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Aliases for OASL Gene

Aliases for OASL Gene

  • 2'-5'-Oligoadenylate Synthetase-Like 2
  • TRIP14 3 4 6
  • 59 KDa 2-5-Oligoadenylate Synthase-Like Protein 3 4
  • Thyroid Receptor-Interacting Protein 14 3 4
  • 2-5-Oligoadenylate Synthetase-Like 2 3
  • TR-Interacting Protein 14 3 4
  • 2-5-OAS-Related Protein 3 4
  • 2-5-OAS-RP 3 4
  • P59 OASL 3 4
  • TRIP-14 3 4
  • P59OASL 3 4
  • 59 KDa 2-5-Oligoadenylate Synthetase-Like Protein 3
  • 2-5-Oligoadenylate Synthase-Like Protein 3
  • P59-OASL 3
  • OASLd 3

External Ids for OASL Gene

Summaries for OASL Gene

GeneCards Summary for OASL Gene

OASL (2'-5'-Oligoadenylate Synthetase-Like) is a Protein Coding gene. Diseases associated with OASL include west nile encephalitis. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include double-stranded RNA binding and 2-5-oligoadenylate synthetase activity. An important paralog of this gene is OAS2.

UniProtKB/Swiss-Prot for OASL Gene

  • Does not have 2-5-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

Gene Wiki entry for OASL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OASL Gene

Genomics for OASL Gene

Genomic Location for OASL Gene

Start:
121,020,292 bp from pter
End:
121,039,242 bp from pter
Size:
18,951 bases
Orientation:
Minus strand

Genomic View for OASL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OASL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OASL Gene

Regulatory Elements for OASL Gene

Proteins for OASL Gene

  • Protein details for OASL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15646-OASL_HUMAN
    Recommended name:
    2-5-oligoadenylate synthase-like protein
    Protein Accession:
    Q15646
    Secondary Accessions:
    • B2RAZ2
    • I1YDD2
    • O75686
    • Q17R95
    • Q9Y6K6
    • Q9Y6K7

    Protein attributes for OASL Gene

    Size:
    514 amino acids
    Molecular mass:
    59226 Da
    Quaternary structure:
    • Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1.
    SequenceCaution:
    • Sequence=AAC41733.1; Type=Frameshift; Positions=386; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OASL Gene

    Alternative splice isoforms for OASL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OASL Gene

Proteomics data for OASL Gene at MOPED

Post-translational modifications for OASL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OASL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OASL Gene

Domains for OASL Gene

UniProtKB/Swiss-Prot:

OASL_HUMAN
Domain:
  • The ubiquitin-like domains are essential for its antiviral activity:
    • Q15646
  • Contains 2 ubiquitin-like domains.:
    • Q15646
Family:
  • Belongs to the 2-5A synthase family.:
    • Q15646
genes like me logo Genes that share domains with OASL: view

No data available for Gene Families for OASL Gene

Function for OASL Gene

Molecular function for OASL Gene

GENATLAS Biochemistry: 2,5 oligoadenylate synthetase-like,interferon induced,cytoplasmic and nucleolar
UniProtKB/Swiss-Prot Function: Does not have 2-5-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.
UniProtKB/Swiss-Prot Induction: By type I interferon (IFN) and viruses.

Gene Ontology (GO) - Molecular Function for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001730 NOT 2-5-oligoadenylate synthetase activity IDA 9826176
GO:0003677 DNA binding IDA 9826176
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding IDA 9826176
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with OASL: view

Phenotypes for OASL Gene

genes like me logo Genes that share phenotypes with OASL: view

Animal Models for OASL Gene

MGI Knock Outs for OASL:

miRNA for OASL Gene

miRTarBase miRNAs that target OASL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for OASL Gene

Localization for OASL Gene

Subcellular locations from UniProtKB/Swiss-Prot for OASL Gene

Isoform p56: Nucleus, nucleolus. Cytoplasm.
Isoform p30: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OASL Gene COMPARTMENTS Subcellular localization image for OASL gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 9826176
GO:0005737 cytoplasm IDA 9826176
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with OASL: view

Pathways for OASL Gene

genes like me logo Genes that share pathways with OASL: view

Gene Ontology (GO) - Biological Process for OASL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response --
GO:0008152 metabolic process IEA --
GO:0009615 response to virus IDA 18931074
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0045071 negative regulation of viral genome replication IDA 18931074
genes like me logo Genes that share ontologies with OASL: view

Compounds for OASL Gene

(1) Novoseek inferred chemical compound relationships for OASL Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 90.1 7

(2) PharmGKB related drug/compound annotations for OASL Gene

Drug/compound Annotation
peginterferon alfa-2b CA
ribavirin CA
genes like me logo Genes that share compounds with OASL: view

Transcripts for OASL Gene

Unigene Clusters for OASL Gene

2-5-oligoadenylate synthetase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OASL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1:
SP2: -
SP3: - -

Relevant External Links for OASL Gene

GeneLoc Exon Structure for
OASL
ECgene alternative splicing isoforms for
OASL

Expression for OASL Gene

mRNA expression in normal human tissues for OASL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OASL Gene

This gene is overexpressed in Whole Blood (18.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OASL Gene

SOURCE GeneReport for Unigene cluster for OASL Gene Hs.118633

mRNA Expression by UniProt/SwissProt for OASL Gene

Q15646-OASL_HUMAN
Tissue specificity: Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis
genes like me logo Genes that share expressions with OASL: view

Orthologs for OASL Gene

This gene was present in the common ancestor of chordates.

Orthologs for OASL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OASL 36
  • 99.35 (n)
  • 98.25 (a)
OASL 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OASL 37
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OASL1 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oasl1 36
  • 77.52 (n)
  • 70.98 (a)
Oasl1 16
Oasl1 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OASL 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oasl 36
  • 78.33 (n)
  • 73.96 (a)
chicken
(Gallus gallus)
Aves OAS*A 37
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OASL 37
  • 42 (a)
OneToOne
Species with no ortholog for OASL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OASL Gene

ENSEMBL:
Gene Tree for OASL (if available)
TreeFam:
Gene Tree for OASL (if available)

Paralogs for OASL Gene

Paralogs for OASL Gene

Selected SIMAP similar genes for OASL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OASL: view

Variants for OASL Gene

Sequence variations from dbSNP and Humsavar for OASL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1984841 -- 121,039,837(-) GCTCA(C/T)GCTGT upstream-variant-2KB
rs2259690 -- 121,020,111(-) AAAAA(A/C)AGGAT downstream-variant-500B
rs2259693 -- 121,020,192(-) CACAC(C/T)GCTAC downstream-variant-500B
rs2259697 -- 121,020,335(-) TATCA(C/T)AGGGA utr-variant-3-prime
rs2259777 -- 121,021,733(-) CCTGT(A/G)TTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OASL Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899559 CNV Gain 21882294
dgv1496n71 CNV Gain 21882294
dgv529e1 CNV Complex 17122850
nsv832531 CNV Gain 17160897

Relevant External Links for OASL Gene

HapMap Linkage Disequilibrium report
OASL

Disorders for OASL Gene

(1) MalaCards Diseases for OASL Gene

Search for OASL Gene in MalaCards »

(1) University of Copenhagen DISEASES for OASL Gene

Relevant External Links for OASL

Genetic Association Database (GAD)
OASL
Human Genome Epidemiology (HuGE) Navigator
OASL
genes like me logo Genes that share disorders with OASL: view

No data available for UniProtKB/Swiss-Prot for OASL Gene

Publications for OASL Gene

  1. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. (PMID: 9722630) Hartmann R. … Justesen J. (Nucleic Acids Res. 1998) 3 4 23
  2. The human 2',5'-oligoadenylate synthetase-like gene (OASL) encoding the interferon-induced 56-kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. (PMID: 10087211) Hovnanian A. … Hovanessian A.G. (Genomics 1999) 2 3 23
  3. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. (PMID: 14728690) Andersen J.B. … Justesen J. (Eur. J. Biochem. 2004) 3 4 23
  4. 2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. (PMID: 20074559) Ishibashi M. … Esumi M. (Biochem. Biophys. Res. Commun. 2010) 3 4 23
  5. [Interferon-inducible genes 2', 5'-ollgoadenylate synthetase-like and tetratricopeptide repeats 2 are correlated with clinical features of patients with systemic lupus erythematosus]. (PMID: 20506645) Zhao Z.Y. … Zhong X. (Sichuan Da Xue Xue Bao Yi Xue Ban 2010) 3 23

Products for OASL Gene

Sources for OASL Gene

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