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Aliases for ASMTL Gene

Aliases for ASMTL Gene

  • Acetylserotonin O-Methyltransferase-Like 2 3 5
  • Acetylserotonin N-Methyltransferase-Like 3
  • EC 2.1.1.- 4
  • ASMTLX 3
  • ASMTLY 3
  • ASTML 3

External Ids for ASMTL Gene

Previous GeneCards Identifiers for ASMTL Gene

  • GC0XM000997
  • GC0XM000838
  • GC0XM001102
  • GC0XM001167
  • GC0YM001565
  • GC0XM001565
  • GC0XM001482
  • GC0XM001522

Summaries for ASMTL Gene

Entrez Gene Summary for ASMTL Gene

  • The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

GeneCards Summary for ASMTL Gene

ASMTL (Acetylserotonin O-Methyltransferase-Like) is a Protein Coding gene. GO annotations related to this gene include O-methyltransferase activity. An important paralog of this gene is ASMT.

UniProtKB/Swiss-Prot for ASMTL Gene

  • Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.

Gene Wiki entry for ASMTL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASMTL Gene

Genomics for ASMTL Gene

Regulatory Elements for ASMTL Gene

Enhancers for ASMTL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ASMTL on UCSC Golden Path with GeneCards custom track

Promoters for ASMTL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ASMTL on UCSC Golden Path with GeneCards custom track

Genomic Location for ASMTL Gene

1,403,139 bp from pter
1,453,795 bp from pter
50,657 bases
Minus strand

Genomic View for ASMTL Gene

Genes around ASMTL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ASMTL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ASMTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASMTL Gene

Proteins for ASMTL Gene

  • Protein details for ASMTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-acetylserotonin O-methyltransferase-like protein
    Protein Accession:
    Secondary Accessions:
    • B4DX75
    • F5GXH4
    • J3JS33
    • Q5JQ53
    • Q8NBH5
    • Q96G02
    • Q9BUL6

    Protein attributes for ASMTL Gene

    621 amino acids
    Molecular mass:
    68857 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It represents a unique fusion product of 2 different genes of different evolutionary origin and function. The N-terminus is homologous to the bacterial maf/orfE genes and the C-terminus is homologous to ASMT. Exon duplication, exon shuffling and gene fusion seem to be common characteristics of the PAR1 region.
    • Sequence=CAA75675.1; Type=Frameshift; Positions=616; Evidence={ECO:0000305}; Sequence=CAA75676.1; Type=Frameshift; Positions=616; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ASMTL Gene

    Alternative splice isoforms for ASMTL Gene


neXtProt entry for ASMTL Gene

Proteomics data for ASMTL Gene at MOPED

Post-translational modifications for ASMTL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ASMTL Gene

No data available for DME Specific Peptides for ASMTL Gene

Domains & Families for ASMTL Gene

Gene Families for ASMTL Gene

Suggested Antigen Peptide Sequences for ASMTL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.
  • In the N-terminal section; belongs to the maf family.
genes like me logo Genes that share domains with ASMTL: view

Function for ASMTL Gene

Molecular function for ASMTL Gene

GENATLAS Biochemistry:
acetylserotonin methyltransferase-like due to a unique fusion product of two genes of different evolutionary origin and function,(see ASMTLY)
UniProtKB/Swiss-Prot Function:
Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity.

Enzyme Numbers (IUBMB) for ASMTL Gene

Gene Ontology (GO) - Molecular Function for ASMTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with ASMTL: view
genes like me logo Genes that share phenotypes with ASMTL: view

miRNA for ASMTL Gene

miRTarBase miRNAs that target ASMTL

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ASMTL Gene

Localization for ASMTL Gene

Subcellular locations from

Jensen Localization Image for ASMTL Gene COMPARTMENTS Subcellular localization image for ASMTL gene
Compartment Confidence
cytosol 3
mitochondrion 3
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ASMTL Gene

Pathways & Interactions for ASMTL Gene

SuperPathways for ASMTL Gene

No Data Available

Gene Ontology (GO) - Biological Process for ASMTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ASMTL: view

No data available for Pathways by source and SIGNOR curated interactions for ASMTL Gene

Drugs & Compounds for ASMTL Gene

(1) Drugs for ASMTL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with ASMTL: view

Transcripts for ASMTL Gene

Unigene Clusters for ASMTL Gene

Acetylserotonin O-methyltransferase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASMTL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - -
SP2: -
SP4: - - - - -
SP6: -

Relevant External Links for ASMTL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASMTL Gene

mRNA expression in normal human tissues for ASMTL Gene

Protein differential expression in normal tissues from HIPED for ASMTL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ASMTL Gene

SOURCE GeneReport for Unigene cluster for ASMTL Gene Hs.533514

mRNA Expression by UniProt/SwissProt for ASMTL Gene

Tissue specificity: Widely expressed. In adult, highly expressed in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Expressed at lower levels in spleen, small intestine and leukocytes. In fetus, expressed at high levels in the lung and kidney and at lower level in brain and liver.
genes like me logo Genes that share expression patterns with ASMTL: view

Protein tissue co-expression partners for ASMTL Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ASMTL Gene

Orthologs for ASMTL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASMTL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ASMTL 35
  • 71.73 (n)
  • 62.42 (a)
  • 58 (a)
(Canis familiaris)
Mammalia ASMTL 35
  • 75.06 (n)
  • 68.61 (a)
  • 66 (a)
(Pan troglodytes)
Mammalia ASMTL 35
  • 97.74 (n)
  • 95.76 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Asmtl 35
  • 58.68 (n)
  • 49.77 (a)
(Monodelphis domestica)
Mammalia ASMTL 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia ASMTL 36
  • 58 (a)
(Gallus gallus)
Aves ASMTL 35
  • 63.19 (n)
  • 62.48 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia ASMTL 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia asmtl 35
  • 59.38 (n)
  • 59.05 (a)
Str.17108 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25671 35
(Danio rerio)
Actinopterygii asmtl 35
  • 58.21 (n)
  • 56.34 (a)
wufc48g07 35
asmtl 36
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008707 35
  • 52.81 (n)
  • 46.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9515 35
  • 46.8 (n)
  • 43.35 (a)
CG9515 36
  • 16 (a)
(Caenorhabditis elegans)
Secernentea dod-18 35
  • 45.34 (n)
  • 38.17 (a)
dod-18 36
  • 13 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL225W 35
  • 50.69 (n)
  • 38.02 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23628g 35
  • 46.47 (n)
  • 39.41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YOR111W 35
  • 48.5 (n)
  • 38 (a)
-- 36
  • 12 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03130 35
  • 54.17 (n)
  • 44 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC3G6.03c 35
  • 46.01 (n)
  • 41.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
Species with no ortholog for ASMTL:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASMTL Gene

Gene Tree for ASMTL (if available)
Gene Tree for ASMTL (if available)

Paralogs for ASMTL Gene

Paralogs for ASMTL Gene

(1) SIMAP similar genes for ASMTL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASMTL: view

Variants for ASMTL Gene

Sequence variations from dbSNP and Humsavar for ASMTL Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_054802 -
VAR_054803 -

Structural Variations from Database of Genomic Variants (DGV) for ASMTL Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
dgv1357e201 CNV Deletion 23290073
esv2666429 CNV Deletion 23128226
esv2739698 CNV Deletion 23290073
esv2739703 CNV Deletion 23290073
esv2667783 CNV Deletion 23128226
esv2669866 CNV Deletion 23128226
esv2739704 CNV Deletion 23290073
esv2739705 CNV Deletion 23290073
esv2678263 CNV Deletion 23128226
esv2739706 CNV Deletion 23290073
esv2739708 CNV Deletion 23290073
esv2196117 CNV Deletion 18987734
esv2739709 CNV Deletion 23290073
esv2739710 CNV Deletion 23290073
dgv1359e201 CNV Deletion 23290073
esv2739712 CNV Deletion 23290073
esv2246827 CNV Deletion 18987734
esv2739714 CNV Deletion 23290073
dgv1360e201 CNV Deletion 23290073
esv2739716 CNV Deletion 23290073
esv2739719 CNV Deletion 23290073
esv2739720 CNV Deletion 23290073
esv2666911 CNV Deletion 23128226
esv1981196 CNV Deletion 18987734

Variation tolerance for ASMTL Gene

Residual Variation Intolerance Score: 94.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.35; 88.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ASMTL Gene

Disorders for ASMTL Gene

Relevant External Links for ASMTL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ASMTL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ASMTL Gene

Publications for ASMTL Gene

  1. Gene duplications as a recurrent theme in the evolution of the human pseudoautosomal region 1: isolation of the gene ASMTL. (PMID: 9736779) Ried K. … Rappold G.A. (Hum. Mol. Genet. 1998) 2 3 4 23 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ASMTL Gene

Sources for ASMTL Gene