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Aliases for PPAP2B Gene

Aliases for PPAP2B Gene

  • Phosphatidic Acid Phosphatase Type 2B 2 3
  • Phosphatidate Phosphohydrolase Type 2b 3 4
  • EC 4 64
  • PAP2B 3 4
  • LPP3 3 4
  • VCIP 3 4
  • Vascular Endothelial Growth Factor And Type I Collagen-Inducible Protein 4
  • Vascular Endothelial Growth Factor And Type I Collagen Inducible 3
  • Type-2 Phosphatidic Acid Phosphatase-Beta 3
  • Lipid Phosphate Phosphohydrolase 3 3
  • Phosphatidic Acid Phosphatase 2b 4
  • PAP2 Beta 3
  • PAP2-Beta 4
  • PAP-2b 4
  • Dri42 3

External Ids for PPAP2B Gene

Summaries for PPAP2B Gene

Entrez Gene Summary for PPAP2B Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPAP2B Gene

PPAP2B (Phosphatidic Acid Phosphatase Type 2B) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway. GO annotations related to this gene include integrin binding and phosphatidate phosphatase activity. An important paralog of this gene is LPPR4.

UniProtKB/Swiss-Prot for PPAP2B Gene

  • Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions

Gene Wiki entry for PPAP2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPAP2B Gene

Genomics for PPAP2B Gene

Genomic Location for PPAP2B Gene

56,494,747 bp from pter
56,645,301 bp from pter
150,555 bases
Minus strand

Genomic View for PPAP2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PPAP2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPAP2B Gene

Regulatory Elements for PPAP2B Gene

Proteins for PPAP2B Gene

  • Protein details for PPAP2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lipid phosphate phosphohydrolase 3
    Protein Accession:
    Secondary Accessions:
    • B2R651
    • D3DQ52
    • Q5U0F7
    • Q96GW0
    • Q99782

    Protein attributes for PPAP2B Gene

    311 amino acids
    Molecular mass:
    35116 Da
    Quaternary structure:
    • Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability.
    • Sequence=AAB50222.1; Type=Frameshift; Positions=225; Evidence={ECO:0000305};

neXtProt entry for PPAP2B Gene

Proteomics data for PPAP2B Gene at MOPED

Selected DME Specific Peptides for PPAP2B Gene

Post-translational modifications for PPAP2B Gene

Other Protein References for PPAP2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PPAP2B Gene

Gene Families for PPAP2B Gene

Protein Domains for PPAP2B Gene


  • Belongs to the PA-phosphatase related phosphoesterase family.:
    • O14495
genes like me logo Genes that share domains with PPAP2B: view

Function for PPAP2B Gene

Molecular function for PPAP2B Gene

UniProtKB/Swiss-Prot CatalyticActivity: A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment
UniProtKB/Swiss-Prot Function: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions
UniProtKB/Swiss-Prot Induction: By EGF, VEGF, FGF2 and phorbol myristate acetate (PMA).

Enzyme Numbers (IUBMB) for PPAP2B Gene

Gene Ontology (GO) - Molecular Function for PPAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004721 phosphoprotein phosphatase activity TAS 9705349
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 20123964
GO:0008195 phosphatidate phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPAP2B: view
genes like me logo Genes that share phenotypes with PPAP2B: view

Animal Models for PPAP2B Gene

MGI Knock Outs for PPAP2B:

miRNA for PPAP2B Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PPAP2B Gene

Localization for PPAP2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPAP2B Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PPAP2B Gene COMPARTMENTS Subcellular localization image for PPAP2B gene
Compartment Confidence
plasma membrane 5
golgi apparatus 3
extracellular 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PPAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0005912 adherens junction TAS 20123964
GO:0016020 membrane TAS 9305923
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PPAP2B: view

Pathways for PPAP2B Gene

genes like me logo Genes that share pathways with PPAP2B: view

Gene Ontology (GO) - Biological Process for PPAP2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development IEA --
GO:0001702 gastrulation with mouth forming second IEA --
GO:0001933 negative regulation of protein phosphorylation IDA 20123964
GO:0006629 lipid metabolic process NAS 9705349
GO:0006644 phospholipid metabolic process IEA --
genes like me logo Genes that share ontologies with PPAP2B: view

Compounds for PPAP2B Gene

(883) HMDB Compounds for PPAP2B Gene

Compound Synonyms Cas Number PubMed IDs
  • L-beta-arachidonoyl-alpha-lysophosphatidic acid
Not Available
Ceramide (d18:1/12:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
Ceramide (d18:1/16:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
Ceramide (d18:1/18:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
Ceramide (d18:1/20:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol

(2) Novoseek inferred chemical compound relationships for PPAP2B Gene

Compound -log(P) Hits PubMed IDs
ceramide 1-phosphate 88 2
lipid 10.4 1
genes like me logo Genes that share compounds with PPAP2B: view

Transcripts for PPAP2B Gene

Unigene Clusters for PPAP2B Gene

Phosphatidic acid phosphatase type 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PPAP2B Gene

No ASD Table

Relevant External Links for PPAP2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPAP2B Gene

mRNA expression in normal human tissues for PPAP2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PPAP2B Gene

SOURCE GeneReport for Unigene cluster for PPAP2B Gene Hs.405156

mRNA Expression by UniProt/SwissProt for PPAP2B Gene

Tissue specificity: Ubiquitously expressed. Highly expressed in heart and placenta
genes like me logo Genes that share expressions with PPAP2B: view

Orthologs for PPAP2B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPAP2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPAP2B 36
  • 95.81 (n)
  • 94.52 (a)
  • 95 (a)
(Bos Taurus)
Mammalia PPAP2B 36
  • 91.94 (n)
  • 95.16 (a)
  • 95 (a)
(Canis familiaris)
Mammalia PPAP2B 36
  • 93.03 (n)
  • 96.78 (a)
  • 96 (a)
(Mus musculus)
Mammalia Ppap2b 36
  • 89.17 (n)
  • 94.86 (a)
Ppap2b 16
Ppap2b 37
  • 95 (a)
(Monodelphis domestica)
Mammalia PPAP2B 37
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia PPAP2B 37
  • 53 (a)
(Rattus norvegicus)
Mammalia Ppap2b 36
  • 88.75 (n)
  • 94.86 (a)
(Gallus gallus)
Aves PPAP2B 36
  • 79.96 (n)
  • 83.6 (a)
  • 84 (a)
(Anolis carolinensis)
Reptilia PPAP2B 37
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppap2b 36
  • 73.79 (n)
  • 80.26 (a)
Str.15806 36
(Danio rerio)
Actinopterygii Dr.28946 36
ppap2b 36
  • 70 (n)
  • 73.23 (a)
ppap2b 37
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11425 37
  • 27 (a)
CG11426 37
  • 29 (a)
CG11437 37
  • 23 (a)
CG11438 37
  • 27 (a)
laza 37
  • 24 (a)
wun 37
  • 32 (a)
wun2 37
  • 28 (a)
CG11426 38
  • 37 (a)
wun 38
  • 41 (a)
wun2 38
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F53C3.13 37
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
Species with no ortholog for PPAP2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPAP2B Gene

Gene Tree for PPAP2B (if available)
Gene Tree for PPAP2B (if available)

Paralogs for PPAP2B Gene

Paralogs for PPAP2B Gene

Selected SIMAP similar genes for PPAP2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PPAP2B: view

Variants for PPAP2B Gene

Sequence variations from dbSNP and Humsavar for PPAP2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4628 -- 56,496,084(+) GAACT(A/G)AAGTC utr-variant-3-prime
rs8016 -- 56,495,814(-) TGTCA(A/G)TTGCA utr-variant-3-prime
rs9636 -- 56,494,992(+) TATTT(A/T)AAAAA utr-variant-3-prime
rs869934 -- 56,533,721(+) GACAA(C/T)CAAAA intron-variant
rs914830 -- 56,578,658(+) TTAAG(C/T)ACGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PPAP2B Gene

Variant ID Type Subtype PubMed ID
esv259501 OTHER Complex 20981092
esv259976 OTHER Complex 20981092
esv270659 CNV Insertion 20981092

Relevant External Links for PPAP2B Gene

HapMap Linkage Disequilibrium report

Disorders for PPAP2B Gene

(1) Novoseek inferred disease relationships for PPAP2B Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for PPAP2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PPAP2B: view

No data available for UniProtKB/Swiss-Prot for PPAP2B Gene

Publications for PPAP2B Gene

  1. Cloning and characterization of two human isozymes of Mg2+- independent phosphatidic acid phosphatase. (PMID: 9305923) Kai M. … Kanoh H. (J. Biol. Chem. 1997) 2 3 4 23
  2. Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. (PMID: 12660161) Humtsoe J.O. … Wary K.K. (EMBO J. 2003) 3 4 23
  3. Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand. (PMID: 16099422) Humtsoe J.O. … Wary K.K. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Sequential actions of phospholipase D and phosphatidic acid phosphohydrolase 2b generate diglyceride in mammalian cells. (PMID: 10564277) Sciorra V.A. … Morris A.J. (Mol. Biol. Cell 1999) 3 23
  5. Cell surface activities of the human type 2b phosphatidic acid phosphatase. (PMID: 10739957) Ishikawa T. … Kanoh H. (J. Biochem. 2000) 3 23

Products for PPAP2B Gene

Sources for PPAP2B Gene

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