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Aliases for YARS Gene

Aliases for YARS Gene

  • Tyrosyl-TRNA Synthetase 2 3 4 5
  • EC 6.1.1.1 4 63
  • TYRRS 3 4
  • Tyrosyl-TRNA Synthetase, Cytoplasmic 3
  • Tyrosine TRNA Ligase 1, Cytoplasmic 3
  • Tyrosine TRNA Ligase 1 2
  • Tyrosyl--TRNA Ligase 3
  • Cytoplasmic 2
  • EC 6.1.1 63
  • CMTDIC 3
  • YRS 3
  • YTS 3

External Ids for YARS Gene

Previous GeneCards Identifiers for YARS Gene

  • GC01M033060
  • GC01M032195
  • GC01M032667
  • GC01M032909
  • GC01M033013
  • GC01M033240
  • GC01M031356

Summaries for YARS Gene

Entrez Gene Summary for YARS Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

GeneCards Summary for YARS Gene

YARS (Tyrosyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with YARS include charcot-marie-tooth disease, dominant intermediate c and autosomal dominant intermediate charcot-marie-tooth disease type c. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include poly(A) RNA binding and signal transducer activity.

UniProtKB/Swiss-Prot for YARS Gene

  • Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Gene Wiki entry for YARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for YARS Gene

Genomics for YARS Gene

Regulatory Elements for YARS Gene

Promoters for YARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around YARS on UCSC Golden Path with GeneCards custom track

Genomic Location for YARS Gene

Chromosome:
1
Start:
32,775,237 bp from pter
End:
32,818,153 bp from pter
Size:
42,917 bases
Orientation:
Minus strand

Genomic View for YARS Gene

Genes around YARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
YARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for YARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for YARS Gene

Proteins for YARS Gene

  • Protein details for YARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54577-SYYC_HUMAN
    Recommended name:
    Tyrosine--tRNA ligase, cytoplasmic
    Protein Accession:
    P54577
    Secondary Accessions:
    • B3KWK4
    • D3DPQ4
    • O43276
    • Q53EN1

    Protein attributes for YARS Gene

    Size:
    528 amino acids
    Molecular mass:
    59143 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB39406.1; Type=Frameshift; Positions=354; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for YARS Gene

neXtProt entry for YARS Gene

Proteomics data for YARS Gene at MOPED

Post-translational modifications for YARS Gene

  • Ubiquitination at Lys 119, Lys 147, Lys 206, and Lys 513
  • Modification sites at PhosphoSitePlus

Other Protein References for YARS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for YARS Gene

Gene Families for YARS Gene

Suggested Antigen Peptide Sequences for YARS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P54577

UniProtKB/Swiss-Prot:

SYYC_HUMAN :
  • Contains 1 tRNA-binding domain.
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
Domain:
  • Contains 1 tRNA-binding domain.
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with YARS: view

Function for YARS Gene

Molecular function for YARS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
UniProtKB/Swiss-Prot Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).

Enzyme Numbers (IUBMB) for YARS Gene

Gene Ontology (GO) - Molecular Function for YARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004831 tyrosine-tRNA ligase activity IEA,TAS --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with YARS: view
genes like me logo Genes that share phenotypes with YARS: view

Human Phenotype Ontology for YARS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for YARS Gene

MGI Knock Outs for YARS:
  • Yars tm1b(KOMP)Wtsi

Animal Model Products

miRNA for YARS Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for YARS Gene

Localization for YARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for YARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for YARS Gene COMPARTMENTS Subcellular localization image for YARS gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 4
cytoskeleton 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for YARS Gene

Pathways & Interactions for YARS Gene

genes like me logo Genes that share pathways with YARS: view

Pathways by source for YARS Gene

1 KEGG pathway for YARS Gene
1 GeneGo (Thomson Reuters) pathway for YARS Gene

Gene Ontology (GO) - Biological Process for YARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 10102815
genes like me logo Genes that share ontologies with YARS: view

No data available for SIGNOR curated interactions for YARS Gene

Drugs & Compounds for YARS Gene

(13) Drugs for YARS Gene - From: HMDB, Novoseek, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Tyrosine Approved Nutra Target 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE Experimental Pharma Target 0
Beta-(2-Naphthyl)-Alanine Experimental Pharma Target 0

(7) Additional Compounds for YARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with YARS: view

Transcripts for YARS Gene

mRNA/cDNA for YARS Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for YARS Gene

Tyrosyl-tRNA synthetase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for YARS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - - - - -
SP2: -
SP3:
SP4:
SP5: - -
SP6:

Relevant External Links for YARS Gene

GeneLoc Exon Structure for
YARS
ECgene alternative splicing isoforms for
YARS

Expression for YARS Gene

mRNA expression in normal human tissues for YARS Gene

Protein differential expression in normal tissues from HIPED for YARS Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for YARS Gene



SOURCE GeneReport for Unigene cluster for YARS Gene Hs.213264

genes like me logo Genes that share expression patterns with YARS: view

Protein tissue co-expression partners for YARS Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for YARS Gene

Orthologs for YARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for YARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YARS 36
  • 100 (a)
OneToOne
YARS 35
  • 99.68 (n)
  • 99.81 (a)
cow
(Bos Taurus)
Mammalia YARS 36
  • 95 (a)
OneToOne
YARS 35
  • 91.35 (n)
  • 94.32 (a)
dog
(Canis familiaris)
Mammalia YARS 35
  • 92.11 (n)
  • 95.64 (a)
YARS 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Yars 36
  • 97 (a)
OneToOne
Yars 35
  • 89.52 (n)
  • 96.59 (a)
Yars 16
oppossum
(Monodelphis domestica)
Mammalia YARS 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia YARS 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Yars 35
  • 89.27 (n)
  • 95.08 (a)
chicken
(Gallus gallus)
Aves YARS 35
  • 78.12 (n)
  • 87.29 (a)
YARS 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia YARS 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4835 35
yars 35
  • 73.42 (n)
  • 79.55 (a)
zebrafish
(Danio rerio)
Actinopterygii yars 36
  • 82 (a)
OneToOne
yars 35
  • 73.93 (n)
  • 82.01 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003003 35
  • 61.9 (n)
  • 62.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4561 37
  • 67 (a)
Aats-tyr 35
  • 65.61 (n)
  • 69.7 (a)
Aats-tyr 36
  • 67 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y105E8A.19 36
  • 32 (a)
OneToOne
Y105E8A.19 37
  • 68 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL148W 35
  • 60.62 (n)
  • 59.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TYS1 35
  • 59.84 (n)
  • 58.48 (a)
TYS1 36
  • 51 (a)
OneToOne
TYS1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15389g 35
  • 57.7 (n)
  • 56.3 (a)
corn
(Zea mays)
Liliopsida Zm.4638 35
rice
(Oryza sativa)
Liliopsida Os04g0303900 35
  • 53.73 (n)
  • 45.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07755 35
  • 54.24 (n)
  • 50.91 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes yrs1 35
  • 57.32 (n)
  • 56.37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10401 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1744 36
  • 66 (a)
OneToOne
Species with no ortholog for YARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for YARS Gene

ENSEMBL:
Gene Tree for YARS (if available)
TreeFam:
Gene Tree for YARS (if available)

Paralogs for YARS Gene

No data available for Paralogs for YARS Gene

Variants for YARS Gene

Sequence variations from dbSNP and Humsavar for YARS Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_026681 Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC)
rs2128600 - 32,806,482(-) CTGCA(G/T)GTACT reference, missense, utr-variant-5-prime
VAR_026684 Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC)
VAR_073292 -
rs699003 -- 32,783,405(-) tgagc(C/T)cagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for YARS Gene

Variant ID Type Subtype PubMed ID
nsv519188 CNV Loss 19592680
nsv509158 CNV Insertion 20534489
nsv322 CNV Loss 18451855

Variation tolerance for YARS Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for YARS Gene

HapMap Linkage Disequilibrium report
YARS
Human Gene Mutation Database (HGMD)
YARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for YARS Gene

Disorders for YARS Gene

MalaCards: The human disease database

(14) MalaCards diseases for YARS Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, dominant intermediate c
  • cmtdic
autosomal dominant intermediate charcot-marie-tooth disease type c
  • charcot-marie-tooth disease, dominant intermediate c
myopathy, lactic acidosis, and sideroblastic anemia 2
  • mlasa2
charcot-marie-tooth disease, axonal, type 2s
  • autosomal recessive axonal charcot-marie-tooth disease type 2
gastric leiomyosarcoma
  • leiomyosarcoma of stomach
- elite association - COSMIC cancer census association via MalaCards
Search YARS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYYC_HUMAN
  • Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC) [MIM:608323]: A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type C is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. {ECO:0000269 PubMed:16429158}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for YARS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
YARS
genes like me logo Genes that share disorders with YARS: view

No data available for Genatlas for YARS Gene

Publications for YARS Gene

  1. Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. (PMID: 9162081) Kleeman T.A. … First E.A. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Tyrosyl-tRNA synthetase: the first crystallization of a human mitochondrial aminoacyl-tRNA synthetase. (PMID: 17401211) Bonnefond L. … Sauter C. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2007) 23 25 26
  3. Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase. (PMID: 19477417) Kapoor M. … Yang X.L. (Chem. Biol. 2009) 3 23
  4. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. (PMID: 19561293) Storkebaum E. … Jordanova A. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  5. Gain-of-function mutational activation of human tRNA synthetase procytokine. (PMID: 18096501) Yang X.L. … Schimmel P. (Chem. Biol. 2007) 3 23

Products for YARS Gene

Sources for YARS Gene

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