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Aliases for PDE5A Gene

Aliases for PDE5A Gene

  • Phosphodiesterase 5A 2 3 5
  • Phosphodiesterase 5A, CGMP-Specific 2 3
  • EC 3.1.4.35 4 63
  • CGB-PDE 3 4
  • PDE5 3 4
  • CGMP-Binding CGMP-Specific 3,5-Cyclic Nucleotide Phosphodiesterase 3
  • CGMP-Binding CGMP-Specific Phosphodiesterase 4
  • CGMP-Specific Phosphodiesterase Type 5A 3
  • CGMP-Specific Phosphodiesterase PDE5A2 3
  • Phosphodiesterase Isozyme 5 3
  • EC 3.1.4 63
  • CN5A 3

External Ids for PDE5A Gene

Previous GeneCards Identifiers for PDE5A Gene

  • GC04M121176
  • GC04M120698
  • GC04M120811
  • GC04M120877
  • GC04M120878
  • GC04M120776
  • GC04M120415
  • GC04M116136

Summaries for PDE5A Gene

Entrez Gene Summary for PDE5A Gene

  • This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDE5A Gene

PDE5A (Phosphodiesterase 5A) is a Protein Coding gene. Diseases associated with PDE5A include priapism and nonarteritic anterior ischemic optic neuropathy. Among its related pathways are Platelet activation, signaling and aggregation and Sweet Taste Signaling. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and 3,5-cyclic-GMP phosphodiesterase activity. An important paralog of this gene is PDE6A.

UniProtKB/Swiss-Prot for PDE5A Gene

  • Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).

Tocris Summary for PDE5A Gene

  • Phosphodiesterases (PDEs) are a family of phosphohydrolyases that catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). PDEs regulate the second messengers by controlling their degradation.

Gene Wiki entry for PDE5A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE5A Gene

Genomics for PDE5A Gene

Regulatory Elements for PDE5A Gene

Promoters for PDE5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PDE5A on UCSC Golden Path with GeneCards custom track

Genomic Location for PDE5A Gene

Chromosome:
4
Start:
119,494,395 bp from pter
End:
119,628,991 bp from pter
Size:
134,597 bases
Orientation:
Minus strand

Genomic View for PDE5A Gene

Genes around PDE5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PDE5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PDE5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE5A Gene

Proteins for PDE5A Gene

  • Protein details for PDE5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76074-PDE5A_HUMAN
    Recommended name:
    cGMP-specific 3,5-cyclic phosphodiesterase
    Protein Accession:
    O76074
    Secondary Accessions:
    • A0AV69
    • A8K2C4
    • O75026
    • O75887
    • Q86UI0
    • Q86V66
    • Q9Y6Z6

    Protein attributes for PDE5A Gene

    Size:
    875 amino acids
    Molecular mass:
    99985 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PDE5A Gene

    Alternative splice isoforms for PDE5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE5A Gene

Proteomics data for PDE5A Gene at MOPED

Post-translational modifications for PDE5A Gene

  • Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by PRKG1 leads to its activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE5A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDE5A (PDE5A)

Domains & Families for PDE5A Gene

Gene Families for PDE5A Gene

Protein Domains for PDE5A Gene

Graphical View of Domain Structure for InterPro Entry

O76074

UniProtKB/Swiss-Prot:

PDE5A_HUMAN :
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B.
  • Belongs to the cyclic nucleotide phosphodiesterase family.
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B.
  • Contains 2 GAF domains.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family.
genes like me logo Genes that share domains with PDE5A: view

Function for PDE5A Gene

Molecular function for PDE5A Gene

GENATLAS Biochemistry:
cGMP specific nucleotide phosphodiesterase,class V,alpha subunit,two alternatively spliced forms A1,A2,100kDa,highly expressed in tissues,aortic smooth muscle cells,heart,placenta,skeletal muscle,pancreas,brain,liver and lung
UniProtKB/Swiss-Prot CatalyticActivity:
Guanosine 3,5-cyclic phosphate + H(2)O = guanosine 5-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A and is effective in the treatment of penile erectile dysfunction. Also inhibited by zaprinast.
UniProtKB/Swiss-Prot Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).

Enzyme Numbers (IUBMB) for PDE5A Gene

Gene Ontology (GO) - Molecular Function for PDE5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity IEA,NAS 9714779
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with PDE5A: view
genes like me logo Genes that share phenotypes with PDE5A: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PDE5A Gene

Localization for PDE5A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE5A Gene COMPARTMENTS Subcellular localization image for PDE5A gene
Compartment Confidence
cytosol 5
plasma membrane 2
cytoskeleton 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PDE5A Gene

Pathways & Interactions for PDE5A Gene

genes like me logo Genes that share pathways with PDE5A: view

Pathways by source for PDE5A Gene

1 GeneGo (Thomson Reuters) pathway for PDE5A Gene
1 Qiagen pathway for PDE5A Gene

UniProtKB/Swiss-Prot O76074-PDE5A_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic GMP degradation; GMP from 3,5-cyclic GMP: step 1/1.

Gene Ontology (GO) - Biological Process for PDE5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010613 positive regulation of cardiac muscle hypertrophy IEA --
GO:0042130 negative regulation of T cell proliferation IEA --
GO:0043406 positive regulation of MAP kinase activity IEA --
GO:0046069 cGMP catabolic process IEA --
GO:0055119 relaxation of cardiac muscle IEA --
genes like me logo Genes that share ontologies with PDE5A: view

No data available for SIGNOR curated interactions for PDE5A Gene

Drugs & Compounds for PDE5A Gene

(61) Drugs for PDE5A Gene - From: IUPHAR, DGIdb, HMDB, Novoseek, DrugBank, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tadalafil Approved, Investigational Pharma inhibitor, Target PDE5 inhibitor 140
Vardenafil Approved Pharma binder, Target, inhibitor PDE5 inhibitor 0
Dipyridamole Approved Pharma Inhibition, Inhibitor, inhibitor, Target Adenosine transport inhibitor 76
sildenafil Approved, Investigational Pharma Inhibition, Inhibitor, inhibitor, Target 0
Theophylline Approved Pharma Antagonist, antagonist, Target, inhibitor 56

(25) Additional Compounds for PDE5A Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
Etazolate hydrochloride
35838-58-5
MMPX
78033-08-6
MY-5445
78351-75-4
Ro 20-1724
29925-17-5

(5) Tocris Compounds for PDE5A Gene

Compound Action Cas Number
Dipyridamole Adenosine transport inhibitor 58-32-2
Etazolate hydrochloride PDE4 inhibitor 35838-58-5
MMPX PDE1 inhibitor 78033-08-6
MY-5445 PDE5 inhibitor 78351-75-4
Ro 20-1724 PDE4 inhibitor 29925-17-5

(6) ApexBio Compounds for PDE5A Gene

Compound Action Cas Number
Avanafil PDE5 inhibitor 330784-47-9
Doxofylline 69975-86-6
Icariin 489-32-7
Sildenafil Citrate Treat erectile dysfunction and PAH 171599-83-0
Tadalafil PDE5 inhibitor 171596-29-5
Vardenafil PDE5 inhibitor 224785-90-4
genes like me logo Genes that share compounds with PDE5A: view

Transcripts for PDE5A Gene

Unigene Clusters for PDE5A Gene

Phosphodiesterase 5A, cGMP-specific:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PDE5A Gene

No ASD Table

Relevant External Links for PDE5A Gene

GeneLoc Exon Structure for
PDE5A
ECgene alternative splicing isoforms for
PDE5A

Expression for PDE5A Gene

mRNA expression in normal human tissues for PDE5A Gene

mRNA differential expression in normal tissues according to GTEx for PDE5A Gene

This gene is overexpressed in Artery - Aorta (x5.1), Artery - Tibial (x5.1), Esophagus - Muscularis (x4.5), and Esophagus - Gastroesophageal Junction (x4.4).

Protein differential expression in normal tissues from HIPED for PDE5A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.9) and Platelet (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE5A Gene



SOURCE GeneReport for Unigene cluster for PDE5A Gene Hs.647971

mRNA Expression by UniProt/SwissProt for PDE5A Gene

O76074-PDE5A_HUMAN
Tissue specificity: Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.
genes like me logo Genes that share expression patterns with PDE5A: view

Protein tissue co-expression partners for PDE5A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PDE5A Gene

Orthologs for PDE5A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PDE5A 35
  • 92.91 (n)
  • 96.42 (a)
PDE5A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE5A 35
  • 94.55 (n)
  • 97.94 (a)
PDE5A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde5a 35
  • 88.79 (n)
  • 93.53 (a)
Pde5a 16
Pde5a 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PDE5A 35
  • 99.76 (n)
  • 99.76 (a)
PDE5A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde5a 35
  • 89.39 (n)
  • 93.46 (a)
oppossum
(Monodelphis domestica)
Mammalia PDE5A 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE5A 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves PDE5A 35
  • 81.99 (n)
  • 88.86 (a)
PDE5A 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE5A 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde5a 35
  • 75.77 (n)
  • 81.06 (a)
zebrafish
(Danio rerio)
Actinopterygii pde5ab 35
  • 70.14 (n)
  • 74.4 (a)
CT826376.1 36
  • 38 (a)
ManyToMany
pde5ab 36
  • 72 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6340 35
fruit fly
(Drosophila melanogaster)
Insecta CG10231 37
  • 48 (a)
CG8279 37
  • 44 (a)
Pde11 35
  • 54.04 (n)
  • 51.06 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008646 35
  • 52.12 (n)
  • 50.06 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for PDE5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE5A Gene

ENSEMBL:
Gene Tree for PDE5A (if available)
TreeFam:
Gene Tree for PDE5A (if available)

Paralogs for PDE5A Gene

Paralogs for PDE5A Gene

genes like me logo Genes that share paralogs with PDE5A: view

Variants for PDE5A Gene

Sequence variations from dbSNP and Humsavar for PDE5A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs3733526 - 119,607,172(+) CAGGG(A/G)CACTG reference, missense
rs17051276 - 119,606,909(+) AGCAG(A/C)TATCA reference, missense
rs722667 -- 119,514,966(+) aagct(A/G)ggcat intron-variant
rs722668 -- 119,515,113(+) TATTA(A/G)TATTT intron-variant
rs1010739 -- 119,542,316(-) TTATT(A/G)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE5A Gene

Variant ID Type Subtype PubMed ID
dgv5698n71 CNV Loss 21882294
dgv5699n71 CNV Loss 21882294
dgv5700n71 CNV Loss 21882294
nsv879848 CNV Loss 21882294
nsv822710 CNV Loss 20364138
esv2728237 CNV Deletion 23290073

Variation tolerance for PDE5A Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PDE5A Gene

HapMap Linkage Disequilibrium report
PDE5A
Human Gene Mutation Database (HGMD)
PDE5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE5A Gene

Disorders for PDE5A Gene

MalaCards: The human disease database

(25) MalaCards diseases for PDE5A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
priapism
  • mentulagra
nonarteritic anterior ischemic optic neuropathy
  • ischemic optic neuropathy
pulmonary hypertension
  • primary pulmonary hypertension
transient global amnesia
  • tga
sexual disorder
  • sexual dysfunction
- elite association - COSMIC cancer census association via MalaCards
Search PDE5A in MalaCards View complete list of genes associated with diseases

Relevant External Links for PDE5A

Genetic Association Database (GAD)
PDE5A
Human Genome Epidemiology (HuGE) Navigator
PDE5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PDE5A
genes like me logo Genes that share disorders with PDE5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PDE5A Gene

Publications for PDE5A Gene

  1. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP- binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. (PMID: 9714779) Loughney K. … Ferguson K. (Gene 1998) 2 3 4 23 67
  2. Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. (PMID: 17959709) Wang H. … Ke H. (Mol. Pharmacol. 2008) 23 25 26
  3. Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress. (PMID: 18491987) Gur S. … Hellstrom W.J. (Expert Opin Investig Drugs 2008) 23 25 26
  4. Characterization of renal ecto-phosphodiesterase. (PMID: 17308037) Jackson E.K. … Mi Z. (J. Pharmacol. Exp. Ther. 2007) 23 25 26
  5. Dipyridamole may induce migraine in patients with migraine without aura. (PMID: 16886928) Kruuse C. … Olesen J. (Cephalalgia 2006) 23 25 26

Products for PDE5A Gene

Sources for PDE5A Gene

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