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Aliases for STX10 Gene

Aliases for STX10 Gene

  • Syntaxin 10 2 3 5
  • SYN10 3 4
  • Hsyn10 3

External Ids for STX10 Gene

Previous GeneCards Identifiers for STX10 Gene

  • GC19M013587
  • GC19M013100
  • GC19M013116
  • GC19M013115
  • GC19M013254
  • GC19M012827

Summaries for STX10 Gene

Entrez Gene Summary for STX10 Gene

  • This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

GeneCards Summary for STX10 Gene

STX10 (Syntaxin 10) is a Protein Coding gene. Among its related pathways are Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics and Golgi-to-ER retrograde transport. GO annotations related to this gene include syntaxin binding and SNAP receptor activity. An important paralog of this gene is STX6.

UniProtKB/Swiss-Prot for STX10 Gene

  • SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Gene Wiki entry for STX10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STX10 Gene

Genomics for STX10 Gene

Regulatory Elements for STX10 Gene

Enhancers for STX10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around STX10 on UCSC Golden Path with GeneCards custom track

Promoters for STX10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around STX10 on UCSC Golden Path with GeneCards custom track

Genomic Location for STX10 Gene

13,144,058 bp from pter
13,151,334 bp from pter
7,277 bases
Minus strand

Genomic View for STX10 Gene

Genes around STX10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STX10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STX10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STX10 Gene

Proteins for STX10 Gene

  • Protein details for STX10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NC41
    • Q6IAP4
    • Q96AE8

    Protein attributes for STX10 Gene

    249 amino acids
    Molecular mass:
    28114 Da
    Quaternary structure:
    • Interacts with VPS52.

    Three dimensional structures from OCA and Proteopedia for STX10 Gene

    Alternative splice isoforms for STX10 Gene


neXtProt entry for STX10 Gene

Proteomics data for STX10 Gene at MOPED

Post-translational modifications for STX10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STX10 Gene

Domains & Families for STX10 Gene

Gene Families for STX10 Gene

Protein Domains for STX10 Gene

Suggested Antigen Peptide Sequences for STX10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
  • Contains 1 t-SNARE coiled-coil homology domain.
  • Belongs to the syntaxin family.
genes like me logo Genes that share domains with STX10: view

Function for STX10 Gene

Molecular function for STX10 Gene

UniProtKB/Swiss-Prot Function:
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
genes like me logo Genes that share phenotypes with STX10: view

Animal Model Products

miRNA for STX10 Gene

miRTarBase miRNAs that target STX10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STX10 Gene

Localization for STX10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STX10 Gene

Golgi apparatus membrane; Single-pass type IV membrane protein.

Subcellular locations from

Jensen Localization Image for STX10 Gene COMPARTMENTS Subcellular localization image for STX10 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
endosome 2
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for STX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0016021 integral component of membrane IBA --
GO:0032588 trans-Golgi network membrane TAS --
genes like me logo Genes that share ontologies with STX10: view

Pathways & Interactions for STX10 Gene

genes like me logo Genes that share pathways with STX10: view

Gene Ontology (GO) - Biological Process for STX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA,IBA --
GO:0032880 regulation of protein localization IMP 16154903
GO:0042147 retrograde transport, endosome to Golgi IDA 18195106
GO:0061025 membrane fusion IEA --
genes like me logo Genes that share ontologies with STX10: view

No data available for SIGNOR curated interactions for STX10 Gene

Drugs & Compounds for STX10 Gene

No Compound Related Data Available

Transcripts for STX10 Gene

Unigene Clusters for STX10 Gene

Syntaxin 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for STX10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: -

Relevant External Links for STX10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STX10 Gene

mRNA expression in normal human tissues for STX10 Gene

mRNA differential expression in normal tissues according to GTEx for STX10 Gene

This gene is overexpressed in Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for STX10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.9), Bone (11.6), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for STX10 Gene

SOURCE GeneReport for Unigene cluster for STX10 Gene Hs.43812

mRNA Expression by UniProt/SwissProt for STX10 Gene

Tissue specificity: Expressed at high levels in heart, skeletal muscle and pancreas.
genes like me logo Genes that share expression patterns with STX10: view

Protein tissue co-expression partners for STX10 Gene

Primer Products

Orthologs for STX10 Gene

This gene was present in the common ancestor of animals.

Orthologs for STX10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia STX10 35
  • 88.62 (n)
  • 91.16 (a)
STX10 36
  • 90 (a)
(Canis familiaris)
Mammalia STX10 35
  • 92.37 (n)
  • 91.97 (a)
STX10 36
  • 91 (a)
(Pan troglodytes)
Mammalia STX10 35
  • 94.78 (n)
  • 93.57 (a)
STX10 36
  • 98 (a)
(Anolis carolinensis)
Reptilia STX10 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia stx10 35
  • 69.86 (n)
  • 65.65 (a)
(Danio rerio)
Actinopterygii LOC100151249 35
  • 64.94 (n)
  • 63.64 (a)
CR847925.1 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Syx6 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea syx-6 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7279 36
  • 44 (a)
Species with no ortholog for STX10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STX10 Gene

Gene Tree for STX10 (if available)
Gene Tree for STX10 (if available)

Paralogs for STX10 Gene

Paralogs for STX10 Gene

(1) SIMAP similar genes for STX10 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with STX10: view

Variants for STX10 Gene

Sequence variations from dbSNP and Humsavar for STX10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7508633 -- 13,147,476(+) aaaaa(A/G)GGAAG intron-variant
rs71168666 -- 13,146,048(-) GGTAA(-/TT)TTTTT intron-variant
rs73006877 -- 13,144,774(+) CTGCT(C/T)GTCCA reference, missense
rs186071524 -- 13,146,866(+) TTTGG(A/T)CTTGA intron-variant
rs186203187 -- 13,144,555(+) ACTGA(A/C)CCCTC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for STX10 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv911087 CNV Loss 21882294
dgv3737n71 CNV Loss 21882294

Variation tolerance for STX10 Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for STX10 Gene

Disorders for STX10 Gene

Relevant External Links for STX10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for STX10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STX10 Gene

Publications for STX10 Gene

  1. Syntaxin 10: a member of the syntaxin family localized to the trans- Golgi network. (PMID: 9446797) Tang B.L. … Hong W. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23 67
  2. A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells. (PMID: 18195106) Ganley I.G. … Pfeffer S.R. (J. Cell Biol. 2008) 3 23
  3. Characterization of the human GARP (Golgi associated retrograde protein) complex. (PMID: 15878329) Liewen H. … Stenner-Liewen F. (Exp. Cell Res. 2005) 3 23
  4. Trans-Golgi network syntaxin 10 functions distinctly from syntaxins 6 and 16. (PMID: 16154903) Wang Y. … Tang B.L. (Mol. Membr. Biol. 2005) 3 23
  5. Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. (PMID: 10080545) Martin-Martin B. … Mollinedo F. (J. Leukoc. Biol. 1999) 3 23

Products for STX10 Gene

Sources for STX10 Gene