Aliases for EIF3J Gene
- Eukaryotic Translation Initiation Factor 3 Subunit J 2 3 5
- Eukaryotic Translation Initiation Factor 3, Subunit J 2 3
- EIF3S1 3 4
- Eukaryotic Translation Initiation Factor 3, Subunit 1 (Alpha, 35kD) 3
- Eukaryotic Translation Initiation Factor 3, Subunit 1 Alpha, 35kDa 2
- Eukaryotic Translation Initiation Factor 3 Subunit 1 4
External Ids for EIF3J Gene
Previous HGNC Symbols for EIF3J Gene
Previous GeneCards Identifiers for EIF3J Gene
This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
GeneCards Summary for EIF3J Gene
EIF3J (Eukaryotic Translation Initiation Factor 3 Subunit J) is a Protein Coding gene. Among its related pathways are Gene Expression and Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S. GO annotations related to this gene include translation initiation factor activity.
UniProtKB/Swiss-Prot for EIF3J Gene
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.