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Aliases for AKR7A2 Gene

Aliases for AKR7A2 Gene

  • Aldo-Keto Reductase Family 7, Member A2 2 3 5
  • Succinic Semialdehyde Reductase 3 4
  • Aflatoxin Aldehyde Reductase 2 3
  • AFB1 Aldehyde Reductase 1 3 4
  • Aldoketoreductase 7 3 4
  • SSA Reductase 3 4
  • AFB1-AR 1 3 4
  • AFAR1 3 4
  • AFAR 3 4
  • AKR7 3 4
  • Aldo-Keto Reductase Family 7, Member A2 (Aflatoxin Aldehyde Reductase) 3
  • Epididymis Secretory Sperm Binding Protein Li 166mP 3
  • Aflatoxin Beta1 Aldehyde Reductase 3
  • EC 1.1.1.n11 4
  • HEL-S-166mP 3
  • AFB1-AR1 3

External Ids for AKR7A2 Gene

Previous GeneCards Identifiers for AKR7A2 Gene

  • GC01M019169
  • GC01M018618
  • GC01M018755
  • GC01M019101
  • GC01M019102
  • GC01M019375
  • GC01M019503
  • GC01M019630
  • GC01M017876

Summaries for AKR7A2 Gene

Entrez Gene Summary for AKR7A2 Gene

  • The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

GeneCards Summary for AKR7A2 Gene

AKR7A2 (Aldo-Keto Reductase Family 7, Member A2) is a Protein Coding gene. Diseases associated with AKR7A2 include pancreatic cystadenoma and intermediate charcot-marie-tooth neuropathy. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include electron carrier activity and phenanthrene-9,10-epoxide hydrolase activity. An important paralog of this gene is KCNAB1.

UniProtKB/Swiss-Prot for AKR7A2 Gene

  • Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Gene Wiki entry for AKR7A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR7A2 Gene

Genomics for AKR7A2 Gene

Regulatory Elements for AKR7A2 Gene

Genomic Location for AKR7A2 Gene

Chromosome:
1
Start:
19,302,708 bp from pter
End:
19,312,146 bp from pter
Size:
9,439 bases
Orientation:
Minus strand

Genomic View for AKR7A2 Gene

Genes around AKR7A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AKR7A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AKR7A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR7A2 Gene

Proteins for AKR7A2 Gene

  • Protein details for AKR7A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43488-ARK72_HUMAN
    Recommended name:
    Aflatoxin B1 aldehyde reductase member 2
    Protein Accession:
    O43488
    Secondary Accessions:
    • O75749
    • Q5TG63

    Protein attributes for AKR7A2 Gene

    Size:
    359 amino acids
    Molecular mass:
    39589 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC52104.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH04111.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10852.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH11586.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12171.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13996.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP36011.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA76347.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB72321.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AKR7A2 Gene

neXtProt entry for AKR7A2 Gene

Proteomics data for AKR7A2 Gene at MOPED

Post-translational modifications for AKR7A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AKR7A2 Gene

Antibody Products

No data available for DME Specific Peptides for AKR7A2 Gene

Domains & Families for AKR7A2 Gene

Gene Families for AKR7A2 Gene

Protein Domains for AKR7A2 Gene

Suggested Antigen Peptide Sequences for AKR7A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43488

UniProtKB/Swiss-Prot:

ARK72_HUMAN :
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Family:
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
genes like me logo Genes that share domains with AKR7A2: view

Function for AKR7A2 Gene

Molecular function for AKR7A2 Gene

GENATLAS Biochemistry:
aldo-ketoreductase 7,homolog of rattus norvegicus gene,expressed in brain,heart,lung,prostate,skeletal,muscle,spleen,testis,stomach,pancreas,kidney,liver,also expressed in renal carcinoma cells,involved in endogenous detoxication pathway,catalyzing the recuction of 2-carboxybenzaldehyde (2-CBA) and related molecules
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=20 uM for succinic semialdehyde {ECO:0000269 PubMed:10510318}; KM=17 uM for 2-carboxybenzaldehyde {ECO:0000269 PubMed:10510318}; KM=8 uM for 9,10-phenanthrenequinone {ECO:0000269 PubMed:10510318}; KM=102 uM for 1,2-naphthoquinone {ECO:0000269 PubMed:10510318};
UniProtKB/Swiss-Prot CatalyticActivity:
4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Enzyme Numbers (IUBMB) for AKR7A2 Gene

genes like me logo Genes that share phenotypes with AKR7A2: view

Animal Model Products

CRISPR Products

miRNA for AKR7A2 Gene

miRTarBase miRNAs that target AKR7A2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AKR7A2 Gene

Localization for AKR7A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR7A2 Gene

Golgi apparatus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKR7A2 Gene COMPARTMENTS Subcellular localization image for AKR7A2 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 4
golgi apparatus 3
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for AKR7A2 Gene

Pathways & Interactions for AKR7A2 Gene

genes like me logo Genes that share pathways with AKR7A2: view

Pathways by source for AKR7A2 Gene

1 KEGG pathway for AKR7A2 Gene
1 GeneGo (Thomson Reuters) pathway for AKR7A2 Gene

Gene Ontology (GO) - Biological Process for AKR7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006081 cellular aldehyde metabolic process TAS 9576847
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with AKR7A2: view

No data available for SIGNOR curated interactions for AKR7A2 Gene

Drugs & Compounds for AKR7A2 Gene

(1) Drugs for AKR7A2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gamma Hydroxybutyric Acid Approved, Illicit Pharma 0

(11) Additional Compounds for AKR7A2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Aflatoxin B1
  • AFB1
  • AFBI
1162-65-8
Aflatoxin B1 dialcohol
  • AFB1 dialcohol
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
Succinic acid semialdehyde
  • 2-Formylpropionic acid ethyl ester
  • 3-Formylpropanoate
  • 3-Formylpropanoic acid
  • 4-Oxobutanoate
  • 4-Oxobutanoic acid
692-29-5
genes like me logo Genes that share compounds with AKR7A2: view

Transcripts for AKR7A2 Gene

Unigene Clusters for AKR7A2 Gene

Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for AKR7A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for AKR7A2 Gene

GeneLoc Exon Structure for
AKR7A2
ECgene alternative splicing isoforms for
AKR7A2

Expression for AKR7A2 Gene

mRNA expression in normal human tissues for AKR7A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for AKR7A2 Gene



SOURCE GeneReport for Unigene cluster for AKR7A2 Gene Hs.571886

mRNA Expression by UniProt/SwissProt for AKR7A2 Gene

O43488-ARK72_HUMAN
Tissue specificity: Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowmans capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.
genes like me logo Genes that share expression patterns with AKR7A2: view

Protein tissue co-expression partners for AKR7A2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for AKR7A2 Gene

Orthologs for AKR7A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR7A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia AKR7A2 35
  • 86.41 (n)
  • 85.75 (a)
-- 36
  • 81 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia AKR7A2 35
  • 87.47 (n)
  • 86.91 (a)
mouse
(Mus musculus)
Mammalia Akr7a5 35
  • 85.98 (n)
  • 88.3 (a)
Akr7a5 16
chimpanzee
(Pan troglodytes)
Mammalia AKR7A2 35
  • 98.89 (n)
  • 98.61 (a)
AKR7A2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Akr7a2 35
  • 86.81 (n)
  • 88.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
chicken
(Gallus gallus)
Aves AKR7A2 35
  • 73.23 (n)
  • 72.19 (a)
-- 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia akr7a2 35
  • 70.23 (n)
  • 70.03 (a)
zebrafish
(Danio rerio)
Actinopterygii akr7a3 35
  • 68.67 (n)
  • 69.62 (a)
wufb48h07 35
akr7a3 36
  • 68 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11179 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for AKR7A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR7A2 Gene

ENSEMBL:
Gene Tree for AKR7A2 (if available)
TreeFam:
Gene Tree for AKR7A2 (if available)

Paralogs for AKR7A2 Gene

Paralogs for AKR7A2 Gene

(2) SIMAP similar genes for AKR7A2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for AKR7A2 Gene

genes like me logo Genes that share paralogs with AKR7A2: view

Variants for AKR7A2 Gene

Sequence variations from dbSNP and Humsavar for AKR7A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1043657 - 19,308,517(-) TACAC(A/C/G)CACCT nc-transcript-variant, reference, missense
rs859208 - 19,308,470(-) TGCCA(C/G)CGGCT nc-transcript-variant, reference, missense
VAR_017415 -
rs6670759 - 19,308,538(+) GTCCA(C/T)TTGGG nc-transcript-variant, reference, missense
rs2231200 - 19,307,410(-) TGCAG(A/G)GCATG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for AKR7A2 Gene

Variant ID Type Subtype PubMed ID
nsv871933 CNV Loss 21882294
nsv871934 CNV Loss 21882294

Variation tolerance for AKR7A2 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.01; 80.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AKR7A2 Gene

HapMap Linkage Disequilibrium report
AKR7A2
Human Gene Mutation Database (HGMD)
AKR7A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR7A2 Gene

Disorders for AKR7A2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for AKR7A2 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for AKR7A2

Genetic Association Database (GAD)
AKR7A2
Human Genome Epidemiology (HuGE) Navigator
AKR7A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AKR7A2
genes like me logo Genes that share disorders with AKR7A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AKR7A2 Gene

Publications for AKR7A2 Gene

  1. Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase. (PMID: 9576847) Ireland L.S. … Hayes J.D. (Biochem. J. 1998) 2 3 4 23 67
  2. Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma. (PMID: 19077459) Cui Y. … Han J. (Pancreatology 2009) 3 23
  3. Genetic variation of aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells. (PMID: 18752886) Praml C. … Henrich K.-O. (Cancer Lett. 2008) 3 23
  4. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells. (PMID: 12879023) Praml C. … Schwab M. (Oncogene 2003) 3 23
  5. Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. (PMID: 12071861) Kelly V.P. … Hayes J.D. (Biochem. J. 2002) 3 23

Products for AKR7A2 Gene

Sources for AKR7A2 Gene

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