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Aliases for PLPP3 Gene

Aliases for PLPP3 Gene

  • Phospholipid Phosphatase 3 2 3
  • Phosphatidate Phosphohydrolase Type 2b 3 4
  • Phosphatidic Acid Phosphatase Type 2B 2 3
  • EC 3.1.3.4 4 63
  • PPAP2B 3 4
  • PAP2B 3 4
  • LPP3 3 4
  • VCIP 3 4
  • Vascular Endothelial Growth Factor And Type I Collagen-Inducible Protein 4
  • Vascular Endothelial Growth Factor And Type I Collagen Inducible 3
  • Type-2 Phosphatidic Acid Phosphatase-Beta 3
  • Phosphatidic Acid Phosphatase 2b 4
  • PAP2 Beta 3
  • PAP2-Beta 4
  • PAP-2b 4
  • Dri42 3

External Ids for PLPP3 Gene

Previous HGNC Symbols for PLPP3 Gene

  • PPAP2B

Summaries for PLPP3 Gene

Entrez Gene Summary for PLPP3 Gene

  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

GeneCards Summary for PLPP3 Gene

PLPP3 (Phospholipid Phosphatase 3) is a Protein Coding gene. Diseases associated with PLPP3 include childhood oligodendroglioma. Among its related pathways are NF-KappaB Family Pathway and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is PLPPR4.

UniProtKB/Swiss-Prot for PLPP3 Gene

  • Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions

Gene Wiki entry for PLPP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLPP3 Gene

Genomics for PLPP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PLPP3 Gene

Chromosome:
1
Start:
56,494,747 bp from pter
End:
56,645,301 bp from pter
Size:
150,555 bases
Orientation:
Minus strand

Genomic View for PLPP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLPP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLPP3 Gene

No data available for Regulatory Elements for PLPP3 Gene

Proteins for PLPP3 Gene

  • Protein details for PLPP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14495-LPP3_HUMAN
    Recommended name:
    Lipid phosphate phosphohydrolase 3
    Protein Accession:
    O14495
    Secondary Accessions:
    • B2R651
    • D3DQ52
    • Q5U0F7
    • Q96GW0
    • Q99782

    Protein attributes for PLPP3 Gene

    Size:
    311 amino acids
    Molecular mass:
    35116 Da
    Quaternary structure:
    • Homodimer. This complex seems not to be involved in substrate recognition, it may confer only structural or functional stability.
    SequenceCaution:
    • Sequence=AAB50222.1; Type=Frameshift; Positions=225; Evidence={ECO:0000305};

neXtProt entry for PLPP3 Gene

Proteomics data for PLPP3 Gene at MOPED

Selected DME Specific Peptides for PLPP3 Gene

Post-translational modifications for PLPP3 Gene

  • N-glycosylated. Contains high-mannose oligosaccharides
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLPP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PLPP3 Gene

Gene Families for PLPP3 Gene

Protein Domains for PLPP3 Gene

Suggested Antigen Peptide Sequences for PLPP3 Gene

Graphical View of Domain Structure for InterPro Entry

O14495

UniProtKB/Swiss-Prot:

LPP3_HUMAN :
  • Belongs to the PA-phosphatase related phosphoesterase family.
Family:
  • Belongs to the PA-phosphatase related phosphoesterase family.
genes like me logo Genes that share domains with PLPP3: view

Function for PLPP3 Gene

Molecular function for PLPP3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sphingosine, zinc ions and propanolol. Not inhibited by N-ethylmaleimide treatment
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions
UniProtKB/Swiss-Prot Induction:
By EGF, VEGF, FGF2 and phorbol myristate acetate (PMA).

Enzyme Numbers (IUBMB) for PLPP3 Gene

Gene Ontology (GO) - Molecular Function for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004721 phosphoprotein phosphatase activity TAS 9705349
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 20123964
GO:0008195 phosphatidate phosphatase activity IEA --
genes like me logo Genes that share ontologies with PLPP3: view
genes like me logo Genes that share phenotypes with PLPP3: view

Animal Models for PLPP3 Gene

MGI Knock Outs for PLPP3:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for PLPP3 Gene

Localization for PLPP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLPP3 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005912 adherens junction TAS 20123964
genes like me logo Genes that share ontologies with PLPP3: view

No data available for Subcellular locations from COMPARTMENTS for PLPP3 Gene

Pathways & Interactions for PLPP3 Gene

genes like me logo Genes that share pathways with PLPP3: view

Gene Ontology (GO) - Biological Process for PLPP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development IEA --
GO:0001702 gastrulation with mouth forming second IEA --
GO:0001933 negative regulation of protein phosphorylation IDA 20123964
GO:0006470 protein dephosphorylation TAS 9705349
GO:0006629 lipid metabolic process NAS 9705349
genes like me logo Genes that share ontologies with PLPP3: view

No data available for SIGNOR curated interactions for PLPP3 Gene

Drugs & Compounds for PLPP3 Gene

(3) Drugs for PLPP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
sphingosine 1-phosphate Pharma Agonist Endogenous agonist at S1P1-5 0

(37) Additional Compounds for PLPP3 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Cer(d18:1/26:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • Ceramide (d18:1/24:1(15Z))
104404-17-3
Ceramide (d18:1/12:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/16:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/20:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
Ceramide (d18:1/24:0)
  • (2S,3R,4E)-2-acylamino-1,3-octadec-4-enediol
  • (2S,3R,4E)-2-acylaminooctadec-4-ene-1,3-diol
  • Cer
  • Ceramide
  • N-Acylsphingosine
104404-17-3
genes like me logo Genes that share compounds with PLPP3: view

Transcripts for PLPP3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for PLPP3 Gene

No ASD Table

Relevant External Links for PLPP3 Gene

GeneLoc Exon Structure for
PLPP3
ECgene alternative splicing isoforms for
PLPP3

Expression for PLPP3 Gene

mRNA Expression by UniProt/SwissProt for PLPP3 Gene

O14495-LPP3_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in heart and placenta

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for PLPP3 Gene

Orthologs for PLPP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLPP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPAP2B 35
  • 91.94 (n)
  • 95.16 (a)
PPAP2B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PPAP2B 35
  • 93.03 (n)
  • 96.78 (a)
PPAP2B 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppap2b 35
  • 89.17 (n)
  • 94.86 (a)
Ppap2b 16
Ppap2b 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PPAP2B 35
  • 95.81 (n)
  • 94.52 (a)
PPAP2B 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppap2b 35
  • 88.75 (n)
  • 94.86 (a)
oppossum
(Monodelphis domestica)
Mammalia PPAP2B 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPAP2B 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPAP2B 35
  • 79.96 (n)
  • 83.6 (a)
PPAP2B 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPAP2B 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppap2b 35
  • 73.79 (n)
  • 80.26 (a)
Str.15806 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28946 35
ppap2b 35
  • 70 (n)
  • 73.23 (a)
ppap2b 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11425 36
  • 27 (a)
ManyToMany
CG11426 36
  • 29 (a)
ManyToMany
CG11437 36
  • 23 (a)
ManyToMany
CG11438 36
  • 27 (a)
ManyToMany
laza 36
  • 24 (a)
ManyToMany
wun 36
  • 32 (a)
ManyToMany
wun2 36
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F53C3.13 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for PLPP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLPP3 Gene

ENSEMBL:
Gene Tree for PLPP3 (if available)
TreeFam:
Gene Tree for PLPP3 (if available)

Paralogs for PLPP3 Gene

Paralogs for PLPP3 Gene

genes like me logo Genes that share paralogs with PLPP3: view

Variants for PLPP3 Gene

Sequence variations from dbSNP and Humsavar for PLPP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4628 -- 56,496,084(+) GAACT(A/G)AAGTC utr-variant-3-prime
rs8016 -- 56,495,814(-) TGTCA(A/G)TTGCA utr-variant-3-prime
rs9636 -- 56,494,992(+) TATTT(A/T)AAAAA utr-variant-3-prime
rs869934 -- 56,533,721(+) GACAA(C/T)CAAAA intron-variant
rs914830 -- 56,578,658(+) TTAAG(C/T)ACGCC intron-variant

Variation tolerance for PLPP3 Gene

Residual Variation Intolerance Score: 27.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLPP3 Gene

HapMap Linkage Disequilibrium report
PLPP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLPP3 Gene

Disorders for PLPP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLPP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
childhood oligodendroglioma
  • pediatric oligodendroglioma
- elite association
Search PLPP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PLPP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLPP3
genes like me logo Genes that share disorders with PLPP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLPP3 Gene

Publications for PLPP3 Gene

  1. Cloning and characterization of two human isozymes of Mg2+- independent phosphatidic acid phosphatase. (PMID: 9305923) Kai M. … Kanoh H. (J. Biol. Chem. 1997) 2 23 67
  2. Inducible capillary formation in lymphatic endothelial cells by blocking lipid phosphate phosphatase-3 activity. (PMID: 19473074) Senda K. … Saiki I. (Lymphat Res Biol 2009) 23 67
  3. Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function. (PMID: 18215144) Long J.S. … Pyne S. (Biochem. J. 2008) 23 67
  4. Gene expression profiling of human endometrial-trophoblast interaction in a coculture model. (PMID: 16946011) Popovici R.M. … von Wolff M. (Endocrinology 2006) 23 67
  5. Anti-lipid phosphate phosphohydrolase-3 (LPP3) antibody inhibits bFGF- and VEGF-induced capillary morphogenesis of endothelial cells. (PMID: 16076388) Wary K.K. … Humtsoe J.O. (Cell Commun. Signal 2005) 23 67

Products for PLPP3 Gene

Sources for PLPP3 Gene

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