • Member 2 2

External Ids for MARCO Gene

Previous GeneCards Identifiers for MARCO Gene

  • GC02P116905
  • GC02P117620
  • GC02P119606
  • GC02P119794
  • GC02P119415
  • GC02P112024

Summaries for MARCO Gene

Entrez Gene Summary for MARCO Gene

  • The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]

GeneCards Summary for MARCO Gene

MARCO (Macrophage Receptor With Collagenous Structure) is a Protein Coding gene. Diseases associated with MARCO include Spondylarthropathy and Waterhouse-Friderichsen Syndrome. Among its related pathways are A-beta Pathways: Uptake and Degradation and Phagosome. GO annotations related to this gene include transmembrane signaling receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is LOXL1.

UniProtKB/Swiss-Prot for MARCO Gene

  • Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

Gene Wiki entry for MARCO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MARCO Gene

Genomics for MARCO Gene

Regulatory Elements for MARCO Gene

Enhancers for MARCO Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MARCO on UCSC Golden Path with GeneCards custom track

Promoters for MARCO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MARCO on UCSC Golden Path with GeneCards custom track

Genomic Location for MARCO Gene

118,942,166 bp from pter
118,994,664 bp from pter
52,499 bases
Plus strand

Genomic View for MARCO Gene

Genes around MARCO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MARCO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MARCO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MARCO Gene

Proteins for MARCO Gene

  • Protein details for MARCO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Macrophage receptor MARCO
    Protein Accession:
    Secondary Accessions:
    • B4DW79
    • Q9Y5S3

    Protein attributes for MARCO Gene

    520 amino acids
    Molecular mass:
    52658 Da
    Quaternary structure:
    • Homotrimer. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands (By similarity).

    Alternative splice isoforms for MARCO Gene


neXtProt entry for MARCO Gene

Proteomics data for MARCO Gene at MOPED

Post-translational modifications for MARCO Gene

  • Glycosylation at Asn 83 and Asn 136
  • Modification sites at PhosphoSitePlus

Other Protein References for MARCO Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for MARCO

No data available for DME Specific Peptides for MARCO Gene

Domains & Families for MARCO Gene

Gene Families for MARCO Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 collagen-like domain.
  • Contains 1 collagen-like domain.
  • Contains 1 SRCR domain.
genes like me logo Genes that share domains with MARCO: view

Function for MARCO Gene

Molecular function for MARCO Gene

GENATLAS Biochemistry:
macrophage receptor with collagenous structure,constitutively expressed in macrophages of spleen and lymph nodes and in other tissues following systemic,bacterial infection
UniProtKB/Swiss-Prot Function:
Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.

Gene Ontology (GO) - Molecular Function for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005044 scavenger receptor activity IEA --
genes like me logo Genes that share ontologies with MARCO: view
genes like me logo Genes that share phenotypes with MARCO: view

Animal Models for MARCO Gene

MGI Knock Outs for MARCO:

Animal Model Products

  • Taconic Biosciences Mouse Models for MARCO

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MARCO Gene

Localization for MARCO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MARCO Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for MARCO Gene COMPARTMENTS Subcellular localization image for MARCO gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 9468508
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MARCO: view

Pathways & Interactions for MARCO Gene

genes like me logo Genes that share pathways with MARCO: view

Pathways by source for MARCO Gene

1 R&D Systems pathway for MARCO Gene
1 Qiagen pathway for MARCO Gene

Interacting Proteins for MARCO Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9UEW3-MARCO_HUMAN ENSP00000318916 for MARCO Gene via MINT STRING I2D

SIGNOR curated interactions for MARCO Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MARCO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043277 apoptotic cell clearance IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with MARCO: view

Drugs & Compounds for MARCO Gene

(2) Additional Compounds for MARCO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MARCO: view

Transcripts for MARCO Gene

Unigene Clusters for MARCO Gene

Macrophage receptor with collagenous structure:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MARCO Gene

No ASD Table

Relevant External Links for MARCO Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MARCO Gene

mRNA expression in normal human tissues for MARCO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MARCO Gene

This gene is overexpressed in Lung (x9.0), Whole Blood (x6.8), Spleen (x6.6), and Liver (x4.1).

Protein differential expression in normal tissues from HIPED for MARCO Gene

This gene is overexpressed in Urine (34.9), Plasma (10.3), and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MARCO Gene

SOURCE GeneReport for Unigene cluster for MARCO Gene Hs.67726

genes like me logo Genes that share expression patterns with MARCO: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MARCO Gene

Orthologs for MARCO Gene

This gene was present in the common ancestor of chordates.

Orthologs for MARCO Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MARCO 35
  • 79.87 (n)
  • 72.81 (a)
  • 66 (a)
(Mus musculus)
Mammalia Marco 35
  • 74.64 (n)
  • 67.9 (a)
Marco 16
Marco 36
  • 62 (a)
(Pan troglodytes)
Mammalia MARCO 35
  • 98.46 (n)
  • 97.88 (a)
  • 91 (a)
(Rattus norvegicus)
Mammalia Marco 35
  • 74.32 (n)
  • 67.51 (a)
(Bos Taurus)
Mammalia MARCO 36
  • 54 (a)
(Monodelphis domestica)
Mammalia MARCO 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia MARCO 36
  • 46 (a)
(Gallus gallus)
Aves MARCO 35
  • 53.87 (n)
  • 43.75 (a)
  • 37 (a)
(Anolis carolinensis)
Reptilia MARCO 36
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492872 35
  • 58.38 (n)
  • 50.89 (a)
(Danio rerio)
Actinopterygii LOC571584 35
  • 46.57 (n)
  • 42.86 (a)
marco 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for MARCO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MARCO Gene

Gene Tree for MARCO (if available)
Gene Tree for MARCO (if available)

Paralogs for MARCO Gene

Paralogs for MARCO Gene

genes like me logo Genes that share paralogs with MARCO: view

Variants for MARCO Gene

Sequence variations from dbSNP and Humsavar for MARCO Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6761637 - 118,981,487(+) TGACT(C/T)CGGGA reference, missense
rs767882 -- 118,984,970(+) AGTGC(A/G)TTGGC intron-variant
rs1583780 -- 118,964,662(+) GTGGG(C/T)GGATC intron-variant
rs1813376 -- 118,955,641(+) ctaga(C/T)acatt intron-variant
rs1813638 -- 118,948,409(+) TTACA(A/G)AAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MARCO Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
esv2380956 CNV Deletion 18987734
esv2720622 CNV Deletion 23290073
esv2544799 CNV Deletion 19546169
esv2660693 CNV Deletion 23128226
nsv522323 CNV Loss 19592680
esv2720623 CNV Deletion 23290073
nsv528763 CNV Loss 19592680
nsv527208 CNV Loss 19592680

Variation tolerance for MARCO Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MARCO Gene

Disorders for MARCO Gene

MalaCards: The human disease database

(2) MalaCards diseases for MARCO Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • spondylarthropathies
waterhouse-friderichsen syndrome
  • wolfram syndrome
- elite association - COSMIC cancer census association via MalaCards
Search MARCO in MalaCards View complete list of genes associated with diseases

Relevant External Links for MARCO

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MARCO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MARCO Gene

Publications for MARCO Gene

  1. Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. (PMID: 10331948) Kangas M. … Tryggvason K. (Genomics 1999) 2 3 4 23 67
  2. Structure of the human macrophage MARCO receptor and characterization of its bacteria-binding region. (PMID: 9468508) Elomaa O. … Tryggvason K. (J. Biol. Chem. 1998) 2 3 23
  3. Pivotal Advance: Expansion of small sputum macrophages in CF: failure to express MARCO and mannose receptors. (PMID: 19403625) Wright A.K. … Ziegler-Heitbrock L. (J. Leukoc. Biol. 2009) 3 23
  4. Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO. (PMID: 11820786) BrAonnstrAPm A. … Pikkarainen T. (Biochem. Biophys. Res. Commun. 2002) 3 23
  5. Characterization of recombinant soluble macrophage scavenger receptor MARCO. (PMID: 12097327) Sankala M. … Pikkarainen T. (J. Biol. Chem. 2002) 3 23

Products for MARCO Gene

Sources for MARCO Gene