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Aliases for AKR7A2 Gene

Aliases for AKR7A2 Gene

  • Aldo-Keto Reductase Family 7, Member A2 (Aflatoxin Aldehyde Reductase) 2 3
  • AFAR 3 4 6
  • AKR7 3 4 6
  • Succinic Semialdehyde Reductase 3 4
  • AFB1 Aldehyde Reductase 1 3 4
  • Aldoketoreductase 7 3 4
  • SSA Reductase 3 4
  • AFB1-AR 1 3 4
  • AFAR1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 166mP 3
  • Aflatoxin B1 Aldehyde Reductase Member 2 3
  • Aflatoxin Beta1 Aldehyde Reductase 3
  • EC 1.1.1.n11 4
  • HEL-S-166mP 3
  • AFB1-AR1 3

External Ids for AKR7A2 Gene

Previous GeneCards Identifiers for AKR7A2 Gene

  • GC01M019169
  • GC01M018618
  • GC01M018755
  • GC01M019101
  • GC01M019102
  • GC01M019375
  • GC01M019503
  • GC01M019630
  • GC01M017876

Summaries for AKR7A2 Gene

Entrez Gene Summary for AKR7A2 Gene

  • The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. [provided by RefSeq, Oct 2011]

GeneCards Summary for AKR7A2 Gene

AKR7A2 (Aldo-Keto Reductase Family 7, Member A2 (Aflatoxin Aldehyde Reductase)) is a Protein Coding gene. Diseases associated with AKR7A2 include succinic semialdehyde dehydrogenase deficiency and urinary schistosomiasis. Among its related pathways are Biological oxidations and Naphthalene metabolism. GO annotations related to this gene include electron carrier activity and phenanthrene-9,10-epoxide hydrolase activity. An important paralog of this gene is KCNAB2.

UniProtKB/Swiss-Prot for AKR7A2 Gene

  • Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Gene Wiki entry for AKR7A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKR7A2 Gene

Genomics for AKR7A2 Gene

Regulatory Elements for AKR7A2 Gene

Genomic Location for AKR7A2 Gene

Start:
19,302,708 bp from pter
End:
19,312,146 bp from pter
Size:
9,439 bases
Orientation:
Minus strand

Genomic View for AKR7A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKR7A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKR7A2 Gene

Proteins for AKR7A2 Gene

  • Protein details for AKR7A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43488-ARK72_HUMAN
    Recommended name:
    Aflatoxin B1 aldehyde reductase member 2
    Protein Accession:
    O43488
    Secondary Accessions:
    • O75749
    • Q5TG63

    Protein attributes for AKR7A2 Gene

    Size:
    359 amino acids
    Molecular mass:
    39589 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC52104.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH04111.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH10852.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH11586.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12171.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH13996.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP36011.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA76347.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB72321.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for AKR7A2 Gene

neXtProt entry for AKR7A2 Gene

Proteomics data for AKR7A2 Gene at MOPED

Post-translational modifications for AKR7A2 Gene

  • Ubiquitination at Lys236
  • Modification sites at PhosphoSitePlus

Other Protein References for AKR7A2 Gene

No data available for DME Specific Peptides for AKR7A2 Gene

Domains for AKR7A2 Gene

Gene Families for AKR7A2 Gene

HGNC:
  • AKR :Aldo-keto reductases

Protein Domains for AKR7A2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for AKR7A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43488

UniProtKB/Swiss-Prot:

ARK72_HUMAN :
  • O43488
Family:
  • Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
genes like me logo Genes that share domains with AKR7A2: view

Function for AKR7A2 Gene

Molecular function for AKR7A2 Gene

GENATLAS Biochemistry: aldo-ketoreductase 7,homolog of rattus norvegicus gene,expressed in brain,heart,lung,prostate,skeletal,muscle,spleen,testis,stomach,pancreas,kidney,liver,also expressed in renal carcinoma cells,involved in endogenous detoxication pathway,catalyzing the recuction of 2-carboxybenzaldehyde (2-CBA) and related molecules
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=20 uM for succinic semialdehyde {ECO:0000269 PubMed:10510318}; KM=17 uM for 2-carboxybenzaldehyde {ECO:0000269 PubMed:10510318}; KM=8 uM for 9,10-phenanthrenequinone {ECO:0000269 PubMed:10510318}; KM=102 uM for 1,2-naphthoquinone {ECO:0000269 PubMed:10510318};
UniProtKB/Swiss-Prot CatalyticActivity: 4-hydroxybutanoate + NADP(+) = succinate semialdehyde + NADPH.
UniProtKB/Swiss-Prot Function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.

Enzyme Numbers (IUBMB) for AKR7A2 Gene

Gene Ontology (GO) - Molecular Function for AKR7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004032 alditol:NADP+ 1-oxidoreductase activity IEA --
GO:0009055 electron carrier activity TAS 9576847
GO:0019119 phenanthrene-9,10-epoxide hydrolase activity IDA 20837989
genes like me logo Genes that share ontologies with AKR7A2: view

Phenotypes for AKR7A2 Gene

GenomeRNAi human phenotypes for AKR7A2:
genes like me logo Genes that share phenotypes with AKR7A2: view

miRNA for AKR7A2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for AKR7A2 Gene

Localization for AKR7A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKR7A2 Gene

Golgi apparatus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKR7A2 Gene COMPARTMENTS Subcellular localization image for AKR7A2 gene
Compartment Confidence
cytosol 2
golgi apparatus 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for AKR7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with AKR7A2: view

Pathways for AKR7A2 Gene

genes like me logo Genes that share pathways with AKR7A2: view

Pathways by source for AKR7A2 Gene

2 BioSystems pathways for AKR7A2 Gene
1 KEGG pathway for AKR7A2 Gene
1 GeneGo (Thomson Reuters) pathway for AKR7A2 Gene

Gene Ontology (GO) - Biological Process for AKR7A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 9576847
GO:0006081 cellular aldehyde metabolic process TAS 9576847
GO:0006805 xenobiotic metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0044597 daunorubicin metabolic process IMP 20837989
genes like me logo Genes that share ontologies with AKR7A2: view

Compounds for AKR7A2 Gene

(2) HMDB Compounds for AKR7A2 Gene

Compound Synonyms Cas Number PubMed IDs
Aflatoxin B1
  • AFB1
1162-65-8
Aflatoxin B1 dialcohol
  • AFB1 dialcohol
Not Available

(7) Novoseek inferred chemical compound relationships for AKR7A2 Gene

Compound -log(P) Hits PubMed IDs
2-carboxybenzaldehyde 95.8 2
succinic semialdehyde 89.8 4
9,10-phenanthrenequinone 81.3 1
gamma-hydroxybutyrate 79.8 2
aflatoxin b1 75.1 6
genes like me logo Genes that share compounds with AKR7A2: view

Transcripts for AKR7A2 Gene

Unigene Clusters for AKR7A2 Gene

Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKR7A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -

Relevant External Links for AKR7A2 Gene

GeneLoc Exon Structure for
AKR7A2
ECgene alternative splicing isoforms for
AKR7A2

Expression for AKR7A2 Gene

mRNA expression in normal human tissues for AKR7A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKR7A2 Gene

SOURCE GeneReport for Unigene cluster for AKR7A2 Gene Hs.571886

mRNA Expression by UniProt/SwissProt for AKR7A2 Gene

O43488-ARK72_HUMAN
Tissue specificity: Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowmans capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.
genes like me logo Genes that share expressions with AKR7A2: view

No data available for mRNA differential expression in normal tissues for AKR7A2 Gene

Orthologs for AKR7A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AKR7A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKR7A2 35
  • 98.89 (n)
  • 98.61 (a)
AKR7A2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 81 (a)
ManyToMany
AKR7A2 35
  • 86.41 (n)
  • 85.75 (a)
dog
(Canis familiaris)
Mammalia AKR7A2 35
  • 87.47 (n)
  • 86.91 (a)
mouse
(Mus musculus)
Mammalia Akr7a5 35
  • 85.98 (n)
  • 88.3 (a)
Akr7a5 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Akr7a2 35
  • 86.81 (n)
  • 88.39 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 64 (a)
OneToMany
AKR7A2 35
  • 73.23 (n)
  • 72.19 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia akr7a2 35
  • 70.23 (n)
  • 70.03 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11179 35
zebrafish
(Danio rerio)
Actinopterygii akr7a3 35
  • 68.67 (n)
  • 69.62 (a)
akr7a3 36
  • 68 (a)
OneToMany
wufb48h07 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for AKR7A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AKR7A2 Gene

ENSEMBL:
Gene Tree for AKR7A2 (if available)
TreeFam:
Gene Tree for AKR7A2 (if available)

Paralogs for AKR7A2 Gene

Paralogs for AKR7A2 Gene

Selected SIMAP similar genes for AKR7A2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for AKR7A2 Gene

genes like me logo Genes that share paralogs with AKR7A2: view

Variants for AKR7A2 Gene

Sequence variations from dbSNP and Humsavar for AKR7A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs859208 - 19,308,470(-) TGCCA(C/G)CGGCT missense, reference
rs859209 -- 19,308,289(-) ACTGC(A/G)TTCTG intron-variant
rs859210 - 19,308,211(-) TGGCC(A/G)AGATC missense, reference
rs859211 -- 19,307,801(-) CAGTC(C/T)CCAAA intron-variant
rs859212 -- 19,304,537(-) GGTAC(A/T)GCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AKR7A2 Gene

Variant ID Type Subtype PubMed ID
nsv871933 CNV Loss 21882294
nsv871934 CNV Loss 21882294

Relevant External Links for AKR7A2 Gene

HapMap Linkage Disequilibrium report
AKR7A2
Human Gene Mutation Database (HGMD)
AKR7A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AKR7A2 Gene

Disorders for AKR7A2 Gene

(2) University of Copenhagen DISEASES for AKR7A2 Gene

(1) Novoseek inferred disease relationships for AKR7A2 Gene

Disease -log(P) Hits PubMed IDs
cancer 1.01 1

Relevant External Links for AKR7A2

Genetic Association Database (GAD)
AKR7A2
Human Genome Epidemiology (HuGE) Navigator
AKR7A2
genes like me logo Genes that share disorders with AKR7A2: view

No data available for UniProtKB/Swiss-Prot for AKR7A2 Gene

Publications for AKR7A2 Gene

  1. Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase. (PMID: 9576847) Ireland L.S. … Hayes J.D. (Biochem. J. 1998) 2 3 4 23
  2. Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35- 1p36.1 in a region frequently altered in human tumor cells. (PMID: 9823300) Praml C. … Schwab M. (Cancer Res. 1998) 3 4 23
  3. Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins. (PMID: 12071861) Kelly V.P. … Hayes J.D. (Biochem. J. 2002) 3 4 23
  4. Genetic variation of aflatoxin B1 aldehyde reductase genes (AFAR) in human tumour cells. (PMID: 18752886) Praml C. … Henrich K.-O. (Cancer Lett. 2008) 3 4 23
  5. Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma. (PMID: 19077459) Cui Y. … Han J. (Pancreatology 2009) 3 23

Products for AKR7A2 Gene

Sources for AKR7A2 Gene

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