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Aliases for RNASET2 Gene

Aliases for RNASET2 Gene

  • Ribonuclease T2 2 3 5
  • Ribonuclease 6 3 4
  • RNASE6PL 3 4
  • EC 3.1.27.1 63
  • EC 3.1.27.- 4
  • BA514O12.3 3

External Ids for RNASET2 Gene

Previous GeneCards Identifiers for RNASET2 Gene

  • GC06M167252
  • GC06M167313
  • GC06M164815
  • GC06M167342

Summaries for RNASET2 Gene

Entrez Gene Summary for RNASET2 Gene

  • This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNASET2 Gene

RNASET2 (Ribonuclease T2) is a Protein Coding gene. Diseases associated with RNASET2 include Leukoencephalopathy, Cystic, Without Megalencephaly and Megalencephaly. GO annotations related to this gene include RNA binding and endoribonuclease activity. An important paralog of this gene is ENSG00000249141.

UniProtKB/Swiss-Prot for RNASET2 Gene

  • Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.

Gene Wiki entry for RNASET2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASET2 Gene

Genomics for RNASET2 Gene

Regulatory Elements for RNASET2 Gene

Enhancers for RNASET2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNASET2 on UCSC Golden Path with GeneCards custom track

Promoters for RNASET2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNASET2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASET2 Gene

Chromosome:
6
Start:
166,929,504 bp from pter
End:
166,957,191 bp from pter
Size:
27,688 bases
Orientation:
Minus strand

Genomic View for RNASET2 Gene

Genes around RNASET2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASET2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASET2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASET2 Gene

Proteins for RNASET2 Gene

  • Protein details for RNASET2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00584-RNT2_HUMAN
    Recommended name:
    Ribonuclease T2
    Protein Accession:
    O00584
    Secondary Accessions:
    • B2RDA7
    • E1P5C3
    • Q5T8Q0
    • Q8TCU2
    • Q9BZ46
    • Q9BZ47

    Protein attributes for RNASET2 Gene

    Size:
    256 amino acids
    Molecular mass:
    29481 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASET2 Gene

    Alternative splice isoforms for RNASET2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASET2 Gene

Proteomics data for RNASET2 Gene at MOPED

Selected DME Specific Peptides for RNASET2 Gene

Post-translational modifications for RNASET2 Gene

  • Ubiquitination at Lys 157
  • Glycosylation at Asn 76, Asn 106, and Asn 212
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for RNASET2 Gene

Protein Domains for RNASET2 Gene

Suggested Antigen Peptide Sequences for RNASET2 Gene

Graphical View of Domain Structure for InterPro Entry

O00584

UniProtKB/Swiss-Prot:

RNT2_HUMAN :
  • Belongs to the RNase T2 family.
Family:
  • Belongs to the RNase T2 family.
genes like me logo Genes that share domains with RNASET2: view

No data available for Gene Families for RNASET2 Gene

Function for RNASET2 Gene

Molecular function for RNASET2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Zn(2+) and Cu(2+).
UniProtKB/Swiss-Prot Function:
Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.

Enzyme Numbers (IUBMB) for RNASET2 Gene

genes like me logo Genes that share phenotypes with RNASET2: view

Human Phenotype Ontology for RNASET2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RNASET2 Gene

MGI Knock Outs for RNASET2:

Animal Model Products

miRNA for RNASET2 Gene

miRTarBase miRNAs that target RNASET2

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for RNASET2 Gene

Localization for RNASET2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASET2 Gene

Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASET2 Gene COMPARTMENTS Subcellular localization image for RNASET2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
lysosome 5
vacuole 5

Gene Ontology (GO) - Cellular Components for RNASET2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 16620762
genes like me logo Genes that share ontologies with RNASET2: view

Pathways & Interactions for RNASET2 Gene

SuperPathways for RNASET2 Gene

No Data Available

Interacting Proteins for RNASET2 Gene

Gene Ontology (GO) - Biological Process for RNASET2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9192857
genes like me logo Genes that share ontologies with RNASET2: view

No data available for Pathways by source and SIGNOR curated interactions for RNASET2 Gene

Drugs & Compounds for RNASET2 Gene

No Compound Related Data Available

Transcripts for RNASET2 Gene

Unigene Clusters for RNASET2 Gene

Ribonuclease T2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNASET2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2:
SP3: - - - - - - - -

Relevant External Links for RNASET2 Gene

GeneLoc Exon Structure for
RNASET2
ECgene alternative splicing isoforms for
RNASET2

Expression for RNASET2 Gene

mRNA expression in normal human tissues for RNASET2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASET2 Gene

This gene is overexpressed in Whole Blood (x13.1) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for RNASET2 Gene

This gene is overexpressed in Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASET2 Gene



SOURCE GeneReport for Unigene cluster for RNASET2 Gene Hs.529989

mRNA Expression by UniProt/SwissProt for RNASET2 Gene

O00584-RNT2_HUMAN
Tissue specificity: Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
genes like me logo Genes that share expression patterns with RNASET2: view

Protein tissue co-expression partners for RNASET2 Gene

Primer Products

Orthologs for RNASET2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNASET2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASET2 35
  • 71.94 (n)
  • 62.5 (a)
RNASET2 36
  • 51 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RNASET2 35
  • 75.5 (n)
  • 74.3 (a)
-- 36
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rnaset2a 35
  • 77.83 (n)
  • 72.32 (a)
Rnaset2b 16
Rnaset2a 36
  • 64 (a)
ManyToMany
Rnaset2b 36
  • 64 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia RNASET2 35
  • 99.61 (n)
  • 99.22 (a)
RNASET2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnaset2 35
  • 76.77 (n)
  • 71.95 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves RNASET2 35
  • 65.45 (n)
  • 59.36 (a)
RNASET2 36
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rnaset2 35
  • 61.97 (n)
  • 55.45 (a)
Str.9691 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7197 35
zebrafish
(Danio rerio)
Actinopterygii rnaset2 35
  • 56.84 (n)
  • 50.72 (a)
rnaset2 36
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009842 35
  • 45.02 (n)
  • 34.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta RNaseX25 35
  • 46.63 (n)
  • 34.68 (a)
RNaseX25 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K10C9.3 35
  • 45.23 (n)
  • 32.43 (a)
K10C9.3 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNY1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RNS3 35
  • 44.76 (n)
  • 33.14 (a)
rice
(Oryza sativa)
Liliopsida Os08g0434100 35
  • 47.1 (n)
  • 34.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1740 36
  • 30 (a)
OneToMany
Species with no ortholog for RNASET2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNASET2 Gene

ENSEMBL:
Gene Tree for RNASET2 (if available)
TreeFam:
Gene Tree for RNASET2 (if available)

Paralogs for RNASET2 Gene

Paralogs for RNASET2 Gene

(1) SIMAP similar genes for RNASET2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RNASET2 Gene

genes like me logo Genes that share paralogs with RNASET2: view

Variants for RNASET2 Gene

Sequence variations from dbSNP and Humsavar for RNASET2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11159 - 166,929,653(-) AGAGC(A/C/T)GGGGT reference, missense
VAR_063596 Leukoencephalopathy, cystic, without megalencephaly (LCWM)
rs1044059 -- 166,956,409(-) GGGTC(G/T)CCAGG utr-variant-5-prime
rs1077453 -- 166,946,536(+) CAATA(C/T)TTACT intron-variant
rs1079145 -- 166,947,236(-) ATCTT(C/T)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNASET2 Gene

Variant ID Type Subtype PubMed ID
esv2733211 CNV Deletion 23290073
esv2733212 CNV Deletion 23290073

Variation tolerance for RNASET2 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASET2 Gene

Human Gene Mutation Database (HGMD)
RNASET2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASET2 Gene

Disorders for RNASET2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RNASET2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
leukoencephalopathy, cystic, without megalencephaly
  • cystic leukoencephalopathy without megalencephaly
megalencephaly
  • macrencephaly
congenital cytomegalovirus
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RNT2_HUMAN
  • Leukoencephalopathy, cystic, without megalencephaly (LCWM) [MIM:612951]: An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. {ECO:0000269 PubMed:19525954}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RNASET2

Genetic Association Database (GAD)
RNASET2
Human Genome Epidemiology (HuGE) Navigator
RNASET2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASET2
genes like me logo Genes that share disorders with RNASET2: view

No data available for Genatlas for RNASET2 Gene

Publications for RNASET2 Gene

  1. Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies. (PMID: 9192857) Trubia M. … Taramelli R. (Genomics 1997) 2 3 4 67
  2. RNASET2 as a tumor antagonizing gene in a melanoma cancer model. (PMID: 18543608) Monti L. … Taramelli R. (Oncol. Res. 2008) 3 23
  3. Tumor and metastasis suppression by the human RNASET2 gene. (PMID: 15809705) Acquati F. … Taramelli R. (Int. J. Oncol. 2005) 3 23
  4. Cloning and characterization of a senescence inducing and class II tumor suppressor gene in ovarian carcinoma at chromosome region 6q27. (PMID: 11314033) Acquati F. … Taramelli R. (Oncogene 2001) 3 23
  5. New Strategies for Expression and Purification of Recombinant Human RNASET2 Protein in Pichia pastoris. (PMID: 25663099) Lualdi M. … Acquati F. (Mol. Biotechnol. 2015) 3

Products for RNASET2 Gene

Sources for RNASET2 Gene

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