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Aliases for EIF3J Gene

Aliases for EIF3J Gene

  • Eukaryotic Translation Initiation Factor 3, Subunit J 2 3
  • EIF3S1 3 4 6
  • Eukaryotic Translation Initiation Factor 3, Subunit 1 (Alpha, 35kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 1 Alpha, 35kDa 2
  • Eukaryotic Translation Initiation Factor 3 Subunit J 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 1 4
  • EIF-3-Alpha 4
  • EIF3-Alpha 3
  • EIF3-P35 3
  • EIF3 P35 4
  • EIF3j 4

External Ids for EIF3J Gene

Previous HGNC Symbols for EIF3J Gene

  • EIF3S1

Previous GeneCards Identifiers for EIF3J Gene

  • GC15P042617
  • GC15P044829
  • GC15P021653

Summaries for EIF3J Gene

Entrez Gene Summary for EIF3J Gene

  • This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

GeneCards Summary for EIF3J Gene

EIF3J (Eukaryotic Translation Initiation Factor 3, Subunit J) is a Protein Coding gene. Among its related pathways are p70S6K Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3J Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA

Gene Wiki entry for EIF3J Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3J Gene

Genomics for EIF3J Gene

Regulatory Elements for EIF3J Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EIF3J Gene

Start:
44,537,057 bp from pter
End:
44,563,029 bp from pter
Size:
25,973 bases
Orientation:
Plus strand

Genomic View for EIF3J Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EIF3J Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3J Gene

Proteins for EIF3J Gene

  • Protein details for EIF3J Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75822-EIF3J_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit J
    Protein Accession:
    O75822
    Secondary Accessions:
    • B4DUI3
    • F5H425
    • Q9BUD2
    • Q9H8Q2
    • Q9UI65

    Protein attributes for EIF3J Gene

    Size:
    258 amino acids
    Molecular mass:
    29062 Da
    Quaternary structure:
    • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.

    Three dimensional structures from OCA and Proteopedia for EIF3J Gene

    Alternative splice isoforms for EIF3J Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3J Gene

Proteomics data for EIF3J Gene at MOPED

Post-translational modifications for EIF3J Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at Lys161
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3J Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF3J (eIF3-alpha)

No data available for DME Specific Peptides for EIF3J Gene

Domains for EIF3J Gene

Protein Domains for EIF3J Gene

Suggested Antigen Peptide Sequences for EIF3J Gene

Graphical View of Domain Structure for InterPro Entry

O75822

UniProtKB/Swiss-Prot:

EIF3J_HUMAN :
  • O75822
Family:
  • Belongs to the eIF-3 subunit J family.
genes like me logo Genes that share domains with EIF3J: view

No data available for Gene Families for EIF3J Gene

Function for EIF3J Gene

Molecular function for EIF3J Gene

UniProtKB/Swiss-Prot Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA

Gene Ontology (GO) - Molecular Function for EIF3J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003743 contributes_to translation initiation factor activity IC 17322308
GO:0005515 protein binding IPI 14688252
genes like me logo Genes that share ontologies with EIF3J: view

Phenotypes for EIF3J Gene

GenomeRNAi human phenotypes for EIF3J:
genes like me logo Genes that share phenotypes with EIF3J: view

Animal Model Products

CRISPR Products

miRNA for EIF3J Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for EIF3J Gene

Localization for EIF3J Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3J Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3J Gene COMPARTMENTS Subcellular localization image for EIF3J gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for EIF3J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016282 eukaryotic 43S preinitiation complex IEA --
GO:0033290 eukaryotic 48S preinitiation complex IEA --
genes like me logo Genes that share ontologies with EIF3J: view

Pathways for EIF3J Gene

genes like me logo Genes that share pathways with EIF3J: view

Pathways by source for EIF3J Gene

2 Qiagen pathways for EIF3J Gene
1 Cell Signaling Technology pathway for EIF3J Gene
1 BioSystems pathway for EIF3J Gene

Gene Ontology (GO) - Biological Process for EIF3J Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001731 formation of translation preinitiation complex IEA --
GO:0002181 cytoplasmic translation IBA --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
genes like me logo Genes that share ontologies with EIF3J: view

Transcripts for EIF3J Gene

Unigene Clusters for EIF3J Gene

Eukaryotic translation initiation factor 3, subunit J:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EIF3J

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3J Gene

No ASD Table

Relevant External Links for EIF3J Gene

GeneLoc Exon Structure for
EIF3J
ECgene alternative splicing isoforms for
EIF3J

Expression for EIF3J Gene

mRNA expression in normal human tissues for EIF3J Gene

mRNA differential expression in normal tissues according to GTEx for EIF3J Gene

This gene is overexpressed in Muscle - Skeletal (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3J Gene

SOURCE GeneReport for Unigene cluster for EIF3J Gene Hs.404056

genes like me logo Genes that share expressions with EIF3J: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for EIF3J Gene

Orthologs for EIF3J Gene

This gene was present in the common ancestor of animals.

Orthologs for EIF3J Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EIF3J 35
  • 99.73 (n)
  • 99.6 (a)
cow
(Bos Taurus)
Mammalia EIF3J 35
  • 93.59 (n)
  • 98.04 (a)
EIF3J 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EIF3J 35
  • 95.85 (n)
  • 98.05 (a)
EIF3J 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3j1 35
  • 93.87 (n)
  • 96.8 (a)
Eif3j1 16
Eif3j1 36
  • 95 (a)
OneToMany
Eif3j2 36
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3J 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3j 35
  • 94.27 (n)
  • 97.2 (a)
chicken
(Gallus gallus)
Aves EIF3J 35
  • 78.31 (n)
  • 80.72 (a)
EIF3J 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EIF3J 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21408 35
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3j 35
  • 68.94 (n)
  • 67.47 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
EIF3J (3 of 3) 36
  • 56 (a)
OneToMany
eif3ja 35
  • 70.61 (n)
  • 68.16 (a)
eif3ja 36
  • 67 (a)
OneToMany
eif3jb 36
  • 60 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3J_ANOGA 35
  • 48.06 (n)
  • 42.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Adam 35
  • 50.16 (n)
  • 42.86 (a)
Adam 36
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for EIF3J:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for EIF3J Gene

ENSEMBL:
Gene Tree for EIF3J (if available)
TreeFam:
Gene Tree for EIF3J (if available)

Paralogs for EIF3J Gene

genes like me logo Genes that share paralogs with EIF3J: view

No data available for Paralogs for EIF3J Gene

Variants for EIF3J Gene

Sequence variations from dbSNP and Humsavar for EIF3J Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs14651 -- 44,561,461(+) CGTGA(A/C)AAAAA utr-variant-3-prime
rs1058918 -- 44,562,108(+) CCCAA(G/T)AGATA utr-variant-3-prime
rs1058919 -- 44,562,110(+) CAAGA(G/T)ATACT utr-variant-3-prime
rs1804977 -- 44,561,965(+) TTTAT(A/G)AAACA utr-variant-3-prime
rs2251889 -- 44,546,637(+) GGTGG(C/T)TGCTG intron-variant

Relevant External Links for EIF3J Gene

HapMap Linkage Disequilibrium report
EIF3J

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for EIF3J Gene

Disorders for EIF3J Gene

No disorders were found for EIF3J Gene.

No data available for UniProtKB/Swiss-Prot for EIF3J Gene

Publications for EIF3J Gene

  1. Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3. (PMID: 9822659) Block K.L. … Hershey J.W.B. (J. Biol. Chem. 1998) 2 3 4 23
  2. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. (PMID: 17322308) Damoc E. … Leary J.A. (Mol. Cell. Proteomics 2007) 3 4
  3. Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit. (PMID: 17190833) ElAntak L. … Lukavsky P.J. (J. Biol. Chem. 2007) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for EIF3J Gene

Sources for EIF3J Gene

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