Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SERPINA6 Gene

Aliases for SERPINA6 Gene

  • Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 2 3
  • Transcortin 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6 2 3
  • Corticosteroid Binding Globulin 2 3
  • Serpin A6 3 4
  • CBG 3 4

External Ids for SERPINA6 Gene

Previous HGNC Symbols for SERPINA6 Gene

  • CBG

Previous GeneCards Identifiers for SERPINA6 Gene

  • GC14M092277
  • GC14M088587
  • GC14M092760
  • GC14M093840
  • GC14M094770
  • GC14M074950

Summaries for SERPINA6 Gene

Entrez Gene Summary for SERPINA6 Gene

  • This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

GeneCards Summary for SERPINA6 Gene

SERPINA6 (Serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 6) is a Protein Coding gene. Diseases associated with SERPINA6 include corticosteroid-binding globulin deficiency and adrenal gland hyperfunction. Among its related pathways are Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics. GO annotations related to this gene include serine-type endopeptidase inhibitor activity and steroid binding. An important paralog of this gene is SERPINA10.

UniProtKB/Swiss-Prot for SERPINA6 Gene

  • Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Gene Wiki entry for SERPINA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINA6 Gene

Genomics for SERPINA6 Gene

Regulatory Elements for SERPINA6 Gene

Genomic Location for SERPINA6 Gene

Chromosome:
14
Start:
94,304,248 bp from pter
End:
94,323,394 bp from pter
Size:
19,147 bases
Orientation:
Minus strand

Genomic View for SERPINA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINA6 Gene

Proteins for SERPINA6 Gene

  • Protein details for SERPINA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08185-CBG_HUMAN
    Recommended name:
    Corticosteroid-binding globulin
    Protein Accession:
    P08185
    Secondary Accessions:
    • A8K456
    • Q7Z2Q9

    Protein attributes for SERPINA6 Gene

    Size:
    405 amino acids
    Molecular mass:
    45141 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SERPINA6 Gene

neXtProt entry for SERPINA6 Gene

Proteomics data for SERPINA6 Gene at MOPED

Post-translational modifications for SERPINA6 Gene

  • Glycosylation in position Asn-260 is needed for steroid binding
  • N-glycosylated; binds 5 oligosaccharide chains
  • Glycosylation at Asn 31, Asn 96, Asn 176, Asn 260, Asn 330, and Asn 369
  • Modification sites at PhosphoSitePlus

Other Protein References for SERPINA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SERPINA6 Gene

Domains & Families for SERPINA6 Gene

Gene Families for SERPINA6 Gene

Protein Domains for SERPINA6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SERPINA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08185

UniProtKB/Swiss-Prot:

CBG_HUMAN :
  • Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.
  • Belongs to the serpin family.
Domain:
  • Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids.
Family:
  • Belongs to the serpin family.
genes like me logo Genes that share domains with SERPINA6: view

Function for SERPINA6 Gene

Molecular function for SERPINA6 Gene

UniProtKB/Swiss-Prot Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.

Gene Ontology (GO) - Molecular Function for SERPINA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity TAS 3299377
GO:0005496 steroid binding IDA 18513745
genes like me logo Genes that share ontologies with SERPINA6: view
genes like me logo Genes that share phenotypes with SERPINA6: view

Animal Models for SERPINA6 Gene

MGI Knock Outs for SERPINA6:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SERPINA6 Gene

Localization for SERPINA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINA6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINA6 Gene COMPARTMENTS Subcellular localization image for SERPINA6 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SERPINA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SERPINA6: view

Pathways & Interactions for SERPINA6 Gene

genes like me logo Genes that share pathways with SERPINA6: view

Pathways by source for SERPINA6 Gene

Interacting Proteins for SERPINA6 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000342850%0d%0a9606.ENSP00000305529%0d%0a9606.ENSP00000346839%0d%0a9606.ENSP00000053867%0d%0a9606.ENSP00000306245%0d%0a
Selected Interacting proteins: ENSP00000342850 for SERPINA6 Gene via STRING

Gene Ontology (GO) - Biological Process for SERPINA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008211 glucocorticoid metabolic process IEA --
GO:0010951 negative regulation of endopeptidase activity IBA --
genes like me logo Genes that share ontologies with SERPINA6: view

No data available for SIGNOR curated interactions for SERPINA6 Gene

Drugs & Compounds for SERPINA6 Gene

(53) Drugs for SERPINA6 Gene - From: NovoSeek, DrugBank, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alclometasone Approved Pharma binder, Carrier 0
Beclomethasone Approved, Investigational Pharma binder, Carrier 155
Ciclesonide Approved, Investigational Pharma binder, Carrier 72
Paramethasone Approved Pharma binder, Carrier 0
Rimexolone Approved Pharma binder, Carrier 0

(22) Additional Compounds for SERPINA6 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,5-Difluoro-2,4-dinitrobenzene
11 deoxycortisol
11beta-Hydroxysteroid
17-Hydroxyprogesterone
  • 17-alpha-Hydroxyprogesterone
  • 17-Hydroxypregn-4-ene-3,20-dione
  • 17-Hydroxyprogesterone
  • 17-OH Progesterone
  • 17-OHP
68-96-2
ACTH 1-24
genes like me logo Genes that share compounds with SERPINA6: view

Transcripts for SERPINA6 Gene

mRNA/cDNA for SERPINA6 Gene

Unigene Clusters for SERPINA6 Gene

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SERPINA6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINA6 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5
SP1: - -
SP2:
SP3: -

Relevant External Links for SERPINA6 Gene

GeneLoc Exon Structure for
SERPINA6
ECgene alternative splicing isoforms for
SERPINA6

Expression for SERPINA6 Gene

mRNA expression in normal human tissues for SERPINA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINA6 Gene

This gene is overexpressed in Liver (x48.9).

Protein differential expression in normal tissues from HIPED for SERPINA6 Gene

This gene is overexpressed in Serum (20.4), Vitreous humor (9.1), and Plasma (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SERPINA6 Gene



SOURCE GeneReport for Unigene cluster for SERPINA6 Gene Hs.532635

mRNA Expression by UniProt/SwissProt for SERPINA6 Gene

P08185-CBG_HUMAN
Tissue specificity: Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells
genes like me logo Genes that share expression patterns with SERPINA6: view

Protein tissue co-expression partners for SERPINA6 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SERPINA6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SERPINA6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SERPINA6 35
  • 79.87 (n)
  • 68.92 (a)
SERPINA6 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SERPINA6 35
  • 79.98 (n)
  • 69.98 (a)
SERPINA6 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Serpina6 35
  • 72.06 (n)
  • 58.75 (a)
Serpina6 16
Serpina6 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SERPINA6 35
  • 99.09 (n)
  • 98.02 (a)
SERPINA6 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Serpina6 35
  • 72.34 (n)
  • 61.26 (a)
oppossum
(Monodelphis domestica)
Mammalia SERPINA6 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
Species with no ortholog for SERPINA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SERPINA6 Gene

ENSEMBL:
Gene Tree for SERPINA6 (if available)
TreeFam:
Gene Tree for SERPINA6 (if available)

Paralogs for SERPINA6 Gene

Pseudogenes.org Pseudogenes for SERPINA6 Gene

genes like me logo Genes that share paralogs with SERPINA6: view

Variants for SERPINA6 Gene

Sequence variations from dbSNP and Humsavar for SERPINA6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs9115 -- 94,304,442(-) TTCCT(A/G)GCGAG synonymous-codon, reference
rs941601 -- 94,305,204(-) GAGTC(A/G)CTGGA intron-variant
rs1803252 -- 94,304,306(-) CTCCC(C/T)CCAAC utr-variant-3-prime
rs1956179 -- 94,319,405(-) ttttt(A/G)aagaa intron-variant
rs1956180 -- 94,315,820(-) acagt(A/T)atata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SERPINA6 Gene

Variant ID Type Subtype PubMed ID
nsv832862 CNV Gain 17160897
nsv470662 CNV Gain 18288195

Variation tolerance for SERPINA6 Gene

Residual Variation Intolerance Score: 54.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINA6 Gene

HapMap Linkage Disequilibrium report
SERPINA6
Human Gene Mutation Database (HGMD)
SERPINA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINA6 Gene

Disorders for SERPINA6 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SERPINA6 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
corticosteroid-binding globulin deficiency
  • corticosteroid-binding globulin
adrenal gland hyperfunction
  • pituitary-dependent cushing's disease
subacute thyroiditis
  • giant-cell thyroiditis
prostate disease
  • prostate diseases
pituitary-dependent cushing's disease
  • pituitary-dependent cushing disease
- elite association

UniProtKB/Swiss-Prot

CBG_HUMAN
  • Corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]: Extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue. {ECO:0000269 PubMed:10634411, ECO:0000269 PubMed:1504007, ECO:0000269 PubMed:17245537, ECO:0000269 PubMed:8212073}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SERPINA6

Genetic Association Database (GAD)
SERPINA6
Human Genome Epidemiology (HuGE) Navigator
SERPINA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINA6
genes like me logo Genes that share disorders with SERPINA6: view

No data available for Genatlas for SERPINA6 Gene

Publications for SERPINA6 Gene

  1. Mitotane has an estrogenic effect on sex hormone-binding globulin and corticosteroid-binding globulin in humans. (PMID: 16551731) Nader N. … Pugeat M. (J. Clin. Endocrinol. Metab. 2006) 23 25 67
  2. Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity. (PMID: 10634411) Emptoz-Bonneton A. … Pugeat M. (J. Clin. Endocrinol. Metab. 2000) 23 25 67
  3. Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency. (PMID: 7912884) Byth B.C. … Cox D.W. (Am. J. Hum. Genet. 1994) 2 23 67
  4. A Leu-->His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol. (PMID: 1504007) Smith C.L. … Hammond G.L. (J. Steroid Biochem. Mol. Biol. 1992) 23 25 67
  5. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 67

Products for SERPINA6 Gene

Sources for SERPINA6 Gene

Back to Top

Content