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Aliases for EIF3A Gene

Aliases for EIF3A Gene

  • Eukaryotic Translation Initiation Factor 3 Subunit A 2 3 5
  • Eukaryotic Translation Initiation Factor 3, Subunit 10 Theta, 150/170kDa 2 3
  • Eukaryotic Translation Initiation Factor 3, Subunit A 2 3
  • Eukaryotic Translation Initiation Factor 3 Subunit 10 3 4
  • EIF-3-Theta 3 4
  • EIF3 P167 3 4
  • EIF3 P180 3 4
  • EIF3 P185 3 4
  • EIF3S10 3 4
  • Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 150/170kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 10 (Theta, 170kD) 3
  • Eukaryotic Translation Initiation Factor 3, Subunit 10, 170kD 3
  • Cytoplasmic Protein P167 3
  • Centrosomin Homolog 3
  • EIF3, P180 Subunit 3
  • EIF3-Theta 3
  • EIF3-P170 3
  • KIAA0139 4
  • TIF32 3
  • EIF3a 4
  • P180 3
  • P167 3
  • P185 3
  • EIF3 3

External Ids for EIF3A Gene

Previous HGNC Symbols for EIF3A Gene

  • EIF3
  • EIF3S10

Previous GeneCards Identifiers for EIF3A Gene

  • GC10M120785
  • GC10M120794
  • GC10M114423

Summaries for EIF3A Gene

GeneCards Summary for EIF3A Gene

EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A) is a Protein Coding gene. Among its related pathways are Gene Expression and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and translation initiation factor activity.

UniProtKB/Swiss-Prot for EIF3A Gene

  • Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Wiki entry for EIF3A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EIF3A Gene

Genomics for EIF3A Gene

Regulatory Elements for EIF3A Gene

Promoters for EIF3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around EIF3A on UCSC Golden Path with GeneCards custom track

Genomic Location for EIF3A Gene

Chromosome:
10
Start:
119,033,670 bp from pter
End:
119,080,823 bp from pter
Size:
47,154 bases
Orientation:
Minus strand

Genomic View for EIF3A Gene

Genes around EIF3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
EIF3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for EIF3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EIF3A Gene

Proteins for EIF3A Gene

  • Protein details for EIF3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14152-EIF3A_HUMAN
    Recommended name:
    Eukaryotic translation initiation factor 3 subunit A
    Protein Accession:
    Q14152
    Secondary Accessions:
    • B1AMV5
    • B4DYS1
    • F5H335
    • O00653
    • Q15778

    Protein attributes for EIF3A Gene

    Size:
    1382 amino acids
    Molecular mass:
    166569 Da
    Quaternary structure:
    • Interacts with EIF4G1 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2.
    SequenceCaution:
    • Sequence=BAA09488.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for EIF3A Gene

    Alternative splice isoforms for EIF3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for EIF3A Gene

Proteomics data for EIF3A Gene at MOPED

Post-translational modifications for EIF3A Gene

  • Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
  • Ubiquitination at Lys 13, Lys 45, Lys 75, Lys 351, Lys 409, Lys 420, Lys 672, Lys 711, and Lys 775
  • Modification sites at PhosphoSitePlus

Other Protein References for EIF3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EIF3A (eIF3-theta)

No data available for DME Specific Peptides for EIF3A Gene

Domains & Families for EIF3A Gene

Gene Families for EIF3A Gene

Protein Domains for EIF3A Gene

Graphical View of Domain Structure for InterPro Entry

Q14152

UniProtKB/Swiss-Prot:

EIF3A_HUMAN :
  • Contains 1 PCI domain.
  • Belongs to the eIF-3 subunit A family.
Domain:
  • Contains 1 PCI domain.
Family:
  • Belongs to the eIF-3 subunit A family.
genes like me logo Genes that share domains with EIF3A: view

Function for EIF3A Gene

Molecular function for EIF3A Gene

UniProtKB/Swiss-Prot Function:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426).

Gene Ontology (GO) - Molecular Function for EIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 11169732
genes like me logo Genes that share ontologies with EIF3A: view
genes like me logo Genes that share phenotypes with EIF3A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for EIF3A Gene

Localization for EIF3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for EIF3A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EIF3A Gene COMPARTMENTS Subcellular localization image for EIF3A gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for EIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005829 cytosol TAS --
GO:0005852 eukaryotic translation initiation factor 3 complex IDA 17322308
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with EIF3A: view

Pathways & Interactions for EIF3A Gene

genes like me logo Genes that share pathways with EIF3A: view

Pathways by source for EIF3A Gene

Gene Ontology (GO) - Biological Process for EIF3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006413 translational initiation TAS --
GO:0006446 regulation of translational initiation IEA --
GO:0010467 gene expression TAS --
GO:0075522 IRES-dependent viral translational initiation IDA 9573242
genes like me logo Genes that share ontologies with EIF3A: view

No data available for SIGNOR curated interactions for EIF3A Gene

Drugs & Compounds for EIF3A Gene

(6) Drugs for EIF3A Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1885
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2540

(4) Additional Compounds for EIF3A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with EIF3A: view

Transcripts for EIF3A Gene

mRNA/cDNA for EIF3A Gene

Unigene Clusters for EIF3A Gene

Eukaryotic translation initiation factor 3, subunit A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for EIF3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:

ExUns: 22a · 22b ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for EIF3A Gene

GeneLoc Exon Structure for
EIF3A
ECgene alternative splicing isoforms for
EIF3A

Expression for EIF3A Gene

mRNA expression in normal human tissues for EIF3A Gene

Protein differential expression in normal tissues from HIPED for EIF3A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for EIF3A Gene



SOURCE GeneReport for Unigene cluster for EIF3A Gene Hs.523299

genes like me logo Genes that share expression patterns with EIF3A: view

Protein tissue co-expression partners for EIF3A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for EIF3A Gene

Orthologs for EIF3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EIF3A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia EIF3A 35
  • 91.04 (n)
  • 95.97 (a)
EIF3A 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eif3a 35
  • 88.51 (n)
  • 96.04 (a)
Eif3a 16
Eif3a 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EIF3A 35
  • 99.76 (n)
  • 99.93 (a)
EIF3A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eif3a 35
  • 88.86 (n)
  • 96.34 (a)
cow
(Bos Taurus)
Mammalia EIF3A 36
  • 95 (a)
OneToOne
EIF3A 35
  • 90.38 (n)
  • 95.83 (a)
oppossum
(Monodelphis domestica)
Mammalia EIF3A 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EIF3A 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves EIF3A 36
  • 82 (a)
OneToOne
EIF3A 35
  • 75.8 (n)
  • 83.89 (a)
lizard
(Anolis carolinensis)
Reptilia EIF3A 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eif3a 35
  • 72.74 (n)
  • 83.55 (a)
Str.7667 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68848 35
zebrafish
(Danio rerio)
Actinopterygii wufi15c03 35
eif3s10 36
  • 80 (a)
OneToOne
eif3s10 35
  • 71.48 (n)
  • 83.56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10408 35
African malaria mosquito
(Anopheles gambiae)
Insecta EIF3A_ANOGA 35
  • 52.47 (n)
  • 52.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta eIF3-S10 35
  • 54.05 (n)
  • 51.9 (a)
eIF3-S10 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea egl-45 35
  • 51.66 (n)
  • 41.99 (a)
egl-45 36
  • 36 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL065W 35
  • 43.94 (n)
  • 31.81 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14498g 35
  • 45.8 (n)
  • 33.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPG1 35
  • 44.05 (n)
  • 30.11 (a)
RPG1 36
  • 28 (a)
OneToOne
RPG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons EIF3A 35
  • 49.8 (n)
  • 40.26 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12705 35
rice
(Oryza sativa)
Liliopsida Os.28076 35
Os01g0120800 35
  • 49.03 (n)
  • 40.45 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13478 35
corn
(Zea mays)
Liliopsida Zm.6558 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2509 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00040 35
  • 46.33 (n)
  • 40.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tif32 35
  • 47.57 (n)
  • 37.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1934 36
  • 54 (a)
OneToOne
Species with no ortholog for EIF3A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for EIF3A Gene

ENSEMBL:
Gene Tree for EIF3A (if available)
TreeFam:
Gene Tree for EIF3A (if available)

Paralogs for EIF3A Gene

(1) SIMAP similar genes for EIF3A Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for EIF3A Gene

genes like me logo Genes that share paralogs with EIF3A: view

No data available for Paralogs for EIF3A Gene

Variants for EIF3A Gene

Sequence variations from dbSNP and Humsavar for EIF3A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_024438 -
rs431898 - 119,056,936(-) AAGAA(C/G)GTAAA reference, missense
rs532138 - 119,042,541(+) TCATC(A/T)TCTGT reference, missense
rs371759 -- 119,066,616(+) AGGGA(A/G)AGGGG intron-variant
rs376329 -- 119,053,556(+) aaaat(A/C)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EIF3A Gene

Variant ID Type Subtype PubMed ID
nsv825582 CNV Gain 20364138
esv990531 CNV Deletion 20482838

Variation tolerance for EIF3A Gene

Residual Variation Intolerance Score: 6.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.16; 61.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for EIF3A Gene

HapMap Linkage Disequilibrium report
EIF3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EIF3A Gene

Disorders for EIF3A Gene

Relevant External Links for EIF3A

Genetic Association Database (GAD)
EIF3A
Human Genome Epidemiology (HuGE) Navigator
EIF3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
EIF3A

No disorders were found for EIF3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for EIF3A Gene

Publications for EIF3A Gene

  1. Identification of cDNA clones for the large subunit of eukaryotic translation initiation factor 3. Comparison of homologues from human, Nicotiana tabacum, Caenorhabditis elegans, and Saccharomyces cerevisiae. (PMID: 9054404) Johnson K.R. … Zhu Y. (J. Biol. Chem. 1997) 2 3 4 67
  2. Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. (PMID: 19245811) Shi J. … Nelson M.A. (FEBS Lett. 2009) 3 23
  3. Role of eIF3a in regulating cell cycle progression. (PMID: 19327350) Dong Z. … Zhang J.T. (Exp. Cell Res. 2009) 3 23
  4. Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. (PMID: 18423202) Isken O. … Maquat L.E. (Cell 2008) 3 23
  5. Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. (PMID: 18628297) Lee C.S. … Reed R. (Nucleic Acids Res. 2008) 3 23

Products for EIF3A Gene

Sources for EIF3A Gene

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