Aliases for KLF7 Gene
External Ids for KLF7 Gene
Previous GeneCards Identifiers for KLF7 Gene
The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for KLF7 Gene
KLF7 (Kruppel-Like Factor 7 (Ubiquitous)) is a Protein Coding gene. Diseases associated with KLF7 include bruxism. Among its related pathways are Adipogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is KLF2.
UniProtKB/Swiss-Prot for KLF7 Gene
Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence