Aliases for CAV2 Gene
External Ids for CAV2 Gene
Previous GeneCards Identifiers for CAV2 Gene
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]
GeneCards Summary for CAV2 Gene
CAV2 (Caveolin 2) is a Protein Coding gene. Diseases associated with CAV2 include Open-Angle Glaucoma and Glaucoma, Primary Open Angle. Among its related pathways are Endocytic Trafficking of EGFR and Endocytosis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and D1 dopamine receptor binding. An important paralog of this gene is CAV1.
UniProtKB/Swiss-Prot for CAV2 Gene
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).