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Aliases for PDE5A Gene

Aliases for PDE5A Gene

  • Phosphodiesterase 5A, CGMP-Specific 2 3
  • EC 3.1.4.35 4 63
  • CGB-PDE 3 4
  • PDE5 3 4
  • CGMP-Binding CGMP-Specific 3,5-Cyclic Nucleotide Phosphodiesterase 3
  • CGMP-Binding CGMP-Specific Phosphodiesterase 4
  • CGMP-Specific 3,5-Cyclic Phosphodiesterase 3
  • CGMP-Specific Phosphodiesterase Type 5A 3
  • CGMP-Specific Phosphodiesterase PDE5A2 3
  • Phosphodiesterase Isozyme 5 3
  • EC 3.1.4 63
  • CN5A 3

External Ids for PDE5A Gene

Previous GeneCards Identifiers for PDE5A Gene

  • GC04M121176
  • GC04M120698
  • GC04M120811
  • GC04M120877
  • GC04M120878
  • GC04M120776
  • GC04M120415
  • GC04M116136

Summaries for PDE5A Gene

Entrez Gene Summary for PDE5A Gene

  • This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for PDE5A Gene

PDE5A (Phosphodiesterase 5A, CGMP-Specific) is a Protein Coding gene. Diseases associated with PDE5A include transient global amnesia and impotence. Among its related pathways are Platelet homeostasis and Hemostasis. GO annotations related to this gene include cGMP binding and 3,5-cyclic-GMP phosphodiesterase activity. An important paralog of this gene is PDE6A.

UniProtKB/Swiss-Prot for PDE5A Gene

  • Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5-GMP

Tocris Summary for PDE5A Gene

  • Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11; PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously, with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility, platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Gene Wiki entry for PDE5A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDE5A Gene

Genomics for PDE5A Gene

Regulatory Elements for PDE5A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PDE5A Gene

Start:
119,494,395 bp from pter
End:
119,628,991 bp from pter
Size:
134,597 bases
Orientation:
Minus strand

Genomic View for PDE5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDE5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDE5A Gene

Proteins for PDE5A Gene

  • Protein details for PDE5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76074-PDE5A_HUMAN
    Recommended name:
    cGMP-specific 3,5-cyclic phosphodiesterase
    Protein Accession:
    O76074
    Secondary Accessions:
    • A0AV69
    • A8K2C4
    • O75026
    • O75887
    • Q86UI0
    • Q86V66
    • Q9Y6Z6

    Protein attributes for PDE5A Gene

    Size:
    875 amino acids
    Molecular mass:
    99985 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PDE5A Gene

    Alternative splice isoforms for PDE5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDE5A Gene

Proteomics data for PDE5A Gene at MOPED

Post-translational modifications for PDE5A Gene

  • Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by PRKG1 leads to its activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PDE5A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDE5A (PDE5A)

Domains for PDE5A Gene

Gene Families for PDE5A Gene

HGNC:
  • PDE :Phosphodiesterases
IUPHAR :

Protein Domains for PDE5A Gene

Graphical View of Domain Structure for InterPro Entry

O76074

UniProtKB/Swiss-Prot:

PDE5A_HUMAN :
  • O76074
Domain:
  • Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain which contains two homologous allosteric cGMP-binding regions, A and B
  • Contains 2 GAF domains.
Family:
  • Belongs to the cyclic nucleotide phosphodiesterase family.
genes like me logo Genes that share domains with PDE5A: view

Function for PDE5A Gene

Molecular function for PDE5A Gene

GENATLAS Biochemistry: cGMP specific nucleotide phosphodiesterase,class V,alpha subunit,two alternatively spliced forms A1,A2,100kDa,highly expressed in tissues,aortic smooth muscle cells,heart,placenta,skeletal muscle,pancreas,brain,liver and lung
UniProtKB/Swiss-Prot CatalyticActivity: Guanosine 3,5-cyclic phosphate + H(2)O = guanosine 5-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A and is effective in the treatment of penile erectile dysfunction. Also inhibited by zaprinast
UniProtKB/Swiss-Prot Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5-GMP

Enzyme Numbers (IUBMB) for PDE5A Gene

Gene Ontology (GO) - Molecular Function for PDE5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004112 cyclic-nucleotide phosphodiesterase activity --
GO:0004114 3,5-cyclic-nucleotide phosphodiesterase activity NAS 9714779
GO:0005515 protein binding --
GO:0030553 cGMP binding TAS 15938621
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PDE5A: view

Animal Model Products

CRISPR Products

miRNA for PDE5A Gene

miRTarBase miRNAs that target PDE5A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE5A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PDE5A Gene

Localization for PDE5A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDE5A Gene COMPARTMENTS Subcellular localization image for PDE5A gene
Compartment Confidence
cytosol 4
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PDE5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PDE5A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PDE5A Gene

Pathways for PDE5A Gene

genes like me logo Genes that share pathways with PDE5A: view

Pathways by source for PDE5A Gene

1 Qiagen pathway for PDE5A Gene
1 Cell Signaling Technology pathway for PDE5A Gene
1 KEGG pathway for PDE5A Gene
1 GeneGo (Thomson Reuters) pathway for PDE5A Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O76074-PDE5A_HUMAN

  • Pathway: Purine metabolism; 3,5-cyclic GMP degradation; GMP from 3,5-cyclic GMP: step 1/1

Gene Ontology (GO) - Biological Process for PDE5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007596 blood coagulation TAS --
GO:0010613 positive regulation of cardiac muscle hypertrophy IEA --
GO:0030823 regulation of cGMP metabolic process IEA --
GO:0042130 negative regulation of T cell proliferation IEA --
genes like me logo Genes that share ontologies with PDE5A: view

Compounds for PDE5A Gene

(5) Tocris Compounds for PDE5A Gene

Compound Action Cas Number
(R)-(-)-Rolipram PDE4 inhibitor. More active enantiomer of rolipram (Cat. No. 0905) [85416-75-7]
Cilostamide PDE3 inhibitor [68550-75-4]
IBMX PDE inhibitor (non-selective) [28822-58-4]
Rolipram PDE4 inhibitor [61413-54-5]
Sildenafil citrate Orally active, potent PDE5 inhibitor [171599-83-0]

(10) HMDB Compounds for PDE5A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Cobalt
  • Co
7440-48-4
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine monophosphate
  • 5'-GMP
85-32-5

(13) Drugbank Compounds for PDE5A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
3-ISOBUTYL-1-METHYLXANTHINE
target
5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide
target
Avanafil
330784-47-9 target inhibitor
Citric Acid
77-92-9 target
Dipyridamole
  • Dipiridamol
58-32-2 target inhibitor

(4) IUPHAR Ligand for PDE5A Gene

Ligand Type Action Affinity Pubmed IDs
T0156 Inhibitor Inhibition 9.5
SCH51866 Inhibitor Inhibition 7.2
zaprinast Inhibitor Inhibition 6.8
sildenafil Inhibitor Inhibition

(58) Novoseek inferred chemical compound relationships for PDE5A Gene

Compound -log(P) Hits PubMed IDs
vardenafil 97.8 138
tadalafil 97.5 132
sildenafil 96.9 206
cgmp 90.5 262
zaprinast 82.5 27
genes like me logo Genes that share compounds with PDE5A: view

Transcripts for PDE5A Gene

Unigene Clusters for PDE5A Gene

Phosphodiesterase 5A, cGMP-specific:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDE5A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PDE5A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDE5A Gene

No ASD Table

Relevant External Links for PDE5A Gene

GeneLoc Exon Structure for
PDE5A
ECgene alternative splicing isoforms for
PDE5A

Expression for PDE5A Gene

mRNA expression in normal human tissues for PDE5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDE5A Gene

This gene is overexpressed in Artery - Aorta (5.1), Artery - Tibial (5.1), Esophagus - Muscularis (4.5), and Esophagus - Gastroesophageal Junction (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDE5A Gene

SOURCE GeneReport for Unigene cluster for PDE5A Gene Hs.647971

mRNA Expression by UniProt/SwissProt for PDE5A Gene

O76074-PDE5A_HUMAN
Tissue specificity: Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung
genes like me logo Genes that share expressions with PDE5A: view

In Situ Assay Products

Orthologs for PDE5A Gene

This gene was present in the common ancestor of animals.

Orthologs for PDE5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDE5A 35
  • 99.76 (n)
  • 99.76 (a)
PDE5A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDE5A 35
  • 92.91 (n)
  • 96.42 (a)
PDE5A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDE5A 35
  • 94.55 (n)
  • 97.94 (a)
PDE5A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pde5a 35
  • 88.79 (n)
  • 93.53 (a)
Pde5a 16
Pde5a 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDE5A 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDE5A 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pde5a 35
  • 89.39 (n)
  • 93.46 (a)
chicken
(Gallus gallus)
Aves PDE5A 35
  • 81.99 (n)
  • 88.86 (a)
PDE5A 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PDE5A 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pde5a 35
  • 75.77 (n)
  • 81.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6340 35
zebrafish
(Danio rerio)
Actinopterygii CT826376.1 36
  • 38 (a)
ManyToMany
pde5ab 35
  • 70.14 (n)
  • 74.4 (a)
pde5ab 36
  • 72 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008646 35
  • 52.12 (n)
  • 50.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pde11 35
  • 54.04 (n)
  • 51.06 (a)
CG8279 37
  • 44 (a)
CG10231 37
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for PDE5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDE5A Gene

ENSEMBL:
Gene Tree for PDE5A (if available)
TreeFam:
Gene Tree for PDE5A (if available)

Paralogs for PDE5A Gene

Paralogs for PDE5A Gene

genes like me logo Genes that share paralogs with PDE5A: view

Variants for PDE5A Gene

Sequence variations from dbSNP and Humsavar for PDE5A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs722667 -- 119,514,966(+) aagct(A/G)ggcat intron-variant
rs722668 -- 119,515,113(+) TATTA(A/G)TATTT intron-variant
rs1010739 -- 119,542,316(-) TTATT(A/G)TCCTC intron-variant
rs1010740 -- 119,542,254(-) ATGTC(A/G)TATAA intron-variant
rs1155576 -- 119,529,004(-) GCTAG(G/T)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PDE5A Gene

Variant ID Type Subtype PubMed ID
dgv5698n71 CNV Loss 21882294
dgv5699n71 CNV Loss 21882294
dgv5700n71 CNV Loss 21882294
nsv879848 CNV Loss 21882294
nsv822710 CNV Loss 20364138
esv2728237 CNV Deletion 23290073

Relevant External Links for PDE5A Gene

HapMap Linkage Disequilibrium report
PDE5A
Human Gene Mutation Database (HGMD)
PDE5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDE5A Gene

Disorders for PDE5A Gene

(50) Novoseek inferred disease relationships for PDE5A Gene

Disease -log(P) Hits PubMed IDs
erectile dysfunction 95.8 126
hypertension pulmonary 71.8 41
benign prostatic hyperplasia 66.3 11
naion 64.7 17
hypertension arterial 63.6 26

Relevant External Links for PDE5A

Genetic Association Database (GAD)
PDE5A
Human Genome Epidemiology (HuGE) Navigator
PDE5A
genes like me logo Genes that share disorders with PDE5A: view

No data available for UniProtKB/Swiss-Prot for PDE5A Gene

Publications for PDE5A Gene

  1. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP- binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. (PMID: 9714779) Loughney K. … Ferguson K. (Gene 1998) 2 3 4 23
  2. Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase. (PMID: 9642111) Stacey P. … Phillips S.C. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  3. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules. (PMID: 12955149) Sung B.-J. … Cho J.M. (Nature 2003) 3 4 25
  4. PDE5 is converted to an activated state upon cGMP binding to the GAF A domain. (PMID: 12554648) Rybalkin S.D. … Beavo J.A. (EMBO J. 2003) 3 23 25
  5. Expression, structure and chromosomal localization of the human cGMP- binding cGMP-specific phosphodiesterase PDE5A gene. (PMID: 9716380) Yanaka N. … Omori K. (Eur. J. Biochem. 1998) 3 4

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